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At least 163 records · Page 9Linked to original sources
PubMed1990

Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.

Cromakalim, pinacidil and nitroprusside provoked concentration-dependent relaxations of K(+)-depolarized rat aortae. Glibenclamide, tolbutamide and to a lesser extent tetraethylammonium antagonized the vasorelaxant action of cromakalim and pinacidil. Cromakalim, pinacidil but not nitroprusside elicited a marked increase in 86Rb outflow from preloaded and perifused aortic rings. These increases in 86Rb outflow were inhibited in a concentration-dependent manner by glibenclamide and tetraethylammonium. Our data extend previous observations indicating the involvement of K+ channels in the vasorelaxant properties of cromakalim and pinacidil. Moreover, the present findings suggest that both compounds could interfere with a vascular type of ATP-sensitive K+ channels.

Animals↗
PubMed1977

Effect of sodium salicylate on renal elimination of a quaternary ammonium compound.

Administration of sodium salicylate inhibited elimination of the tetraethylammonium ion in rats. A two-compartment open model was used to describe plasma decline of tetraethylammonium bromide administered intravenously. The rate constant describing elimination from the central compartment was decreased by 25 and 40% in rats predosed with sodium salicylate at 30 and 50 mg/kg, respectively. Salicylate also enhanced the distribution of the tetraethylammonium ion to the peripheral compartment. Urinary excretion is the principal route of elimination for the tetraethylammonium ion, and studies of the effect of sodium salicylate on the uptake of the tetraethylammonium ion by rat renal cortical tissue indicated noncompetitive inhibition by salicylate.

Animals↗