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At least 1,639 records · Page 91Linked to original sources
PubMed1992

Study of myocardial regional wall motion parameter's accuracy by software perfusion phantom.

Gated perfusion myocardial scintigraphy permits simultaneous evaluation of perfusion as well as regional contractile function of the left ventricle. Fourier analysis of regional myocardial spatial movement with respect to the myocardial geometric centre gives circular amplitude and phase profiles of ventricular contraction, in addition to regional maximum activity that represents an index of perfusion. To introduce such combined perfusion-contraction analysis the accuracy of the indices mentioned above should be evaluated for different doses of radioactivity typically administered to a patient. A mathematical software phantom, consisting of a half circularly profiled ring activity embedded in uniform background activity and noise generated by a Poisson-shaped random number generator, was constructed and used for this purpose. A 64 x 64 matrix and sequence of 16 frames per study was used. The maximum number of counts per pixel ranged from 10 to 100, simulating low count thallium and high count rate Tc-MIBI-gated studies. The relative standard error analysis (R.S.E.) with a 95.5% confidence level for a thallium type of 10 counts per pixel study exceeded 11%, while it reached acceptable values below 3% for studies with 60 and more counts per pixel. These results indicate that high count rate gated technetium-MIBI myocardial perfusion studies could also be used for reliable left ventricular regional wall motion evaluation.

Gated Blood-Pool Imaging↗
PubMed2004

A vital sign of the time: CIS software.

New software for clinical information systems (CIS) allows nurses and other providers to access vital patient information through a variety of wired and wireless options.

Decision Support Systems, Clinical↗
PubMedDate not supplied

The child and the medication: education software on administering medication in pediatrics.

Computer science is being introduced in education at an accelerated pace, thus forcing educators and students to become familiar with the technology. The objective of this project was aimed at the development and evaluation of the education software, The Child and the Medication. The program uses multimedia resources in four topics: the child, the medication, who administers it, and medication administration. The evaluation showed good acceptance of the program, with most of the items receiving excellent approval. The emphasis in this report is on the importance of teaching strategy development using computational means to teach nursing, thus capacitating the nurses of the next millennium.

Child↗
PubMedDate not supplied

Adopting best practices: "Agility" moves from software development to healthcare project management.

It is time for a change in mindset in how nurses operationalize system implementations and manage projects. Computers and systems have evolved over time from unwieldy mysterious machines of the past to ubiquitous computer use in every aspect of daily lives and work sites. Yet, disconcertingly, the process used to implement these systems has not evolved. Technology implementation does not need to be a struggle. It is time to adapt traditional plan-driven implementation methods to incorporate agile techniques. Agility is a concept borrowed from software development and is presented here because it encourages flexibility, adaptation, and continuous learning as part of the implementation process. Agility values communication and harnesses change to an advantage, which facilitates the natural evolution of an adaptable implementation process. Specific examples of agility in an implementation are described, and plan-driven implementation stages are adapted to incorporate relevant agile techniques. This comparison demonstrates how an agile approach enhances traditional implementation techniques to meet the demands of today's complex healthcare environments.

Adaptation, Psychological↗
PubMedDate not supplied

Using synchronous software in Web-based nursing courses.

To promote learning and enhance immediacy and satisfaction, a college of nursing at a large research I southern university undertook a pilot project to incorporate synchronous classroom software into an ongoing online program. Two synchronous class sessions using voice over Internet protocol were offered in the Community/Public Health Nursing course through Elluminate Live! Upon conclusion of the lecture, students were divided into breakout groups to work on group projects. Surveys were administered to the students and faculty before and after the class sessions. Evaluation of the pedagogical strategies used in the synchronous sessions was conducted by instructional technology faculty. Students in the pilot group reported higher levels of satisfaction with the Web-based course with synchronous sessions. In addition, students reported that group time at the end of the session was helpful for completing group projects. A majority responded that synchronous session activities and assignments facilitated their understanding of course content. This article presents a description of the synchronous classroom pilot project along with recommendations for implementation and pedagogical approaches.

Adult↗
PubMedDate not supplied

Project planning for health care software implementations.

It is estimated that 78% of projects fail to meet their original objectives. The time spent on project planning will help to improve on this statistic and directly yield a more successful project outcome. Based on the experiences of a panel of experts and the authors' experiences, this article presents a detailed planning guide to increase the chances of success on health care software implementations.

Diffusion of Innovation↗
PubMed2004

TealLock 5.20 security software program for handheld devices.

The TealLock has a simple graphic interface, and the program is user-friendly with well thought out options to customize security settings. The program is inexpensive and works seamlessly with the Palm OS platform's built-in basic Security application. The developer offers a 30-day free trial version and there is no downside to trying it to see if it meets your needs. It seems to be an effective security software program for psychiatrists who keep confidential and sensitive patient information on their PDAs. In keeping with HIPAA regulations, the TealLock bolsters security for protected health information stored on PDAs or other handheld devices by providing safeguards that address authentication, access control, encryption, and selected aspects of transmission.

Computer Security↗
PubMed2006

The EPRI EDE calculator--a software package for assessing effective dose equivalent from hot particles on the skin.

Whole body exposure from photon-emitting hot particles is receiving new attention because of changes in skin dose regulations. A recent study calculated and tabulated effective dose equivalent (EDE) and effective dose (ED) for photon energies between 0.1 MeV and 2 MeV for point sources at 74 locations on the skin. This technical note describes a software package called the EPRI EDE Calculator that allows a user to input exposure data and to calculate the EDE and ED automatically.

Algorithms↗
PubMed2007

Endothelial cell density in donor corneas: a comparison of automatic software programs with manual counting.

PURPOSE: Several automated systems have become available to determine endothelial cell density (ECD) of donor corneas. The purpose of this study was the comparison of 2 systems, the Endothelial Analysis System EAT V1.4 (Rhinetec, Duesseldorf, Germany) and the NAVIS Cell Count Version 3.4.1 (Nidek Technologies, Erlangen, Germany), against manual ECD counts. METHODS: During organ culture, the endothelium of 50 human corneas was photographed on both conventional film and digitally. Manual fixed-frame counting was performed on 2 photographs by 3 experienced ophthalmologists. Three digital pictures of each cornea were analyzed semiautomatically on the Rhinetec EAT system V1.4. Images were imported and analyzed by the fully automatic mode of the NAVIS system V3.4.1 (which also offers a semiautomatic counting mode). In an additional experiment on 11 corneas, the NAVIS counts on the microscopy system previously used only for manual cell counts were directly compared with manual counts. RESULTS: Mean endothelial cell density obtained by manual counting of all observers was 2679 +/- 313 (SD) cells/mm. Values obtained by digital analysis with EAT were a mean of 1.3% higher (2713 +/- 286 cells/mm), which is not a significant difference. In contrast, analysis of the digital pictures with the fully automated NAVIS software mode showed a mean of 7.0% higher measurements (2867 +/- 111 cells/ mm), a significant difference (P = 0.0001). Altman-Bland analysis revealed that the fully automated NAVIS counts gave too low results for high ECDs and too high results for low ECDs. This result was confirmed by the direct comparison with manual counting. CONCLUSIONS: Fully automated analysis of ECD remains problematic. Validation of any computer-assisted system against manual counting is of importance.

Adolescent↗
PubMed2001

FindTarget: software for subtractive genome analysis.

In silico subtractive/differential genome analysis is a powerful approach for identifying genus- or species-specific genes, or groups of genes that are responsible for a unique phenotype. By this method, one searches for genes present in one group of bacteria and absent in another group. A software package has been developed, named FindTarget, that has a user-friendly web interface to facilitate differential genome analysis. The user chooses the genomes to compare, the similarity criteria and the thresholds to decide if a gene has a counterpart in another genome. The searches are based on BLASTP comparisons of proteomes. FindTarget also includes access to sequences, coloured multiple alignments, phylogenetic trees of conserved proteins and links to public annotated databases which provide a means for validation of the results. To illustrate this approach, a FindTarget search for genes putatively involved in the specificity of cell envelope synthesis of Gram-negative bacteria is presented. The results show that most of the identified genes are clearly involved in cell wall processes, underlining the power of such an approach in general and that of FindTarget in particular.

Bacterial Proteins↗
PubMed2005

Databases and software for the comparison of prokaryotic genomes.

The explosion in the number of complete genomes over the past decade has spawned a new and exciting discipline, that of comparative genomics. To exploit the full potential of this approach requires the development of novel algorithms, databases and software which are sophisticated enough to draw meaningful comparisons between complete genome sequences and are widely accessible to the scientific community at large. This article reviews progress towards the development of computational tools and databases for organizing and extracting biological meaning from the comparison of large collections of genomes.

Computational Biology↗
PubMed2003

GANESH: software for customized annotation of genome regions.

GANESH is a software package designed to support the genetic analysis of regions of human and other genomes. It provides a set of components that may be assembled to construct a self-updating database of DNA sequence, mapping data, and annotations of possible genome features. Once one or more remote sources of data for the target region have been identified, all sequences for that region are downloaded, assimilated, and subjected to a (configurable) set of standard database-searching and genome-analysis packages. The results are stored in compressed form in a relational database, and are updated automatically on a regular schedule so that they are always immediately available in their most up-to-date versions. A Java front-end, executed as a stand alone application or web applet, provides a graphical interface for navigating the database and for viewing the annotations. There are facilities for importing and exporting data in the format of the Distributed Annotation System (DAS), enabling a GANESH database to be used as a component of a DAS configuration. The system has been used to construct databases for about a dozen regions of human chromosomes and for three regions of mouse chromosomes.

Animals↗
PubMed1998

Software for constructing and verifying pedigrees within large genealogies and an application to the Old Order Amish of Lancaster County.

This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

Christianity↗
PubMed2001

A new software routine that automates the fitting of protein X-ray crystallographic electron-density maps.

The classical approach to building the amino-acid residues into the initial electron-density map requires days to weeks of a skilled investigator's time. Automating this procedure should not only save time, but has the potential to provide a more accurate starting model for input to refinement programs. The new software routine MAID builds the protein structure into the electron-density map in a series of sequential steps. The first step is the fitting of the secondary alpha-helix and beta-sheet structures. These 'fits' are then used to determine the local amino-acid sequence assignment. These assigned fits are then extended through the loop regions and fused with the neighboring sheet or helix. The program was tested on the unaveraged 2.5 A selenomethionine multiple-wavelength anomalous dispersion (SMAD) electron-density map that was originally used to solve the structure of the 291-residue protein human heart short-chain L-3-hydroxyacyl-CoA dehydrogenase (SHAD). Inputting just the map density and the amino-acid sequence, MAID fitted 80% of the residues with an r.m.s.d. error of 0.43 A for the main-chain atoms and 1.0 A for all atoms without any user intervention. When tested on a higher quality 1.9 A SMAD map, MAID correctly fitted 100% (418) of the residues. A major advantage of the MAID fitting procedure is that it maintains ideal bond lengths and angles and constrains phi/psi angles to the appropriate Ramachandran regions. Recycling the output of this new routine through a partial structure-refinement program may have the potential to completely automate the fitting of electron-density maps.

Crystallography, X-Ray↗
PubMed2006

LAFIRE: software for automating the refinement process of protein-structure analysis.

Manual intervention is usually required in the multiple rounds of refinement of protein crystal structures, including linking and/or extending the fragments of the initial model and rebuilding (fitting) ill-matched residues using computer-graphics software. Such manual modification is both time-consuming and requires a great deal of expertise in crystallography. Consequently, the refinement process becomes the bottleneck for high-throughput structure analysis. A program, Local correlation coefficient-based Automatic FItting for REfinement (LAFIRE), has been developed to achieve manual intervention-free refinement. This program was designed to perform the entire process of protein structural refinement automatically using the refinement programs CNS1.1 (CNS v.1.1) or REFMAC5. The automatic process begins from an initial model, which can be approximate, fragmentary or even only main-chain, and refines it to the final model including water molecules, controlled by monitoring the R(free) factor. More than 30 structures have now been refined successfully in a fully or semi-automatic manner within a few hours or days using LAFIRE.

Animals↗
PubMed2006

Integrated software for macromolecular crystallography synchrotron beamlines II: revision, robots and a database.

This manuscript chronicles the evolution of software used originally to control a diffractometer at a macromolecular crystallography beamline. The system has been augmented and rewritten. A modular and carefully organized suite of programs now handles the whole experimental environment from a single vantage point. It provides automatic logging of the experiment and communication with the user, all the way from an initial proposal to perform the work to the end of data collection. This has included construction of a relational database to organize all details of the experiment and incorporation of a robotic specimen changer to provide automation for high-throughput applications.

Crystallography↗
PubMed1998

Crystallography & NMR system: A new software suite for macromolecular structure determination.

A new software suite, called Crystallography & NMR System (CNS), has been developed for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy. In contrast to existing structure-determination programs, the architecture of CNS is highly flexible, allowing for extension to other structure-determination methods, such as electron microscopy and solid-state NMR spectroscopy. CNS has a hierarchical structure: a high-level hypertext markup language (HTML) user interface, task-oriented user input files, module files, a symbolic structure-determination language (CNS language), and low-level source code. Each layer is accessible to the user. The novice user may just use the HTML interface, while the more advanced user may use any of the other layers. The source code will be distributed, thus source-code modification is possible. The CNS language is sufficiently powerful and flexible that many new algorithms can be easily implemented in the CNS language without changes to the source code. The CNS language allows the user to perform operations on data structures, such as structure factors, electron-density maps, and atomic properties. The power of the CNS language has been demonstrated by the implementation of a comprehensive set of crystallographic procedures for phasing, density modification and refinement. User-friendly task-oriented input files are available for nearly all aspects of macromolecular structure determination by X-ray crystallography and solution NMR.

Computer Simulation↗