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Fifteen years analysis of complications following minilaparotomy female sterilization in Jos Nigeria.

A retrospective analysis of complications following female sterilization via minilaparotomy performed in Jos University Teaching Hospital between January 1985 and December 1999 was undertaken to determine the incidence, the type of complications and identify ways of improving the service. 2986 clients had female surgical contraceptions. Major surgical complications occurred in 0.87% of the clients. Minor complications were seen in 4.15% with wound sepsis contributing 3.75% to the rate. The crude failure rate was 0.23%. Re-anastomosis was the reason for the failures not surgical misapplication of devices nor fistulous opening as found elsewhere. There was no death in the series. Clients seeking surgical contraception should be counseled about the minimal major surgical and minor complications that could occur during the procedures. Our center will need to focus on infection prevention in female surgical contraception in order for the services to enjoy continuous acceptance by the clients.

Adult↗

Biorhythms.

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Animals↗

[Selection in the context of provocation in artificial populations of Drosophila melanogaster].

The experimental potentials of the method for selection against provocative background (autoselection) in artificial populations of Drosophila melanogaster were analysed. The dynamics of adaptation of Drosophila population under increasing NaCl concentration in food was studied. It appeared that selection was successful in case of feedback between the selection pressure, mediated by alteration of salt concentration, and the rate of flies adaptation determined by the intensity of their reproduction. Within a short period of time, as the result of autoselection, the flies' ability for development with NaCl of up to 8% concentration in food was registered. It was shown that this resistance of flies to the salt was inherited within twelve successive generations.

Adaptation, Physiological↗

Sjögren's syndrome diagnosed in pregnancy: a case report.

BACKGROUND: As in most other autoimmune diseases, Sjögren's syndrome is seen predominantly in women. Since the peak age is around the late reproductive and early postmenopausal period, the obstetric aspect has not been well studied. CASE: A 28-years-old woman, pregnant for 22 weeks and 5 days, was admitted with worsening general status, skin lesions, arthralgias, and oral and ocular symptoms typical of Sjögren's syndrome. She underwent hemodialysis for renal insufficiency. To prevent autoantibody formation, progression of the disease, therapy with methyl prednisolone, 100 mg/d intravenously; cyclophosphamide, 500 mg/month in a single intravenous application; hemodialysis 3 times a week; and plasmapheresis 7 times was instituted. An 1,100-g, male infant at 27 weeks and 5 days was delivered by cesarean section because of premature preterm rupture of membranes and severe late decelerations on cardiotocography. The infant was discharged from the neonatal intensive care unit after 30 days, weighing 1,800 g. Postnatal echocardiographic examination of the infant revealed neither cardiac malformations nor arrhythmias. CONCLUSION: Since the presence of autoantibodies against SS-A and SS-B are reported to accompany congenital heart block, the primary goal of therapy should be preventing this untoward effect of the disease. Close monitoring during pregnancy is mandatory to detect preeclampsia, intrauterine growth retardation and preterm labor.

Adult↗

[Effects of nonylphenol on PCNA expression and aromatase expression in reproductive system of F1 generation].

OBJECTIVE: To elucidate the mechanism of the toxicity of nonylphenol (NP) to reproductive development by analyzing the PCNA and Aromatase expression of the F1 generation male reproductive system in perinatal period. METHODS: Nonylphenol was administrated to pregnant rats at doses of 50, 100 and 200 mg/kg, respectively, for 7 to 20 days of pregnancy. The rats were sacrificed at 20 days of pregnancy and 2 days after parturition. Their serum levels of estradiol and nonylphenol were determined. The histopathological examination and immune histochemical analysis on testis and epididymis were also performed. RESULTS: Significantly higher serum estradiol and nonylphenol levels were found in the pregnant rats treated with nonylphenol. Immune histochemical analysis showed that the PCNA expression levels of testis tissues of F1 generation rats, both 20-day-old fetus and 2-day-old neonatal rats, in 100 mg/kg and 200 mg/kg experiment groups were much lower than those in the control group. Both PCNA expression of epididymis and Aromatase expression of testis of the F1 generation rats after 2 days of birth in 200 mg/kg group were also lower than those in the control group. CONCLUSION: Nonylphenol can impair the development of testis and epididymis of the F1 generation in perinatal period.

Animals↗

[The clinical characteristics of atypical endometrial hyperplasia].

An analysis is made on the clinical symptoms of 72 women with diagnosis of atypical hyperplasia established morphologically. The clinical data are manifested in accordance with the periods of the woman: reproductive climacteric and menopausal. Dysfunctional uterine bleedings, combined with endocrine-metabolic disturbances, predominate. A substantial connection between the atypical hyperplasia and the frequency of patients with myoma of the uterus is established as well as the closeness between the clinical picture of atypical characteristic and endometrial adenocarcinoma. Patients with atypical characteristics are formed as risk group for occurrence of endometrial carcinoma. It is necessary to know risk factors for occurrence of endometrial pre-carcinoma as well as indispensable condition for organization of more effective prophylaxis.

Age Factors↗

[Chlamydia trachomatis infection in women and the use of oral contraceptives].

We determined the prevalence of genital Chlamydia trachomatis infection in women who visited a clinic for sexually transmitted diseases (STD) and the influence of the number of partners and the use of oral contraceptives (OC), with special attention to the recognition of pelvic inflammatory disease (PID) and to the results of therapy. Of 217 women, with a mean age of 26 years (range 14-56), who visited the STD clinic of the University Hospital of Groningen from July 1985 until November 1987, anamnestic data were collected as well as the results of swabs from cervix and urethra taken for culture and direct immunofluorescence test of C. trachomatis and for gonococcal culture. The influence of the number of partners (1 versus greater than 1) and OC on the prevalence of C. trachomatis infection was evaluated by logistic regression analysis. PID was excluded in coöperation with the department of gynaecology. C. trachomatis-infected women were treated by doxycycline orally (day 1 2 x 100 mg, day 2-7 1 x 100 mg) according to the dosage scheme advised by the Dutch Health Council in 1986. A control culture was taken 2-3 weeks after treatment. C. trachomatis was detected in 72/217 (33%) women by culture and (or) direct IF test and in 22/41 (54%) women with gonorrhoea. In connection with the number of partners in the year preceding the examination, the following prevalences were found: 18/74 (24%) (1 partner), 43/108 (40%) (2-5 partners) and 10/27 (greater than 5 partners).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Physical and sexual maturation of healthy girls during development of the reproductive system].

The physical and sexual development was evaluated in 488 healthy girls aged 0-18 years, 253 of them underwent an echographic examination of the internal genitalia. The processes of physical and sexual development of the girls' body were shown to be closely related, i.e. sexual maturation occurs at a definite level of physical development. During maturation of the reproductive system, several critical periods were established, each of them showing particular changes in the physical status, which correlated with those in the development of internal genitalia.

Adolescent↗

The effect of infection by Babesia sp. on some biological parameters of engorged females of Boophilus microplus.

Engorged females (EF) of Boophilus microplus tick were collected from Hereford, Criolla and Nelloreheifers of three different herds to study the influence of natural babesial infection on the following biological parameters of the EF: engorgement weight, preoviposition period, minimal egg incubation period, egg hatching and Reproductive Efficiency Index. No detrimental consequences to the reproduction of EF carrying babesial infection were found when compared with those EF in which no kinetes of Babesia were detected. Even the groups of EF most highly parasitized (21 to 110 kinetes per microscope field of hemolymph) showed biological values considered as normal, suggesting the existence of adaptive tolerance between B. microplus and the Babesia protozoa under field conditions.

Animals↗

Seasonal variation of ammonia-quotient in an Indian air-breathing freshwater teleost, Channa punctatus.

The ammonia-quotient, calculated from the data on the levels of ammonia excreted and oxygen consumed from the water, is a potent tool for understanding the utilization of macromolecules as metabolic fuel. The fish, Channa punctatus, utilizes more protein in the summer and spawning months for getting its metabolic energy but in the winter and post-spawning months it also utilizes other substrates like lipid and carbohydrate for its metabolic energy.

Ammonia↗

Storage of sperm in the reptilian oviduct.

Female reptiles have the ability to store sperm within their reproductive tracts for extended periods of time. Sites of sperm storage in lizards and snakes include both the anterior vagina and the infundibulum. Vaginal receptacles are found in between longitudinal folds (snakes) and in tubules formed by invaginations of the epithelium (lizards). Infundibular receptacles are alveolar or tubular in structure and are formed from invaginations into the lamina propria of the oviduct wall. In turtles, sperm are stored in the posterior portion of the tuba, in tubular albumen-secreting glands. Sperm may be embedded within the cells of the receptacles, but the membranes of each remain intact. The morphology of the receptacles is characteristic of the normal glands of the area.

Animals↗

[Synthesis of RNAs and proteins in hoplonemertinian oocytes with and without the effect of gonadostatin (GIH)].

Deprivation of gonadostatin (gonad-inhibiting hormone: GIH) performed during the quiescent period of the annual reproductive cycle in the hoplonemertean, Amphiporus lactifloreus, resulted in precocious sexual maturation. In female worms, the oometrical analysis showed that the hormone target, the ovary, responds to GIH deprivation by accelerated growth of a part of the oocyte population. The qualitative and quantitative histoautoradiographic examination of [3H]uridine and [3H]leucine incorporation enabled us to study RNAs and protein synthesis prerequisite and requisite for the oocyte growth. Early and continuous stimulation of protein synthesis in precociously growing oocytes was testified to by an increase in [3H]leucine incorporation into their ooplasm from day 6. On the other hand, later sequential stimulation of RNAs synthesis was observed, since a strong activation (induction?) of nucleoplasmic RNAs synthesis (tRNA and/or mRNA) from day 10 only took over from the slightly higher rDNA transcriptional activity seen in nucleolus from day 6 to day 9. By forcing the oocyte population of the ovary to retain a juvenile status, the inhibition of traduction into oocytes constitutes the earlier effect of gonadostatin. For bioassays by labelled precursor incorporation labelled aminoacids are the best candidates.

Animals↗