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[Effect of glucose and ammonium nitrogen concentrations on riboxine biosynthesis].

The effect of glucose and ammonium nitrogen concentrations on the riboxine biosynthesis by the culture Bacillus subtilis GEN 265 was investigated. The purpose of the investigation was to optimize the process with respect to these parameters. The investigation was carried out in a 1 m3 fermenter. Glucose and ammonium nitrate were added for various fermentation times. It was shown that riboxine biosynthesis did not require glucose dosing in the course of the process, with the optimal concentration being 13-15%. Optimal concentrations of ammonium nitrogen were determined. It was found that the dose of 0.35 mg/ml provided a 24% increase in the yield.

Bacillus subtilis↗
PubMed1978

[Optimizing the therapeutic process in long-term antiepileptic therapy through the determination of drug levels in patients].

Serum levels of phenytoin, phenobarbital, carbamazepine, and ethosuximide were determined in about 2,000 subjects treated on an outpatient and inpatient basis, respectively. Therapeutical serum level ranges were obtained in about 50 percent of the patients. In the other patients, the values determined were either too low or too high. These studies, in addition to enabling the drug-taking behavior of patients to be objectified, made possible "blood-level-oriented dosage" and allowed differential approaches to be adopted in the control of undesirable effects. Blood level determinations permit the therapeutical procedure to be improved and made more reliable especially in "problem cases". A pharmacokinetic therapy service has proved useful for long-time antiepileptic therapy.

Anticonvulsants↗