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[Prediction of continence in patients with neurogenic bladder who will be treated with bladder augmentation].

Twenty four patient with neurogenic bladder undergoing vesical enlargement were pre-operatively evaluated to determine the need to perform also an anti-incontinence technique. None of them had such a technique performed, so as to control whether our prediction was correct. Each patient had one or more video-urodynamic studies performed to evaluate adjustment and the likely vesical hyperreflexia, critical incontinence pressure, and the presence of leaks with cough and cervicourethral morphology at different filling times. Critical incontinence pressure and presence of contrast leaks with cough, the latter demanded with moderate intravesical pressures, have been the parameters which better predicted the likely incontinence, with reliability over 90%. With regard to myelodysplastic bladders, the study shows the relevance of the detrusor as a cause of incontinence and sustains the practice of implementing only the cervical cuff without the remaining components when the artificial sphincter is chosen as the anti-incontinence technique, when the likely cause, whether sphincter or detrusor, is unclear at the time of considering vesical enlargement.

Adolescent↗

Herniated disk: an obscure cause of neurogenic bladder in males.

A case of neurogenic bladder caused by asymptomatic protruding lumbar disc has been reported in the male. The diagnosis was established by Lapides supersensitivity cystometrogram study. After lumbar laminectomy, the bladder function returned to normal.

Adult↗

[Urodynamic diagnosis and treatment in neurogenic bladder dysfunction].

A group of 55 patients (28M,27F) with neurogenic bladder dysfunction was studied. Patient age ranged from 1m. to 20 years (mean age 9.1 years). Most of the patients had neurogenic bladder secondary myelomeningocele (70%). The urodynamic investigations demonstrated detrusor hyperreflexia in 50 (poor compliance in 28p) detrusor arreflexia in 3 and normal bladder in 2. Six patients hadn't incontinence and didn't need treatment. The rest (49p), couldn't be dry more than 2 hours. After treatment (anticholinergic, alpha adrenergic agonist, alpha-betha adrenergic agonist, I. C. and bladder augmentation), the continence was improved satisfactorily in 38 patients (77.5%). In conclusión, we think that early treatment from neonatal period, supported with urodynamic studies may prevent lon-term renal damage and most patients with neurogenic bladder do not require surgical intervention to improve continence because it can be controlled satisfactorily by other means.

Adolescent↗

[Urodynamic diagnosis and treatment of neurogenic bladder dysfunction].

A group of 55 patients (28M, 27F) with neurogenic bladder dysfunction was studied. Patient age ranged from 1m. to 20 years (mean age 9.1 years). Most of the patients had neurogenic bladder secondary myelomeningocele (70%). The urodynamic investigations demonstrated detrusor hyperreflexia in 50 (poor compliance in 28p) detrusor areflexia in 3 and normal bladder in 2. Six patients hadn't incontinence and didn't need treatment. The rest (49p), couldn't be dry more than 2 hours. After treatment (anticholinergic, alpha adrenergic agonist, alpha-beta adrenergic agonist, I. C. and bladder augmentation), the continence was improved satisfactorily in 38 patients (77.5%). In conclusion, we think that early treatment from neonatal period, supported with urodynamic studies may prevent long-term renal damage and most patients with neurogenic bladder do not require surgical intervention to improve continence because it can be controlled satisfactorily by other means.

Adolescent↗

Long-term analysis of suprapubic cystostomy drainage in patients with neurogenic bladder.

OBJECTIVE: We assessed the roles of suprapubic cystostomy in patients with neurogenic bladder and analyzed the complications and their courses. PATIENTS AND METHODS: We reviewed 118 patients with neurogenic bladder managed with suprapubic cystostomy. The original diseases were spinal cord injury in 90, degenerative disease of the central nervous system in 15, spina bifida in 6, cerebral palsy in 3, pontine bleeding in 1, Parkinson's disease in 1, brain tumor in 1, and dysgenesis of the external sphincter in 1. Fifty-six (62.2%) of spinal cord-injured patients demonstrated cervical damage. Renal function, urinary pH and white blood cell values were measured and evaluated after insertion. The stone-free rate after insertion was estimated by the Kaplan-Meier method. RESULTS: Indications for cystostomy were failure of clean intermittent catheterization in 62 (52.5%) and Credé's maneuver in 2, severe urethral damage in 30 (25.4%), replacement of urethral catheter in 3, worsening of the original disease in 15 (12.7%), deterioration of the general condition in 2, mental retardation in 2, and traumatic vesical rupture in 1. Frequent complications were formation of the bladder calculi in 30 (25%) and urinary leakage through the urethra in 11 (10%). No fatal complications occurred. The stone-free rates 5 and 10 years after insertion were 77 and 64%, respectively. The urinary pH of the stone-forming group was significantly higher than that of the stone-free group. The high urinary pH group (>7.24) had a higher risk of stone formation. CONCLUSIONS: Although continuous cystostomy drainage is not considered to be ideal management for bladder emptying, some patients with neurogenic bladder may benefit from this procedure.

Adult↗

[Renal transplantation in patients with neurogenic bladder].

BACKGROUND: Renal transplantation can be done in patients with neurogenic bladder and clean intermittent self catheterization maintains renal function AIM: To retrospective assess the results of renal transplantation in patients with neurogenic bladder. PATIENTS AND METHODS: The medical records of seven patients aged 10 to 22 years old (3 female) followed during 7 to 32 months were reviewed. All patients had urinary tract infection, prior to transplantation, were instructed on self catheterization and received tri-associated immunosuppression. RESULTS: Grafts came from alive related donors in 5 patients and from cadavers in two. Prior to transplantation, three patients were subjected to nephrectomy and three to bladder enlargement, leaving a pigtail catheter. After transplantation, one lymphocele was drained, one uretherostomy due to an impacted lithiasis and one nephrectomy plus vesical enlargement due to intravesical pressures over 40 cm H2O, were done. One uretheral stricture was treated with dilatation. Seven episodes of pyelonephritis, 19 urinary tract infections and 77 asymptomatic bacteriurias were documented. Serum creatinine at the end of follow up ranged from 0.7 to 2.1 mg/dl. There were 0.7 acute rejection episodes per patient and all grafts survived. CONCLUSIONS: Renal transplantation in patients with neurogenic bladder is feasible, performing a vesical enlargement. There is however a high frequency of infectious episodes.

Acute Disease↗

[The urethrogram in children with neurogenic bladder dysfunction (author's transl)].

Various types of neurogenic bladder dysfunction in children show characteristic changes on micturating cystograms. The reflex bladder shows a short area of narrowing of the urethra at the pelvic floor; the autonomous bladder, during voiding by straining or Credé shows an elongated and deformed urethra, which is narrowed at the pelvic floor and which, because of the low position of the bladder, is angled. Both spastic and paretic pelvic floor in association with neurogenically determined abnormalities of bladder emptying may result in functional obstruction of the urethra. This, like any other stenosis, leads to morphological changes, first in the lower, but subsequently in the upper urinary tract. Children with neurogenic bladder dysfunction occasionally have micturating cystograms which resemble the appearances of urethral valves. The occurrence of so-called occult neurogenic bladders is mentioned and the difficulties in diagnosis associated with this condition are stressed.

Adolescent↗

Symptomatic neurogenic bladder in a cerebral-palsied population.

This study reports the incidence of symptomatic neurogenic bladders in a cerebral-palsied population. Of the 50 patients screened, 13 underwent routine urological assessment, including cystometrograms. Four were found to have a neurogenic bladder. 18 of the total population had one or more symptoms indicative of a neurogenic bladder: enuresis, stress incontinence and dribbling. The authors speculate that a continuum of the disorder exists. Preliminary follow-up revealed a significant response to medication in symptomatic patients, both with and without demonstrable neurogenic bladders.

Adolescent↗

Renal transplantation in children with occult neurogenic bladders drained by intermittent self catheterisation.

Children with neurogenic bladders have usually not been considered for renal transplantation because of the potential complications caused by chronic infections of the urinary tract. Two girls with occult neurogenic bladders who were practising intermittent self catheterisation were given renal transplants. Both took prophylactic antibacterial agents after transplantation, and both experienced infections at some stage, but none of these infections produced a deterioration in renal function. In one patient creatinine clearance fell and signs of obstruction appeared, but this was because the patient had been catheterising herself only two or three times a week. When she resumed catheterisation four times a day creatinine clearance rose and the urographic and renographic appearances returned to normal. These results suggest that, with adequate catheterisation and urinary chemoprophylaxis, infection is not a particular problem in children with bladder dysfunction who undergo renal transplantation.

Child↗

[Perivesical abscess associated with neurogenic bladders: report of two cases].

We report two cases of perivesical abscess associated with neurogenic bladders. One patient suffered from diabetic neurogenic bladder, and the other spinal cord injury. Both patients had an uninhibited contraction at the low capacity on cystometry. They complained of difficulty in micturition and presented with large lower abdominal tumors. Although the extravasation of contrast medium was not confirmed on cystography, we believe that the perivesical abscess was the consequence of urinary leakage out of the bladder. The abscesses disappeared after drainage. We have discussed the possible mechanism involved in the abscess formation which occurred in the neurogenic bladders.

Abscess↗

Response of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2.

The in vitro pharmacological responses of the human neurogenic bladder to KCl, carbachol, ATP and CaCl2 have been analysed. The contractility (contractile strength and ED50) of neurogenic bladders was significantly increased when treated with carbachol, ATP and CaCl2. In contrast, there was no apparent difference in the responsiveness of neurogenic bladders when treated with KCl. There was no apparent correlation between pharmacological responsiveness and clinical parameters, such as gender, age or cystometric data, in the neurogenic bladders.

Adenosine Triphosphate↗

[Trans-appendicular continent cystostomy in the management of the neurogenic bladder].

The comfort obtained in some cases of neurogenic bladder of the girl, thanks to unsterile self catheterization, and usual absence of septic complications, incite to search for a process which could be used for the boys as well as girls in those cases where urethral catheterization cannot be done. What's more, if the catheterization is easy to achieve even by young children and if the process brings complete dryness, almost perfect conditions of comfort would be achieved. A cystostomy with a continent opening easy to catheterize and associated with a closure of the vesical neck, was the objective. We had the idea to use the appendix in order to create a passage between the skin and the bladder, the tip of the appendix opening into the bladder at the end of an anti-reflux submucosal tunnel and the other end hemmed to the skin. The bladder neck is usually closed in the course of the same operation. From October 1976 to January 1979, 16 children have gone through such a vesicostomy. In two more cases a trans-ureteral cystostomy was created. Five cases were a failure owing to a too small bladder and required a cutaneous diversion. The continence of the vesicostomy is total and the comfort obtained is excellent for the other 13 cases. Some complications result directly from this technique. It concerns more particularly cutaneous fistula (1 case) or with urethral repermeation (2 cases). Other problems, common to all conservative treatments of a neurogenic bladder, are discussed:vesico-renal reflux, dilatation of the upper urinary tract, urinary infections and of course, risk for the renal function. They appear to be related with a small and hypertonic bladder. Obviously these problems must be kept in mind and require a strict selection for the vesicostomy and a strict followup.

Adolescent↗

Antireflux in patients with neurogenic bladder.

The results of ureteral reimplantation in 8 neurogenic bladders with a high outflow resistance and severe trabeculation are presented. Operation was successful in all cases. The conditions for a successful intervention in these cases are: (1) previous or simultaneous treatment of the high outflow resistance: intermittent catheterization was found to be an excellent method for this purpose, and (2) the submucosal tunnel should be created preferably upon the trigone which is the only place free of trabeculation. High outflow resistance and severe trabeculation should no longer be considered as contraindications for antireflux surgery in the neurogenic bladder.

Adolescent↗

Augmentation ileocystoplasty in patients with neurogenic bladder due to spinal cord injury or spina bifida.

STUDY DESIGN: Retrospective analysis of augmentation ileocystoplasty for neurogenic bladder. OBJECTIVES: To analyze the effects and complications of augmentation ileocystoplasty in patients with neurogenic bladder due to spinal cord injury (SCI) or spina bifida retrospectively. SETTING: Department of Urology, Kanagawa Rehabilitation Hospital, Japan. METHODS: We have treated 11 patients with neurogenic bladder due to SCI and 10 patients with spinal bifida with augmentation ileocystoplasty since 1989. The purpose of the treatment was to stop vesicoureteral reflux (VUR) and/or amelioration of urinary incontinence. In 17 of 21 cases, the antireflux operation was received simultaneously. All cases performed clean intermittent self catheterization postoperatively. RESULTS: Urinary incontinence improved in all cases and only transient recurrence of VUR was observed in the follow-up term. Complications occurred in patients with SCI, but they could be treated conservatively. CONCLUSION: Augmentation ileocystoplasty is a good treatment option for contracted bladder or VUR, which occurs in patients with neurogenic bladder.

Adult↗

Concentric folds in the bladder: a new sign of chronic outlet obstruction and neurogenic bladder.

The finding of concentric folds in the bladder on excretory urography is a hitherto unreported but reliable sign of chronic urinary retention, usually due to outlet obstruction or neurogenic bladder. In a study of 152 consecutive patients with urinary retention, the presence of typical concentric folds alone was found to be as common and, therefore, as sensitive an indicator as trabeculation. The sign is useful in evaluating the significance of the incompletely emptied bladder on the post-void film, and in detecting unsuspected disease. A false-positive rate of 1.5% was found in a control series of 190 women, and no false-positive findings were seen in 214 men concurrently studied. A hypothesis concerning the mechanism of concentric fold formation is advanced.

Chronic Disease↗

Urethral dilation as treatment for neurogenic bladder.

PURPOSE: We documented the change in bladder physiology and clinical outcomes after urethral dilation for managing neurogenic bladder. MATERIALS AND METHODS: Female patients with neurogenic bladder were identified who underwent urethral dilation due to failure to empty at low pressure or upper tract changes. Urethral dilation was performed using curved sounds to 36Fr (range 18Fr to 36Fr). Clinical charts were reviewed to document urodynamics, infection rates, symptomatology, vesicoureteral reflux and upper tract dilatation before and after dilation. RESULTS: A total of 19 children underwent urethral dilation a mean of 2 times. Mean age at first dilation was 19.3 months. Mean followup was 34.9 months. The indication for dilation was high detrusor leak point pressure in 16 children. The remaining children had recurrent infections (1), poor compliance (1) and bladder spasms (1). Clinical manifestations of increased detrusor leak point pressure in 16 children were vesicoureteral reflux in 11, upper tract dilatation in 9 and recurrent infections in 3. Long-standing improvement occurred in 12 of 16 patients with increased detrusor leak point pressure, in 0 of 1 with infection, in 0 of 1 with poor compliance and in 1 of 1 with bladder spasms. Overall improvement was noted in 13 of 19 cases (68%). Vesicoureteral reflux was identified in 14 of 19 patients. Improvement was seen in 6 of 14 cases, including complete resolution in 5 and improvement in 1. Hydronephrosis was seen in 11 of 19 patients with improvement in 7, including resolution in 1 and improvement in 6. Only 6 children required further surgical intervention, that is vesicostomy in 2 and reimplantation in 4. CONCLUSIONS: Urethral dilation is effective for lowering detrusor leak point pressure in children with neurogenic bladder and for improving upper tract dilatation and vesicoureteral reflux. This procedure may prevent the need for more complicated surgical intervention. It should be investigated further in well designed, prospective studies.

Child, Preschool↗

[Neurogenic bladder: pathophysiology of the disorder of compliance].

Bladder compliance is defined by the ratio of the increase of intravesical pressures to the increase of volume (_V/_P). The pathophysiology of disorders of compliance in neurogenic bladder is still poorly elucidated. It can be evaluated in terms of three elements: 1) The natural history of the appearance of these disorders in neurogenic bladders. Clinical experience shows the existence of prognostic factors that determine the development of these disorders, such as the voiding mode adopted (self-catheterization/hetero-catheterization versus indwelling catheter), the level of the spinal cord lesion (suprasacral versus sacral, incomplete versus complete, and cauda equina lesions), and the presence of meningomyelocele. 2). Data derived from conservative management of these disorders in neurogenic bladders: urethral dilatation, various sphincterotomies, bladder disafferentation, alpha-blockers, vanilloids (resiniferatoxin and capsaicin), intra-detrusor botulinum toxin and intrathecal baclofen, have demonstrated a marked improvement of disorders of compliance associated with neurogenic bladder 3). Data derived from experimentations. Morphometric studies on animal or human bladder strips have demonstrated an increased expression of proteolytic enzymes and endogenous tissue inhibitors of metalloproteinases (MMP-1) and type III collagen mRNA in hypocompliant neurogenic bladders. Reduction of bladder wall blood flow, bilateral section of hypogastric nerves in rats, study of the bladders of spinalized rats, and reduction of oestrogenic hormone impregnation, show that these conditions induce loss of the viscoelastic properties of the bladder With the arrival of new treatments, active on afferent and/or efferent pathways or even on the central nervous system, it is very important to further our understanding of the pathophysiology of disorders of compliance in neurogenic bladders. Reversibility of these disorders constitutes a major therapeutic challenge and its functional consequences make it a critical prognostic factor for the outcome of neurogenic bladder

Animals↗

Pharmacokinetics and effects of intravesical oxybutynin on the paediatric neurogenic bladder.

OBJECTIVE: To evaluate the pharmacokinetics of both oxybutynin and its active metabolite, N-desethyl oxybutynin (NDO), when the drug is instilled directly into the bladder in children with myelodysplasia and neurogenic bladder disturbance, in whom it may improve continence and decrease the risk of upper urinary tract deterioration. PATIENTS AND METHODS: The study comprised 13 children (five girls and eight boys, mean age 9.3 years, range 1-15) with neurogenic bladders who were treated using clean intermittent catheterization and intravesical instillation of a sterile, pharmacy-produced solution of oxybutynin. Steady-state minimum plasma levels of oxybutynin and NDO, together with their effect on urodynamic variables and incontinence, were evaluated. The dose (0.04-0.17 mg/kg, mean 0.1 mg/kg) was instilled twice daily. RESULTS: The effects of the drug on incontinence and urodynamic variables were pronounced, improving both in most cases. Minimum plasma levels were < 0.3-7.2 ng/mL for oxybutynin and 0.8-14 ng/mL for NDO. The ratio of oxybutynin to NDO was 0.29-0.83 (mean 0.47). CONCLUSION: There was no clear relationship between minimum plasma levels of the drug or NDO and their clinical effects; however, the combination of oxybutynin and NDO seemed to be more strongly correlated with the clinical effects.

Administration, Intravesical↗