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Results for “Behavior, Addictive”

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PubMed1998

[Tobacco addiction and current treatment methods].

Smoking currently is considered to be an addiction with severe medical and social effects. It has been implicated in some respiratory and extra-respiratory diseases. In spite of knowing its dangerous effects, many patients cannot stop smoking without outside help. This help usually is provided by health-care personnel. It is necessary to be familiar with disintoxication methods in order to be able to advise patients on the use of any one or a combination of them. The most efficient method is individual medical help. Nicotine substitutes have demonstrated their effectiveness. Other complementary methods are not considered effective unless combined.

Behavior, Addictive↗

PubMed2005

Neurobiochemical and clinical aspects of craving in alcohol addiction: a review.

Craving plays an important role in the pathogenesis of alcohol dependence and relapse. In this review we have tried to analyse how many contrasting theories have been formulated in order to clarify the concept of craving. Many complex neurobiochemical mechanisms are implicated in the etiology of craving; these mechanisms involve several neurotransmitters, such us dopamine, opioids, glutamate, and serotonin. On the other hand comportamental and/or cognitive aspects could also play a role in the etiology of craving. The coexistence of many and often contrasting theories can indicate that different subtypes of patients could have different mechanisms at the basis of alcohol craving, suggesting that it could be advisable to personalize the anti-craving therapy.

Alcoholism↗

PubMed1999

Cue reactivity and effects of cue exposure in abstinent posttreatment drug users.

After 12 months of inpatient treatment, 16 opiate-addicted patients were exposed to drug-related stimuli. The results of this study indicate that cue reactivity in opiate-addicted subjects is still present after 12 months of intensive inpatient treatment. After exposing subjects to drug-related stimuli, there is an increase in craving, feelings of depression, and anger. Because posttreatment subjects are likely to be confronted with these stimuli following discharge, a reduction of this reactivity is desirable. In the present study, cue reactivity (feelings of depression, anger, tension, craving, and physical symptoms) reduced after protocolized cue exposure treatment. This effect maintained for at least 6 weeks after the last cue exposure session.

Adult↗

PubMed1992

Can carrots be addictive? An extraordinary form of drug dependence.

The paper describes three cases of dependence on carotenoids with typical symptoms of irritability and nervousness accompanying their abstinence, with a long-term dependence, and an inability to simply discontinue. Three patients (a man and two women) all being smokers, evaluated this dependence as very similar to that on tobacco. The limitation of further use had the same effect in both cases. The women evaluate the dependence as stronger than that on cigarettes, the man as somewhat weaker. The former patient--a woman--even relapsed, and recently found herself in danger of further relapse. This, however, she nipped in the bud. Laboratory enzyme examinations revealed a disorder in the enzymatic outfit affecting the auto-immunity and the neurovegetative system.

Adult↗

PubMed2001

[Attitudes of alcoholics to addiction-related topics].

PURPOSE: In Germany the attitudes towards alcohol consumption and smoking are rather heterogeneous. Although it is well accepted that both behaviours are harmful and often lead to addiction, thus far the attitudes of alcoholics to addiction-related topics have not been evaluated. METHODS: In this investigation 228 alcoholics were asked to complete a questionnaire of addiction-related topics. RESULTS: The attitudes were rather realistic, concerning the harmful effects of alcohol. The beliefs were only slightly influenced by personal involvement (e.g. divorce). Different opinions were given as to the riskiness of illegal drugs. The attitude towards the reasons of alcoholism are most important for therapeutical decisions. Only a third of the patients believed that they themselves were responsible for their addictive behaviour while nearly half accused socioeconomical factors. The curability of their alcoholism as well as their own competence to overcome alcoholism was estimated rather realistically by the patients. The results could not be generalized since the sample mainly consisted of alcoholics who themselves sought an alcohol-specific treatment service. Furthermore the data analysis shows that about 90 % of them regarded themselves as alcoholics. CONCLUSION: Future studies have to show whether these attitudes differ from those of the general population and from alcoholics not seeking-help.

Adult↗

PubMed2003

Alcohol addiction research: from animal models to clinics.

Addictive behaviour evolves only on the basis of voluntary drug intake. As a consequence, when designing an animal model that covers several aspects of alcohol dependence and other alcohol related-diseases a necessary precondition is that the animal has voluntary access to alcohol. Animal models on voluntary alcohol consumption have a long-standing tradition in biomedical research on alcoholism. However, preference studies allow only limited conclusions regarding alcohol dependence and addictive behaviour. Therefore, new animal models have been developed that mimic different aspects of human alcohol dependence such as craving, relapse and loss of control over drinking. These models include the reinstatement model, the alcohol deprivation model and the point-of-no-return model. These models have now been pharmacologically validated using anti-craving compounds that are used clinically for treating alcoholics. In conclusion, there appears to be a good correspondence between the events that induce relapse and loss of control over alcohol-taking behaviour in laboratory animals and those that provoke relapse and loss of control in humans.

Alcohol Drinking↗

PubMed1996

[Pathologic gambling].

The author presents a review on pathological gambling. Similarly as in other addictive diseases, early therapeutic intervention is important. The latter may include: 1: Evaluation of the problem 2. Recommendation that the subject should avoid places where the gambling is pursued. He should not have larger financial sums on him. 3. Recommendations pertaining to lifestyle and prevention of excessive stress. 4. Handling of printed material (the author mentions the text issued to his patients). In the paper therapeutic procedures are described, incl. the author's experience such as the foundation of the group of Gamblers anonymous. Prevention is also considered. It is important that gambling should be less readily available and the demand for it should be smaller.

Behavior, Addictive↗

PubMed2000

A cognitive processing model of alcohol craving and compulsive alcohol use.

Many addiction theories assume that craving plays a central role in the acquisition and maintenance of drug dependence. For example, craving is often depicted as the subjective experience of the motivational state directly responsible for all drinking in the alcoholic. Craving has two prominent features that must be explained by any viable model of craving. First, craving tends to be highly situationally specific, readily triggered by stimuli previously associated with drug use. Secondly, craving can persist well beyond the cessation of drinking in an alcoholic. Conventional theories typically address craving's cue specificity and persistence by invoking concepts of classical conditioning. These theories fall into two classes: those that emphasize withdrawal and those that focus on the positive-incentive properties of drugs. Both types of theories assume that craving processes are represented by the concomitant activation of craving report, drug-seeking and drug use, and specific patterns of autonomic responses. However, research fails to find more than modest relationships across these putative manifestations of craving. The cognitive processing model, described in this paper, offers a different view of craving's form and function and proposes that drug use can operate independently of the processes controlling craving. According to this model, addictive drug use is regulated by automatic cognitive processes, while craving represents the activation of non-automatic processes. These non-automatic processes are activated to either aid in completing interrupted drug use or block automatic drug-use sequences. From this perspective, craving is neither irrelevant nor central to the alcoholic's drug use, but rather serves as a cognitive marker of processes that, only in some instance, may be associated with alcohol seeking and use. The research and treatment implications of this model's assumptions regarding drug use and craving processes are discussed.

Alcohol-Related Disorders↗

PubMed1999

Prevalence of personality disorders among clients in treatment for addiction.

This study determined the prevalence of personality disorders among clients in treatment for addiction; this prevalence was compared with those found in similar studies and in clinical samples of individuals suffering from other Axis I disorders. Our sample comprised 255 subjects. The first edition of the Millon Clinical Multiaxial Inventory (MCMI) was used. Only 11.8% of the subjects did not score over 84 on any of the 11 Axis II scales. Over one-half had a score of 84 or higher on the passive-aggressive and dependent-personality scales. The mean number of scales in the 84+ category was 2.68. Comparisons show that this sample was more severe in most cases.

Adolescent↗

PubMed2004

[The need for health promotion of medical students and proposal for prevention of addiction].

Alcohol, drug addiction or any other addiction to psychoactive drugs constitutes one of the most serious social problems in Poland. Despite systematic and more professional addiction prophylaxis, increased consumption of psychoactive drugs can be observed among children and youth. Prophylaxis is often limited to giving information on what must not be done and it does not include suggestions connected with constructive ways of coping with problems or of getting satisfaction. The problem of using psychoactive drugs by medical students is often neglected. Only few authors deal with this problem. The aim of the presented project is to educate medical students how to cope with difficult situations, form mutual reliability in a group, better self evaluate and wide the range of learning techniques.

Attitude of Health Personnel↗

PubMed2004

Stress-induced cigarette craving: effects of the DRD2 TaqI RFLP and SLC6A3 VNTR polymorphisms.

Animal models have long implicated dopamine in stress-induced craving for a variety of addictive substances. However, translational studies of dopamine, stress and craving in humans are lacking. Based on the animal literature, this study's objective was to test the hypothesis that cigarette smokers carrying specific variants in dopamine-related genes would have heightened levels of cigarette craving following exposure to a laboratory stressor. Cigarette craving induced by controlled exposure to a laboratory stressor was assessed in healthy adult smokers (n=108) recruited by advertisement. Significantly stronger stress-induced cigarette craving was found for individuals carrying either the DRD2 (D2 dopamine receptor gene) A1, or the SLC6A3 (dopamine transporter gene) nine-repeat allelic variants. Stress-induced craving was markedly higher for those carrying both alleles, compared to those with neither, consistent with the separate biological pathways involved (receptor, transporter). Findings provide strong support for the possibility that dopamine involvement in stress-induced craving well established in animal models also applies to humans, and suggest a potential genetic risk factor for persistent smoking behavior.

Adult↗

PubMed2003

Orphanin FQ/nociceptin blocks methamphetamine place preference in rats.

Orphanin FQ/nociceptin (NOC) has been reported to regulate dopaminergic neurotransmission in rewarding pathway, and to suppress the development of conditioned place preference (CPP) induced by certain addictive drugs. In this study, we investigated the effect of NOC on CPP induced by repeated administration of methamphetamine (MAP) in rats. Repeated administration of MAP (1 mg/kg, i.p.) induced substantial CPP. MAP-induced CPP was completely suppressed by NOC (10 nmol, i.c.v.). Pretreatment with [Nphe1]nociceptin(1-13)NH2 (50 nmol, i.c.v.), an antagonist of the NOC receptor, antagonized the suppressive effect of NOC on MAP-induced CPP. These results suggest that NOC blocks MAP-induced CPP by activation of the NOC receptor.

Animals↗

PubMed1998

The addiction of overeating: self-help groups as treatment models.

This article defines eating disorders and compares it to other addictions, gives a brief etiology, and presents two treatment models: Overeaters Anonymous and Weight Watchers International. The same personality factors that place individuals at risk for substance abuse are often found in individuals with eating disorders. These predispositions are explored from both a developmental and sociological perspective. Resources within our own communities can provide valuable interventions. Overeaters Anonymous emphasizes the psychological and spiritual components, with its main focus being the commitment to the group. Weight Watchers is also rooted in the fellowship of community but adopts a more behavioristic model. Although Weight Watchers supplies more practical strategies for managing overeating, both groups provide a framework for developing positive, adaptive, and self-nurturing modalities.

Behavior, Addictive↗

PubMed1999

Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene.

Norepinephrine is an important chemical messenger in the nervous system. It regulates affective states, learning and memory, endocrine and autonomic functions. It has been implicated in depression, aggression, and addiction, as well as cardiac and thermal dysregulation. The norepinephrine transporter functions by uptaking norepinephrine back into the cell for cyclic use, and is a direct target of a number of antidepressants and psychostimulants. Functional deletion (knockout) of monamine transporters results in increases in extracellular levels of neurotransmitters, thereby prolonging their actions. For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants. Careful use of such an animal model can hopefully provide valuable insight into the multiple roles norepinephrine plays in normal and pathological physiology.

Animals↗

PubMed2006

Recognizing alcohol and drug abuse in patients with eating disorders.

Eating disorders and alcohol/drug abuse are frequently comorbid. Eating-disordered patients are already at an increased risk for morbidity and mortality, so alcohol and drug use pose additional dangers for these patients. Restricting anorexics, binge eaters, and bulimics appear to be distinct subgroups within the eating-disordered population, with binge eaters and bulimics more prone to alcohol and drug use. Personality traits such as impulsivity have been linked to both bulimia nervosa and substance abuse. Many researchers have proposed that an addictive personality is an underlying trait that predisposes individuals to both eating disorders and alcohol abuse. Interviewing is generally the most useful tool in diagnosing alcohol and substance abuse disorders in individuals with eating disorders. It is essential for the physician to be non-judgmental when assessing for substance abuse disorders in this population. We discuss interviewing techniques, screening instruments, physical examination, and biological tests that can be used in evaluating patients with comorbid eating disorders and substance abuse. More studies are needed to understand psychobiological mechanisms of this comorbidity, and to develop treatments for individuals with comorbid eating disorders and substance misuse.

Alcohol-Related Disorders↗

PubMed1998

Transgenic mice in drug dependence research.

Transgenic mice with null mutation of specific genes of the central nervous system obtained by homologous recombination, called also knock-out mice, have been recently used by behavioural neuroscientists to understand better the relevance of certain biological mechanisms of drug dependence or addiction. This article reviews some of the main contributions to this fastly developing field. As addictive drugs exert similar reinforcing effects both in humans and other mammals, changes in behavioural performance produced by the motivational effects of the addictive drugs in knock-out mice can give important information about the relevance of that particular gene product (eg a neurotransmitter receptor) for the pathogenicity of substance abuse disorders. In same cases the deletion of a given gene for a neurotransmitter receptor involved in the action of addictive drugs is associated with a phenotype that reproduces the effects obtained by the pharmacological administration of an antagonist for the same receptor. In other instances, surprising results are obtained, the most striking being the evidence that mice lacking the dopamine transporter gene, the most important binding site of cocaine, retain the capability to self-administer cocaine intravenously. Because the gene deletion is operative during embryogenesis, some adaptive compensatory mechanisms may produce unexpected results, suggesting caution in the interpretation of these results. The advent of tissue-specific inducible knock-out mice will soon produce a second revolution in the field of substance abuse research.

Animals↗

PubMed1995

The Addiction Severity Index: reliability and validity in a Dutch alcoholic population.

The Addiction Severity Index (ASI) was evaluated for its psychometric qualities in a Dutch alcoholic population admitted to an addiction treatment center in The Netherlands. Its factorial structure in this population was found to be consistent with the established six factor structure of the ASI. Reliability analysis revealed that the homogeneity of the subscales was acceptable with the exception of the Alcohol Scale. The six subscales were not highly intercorrelated. The results of this study indicate that the ASI is a useful instrument for the assessment of several problems associated with alcoholism. However, the Alcohol Scale appears to be limited as a diagnostic and research instrument in the field of inpatient treatment of alcohol dependence in The Netherlands.

Adult↗

PubMed1993

Individual behaviour and tobacco consumption: a panel data approach.

This paper considers estimators of tobacco demand equations using Becker and Murphy's model of addiction with a complete panel of households for Spain. With these tools, we face two main problems: first, the endogeneity of past and future consumption and, second, the limited-dependent variable. To control these problems simultaneously is difficult and we proceed to confront them separately. We follow an instrumental variable approach (which also allows us to control for measurement errors in variables and non-independent effects) to tackle the first and we use a consistent within-group procedure to obtain the parameter vector of the structural form, once we have estimated T-Tobit models for the reduced form in order to deal with the limited-dependent variable problem.

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