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PubMed1992

Cognitive patterns in school-age children with end-stage liver disease.

Although children with end-stage liver disease (ESLD) have been found to have cognitive delays, the relationship between patterns of cognitive function and diagnostic category, age of onset, duration and severity of disease has not been assessed before transplantation. Verbal and performance IQ (VIQ, PIQ) scores and scores on Bannatyne's cognitive factors for 43 children with ESLD were compared with those of 15 control children with cystic fibrosis (CF) and with existing normative data. Children with biliary atresia had deficits in PIQ, spatial and sequential scores. Children with alpha-1 antitrypsin deficiency did not differ significantly from CF controls but did show deficits compared with normative data. Children with onset of disease in the first year of life had deficits on all cognitive measures compared with both control groups. In contrast, children with later onset differed from the normative population only on VIQ and the acquired knowledge factor. In multiple regression analyses, duration of disease and indexes of liver dysfunction combine to predict cognitive scores. These preliminary findings suggest that children with early onset of liver disease are at high risk for cognitive impairment.

Biliary Atresia↗

PubMed2004

Do data from children with specific language impairment support the agreement/tense omission model?

One of the most influential recent accounts of pronoun case-marking errors in children's speech is C. T. Schütze and K. Wexler's (1996) agreement/tense omission model (ATOM). This model predicts that non-nominative subjects with agreeing verbs will be so rare that they can be reasonably disregarded as noise in the data. The present study tested this prediction on data from 4 children with specific language impairment (SLI) by comparing the frequency with which each child produced non-nominative subjects with agreeing verbs and the frequency with which they would be expected to produce such errors by chance given the number of nominative and non-nominative subjects and the number of agreeing and nonagreeing verb forms in the data. The results show (a) that although 3 of the 4 children used non-nominative subjects in their speech, only 2 of them (Nathan and Dan) produced non-nominative subjects with agreeing verbs significantly less often than one would expect by chance; (b) that to the extent that there was an asymmetry in Nathan's and Dan's use of nominative and non-nominative subjects with agreeing verbs, this asymmetry could be explained in terms of developmental changes in their ability to mark case and agreement correctly and the use of potentially unanalyzed contractions; and (c) that Nathan and Dan produced non-nominative subjects with noncontracted agreeing forms about as often as one would expect by chance. These findings are discussed in terms of their theoretical implications for the ATOM and their methodological implications for future work on patterns of pronoun case marking error in the speech of typically developing children and children with SLI.

Child, Preschool↗

PubMed2006

Vestibular assessment with Balance Quest Normative data for children and young adults.

OBJECTIVE: The purpose of the present study was to compare equilibrium pattern in 12-year-old children with 20-year-old young adults and to obtain normative data for the BQ in both groups. METHODS: Mean stability percentages and synthesis ratios of 29 healthy children aged 12 years were compared to those of 68 young adults aged 20 years, using BQ. RESULTS: The mean stability percentages for children were significantly lower than for young adults. Vestibular ratios were lower in children compared to young adults, whereas somesthesic ratios were similar for the two groups. Visual dependence was significant higher in children. CONCLUSIONS: Children unlike young adults had lower stability percentages when visual information was not available or was incorrect. Ratio synthesis pattern was different in the two groups. Our results on BQ partially confirms previous results obtained in children assessed with Equitest CDP. This study also provides BQ normative data for these two age groups.

Adult↗

PubMed1991

A caries preventive programme for Robertson school children--baseline data.

This study describes the baseline caries experience of a cohort school children in the Robertson area who were selected to take part in a longterm school-based preventive programme. On the whole baseline DMFT values for the various age groups did not differ significantly except for the 13-year-olds at Vergesig who had significantly higher values than those obtained at the other two schools. The D-component predominated with a moderate M-component and no filled teeth. The teeth at risk for the respective age groups did not differ significantly between the schools. The frequency of caries experience decreased from the molars to the central incisors except for the canines which were least vulnerable. The DMFT values were high and warrant the search for the most suitable preventive measures to facilitate reduction towards the WHO goal of 3 for 12-year-olds by the year 2000.

Adolescent↗

PubMed2005

Long-term data on children implanted with a short electrode array.

Ossification and cochlear malformations are no longer seen as a contra-indication to cochlear implantation. The MED-EL COMBI 40+ short electrode was designed specifically for cases where major ossification has occurred, or where full insertion of an electrode may not be possible due to abnormal structure of the cochlea. This study investigates outcomes of 18 children implanted with the short electrode array. These children were assessed using the EARS test battery pre-operatively and at a number of intervals thereafter. Results show a consistent improvement in time on most tests; these results appear to be independent of aetiology. Data from these children were compared to 18 matched pairs implanted with the standard COMBI 40+ electrode array. The short electrode children do not perform as well as the standard children initially, but do tend to catch-up at later test intervals. Results indicate the benefit of using a short electrode when complete insertion of the standard electrode is not viable.

Adolescent↗

PubMed2001

Prognostic value of evoked potentials and sleep recordings in the prolonged comatose state of children. Preliminary data.

OBJECTIVES: Sleep recordings and evoked potentials (EPs) were used in five comatose children to evaluate their predictive value for outcome following a severe comatose state. METHODS AND SUBJECTS: The protocol included EEG, Brainstem Evoked Responses (BERs), Somatosensory Evoked Potentials (SEPs) and polysomnography. From 10 to 15 days post-coma (D10 to D15), EEG and clinical examinations were carried out every second day, then one day in four from 15 to 30 days post-coma (D15 to D30), and one day in seven from D30 to six months (M6). Evoked potentials and Polysomnography were recorded on D10-D15 or D30 in the second month (M2) and in M6. Of the five children, three were in anoxic coma and two in traumatic coma. All had extensive lesions and a Glasgow Coma Scale (GCS) score of less than five. The results of the EEG, polysomnographic and EP recordings were compared to the clinical outcome. RESULTS AND CONCLUSION: In the three anoxic comas we observed BER abnormalities and the absence of SEP N20 associated with wide cortical lesions with brainstem extension. Sleep recordings showed major alterations of the wake-sleep cycle without any improvement in M6. Abnormalities included loss of the normal REM-sleep pattern associated with alteration of NREM sleep and periods of increase in motor activity without EEG arousal. This sleep pattern appeared to be associated with involvement of the brainstem. In the two traumatic comas, alterations of the early cortical SEP responses were less severe and the BERs were normal. Some sleep spindles were observed as well as the persistence of sleep cycles in the first weeks post-coma. The combined use of EEG, EPs and polysomnography improved the outcome prediction in comparison with the use of just one modality. EPs and sleep recordings were far superior to clinical evaluation and to GCS in the appreciation of the functional status of comatose children. The reappearance of sleep patterns is considered to be of favorable prognosis for outcome of the coma state, as is the presence of sleep spindles in post-trauma coma. This study showed that EPs and sleep recordings help to further distinguish between patients with good or bad outcomes.

Brain Damage, Chronic↗

PubMed2005

Anthropometric reference data for children and adults: U.S. population, 1999-2002.

This report presents national anthropometric reference data based on health examination survey results from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, for all ages of the U.S. population. Weighted population means, standard errors of the means, and selected percentiles are presented for the total U.S. population by sex, race or ethnic group, and age in years or age group. Findings for some population groups are reported in a way that is comparable with results reported from National Health Examination Surveys (NHES) and NHANES conducted between 1960 and 1994. These data add to the knowledge about trends in child growth and development and are used to monitor prevalent conditions in the U.S. population such as overweight and obesity.

Adolescent↗

PubMed1994

Relation between cytokines and routine laboratory data in children with septic shock and purpura.

OBJECTIVE: To establish the relation between routine laboratory data (lactate, fibrinogen, CRP) and cytokines (TNF,IL-1 and -6) and to estimate their prognostic value in pediatric patients with severe infectious purpura on admission. DESIGN: Prospective study. SETTING: Pediatric intensive care unit (PICU). PATIENTS: 17 children aged 5-172 months (median 46) were hospitalized in our PICU in 1989-90 with severe infectious purpura. Neisseria meningitidis was isolated in 15 children and Haemophilus influenzae in two. The patients were divided into 3 groups: non-shock, shock and severe shock leading to death. Shock was defined by standard criteria. MEASUREMENTS: Arterial blood was sampled for lactate, CRP, fibrinogen, TNF, and IL-1 and -6 on admission. The PRISM (pediatric risk of morality)-score was recorded. METHODS: Statistical analysis was performed with the Student's t-test using the logarithmic values of the cytokine concentration, and Spearman correlation analysis. RESULTS: According to the shock criteria, 9 patients were in shock of whom 4 did not survive. Significant differences existed between the 3 groups concerning lactate, TNF, and IL-6. Fibrinogen, CRP, IL-1, and PRISM-score discriminated only between survivors and non-survivors. A highly significant correlation existed between cytokines, the PRISM-score and lactate (TNF: r = 0.69, IL-1: r = 0.56, IL-6: r = 0.65, PRISM: r = 0.65). A significant inverse correlation existed between cytokines and CRP (TNF: r = -0.55, IL-1: r = -0.64, and IL-6: r = -0.56), and IL-6 and fibrinogen (r = -0.65). CONCLUSION: These results show a significant correlation between cytokines and lactate, and lactate, TNF and IL-6 are closely associated with the severity of septic shock with purpura in children.

Adolescent↗

PubMed2003

Burden of influenza in children: preliminary data from a pilot survey network on community diseases.

BACKGROUND: The burden of influenza and its clinical presentation are both poorly documented in French children. METHODS: To measure the prevalence of acute respiratory infections over two winters (2000 to 2001 and 2001 to 2002), we performed a prospective community survey of 0- to 15-year-olds (n = 11 500 and 40 000, respectively) through a network [Grippe et Infections Respiratoires Aiguës Pédiatriques (GIRAP)] of general practitioners and pediatricians. Influenza viruses were detected by antigen detection and culture from nasopharyngeal swabs. Data on the clinical presentation of children infected with influenza A/H1N1, A/H3N2 or B viruses were derived from standardized forms. RESULTS: The prevalences of symptomatic acute respiratory infections were 28% and 27% for 2000 to 2001 and 2001 to 2002, respectively. In the winter of 2000 to 2001, a mild outbreak of influenza A/H1N1 affected 5.4% of the study population. The attack rates of influenza A/H1N1 were highest in children 5 to 15 years of age. In the winter of 2001 to 2002, influenza activity remained at a subepidemic level (5.9%; A/H3N2, 60%; B, 40%). The incidence of influenza A/H3N2 infections was highest in 2- to 4-year-old children, whereas influenza B strains were most frequently detected in children 4 to 10 years of age. CONCLUSIONS: Despite subepidemic levels of influenza, the GIRAP network was able to detect influenza A or B viruses in 35 to 60% of the samples during the peak of influenza epidemic. The frequency of influenza virus excretion in children with mild clinical symptoms indicates that children are an important reservoir and source of transmission of this virus.

Adolescent↗

PubMed1999

Comparison of the entropy technique with two other techniques for detecting disease clustering using data from children with high blood lead levels.

The entropy technique was compared with two other case-control techniques for detecting disease clustering using data on blood lead levels of children who were patients at the King/Drew Medical Center in South-Central Los Angeles in 1991 to 1994. The other two methods are the nearest neighbor technique (NNT) and Moran's IPOP technique, a variation of Moran's I test, in which rates are adjusted for population size. Four different blood lead levels (15 microg/dl, 20 microg/dl, 30 microg/dl, 35 microg/dl) were used as cutoff levels to designate cases. Persons with blood lead levels greater than or equal to the cutoff level were designated as cases. The authors found significant clustering for all four cutoff levels using the entropy method, and for the first three cutoff levels using the NNT. They found significant clustering with Moran's IPOP for some scales for two of the cutoff levels. While performance of the entropy technique and the NNT were independent of scale, that of Moran's IPOP was highly scale-dependent.

Adolescent↗

PubMed1989

Internal diameters of the ventriculo-arterial junctions and great arteries of normal infants and children: a data base for evaluation of congenital cardiac malformations.

In order to obtain reference data for a better evaluation of the operability of infants and children with congenital heart malformations, investigations were made on the growth of the aortic ventriculo-arterial junction along with the aortic arch as well as of the pulmonary root and the pulmonary tree. The internal diameters of the junctions and of various sites of both great arteries were measured in fresh post mortem specimens of 126 children having an age from 21 weeks of gestation up to 10 years after birth and who died from noncardiac diseases. Linear correlations were found between the internal diameters and body length. The post mortem data were in agreement with echocardiographic observations.

Aorta↗

PubMed1978

Longitudinal study of hearing in children: baseline data concerning auditory thresholds, noise exposure, and biological factors.

Serial auditory thresholds are being recorded at six-month intervals from 224 children and youths aged 4--18 years. The data from the first year show girls have lower threshold levels than boys, especially from 12--17 years, and, in both sexes, those aged 12--17 years have lower thresholds than those aged 6--11 years. Median total noise exposure scores tend to be higher in boys than girls, especially after 10 years of age, but these scores are not significantly correlated with auditory thresholds levels. The incidence of exposure to events associated with noise increases markedly in teenage boys and is related to auditory threshold levels. There are no significant associations between auditory thresholds levels and responses to general health questions or attained stature, but there are associations with meatal abnormalities. There is suggestive evidence, particularly in girls, that rapid maturation is associated with lower threshold levels, especially at lower frequencies.

Adolescent↗

PubMed1984

Collection of dietary data from children with cystic fibrosis: some problems and practicalities.

The literature on the collection of dietary data is both extensive and confusing. Few practical details are given, particularly for the clinical situation, which are useful to the novice. In response to this, and calls from various authors, the basis for deciding on methods for collecting dietary data from a group of patients in the clinical setting is illustrated here. Practical aspects of data collection and analysis are detailed.

Adolescent↗

PubMed2002

Septo-optic dysplasia/optic nerve hypoplasia: data from the National Cooperative Growth Study (NCGS).

We analyzed data from 65 children with septo-optic dysplasia (SOD) referred for evaluation and followed in the National Cooperative Growth Study (NCGS) Substudy 8 and from 758 children treated with growth hormone (GH) and followed in the NCGS core study. Compared to other children referred for evaluation of short stature, children with SOD were younger (mean age 3.7 +/- 3.6 vs 8.6 +/- 4.9 years), had less severe short stature (mean +/- SD height SDS -1.80 +/- 1.64 vs -2.17 +/- 0.95), and were more likely to be female (46% F vs 31% M). Children with SOD who received GH were older and shorter than those referred and untreated, but the gender distribution was similar. Other pituitary hormone deficits were reported in untreated patients, including thyroid hormone deficiencies (8%) and adrenocorticotropic hormone (ACTH) deficiency (3%), as compared to 27% and 24%, respectively, in GH-treated children. Data on adult height were available for 71 patients, who showed an average gain in height SDS of 1.17 +/- 1.49. GH therapy was well tolerated in children with SOD.

Body Height↗

PubMed2006

Prevalence of and factors associated with Helicobacter pylori infection in children in the north of Vietnam.

The study aimed at evaluating the seroprevalence of and sociodemographic, health, lifestyle, and environmental hygiene conditions associated with Helicobacter pylori infection in Vietnamese children. Data from 824 children, aged from 6 months to 15 years and gastrointestinal symptom free when consulted, admitted to a university hospital, were collected using a structured questionnaire and ELISA test for H. pylori infection. The data were examined using univariate and multivariate analyses. H. pylori seroprevalence was 34.0%. Age groups from 3 to 6 years and older than 6, and number of offspring were positively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 2.9 (1.5-5.5); 1.9 (1.1-3.1) and 1.8 (1.1-2.6), respectively]. Breastfeeding more than 6 months was negatively and independently associated with H. pylori seropositivity [adjusted OR (95% CI): 0.5 (0.3-0.9)]. Mother's age, history of allergy, gastro-duodenal disease history in the past, initiating collective life before 6 years, sharing bed with parents and time of bed sharing with parents > 24 months were positively but not independently associated with H. pylori seropositivity. None of the other environmental or lifestyle conditions examined was associated with H. pylori infection. Our results support person-to-person transmission and the role of sociodemographic factors in H. pylori infection.

Adolescent↗

PubMed2000

Clinical use of fluoroquinolones in children.

OBJECTIVE: To review the pharmacokinetics, efficacy, and safety of fluoroquinolones in children. DATA SOURCES: A MEDLINE search (January 1966-March 1998) was conducted for relevant literature. STUDY SELECTION AND DATA EXTRACTION: Data from compassionate use and published studies were reviewed for the assessment of pharmacokinetics, efficacy, and safety of fluoroquinolones in children. DATA SYNTHESIS: Fluoroquinolones have a broad spectrum coverage of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa and intracellular organisms. Fluoroquinolones are well absorbed from the gastrointestinal tract, have excellent tissue penetration, low protein binding, and long elimination half-lives. These antibiotics are effective in treating various infections and are well tolerated in adults. However, the use of fluoroquinolones in children has been restricted due to potential cartilage damage that occurred in research with immature animals. Fluoroquinolones have been used in children on a compassionate basis. Ciprofloxacin is the most frequently used fluoroquinolone in children, most often in the treatment of pulmonary infection in cystic fibrosis as well as salmonellosis and shigellosis. Other uses include chronic suppurative otitis media, meningitis, septicemia, and urinary tract infection. Safety data of fluoroquinolones in children appear to be similar to those in adults. Fluoroquinolones are associated with tendinitis and reversible arthralgia in adults and children. However, direct association between fluoroquinolones and arthropathy remains uncertain. CONCLUSIONS: Fluoroquinolones have been found to be effective in treating certain infections in children. Additional research is needed to define the optimal dosage regimens in pediatric patients. Although fluoroquinolones appear to be well tolerated, further investigations are needed to determine the risk of arthropathy in children. However, their use in children should not be withheld when the benefits outweigh the risks.

Animals↗

PubMed1981

Forearm bone mineral content in children. Normative data.

The bone mineral content in the forearm was measured by gamma-absorptiometry in 131 normal children. The bone mineral content was closely related to age, height and weight, to the size of forearm and to the force of the forearm muscles. By correcting for the dimensions of the bones a parameter of density (mass/volume) was calculated. This variable also increased with age. Knowing the necessary corrections factors gamma-absorptiometry could be a useful and harmless method for bone mineral assessment in children with various diseases.

Adolescent↗

PubMed1993

Early cystic/necrotic changes after hyperfractionated radiation therapy in children with brain stem gliomas. Data from the Childrens Cancer Group.

BACKGROUND: A higher total dose of radiation therapy administered in fractionated lower individual doses twice daily (hyperfractionated radiation therapy) has been reported to improve survival for children with brain stem gliomas. However, this higher dose of radiation therapy may cause more sequelae. METHOD: Eighty-eight children with brain stem gliomas were treated with 100 cGy twice daily to a total dose of 7200 cGy. Patients were carefully followed up for treatment-related clinical or radiographic worsening. RESULTS: Thirteen (15%) had intralesional cystic/necrotic changes within 8 weeks of completion of treatment. Children with these changes had a variable clinical course, including steady deterioration in one child; initial improvement, followed by progressive deterioration in three; and initial improvement, followed by deterioration, with subsequent improvement or prolonged stabilization of condition without additional antineoplastic treatment in nine. CONCLUSION: This latter "triphasic" course suggests that "early" worsening after hyperfractionated radiation therapy at 7200 cGy may be a sequelae of therapy, rather than a symptom of progressive tumor growth. This has substantial implications for patient care and evaluation of the efficacy of treatment.

Adult↗