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The arthroscopic appearance of acute temporomandibular joint trauma.

The arthroscopic appearance of the temporomandibular joint following acute trauma sufficient to result in mandibular fracture was described in 40 joints in 20 patients. It was found that 38 of 40 joints showed evidence of intra-articular damage. Hemarthrosis with shredding of the disc and joint surfaces was the most common finding. The hemarthrosis rapidly resolved but the shredding remained. The degree of damage was related to the site of mandibular fracture with the most damage being seen when the condylar neck was not fractured.

Adolescent↗

Comparison of functional recovery after nonsurgical and surgical treatment of condylar fractures.

This article evaluates 16 cases of condylar fracture treated surgically, comparing them with the 20 cases treated nonsurgically, with a 2-year follow-up. Although severely displaced and luxated fractures were involved in the surgical group with rigid internal fixation, satisfactory postoperative function and occlusion were achieved at the same level as in the nonsurgical group, without severe complications.

Adolescent↗

Characterization of the extracellular matrix of the primate temporomandibular joint.

The distribution of type I and II collagens, fibronectin and the fibronectin-integrin receptor, tenascin, laminin, link protein, and cartilage-specific glycosaminoglycans was examined in the primate temporomandibular joint complex using an immunohistochemical approach. In general, type I collagen, fibronectin, and the fibronectin-integrin receptor were found to co-distribute throughout the joint complex. Immunostaining for these proteins was notably intense in the prechondroblastic and mineralization zones of the articular cartilages of the joint. Tenascin was identified in several structures of the joint, including the articular cartilages, where intense staining was observed in the prechondroblastic and cartilagenous zones. Laminin was detected only in the adventitia of blood vessels located in the attachment tissues of the disc and joint synovium. Cartilage-specific glycosaminoglycans and type II collagen were observed in the cartilagenous zones of the articular cartilages of the mandibular condyle and temporal bone. In addition, immunostaining for cartilage-specific glycosaminoglycans also was detected throughout the extracellular matrix surrounding "chondrocyte-like" cells located in the joint disc. Despite the localization of cartilage-specific glycosaminoglycans in the disc, type II collagen was not detected in this structure. It is suggested that a fibronectin-integrin receptor mechanism may be involved in the regulation of growth of the articular cartilages of the temporomandibular joint.

Animals↗

Effect of ibuprofen on the healing and remodeling of bone and articular cartilage in the rabbit temporomandibular joint.

The purpose of this study was to determine the effect of ibuprofen on the healing and remodeling of bone and cartilage in the temporomandibular joint of the rabbit. Forty-two rabbits were operated on to create a groove and a hole in the articular surface of both the right and left mandibular condyles. Following surgery, the animals were divided into three groups. Group A (12 rabbits) was used as a control and the animals did not receive any medication. Group B (15 rabbits) was given a daily dose of 17 mg/kg of ibuprofen. Group C (15 rabbits) was given a daily dose of 34 mg/kg of ibuprofen. All animals were killed after 4 weeks. The 84 condyles were examined clinically and histologically. Statistical analysis showed a highly significant difference in the healing of bone and cartilage between groups A and C (P less than .01) and a significant difference between groups A and B (P less than .05). The results of this study indicate that ibuprofen has an adverse effect on the healing of bone and cartilage in the temporomandibular joint of the rabbit.

Animals↗

Surgical versus conservative treatment of unilateral condylar process fractures: clinical and radiographic evaluation of 80 patients.

Treatment results of 26 surgically and 54 conservatively treated unilateral condylar process fractures were investigated by standardized clinical examination and by evaluation of computer-simulated graphic presentations of posteroanterior (PA) radiographs of the mandible. The radiographic evaluation compared the relation of actual reduction of the condylar process fractures with ideally reduced fractures produced on the computer. Using clinical parameters (maximal mouth opening, deviation, protrusion), no statistical differences between surgically and conservatively treated fractures were found. However, the radiographic examinations showed a statistically better position of the surgically reduced condylar process fractures.

Adolescent↗

Rigid fixation in reconstruction of craniofacial fractures.

Ninety-four patients had either isolated fractures of the skull or midface, or combined fractures of the skull, periorbit, and/or midface. Thirty-five of these patients were treated by conventional methods, including maxillomandibular fixation (MMF) 4 to 6 weeks postoperatively, wire osteosynthesis, suspension ligatures, or a head frame. The remaining 59 patients were treated with either mini-, low-profile, micro-, or 3-D titanium plate fixation (rigid internal fixation [RIF]) and comprise the patient population for this study. Of the 59 patients, 11 were female and 48 male, ranging in age from 6 to 85 years, with a mean age of 34 years. Six patients had isolated skull fractures, 9 had combined skull and periorbital fractures, 31 had isolated midface fractures, and 13 patients had combined skull and midface fractures. The follow-up period ranged from 3 to 48 months. Patients with midface fractures were placed in MMF intraoperatively, and MMF was released at the completion of the procedure. At 2 to 4 days postoperatively, the occlusion was evaluated. Fifteen of the 38 dentate patients with either midface or combined skull and midface fractures were without MMF postoperatively. Twenty-three patients showed slight occlusal discrepancies and were treated with elastic MMF for 3 to 28 days (mean, 10 days). All reductions were judged to be stable throughout the postoperative course. Based on the results, use of RIF is recommended for primary reconstruction in craniofacial trauma patients whenever possible, thereby achieving three-dimensional stability, sufficient functional and cosmetic results, and often avoiding or reducing the need for MMF.

Adolescent↗

Changing trends with mandibular fractures: a review of 1,067 cases.

To evaluate current trends in facial trauma, records from 1,067 patients sustaining 1,515 mandibular fractures from 1979 to 1989 were reviewed. The greatest number of fractures occurred between the ages of 20 to 29 years. Sex distribution was approximately three males to one female. Altercations were found to have caused about half of the fractures, and motor vehicle accidents accounted for nearly one-third. Angle fractures were most common, constituting 26.7% of the total. The most common site of mandibular fracture resulting from altercation was the angle (39.1%); condylar, symphysis, and alveolar fractures less commonly resulted from altercations than from motorcycle and automobile accidents.

Accidents, Traffic↗

An accurate method for open reduction and internal fixation of high and low condylar process fractures.

OBJECTIVE: This study was undertaken to evaluate a protocol for open reduction of both high and low condylar fractures that consistently produces accurate reductions, uses rigid internal fixation, and allows immediate function. MATERIALS AND METHODS: This protocol was retrospectively evaluated in 22 consecutive patients (23 fractures). RESULTS: All patients functioned immediately. There were no inaccurate reductions, malocclusions, wound infections, neurosensory deficits, or reports of chronic pain. No patients required reoperation. CONCLUSION: The results of this study indicate that this protocol consistently produces accurate reduction of condylar process fractures and allows immediate function with a minimum of morbidity.

Adolescent↗

Surgical versus nonsurgical treatment of unilateral dislocated low subcondylar fractures: a clinical study of 52 cases.

To compare open versus closed reduction of unilaterally dislocated low subcondylar fractures in adults, 101 consecutive dentulous patients were treated either by closed reduction with a median of 4 weeks of maxillomandibular fixation, or with a median of 6 weeks of maxillomandibular fixation after surgical repositioning and transosseous wiring of the dislocated condylar fragment. No selection of patients was done for either treatment. Fifty-two patients were seen at a median of 2 years postoperatively. Complications such as malocclusion, mandibular asymmetry, impaired masticatory function, and pain located to the affected joint or masticatory muscles were seen significantly more frequent in patients treated with closed reduction compared with those treated surgically (P = .005). Neither the degree of dislocation of the proximal fragment, concomitant mandibular fractures, nor the absence of posterior occlusal support seemed to influence the results.

Adolescent↗

Magnetic resonance imaging assessment of acute soft tissue injuries to the temporomandibular joint.

PURPOSE: This study involves the use of magnetic resonance imaging (MRI) to document acute soft tissue injuries involving the temporomandibular joint (TMJ) after condylar fractures. MATERIALS AND METHODS: Patients with condylar fractures whose clinical and radiographic examinations, as well as the mechanism of their injury, suggested specific damage to the temporomandibular soft tissues underwent MRI scanning. Thirteen patients who met selected criteria were included in this study. RESULTS: Ten patients demonstrated disc avulsion, usually in the anterior or medial direction. Two patients had disruption of the lateral capsule, and one patient showed no MRI evidence of acute injury. Joint effusions were frequently demonstrated. CONCLUSIONS: MRI of condylar fractures in those patients with displacement, or in whom the mechanism of injury would predispose them to posttraumatic internal derangement, may assist the clinician in determining whether primary or delayed treatment is indicated. Furthermore, MRI may be a useful resource for enhancing the level of understanding regarding soft tissue changes that occur in the TMJ after acute condylar trauma.

Cartilage, Articular↗

STT3, a novel essential gene related to the PKC1/STT1 protein kinase pathway, is involved in protein glycosylation in yeast.

Mutations of genes involved in the STT1/PKC1 pathway in yeast show staurosporine and temperature sensitivities (stt) which are suppressed by the addition of 1 M sorbitol [Yoshida et al., Mol. Gen. Genet. 242 (1994) 631-640]. Among the stt mutants, stt3-2 shares this phenotype. The STT3 gene encodes a novel 718-amino-acid protein with significant homology to potential transmembrane proteins of Caenorhabditis elegans and mouse mandibular condyle (about 80% homologous and 60% identical). Unlike the STT1/PKC1 gene, STT3 is essential for cell growth irrespective of osmotic support. Pulse-chase experiments show that the sst3 mutants are defective in protein glycosylation. The stt3 mutants are sensitive to hygromycin B and resistant to sodium orthovanadate, whose phenotypes are common to those defective in protein glycosylation.

Alkaloids↗