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PubMed1976

The demonstration of carcinoembryonic antigen in colorectal carcinoma and colonic polyps using an immunoperoxidase technique.

Carcinoembryonic antigen (CEA) has been demonstrated in tissues, by immunofluorescence, with conflicting results. Originally thought to be persent in colorectal carcinoma only, the antigen was later demonstrated in inflamed colonic mucosa and polyps. Using formalin-fixed, paraffin-embedded tissues and an immunoperoxidase technique, we have attempted to demonstrate CEA in 12 colorectal carcinomas, in adjacent benign mucosa, and in 42 polyps of varying histologic type. CEA was demonstrated in all colorectal cancers but not in adjacent inflamed mucosa. The antigen could not be demonstrated in polyps except in five cases where CEA was shown in morphologically atypical glands only. With out technique, the demonstration of CEA is a reliable indicator of malignant change in colonic mucosa. The findings in polyps tend to support the concept of carcinoma in situ in adenomatous polyps and the polyp-cancer sequence.

Adenocarcinoma↗
PubMed1975

Polyps caused by gastric erosions.

Gastric erosions, a disease with a tendency to recur through decades, may in advanced age and anacidity give rise to polyps. These histologically benign polyps may be recognized by clinical methods of examination.

Achlorhydria↗
PubMed1990

Profound spatial clustering of polyps in individuals with multiple nonmalignant polyps of the stomach and duodenal bulb: a combined endoscopic and radiographic study.

An individual's simultaneous nonmalignant gastroduodenal polyps were profoundly spatially clustered in a combined endoscopic and radiographic study of 41 consecutive patients. With endoscopic polyp localization, clustering was demonstrated using a nonparametric test of clustering (Kruskal-Wallis statistic with 40 degrees of freedom = 113.35, probability of observing this extreme statistic with no clustering less than 0.0005) and a parametric test of clustering (F test statistic with 40 and 104 degrees of freedom = 17.05, probability of observing this extreme statistic with no clustering less than 0.0005). In the 26 patients with radiographic polyp localization, polyp clustering was confirmed with the same statistical techniques (e.g., Kruskal-Wallis statistic with 25 degrees of freedom = 88.2, probability of observing this extreme statistic with no clustering less than 0.0005). In patients whose largest polyp was in any given region, there was an increased likelihood that their other polyps would be in that same region. For example, at endoscopy, the nine patients whose largest polyp was in the duodenal bulb had 13 of 15, or 87% +/- 9% (SE), of their other polyps in the duodenal bulb. In contrast, the 11 patients who, at endoscopy, had their largest polyp in the proximal stomach had 2 of 30, or 7% +/- 5% (SE), of their other polyps in the duodenal bulb. Polyp clustering was not dependent on the number of gastroduodenal polyps, or patient age or sex. Patients with at least one hyperplastic polyp, one adenomatous polyp, or with both types of polyps also exhibited profound polyp clustering. These findings suggest that local factors may be important in the pathogenesis of multiple polyps of the stomach and duodenal bulb. In particular, these findings suggest a possibly closer relationship between hyperplastic and adenomatous gastroduodenal polyps than previously appreciated.

Aged↗
PubMed1980

Inflammatory tumor of the cecum simulating neoplasm.

Barium enema performed on a 36-year old man prior to the operative repair of a rectal stricture demonstrated a large cecal filling defect which radiologically was consistent with a villous adenoma or carcinoma. At the time of exploratory celiotomy (for possible ileocolectomy) intraoperative colonoscopy revealed a necrotic appearing lesion in the cecum which did not look neoplastic. Local excision of the mass was therefore performed. The lesion proved to be an inflammatory polyp.

Adenoma↗