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Transient hemifacial sensory loss with xerophthalmia following temporal lobectomy.

OBJECTIVE AND IMPORTANCE: The occurrence of a unilateral sensory loss in the second trigeminal distribution and the inability to tear following an ipsilateral temporal lobectomy has not been noted despite a number of reports of cranial nerve compromise under similar situations. CLINICAL PRESENTATION: A 48-year-old woman experienced complex partial seizures over three years attributable to the presence of cavernous malformations of the right temporal lobe. INTERVENTION: An anterior temporal extrahippocampal resection was performed. The surgery was marked by the need for electrocoagulation of the dural base of the temporal lobe where numerous bleeding points were encountered. Postoperatively, the patient experienced an ipsilateral maxillary division sensory loss, absence of tearing, and diminished nasal congestion for an eight-month period until resolution. CONCLUSION: Injury of the fibers of the maxillary division of the trigeminal nerve and the adjacent greater superficial petrosal nerve appears to be the cause. No prior account of such an occurrence has been published.

Electrocoagulation↗

Sequelae of severe xerophthalmia--a follow-up study.

Two-hundred sixteen children with vitamin A deficiency were hospitalized in Hyderabad, India, between 1970 and 1977. Out of these, 22 died during hospitalization. Fifty-six children could be followed-up, of whom 32 had keratomalacia and 24 corneal xerosis. In the keratomalacia group, nine died of reasons attributable to severe protein-energy malnutrition within 3 to 4 months after discharge from the hospital, five became totally blind, nine monocularily blind, and nine had adequate vision, although four of these had leucomas. Of the blind children, no change in condition was noted in the 11 located 1 year after the initial 3 to 4 month follow-up period. Of the 24 children with corneal zerosis, two died within 3 months, 21 retained normal vision, and one had adequate vision with leucoma. The high death rate, i.e., 30% of the keratomalacia cases in this study helps to explain the low prevalence of keratomalacia observed in past and current community surveys. The high return to normalcy of vision in the corneal xerosis cases after proper treatment support the recommendation of treating all children with eye involvement before the keratomalacia state whenever possible, for greater assurance of subsequent eye improvement.

Blindness↗

Early serum changes in severely malnourished children with corneal xerophthalmia after injection of water-miscible vitamin A.

We have studied the response of malnourished, xerophthalmic children to injections of water-miscible vitamin A to assess the most effective dose. Total dose injected was either greater than 100,000, 100,000, or 50,000 IU. Serum levels of retinol-binding protein, prealbumin, retinyl esters, and retinol were estimated. More than half the children given the largest does had exceptionally high serum retinyl esters and a high molar ratio of retinol and retinyl esters to retinol-binding protein. In no group did retinol-binding protein or prealbumin reach normal levels 24 h after dose. Eye recovery and weight gain was so good after 50,000 IU as after higher doses. The possible toxicity of retinyl esters and free retinol in serum is discussed and the level of vitamin A in normal liver is considered in relation to therapeutic doses. The role of protein deficiency in influencing response to dose is reviewed.

Child↗