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PubMed2006

The role of fine-needle aspiration cytology and Ziehl Neelsen staining in the diagnosis of cutaneous tuberculosis.

The present study highlights the role of fine-needle aspiration cytology (FNAC) and Ziehl Neelsen (ZN) staining in diagnosis of cutaneous tuberculosis and correlates the cytomorphological features with histopathology.FNAC and biopsy was performed on 30 cases of cutaneous tuberculosis and along with the routine stains, ZN and periodic acid Schiffs staining was carried out in all cases. On cytology, out of 9 cases of lupus vulgaris, 89% showed cohesive epithelioid cell granulomas with or without chronic inflammatory infiltrate; however, acid fast bacilli (AFB) could be demonstrated only in 22.2% on cytology while none on histopathology. Of 19 cases diagnosed as Scrofuloderma, 79% showed caseation necrosis with or without granulomas, 10.5% revealed granulomas with acute inflammatory infiltrates. AFB was demonstrated in 78.9% cases on cytology when compared with 15.8% on histopathology. No conclusion could be drawn in one case each of TBVC and lichen scrofulosorum.Hence, correlating cytomorphological patterns with clinical presentations often yields diagnostic information in cases of cutaneous tuberculosis and frequently obviates the need for biopsy especially in cases of scrofuloderma.

Adolescent↗
PubMed1998

Inoculation cutaneous tuberculosis.

Two cases of inoculation cutaneous tuberculosis are presented. As commonly occurs, the diagnosis could not be confirmed bacteriologically due to the small numbers of organisms present. However, both patients responded to antituberculosis chemotherapy.

Adolescent↗
PubMed1997

Cutaneous tuberculosis in Blackburn district (U.K.): a 15-year prospective series, 1981-95.

Data collected prospectively on all 1065 cases of tuberculosis occurring in the Blackburn district, U.K. (population 265,000), over a 15-year period have been analysed, and from these 47 cases of cutaneous tuberculosis have been identified. The most common form was scrofuloderma, skin involvement with adjacent structural disease, of which there were 26 cases (55.3%). There was no ethnic bias in this group. The eight white patients with scrofuloderma were of average age 66 years, and are thought to represent reactivation disease. Six patients (12.8%) had lupus vulgaris, four (8.5%) had metastatic tuberculosis and 10 (21.3%) were diagnosed as having one of the tuberculides, of which Bazin's disease (erythema induratum) was the most common. In addition, one patient (2.2%) had orificial tuberculosis. In contrast to scrofuloderma, all other forms of cutaneous tuberculosis occurred almost exclusively in patients from the Indian Subcontinent (ISC). The high incidence of tuberculosis in Blackburn is mainly linked to its significant proportion of residents of ISC ethnic origin. There were no cases of HIV infection coexisting with either cutaneous or other forms of tuberculosis. Recommendations for the treatment of cutaneous tuberculosis are made.

Adolescent↗