Phase-dependent interaction of widely separated spatial frequencies in pattern discrimination.
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Differential Threshold↗
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Results for “spatial dependency”
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The influence of spatial frequency on the reaction times and evoked potentials recorded to grating pattern stimuli.
The simple reaction times recorded to sine-wave and square-wave grating stimulus patterns of both constant physical contrast and of constant suprathreshold contrast were appreciably delayed by an increase in spatial frequency from 0.5 to 10 c/deg. There was no comparable increase, however, in the peak latency of the initial visual evoked potential component, C1, recorded to the same stimulus patterns. In view of the evidence that C1 has a striate cortical origin, these results suggest that the large spatial-frequency dependent variations in RT do not reflect delays of stimulus-induced neuronal responses in the primary visual pathway from retina to striate cortex.
Evoked Potentials, Visual↗
Perceptual latency and spatial frequency.
Subjects estimated the perceived onset of sinusoidal gratings by adjusting a visual probe so that grating and probe were phenomenally simultaneous. The first experiment found that perceptual latency increased by an average of 21 msec over a range of 0.5-9.0 c/deg, or approximately 5 msec per octave of spatial frequency. A second experiment found, that when a fundamental frequency and its third harmonic at one third contrast are compared, a lag of between 21 and 25 msec for the higher frequency lower amplitude grating is obtained. These spatial frequency dependent delays are substantially lower than those reported using other methods.
Adult↗
Failure of rivalry at low contrast: evidence of a suprathreshold binocular summation process.
Presentation of different images to the two eyes normally results in a time-varying alternation between the two images (binocular rivalry). However, we find that when orthogonal gratings are viewed dichoptically at low contrast, a stable summation between the two images is perceived in the form of a dichoptic plaid. The range of perception of the dichoptic plaid depends on spatial frequency, contrast and luminance of the gratings. This phenomenon differs from the "false fusion", a fleeting summation of different images perceived only under very brief presentation of the stimuli. The observations suggest that there exists a neural process that performs a summation of dissimilar images, and that is distinct from the competitive process of suppression and binocular rivalry.
Contrast Sensitivity↗
Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1.
Cells of the yeast S. cerevisiae choose bud sites in an axial or bipolar spatial pattern depending on their cell type. We have identified a gene, BUD5, that resembles BUD1 and BUD2 in being required for both patterns; bud5- mutants also exhibit random budding in all cell types. The BUD5 nucleotide sequence predicts a protein of 538 amino acids that has similarity to the S. cerevisiae CDC25 product, an activator of RAS proteins that catalyzes GDP-GTP exchange. Two potential targets of BUD5 are known: BUD1 (RSR1) and CDC42, proteins involved in bud site selection and bud formation, respectively, that have extensive similarity to RAS. We also show that BUD5 interacts functionally with a gene, BEM1, that is required for bud formation. This interaction provides further support for the view that products involved in bud site selection guide the positioning of a complex necessary for bud formation.
Amino Acid Sequence↗
Three dimensional vector analysis of the spatial components and voltage magnitudes of the P300 response during different attentional states and stimulus modalities.
The spatial orientation and vector magnitude of the P300 event related potential (ERP) were investigated under both passive and active attentional states using stimuli presented to two sensory modalities. Three orthogonal electrode pairs were used to establish a tri-axial reference frame. By combining the separate single channel data recordings into a Cartisian coordinate system, both the spatial orientation and the vector magnitude of the P300 response could be derived and described as a hypothetical dipole. Results suggested that changes in amplitudes, recorded with individual electrode pairs, can be attributed largely to changes in the spatial orientation of a rotating P300 response dipole, and not simply to the altered magnitude of the response. The combined-axes P300 response occurs in two separate spatial domains, depending on stimulus modality and attentional state.
Acoustic Stimulation↗
Philothermal response, microtubules and dementia.
The role of microtubules in the philothermal response of polymorphonuclear leukocytes (PMNs) was examined using colchicine, a known microtubule disrupting agent. Colchicine inhibited PMN migration in a dose dependent fashion. Spatial distribution analysis of the responding cell population revealed a preferential inhibition of distal cell migration, a pattern similar to that found for PMNs obtained from patients with dementia of the Alzheimer type (DAT). The result is consistent with the known role of microtubules in directed cell migration and the hypothesized microtubular defect in DAT. Further investigations of microtubules may provide insight into the etiology and pathogenesis of DAT.
Adult↗
On estimating the number density of random scatterers from backscattered acoustic signals.
When an acoustic pulse interacts with an inhomogeneous, attenuating medium, the backscattered signals exhibit random fluctuations which are correlated with the physical properties of the medium. This paper proposes a robust model for characterizing the statistical nature of these backscattered signals. This model takes into account frequency-dependent attenuation, spatially varying media statistics, arbitrary beam geometries, and arbitrary pulse shapes. Based on this model, statistical estimation schemes are proposed for estimating both the attenuation coefficient and scatterer number density of the medium. Using appropriate simplifying assumptions, it is shown that this model is consistent with attenuation estimation algorithms currently used for ultrasonic tissue characterization. A statistical approach for estimating the number density of scatterers is described and its theoretical performance is evaluated. The algorithm for estimating the scatterer number density incorporates measurements of both the statistical moments of the backscattered signals and the point spread function of the acoustic system. The number density algorithm has been applied to simulated waveforms, waveforms obtained from ultrasonic phantoms with known number densities, and in vitro mammalian tissues. There is an excellent agreement between theoretical, simulation, and experimental results. The application of this technique to ultrasonic tissue characterization is also discussed.
Algorithms↗
Quantitative NMR imaging of multiphase flow in porous media.
Quantitative description of multiphase flow in porous media and local saturation distributions at steady states are of fundamental importance for petroleum recovery. The use of MRI provides an unprecedented means for obtaining such information. In this paper, profile imaging techniques for quantitative evaluation of fluid saturations during flow experiments in porous media are developed. The procedures for overcoming problems arising from very short, fluid saturation-dependent and spatial variation of T2, which are common in porous media, were addressed. The general methods developed should also be applicable to similar inhomogeneous biological systems. Experimental NMR imaging measurements of two-phase displacement were conducted in several limestones and sandstones representing various different types of pore structures, including a macroscopically homogeneous structure, a laminated structure, and a sample that exhibits porosity at different scales. The advantages of using each different type of profile imaging sequence to investigate flow in different types of porous structures are demonstrated. Images showing many features of multiphase flow, including nonuniform flow through different bedding structures, are obtained during the flow experiments. The use of profile images for obtaining many important petrophysical properties, such as permeability, porosity, saturation, and pore structural information, is discussed.
Geological Phenomena↗
Frequency content of the electrocardiogram. Spatial features and effects of myocardial infarction.
The frequency content of electrocardiographic signals has been used to define amplifier characteristics and, more recently, to detect myocardial pathology. It was the purpose of this study to evaluate the differences in frequency content of ECG signals recorded from different volume conductor surface sites and to determine the effects of coronary ligation on these spatial features. To do so, 15 isolated perfused rabbit hearts, enclosed within a precisely machined sphere, were studied; ten were examined prior to and 15 minutes after ligation of the anterior descending coronary artery. ECG signals, recorded from 32 surface electrodes, were subjected to Fourier analysis. Prior to occlusion, the frequency content of the different electrode signals varied widely, with a greater variance between electrodes than between hearts (p less than 0.01). This variation was related to a reproducible spatial effect, with records over the basal left ventricle having higher frequency components than waves from other sites. After litigation, ECG records from electrodes over electrodes over ischemic areas showed augmented R-wave amplitude and ST-segment elevation. This was associated with a spatial shift of the control high frequency peak to a site overlying the ischemic lesion. Thus the frequency content of ECG is spatially variable and hence lead-dependent, and this spatial variability is directly affected by acute myocardial infarction.
Animals↗
Real-time imaging of evoked activity in local circuits of the salamander olfactory bulb.
The encoding of olfactory information in the central nervous system (CNS) depends on spatially distributed patterns of activity generated simultaneously in many neuronal circuits. Optical neurophysiological recording permits analysis of neural activity non-invasively and with high spatial and temporal resolution. Here, a video method for imaging voltage-sensitive dye fluorescence in vivo is used to map neuronal activity in local circuits of the salamander olfactory bulb. The method permits the imaging of simultaneous ensemble transmembrane activity in real time. After electrical stimulation of the olfactory nerve, activity spreads centripetally from the sites of synaptic input to generate nonhomogeneous response patterns that are presumably mediated by local circuits within the bulbar layers. The results also show the overlapping temporal sequences of activation of cell groups in each layer. The method thus provides high resolution, sequential video images of the spatial and temporal progression of transmembrane events in neuronal circuits after afferent stimulation and offers the opportunity for studying ensemble events in other brain regions.
Animals↗
Independent hemispheric attentional systems mediate visual search in split-brain patients.
The primate visual system is adept at identifying objects embedded within complex displays that contain a variety of potentially distracting elements. Theories of visual perception postulate that this ability depends on spatial selective attention, a mechanism analogous to a spotlight or zoom lens, which concentrates high-level processing resources on restricted portions of the visual field. Previous studies in which attention was pre-cued to specific locations in the visual field have shown that the spotlight has a single, unified focus, even in the disconnected hemispheres of patients who have undergone surgical transection of the corpus callosum. Here we demonstrate that an independent focus of attention is deployed by each of the surgically separated hemispheres in a visual search task, such that bilateral stimulus arrays can be scanned at a faster rate by 'split-brain' subjects than by normal control subjects. The attentional system used for visual search therefore seems to be functionally and anatomically distinct from the system that mediates voluntary orienting of attention.
Attention↗
Whole-body vibration and visual performance: an examination of spatial filtering and time-dependency.
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Humans↗
The electrical activity of embryonic chick heart cells isolated in tissue culture singly or in interconnected cell sheets.
Embryonic chick heart cells were cultured on a plastic surface in sparse sheets of 2-50 cells mutually in contact, or isolated as single cells. Conditions are described which permitted conjoint cells to be impaled with recording microelectrodes with 75 % success, and isolated single cells with 8 % success. It is proposed that cells in electrical contact with neighbors are protected from irreversible damage by the penetrating electrode, by a flow of ions or other substances from connected cells across low-impedance intercellular junctions. Action potentials recorded from conjoint and isolated single cells were similar in form and amplitude. The height or shape of the action potential thus appears not to depend upon spatial relationships of one cell to another. As the external potassium concentration was increased from 1.3 mM to 6 mM, cells became hyperpolarized while the afterhyperpolarization was reduced. At higher potassium levels, the afterhyperpolarization disappeared, the slope of the slow diastolic depolarization decreased, and resting potential fell along a linear curve with a slope of 61 mv per 10-fold increase in potassium. In pacemaker cells the diastolic depolarization consists of two phases: (a) recovery from the afterpotential of the previous action potential and (b) the pacemaker potential. These phases are separated by a point of inflection, and represent manifestations of different mechanisms. Evidence is presented that it is the point of inflection (PBA) rather than the point of maximal diastolic potential, that should be taken as the resting potential.
Action Potentials↗
Differential effect of compression-ischaemia block on warm sensation and heat-induced pain.
The effect of compression-ischaemia nerve block on psychophysical thresholds for warm sensation and heat-induced pain was studied on 19 normal human volunteers. Although those two sensory submodalities should be predicted to block simultaneously, based on the fact that both are served by unmyelinated primary afferents, it was actually found that warm sensation was much more vulnerable to compression-ischaemia than heat-induced pain. This is interpreted as resulting from different summation requirements for each of the two sensory modalities; sensation of warmth depends on spatial summation to a larger extent than heat-induced pain. Such differential vulnerability is in line with recent clinical studies reporting deterioration of warm sensation associated with preservation of heat pain in peripheral nerve disorders caused by diabetes, ageing and other neuropathic processes.
Afferent Pathways↗
From stripes to spots: prepatterns which can be produced in the skin by a reaction-diffusion system.
A key question in the area of spatial pattern formation in developmental biology is: how do groups of cells in a homogeneous tissue suddenly differentiate along entirely different developmental paths compared to neighbouring cells? Although experiments are now beginning to provide answers to this question, the mechanisms responsible for the development of repeated or periodic structures and spatial patterns, e.g., hair follicles and pigmentation patterns, are still unknown. Theoretical biologists and applied mathematicians have suggested various prepattern mechanisms as the primary cause of repeated or periodic spatial patterns. A class of biochemical reactions referred to here as reaction-diffusion (RD) systems, having the capacity to spontaneously generate stable stationary wavelike spatial patterns (Turing, 1952), has been suggested as a possible prepattern mechanisms, e.g., during hair follicle initiation and development (Nagorcka, 1989), and pigmentation patterns (Murray, 1989). Spatial patterns arising during development of the vertebrate skin are frequently complex. Spatial patterns in the skin can be seen to vary within an individual from one region of the skin to another. One pattern change commonly observed across the skin is from stripes to spots. An RD system is defined which is able to generate different spatial patterns depending on the value of a single parameter. The parameter varied controls the transport of the chemical components of the RD system across the basement membrane separating the epidermis and dermis. The patterns produced range from stripes to an irregular array of spots. Not only are different patterns produced, but a different time sequence of prepatterns is expected to arise in the different skin regions depending on whether the first prepattern in an array of spots or stripes. As a consequence it is possible to account for hair follicle initiation in the hair-bearing regions of the mammalian skin as well as the sequence of events required for the formation of dermatoglyphics in the volar regions.
Animals↗
Numerical solutions for steady and unsteady flow in a model of the pulmonary airways.
A computational model is presented for unsteady flow through a collapsible tube with variable wall stiffness. The one-dimensional flow equations are solved for inlet, outlet and external conditions that vary with time and for a tube with time-dependent, spatially-distributed local properties. In particular, the effects of nonuniformities and local perturbations in stiffness distribution in the tube are studied. By allowing the flow to evolve in time, asymptotically steady flows are calculated. When simulating a quasi-steady reduction in downstream pressure, the model demonstrates critical transitions, the phenomena of wave-speed limitation and the sites of flow limitation. It also exhibits conditions for which viscous flow limitation occurs. Computations of rapid, unsteady changes of the exit pressure illustrate the phenomena occurring at the onset of a cough, and the generation and propagation of elastic jumps.
Computer Simulation↗
Measurement of the spatial Wiener spectrum of nonstorage imaging devices.
All previous methods for measuring image noise spectra require a noise realization, a static image, typified as a photograph which can be scanned to create the Wiener spectrum. We wished to analyze the spatial noise power spectrum at the output phosphor of a continuously irradiated imaging device, an x-ray image intensifier (XRII), which is incapable of image storage and thus the image is continually changing as a function of both time and space. Our new method utilizes a pair of slits to measure the relative Wiener spectrum of the temporally changing components of the image (i.e., x-ray quantum and XRII gain noises). By measuring the modulation transfer function and the Wiener spectrum of the same XRII on the same apparatus it was possible to demonstrate the spatial frequency dependence of the detective quantum efficiency. Adaptations of the method should permit the measurement of Wiener spectra of fluoroscopic television systems directly from the TV monitor.
Fourier Analysis↗