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Medical conditions affecting the success of dental implants.

The development of endosseous implants has proven to be one of the most significant benefits dentistry has offered its patients to restore predictable oral function and improve their quality of life. There do exist however, some whose medical condition or medications preclude the successful placement and retention of fixtures. Over the years the number of these compromising situations has decreased, and will continue to do so, as a better understanding of metabolic and pathologic processes is forthcoming, as well as a willingness by dentists and physicians to explore those perceived contraindications that may not be justified. This manuscript reviews conditions previously thought to be, and those that actually are not, indications for implant placement as a guide for the practicing implantologist. It is present history only and by no means implies that subtractions and additions may not be forthcoming.

Contraindications↗

Evaluation of titanium dental implant osseointegration in posterior edentulous areas of micro swine.

This study investigated the micro swine (Sus scrofa) as an animal model for research in osseointegrated implant systems. As the first in a series of investigations based on this model, the study focused on the histological evaluation of the bone-implant interface of Brånemark implants. Ten titanium implants were placed in posterior edentulous areas of the swine for longitudinal evaluation of healing and osseointegration. Six-week and 18-week post-operative specimens were removed en bloc at the time of death. The samples were fixed in glutaraldehyde, embedded in acrylic, and sectioned with a diamond wafering saw. The specimens were viewed under SEM and photographed. The percentage of bone that was in direct contact with the coronal, middle, and apical segments of the implant, referred to as the contact length fraction (CLF), was determined by use of a digitizing analyzer. All implant fixtures became exposed through the soft tissue within one week of placement. Of the ten titanium fixtures placed, three failed--one by post-surgical day 14 due to food impaction into the surgical site, and the other two because of failure to osseo-integrate. Bone contact with the successfully integrated implant surfaces ranged from 19.2 to 58.5%, with a mean of approximately 34%. Osseointegration did not appear to increase over the experimental time period, since there was no difference in the percentage of bone contact between the 18-week and the six-week specimens. The lack of soft-tissue coverage over the implants caused bone loss, but did not significantly affect osseointegration in the coronal third. The micro swine appears to be a suitable animal model for use in implant research in posterior edentulous regions.

Alveolar Process↗

Soluble RANKL in crevicular fluid of dental implants: a pilot study.

BACKGROUND: Receptor activator of NF-kappaB ligand (RANKL), a member of the tumor necrosis factor superfamily, is a key mediator of osteoclast formation, activation, and survival. Thus, it is reasonable to hypothesize that there might be a functional relationship between RANKL expression and peri-implantitis. PURPOSE: This pilot study was performed to determine the reference levels for soluble RANKL (sRANKL) in peri-implant crevicular fluid and to correlate them with the clinical parameters associated with inflammatory reactions and bone destruction. MATERIALS AND METHODS: The clinical parameters probing depth (PD), modified bleeding index (MBI), and modified plaque index (MPI) served as indicators for bone resorption and inflammation. Exclusion criteria for calculations were the detection limit of the immunoassay and the minimum acceptable crevicular volume for measurement. From the 84 collected samples of 16 patients, 30-84 years of age, with a total of 19 implants, 29 met these criteria. The absolute amount of sRANKL within crevicular fluid adsorbed to filter strips was a median of 0.18 femtomol (fmol; range, 0.08-0.53) and 0.26 nM (range, 0.09-1.21) when normalized by volume. PD was 4 mm in median and varied within a range between 2 and 12 mm. RESULTS: Absolute amounts of sRANKL showed no correlation with the adsorbed volume and the clinical parameters PD, MBI, and MPI. When sRANKL was normalized by volume, no correlation with the clinical parameters PD, MBI, and MPI was observed either. The patients' age was not associated with total sRANKL and the concentration of RANKL within crevicular fluid. Absolute levels of sRANKL and sRANKL concentration did not show any differences based on the sampling sites buccal and lingual, or on the patients' gender. A significant difference in sRANKL concentration was detectable when samples from maxillary implants (0.31 nM median; range, 0.12-1.21) were compared with samples from mandibular implants (0.21 nM median; range, 0.09-0.6) (p=.03). Absolute levels of sRANKL were not different between the maxilla and the mandible. CONCLUSION: Given the limited sample size, our data provide a basis for future prospective longitudinal studies on the possible relevance of sRANKL as a prognostic marker in peri-implantitis, and for an understanding of the pathophysiologic process of the disease as a prerequisite for the design of treatment strategies.

Adult↗

The clinical assessment of a ceramic-coated transmucosal dental implant collar.

This study compared the superficial tissue responses to titanium and ceramic surfaces of transmucosal elements of established IMZ implants. In a splitmouth study on 14 patients with two mandibular implants and a bar-retained complete mandibular denture, a conventional titanium and a newly developed ceramic-coated transmucosal element were placed. A range of clinical parameters were recorded before transmucosal-element replacement and at 1, 4, and 12 weeks postplacement. A comparison of the recorded soft tissue responses revealed no significant differences between a group of implants fitted with ceramic-coated transmucosal elements and a group of contralateral implants fitted with titanium transmucosal elements. Further analysis suggested that the peri-implant soft tissues adjacent to titanium and ceramic surfaces may differ in features that are not apparent when routine clinical parameters are used. The plaque accumulation scores for ceramic-coated transmucosal elements were significantly lower than those recorded in titanium transmucosal elements. These results suggest that the further development of a ceramic implant transmucosal collar may assist plaque control at the soft tissue-implant interface and may favourably influence the tissues in this region. This investigation should be considered a pilot study in view of the duration of the observations and number of patients involved.

Adult↗

Maxillary sinus augmentation using different grafting materials and dental implants in monkeys. Part III. Evaluation of autogenous bone combined with porous hydroxyapatite.

The aim of this study was to evaluate clinically, histologically, and histometrically the use of autogenous bone combined with porous hydroxyapatite (Interpore 200) as a grafting material for maxillary sinus augmentation procedures. In 4 adult male rhesus monkeys (Macaca mulatta) the 1st, 2nd and 3rd maxillary molars on one side of the jaws were extracted. After a healing period of 3 months, maxillary sinus augmentation procedures were performed in each monkey, and the sinuses were grafted with autogenous bone from the monkeys' tibia mixed in a 3:1 ratio with porous hydroxyapatite. At the same time, 2 pure titanium plasma-sprayed IMZ cylinder implants were immediately placed into the augmented sinuses (i.e. simultaneous implants-loaded group). After 4 months, 2 additional similar implants were placed into the previously augmented sinuses (i.e. delayed implants-loaded group). Four months later, the abutment connection was performed and all 4 implants were loaded with a gold-alloy bridge for 6 months (i.e. until sacrifice of the animals). The contralateral side of each monkey received similar treatment with the exception that the extractions were performed 7 months after those in the opposite side and that the implants were not loaded. Thus, 2 additional study groups (i.e. simultaneous implants unloaded group and delayed implants unloaded group) were obtained. Clinically, all loaded implants were stable at the day of sacrifice. Histologically, the grafted sinuses exhibited a significant amount of new bone formation. The porous hydroxyapatite granules appeared integrated with the newly formed bone. Histometric analyses revealed that delayed implant placement resulted in a greater amount of direct mineralized bone-to-implant contact in the augmented area than the simultaneous implant placement. Furthermore, the percentage of direct mineralized bone-to-implant contact was far more significant in the residual bone than in the augmented area. It was concluded that the autogenous bone/porous hydroxyapatite graft combination enhanced bone formation and mineralized bone-to-implant contact in the augmented sinuses and that the delayed implant placement may be favorable for sinus augmentation procedures.

Animals↗