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PubMed1992

Salivary stimulation by chewing gum and its role in the remineralization of caries-like lesions in human enamel in situ.

Salivary stimulation elicited reflexively by taste and mastication leads to an increase in the pH, buffering power, and supersaturation of saliva, which can affect beneficially the balance between enamel de- and remineralization in early caries. In a previous study in which a sorbitol chewing gum was used as a salivary stimulant for 20 minutes, five times daily after meals and snacks over a three-week period (during which fluoride toothpaste was used daily), significant remineralization of caries-like lesions in human enamel attached to intraoral appliances in human subjects was observed. In view of the continued public preference for sucrose-sweetened chewing gums, the study was repeated using a sucrose gum. The mean results showed a trend toward remineralization with the use of sucrose chewing gum, which was significant in 10 subjects who chewed for 30 minutes but not in 9 who chewed for 20 minutes. The use of chewing gum after meals and snacks (in the presence of fluoride from toothpaste) can thus enhance the remineralizing potential of the mouth, probably as a result of salivary stimulation.

Analysis of Variance↗
PubMed2004

Potential remineralization of demineralized enamel after application of fluoride varnish.

PURPOSE: To evaluate remineralization effects of a topical fluoride varnish applied over a caries-like lesion compared to around a caries-like lesion. METHODS: Caries-like lesions were created on 30 molar surfaces. Sections were cut through each lesion, photographed under polarized light microscopy, and quantitated with a computerized imaging system. The sections were repositioned with only the lesion exposed. Half were painted with a 5% NaF varnish, including the surface of lesion. The remaining half were painted excluding the surface of the lesion. The sections were placed in artificial saliva for 30 days, re-photographed and re-quantitated. RESULTS: Using a student t-test for analysis, the results demonstrated the mean (+/- S.E.) percent remineralization of lesion size to be 10.8 (4.8) for lesions completely covered by the fluoridated varnish and 9.5 (2.9) for lesions that had the fluoridated varnish surrounding the lesion. Both application techniques indicated remineralization effects, yet there was no significant difference between the two application techniques evaluated in this study (P < 0.05). The data from this in vitro study indicated that there was no significant difference in methods of application for fluoridated varnish. Both application techniques demonstrated effective remineralization.

Cariostatic Agents↗
PubMed1989

[Induced remineralization of carious dentin. Electronic microprobe analysis].

Our electron microprobe studies show the preferential incorporation in vitro of tin and fluorure into carious dentin. These ions do penetrate only into carious dentin through the body of the lesion. These ions do not progress through the sclerotic dentin barrier, when it exists which tend to demonstrate their affinity for demineralized tissues. Results of microprobe analysis may suggest the hypothesis of a crystalline arrangement as the product of reaction between residual apatite in carious dentin with stannous fluoride. A new crystalline phase could occur within the carious zone, up to the sclerotic barrier. This method does not permit to indicate its identity or its structure. However, it has been recognized in previous studies as a tin phosphate compound. Further analytic studies, using crystallographic technics of the treated zones could provide additional data of the observations from the electron microprobe and confirm the hypothesis of the ability of carious dentin to be remineralized by the use of stannous fluoride containing solutions or materials.

Dental Caries↗
PubMed1994

Fluoride, remineralization and root caries.

This paper reviews the probable mechanism of dental caries and the role of fluoride in the inhibition or reversal of that process. The initial stages of root caries are comparable to enamel caries, being the acid dissolution of mineral resulting from acids generated by bacterial metabolism. The fermentation of carbohydrates by oral bacteria including mutans streptococci and lactobacilli initiate the root caries process, removing mineral from among the organic matrix which is primarily composed of collagen. Subsequent to this demineralization, the organic material can be further broken down by bacterial enzymes. Fluoride inhibits mineral loss during the acid dissolution process and enhances remineralization in a similar manner to that which occurs in dental enamel.

Bacteria↗
PubMed1999

Evaluating the effects of fluoride-releasing dental materials on adjacent interproximal caries.

BACKGROUND: The authors examined several restorative materials to evaluate their ability to inhibit demineralization and enhance remineralization of incipient carious lesions on the interproximal enamel of teeth adjacent to those restored with the materials. METHODS: Twenty-one subjects in need of a crown on a mandibular molar and a Class II inlay on an adjacent tooth took part in this six-phase study. Artificial enamel lesions were created and positioned within the interproximal portion of a crown. Lesions were photographed with polarized light microscopy and characterized before and after 30-day intraoral exposures. Each phase included the placement of a new section in the crown model and a new Class II inlay restorative material in the adjacent tooth. RESULTS: Results demonstrated that nonfluoridated resin composite, fluoridated resin composite and resin-modified glass ionomer restorative materials, when placed in subjects who brushed with a fluoridated dentifrice, demonstrated significantly (P < .05) less enamel demineralization than the nonfluoridated resin composite control placed in subjects who brushed with a nonfluoridated dentifrice. The resin-modified glass ionomer cement, however, even when brushed with a nonfluoridated dentifrice, exhibited significantly (P < .05) less demineralization than the nonfluoridated resin composite control brushed with a nonfluoridated dentifrice. CONCLUSIONS: Resin-modified glass ionomer cement appears to significantly inhibit demineralization of interproximal enamel of teeth adjacent to those restored with the material. CLINICAL IMPLICATIONS: Resin-modified glass ionomer cement restorations can enhance prevention of enamel demineralization on adjacent teeth.

Acrylic Resins↗
PubMed1990

[The micromorphology of the superficial remineralization of the dental enamel].

The remineralization process in the oral environment is the presumption of enamel structural integrity and function. Strong or frequent acid attacks may be followed by pathological alterations. Remineralization of human enamel after phosphoric acid demineralization was investigated. 4 subjects were selected for in-vivo experiments using specialized oral applicators with 52 etched enamel specimen, incorporated for 10 or 28 days and 59 probes remineralized in a synthetic mineral solution over the same period. Mineral deposition and rehardening took place. After 28 days the reparation of acid defects was incomplete. The in-vitro remineralization is less pronounced and does not reflect the complex remineralization mechanism in vivo.

Adolescent↗
PubMed1991

Acid-susceptibility of lesions in bovine enamel after remineralization at different pH values and in the presence of different fluoride concentrations.

Artificial caries lesions were created in sound bovine enamel slices demineralized at pH 5.0. The lesions were then remineralized at either pH 5.5 or pH 6.8 in solutions containing either 1.5, 15, or 50 mumol/L fluoride. The remineralized slices were then demineralized at pH 5.0 for investigation of acid-susceptibility by means of quantitative microradiography. The results indicated that fluoride, incorporated during the preceding remineralization, had a retarding effect on the demineralization after remineralization, and that for the lowest concentration of fluoride in the remineralizing solution, the inhibitory influence of fluoride depended on the pH of the remineralization solutions used.

Acids↗
PubMed1992

Findings from an in situ thin-section sandwich model for evaluating cariogenic and anti-cariogenic activity.

This report summarizes the findings from eight individual remineralization studies that used the thin-section sandwich model. This model uses thin sections of human enamel (or dentin) containing caries-like lesions sandwiched between sheets of thin plastic which are then implanted into the buccal surfaces of molars in removable partial mandibular dentures. Toothbrushing with a sodium fluoride-positive control dentifrice for two-week periods always produced positive remineralization of the lesions, and similar use of a placebo always produced mean mineral loss. In most studies, the difference was significant at p less than 0.01. However, variation among specimens placed within an individual mouth were often large and even included cases where one lesion gained mineral while a closely adjacent lesion lost mineral. Similarly, mean mineral changes produced by an individual subject were not consistent from study to study and ranged from net demineralization in one study to net remineralization in another study. Nevertheless, mean mineral changes from all eight studies showed that all subjects produced more remineralization than demineralization when using a sodium fluoride-positive control dentifrice. Data are presented showing remineralization of thin-section lesions from a number of other fluoride and non-fluoride dentifrices and mouthrinses and showing that a product with reduced anti-caries activity (as measured by several tests) also resulted in reduced remineralization by the thin-section model.

Cariogenic Agents↗
PubMed2001

[Comparison of the effect of fluoride and non-fluoride dentifrices on enamel demineralization and remineralization in vitro].

OBJECTIVE: The purpose of the experiment is to investigate the effect of fluoride dentifrices in China on the intact and artificial caries-like bovine enamels. METHODS: The artificial caries-like lesions were created by dipping the teeth into an acid buffered solution. Both the bovine intact enamels and the artificial caries-like enamels were assigned tooth brushing 20 times every half an hour with 3 kinds of fluoride dentifrices and one kind of non-fluoride dentifrices respectively. The amount of calcium dissolved by lactic acid was determined as the susceptibility of demineralization by atomic adsorption spectrometry (AAS). RESULTS: The group treated with fluoride dentifrice showed significantly less demineralization than the non-fluoride group (P < 0.02). The effect of inhibition of acid solubility in artificial caries-like enamel after tooth brushing is significantly greater than that in intact enamel. CONCLUSION: Fluoride dentifrices in this experiment can prevent both intact enamel and artificial caries-like enamel from acid solubility after tooth brushing, and it seems that the effect of the fluoride dentifrices on the redemineralization is greater than the reduction of enamel solubility.

Animals↗
PubMedDate not supplied

Relationship between electrical resistance measurements and microradiographic variables during remineralization of softened enamel lesions.

The purpose of this study was to investigate the relationship between electrical resistance (ECM) measurements and microradiographic variables during remineralization of softened enamel lesions. Sound bovine enamel blocks were demineralized and, subsequently, were remineralized for 3, 4, 5, 7 or 14 days. All the specimens were assessed by ECM and transversal microradiography. The mean ECM values in each group increased after remineralization. The ECM values after remineralization (ECM1), mineral loss (DeltaZ) and maximum mineral content in the surface layer (V(max)) were significantly correlated with the remineralization time. The ECM1 values were also significantly correlated with DeltaZ and V(max). It is suggested that ECM could be used as a device to monitor mineral accumulation as a result of preventive treatment in vitro. However, it may take a much longer time to follow up the remineralization changes compared with demineralization.

Animals↗
PubMed1991

Influence of fluoride and carbonate on in vitro remineralization of bovine enamel.

The influence of fluoride, carbonate, and fluoride in combination with carbonate on the in vitro remineralization of bovine enamel was investigated with the use of a sandwich technique. After demineralization, enamel slices were subjected for 610 h to remineralizing solutions with 0.03 or 1.0 ppm fluoride. At each fluoride level, either 0, 1, 10, 20, or 25 mmol/L carbonate was tested. After 0, 22, 62, 126, 192, 329, and 610 h of remineralization, contact microradiographs were made by Cu K alpha-radiation. At 0.03 ppm fluoride, carbonate had an inhibiting influence on remineralization. At 1.0 ppm fluoride, the inhibiting influence of carbonate changed into a stimulation of remineralizatization at 20 and 25 mmol/L carbonate. At 0, 1, and 10 mmol/L carbonate, fluoride had an inhibiting influence on remineralization. The differences in remineralization between the groups were explained by events concerning crystal growth, i.e., different types of minerals might have precipitated with differences in precipitation rates, and retardation of a precipitation step might have occurred under the various remineralization conditions. There was a mutual influence of fluoride and carbonate on the remineralization process. We conclude that the composition of the remineralizing solution with respect to fluoride and carbonate concentrations is important for the remineralization process.

Animals↗
PubMed2003

Dental erosion in gastroesophageal reflux disease.

Dentists are often the first health care professionals to diagnose dental erosion in patients with gastroesophageal reflux disease (GERD). Gastroesophageal reflux (GER) is the passage of gastric contents into the esophagus, and GERD is defined as symptoms or complications of GER. Twenty-four-hour monitoring of esophageal pH is helpful in diagnosing GERD. Treatment of dental erosion resulting from GERD involves a multidisciplinary approach among family physician, dentist, prosthodontist, orthodontist and gastroenterologist. When possible, dental erosion should be treated with minimal intervention, and such treatment should include control of microflora, remineralization, adhesive restorations and use of biomimetic materials.

Dental Restoration, Permanent↗
PubMedDate not supplied

Fluoride varnish concentration gradient and its effect on enamel demineralization.

PURPOSE: Two of the 4 fluoride varnishes available on the American market today are sold in 10-mL tubes of 5% NaF varnish (Duraphat and Duraflor). Pilot studies have shown that a separation of contents within these tubes exists. The purpose of the current study was 4-fold: (1) to measure the fluoride concentration gradient in 10-mL tubes of fluoride varnish, based on resting position of the tube prior to use; (2) to compare and contrast fluoride concentration gradients of Duraphat, Duraflor, and CavityShield; (3) to compare this gradient to the ability to inhibit caries in an artificial caries environment; and finally, (4) to determine if quantitative light fluorescence (QLF) can detect differences in lesions developed when exposed to an artificial caries environment and fluoride varnish. METHODS: Human teeth specimens were subjected to a caries challenge and treated with a sample of fluoride varnish from 1 of 5 categories: Duraphat stored horizontally and vertically for 1 week, Duraflor stored horizontally and vertically for 1 week, or a CavityShield 0.4 mL "unidose." All specimens were then analyzed with the QLF system and with confocal microscopy. RESULTS: Results showed no significant fluoride ppm differences exist between groups (P=.29). It was shown that the order in which Duraflor varnish was dispensed from tubes significantly affected the fluoride concentration (P<.05). The order effect was not significant for Duraphat (P=.99). QLF data analysis showed there was no significant difference (P>.05) in the amount of remineralization obtained by using any varnish stored in any position. CONCLUSIONS: These results indicate that all 3 brands of fluoride varnish are able to remineralize incipient in vitro carious lesions, regardless of what part of the 10-mL tube the varnish is taken from. However, a fluoride concentration gradient exists in tubes of Duraflor. Also, QLF is able to detect demineralized and remineralized incipient lesions.

Analysis of Variance↗