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PubMed1975

Gonorrhea: recommended treatment schedules.

Appropriate drugs and their proper use are described for the care of adult and pediatric patients with uncomplicated and complicated gonococcal infections in men and women. Special diagnostic considerations in some cases are indicated. These recommendations were established by the Venereal Disease Control Advisory Committee after deliberation with therapy consultants.

Acute Disease↗
PubMed2001

Intestinal spirochete infections of chickens: a review of disease associations, epidemiology and control.

This paper presents an overview of intestinal spirochete infections of chickens. It focuses particularly on studies in Australia, where recent surveys of 136 layer and broiler breeder flocks have revealed a high rate of infection (>40%) with intestinal spirochetes. Infection was not detected in broiler flocks. Approximately 50% of isolates from infected flocks were Brachyspira (Serpulina) intermedia or B. pilosicoli, with the other isolates being B. innocens, B. murdochii or the proposed species 'B. pulli'. No isolates of B. alvinipulli were found. Intestinal spirochetes were significantly associated with wet litter problems and/or reduced egg production. Experimental infection of point-of-lay birds with either B. intermedia or B. pilosicoli caused reduced egg production, and, with B. intermedia, a significant increase in fecal moisture content. Infection with B. innocens caused no significant changes. In-water treatment of a flock with a mixed spirochete infection using lincospectin resulted in a slimy diarrhea lasting for 2-3 weeks, followed by absence of spirochetes for 3 months. Birds treated with tiamulin remained healthy, and had a reduced level of infection with intestinal spirochetes (30%) for 3 months. Trials are under way to test the efficacy of antimicrobials in point-of-lay chickens experimentally infected with either B. intermedia or B. pilosicoli.

Animals↗
PubMed1975

Determination of sensitivity of Mycoplasma hyosynoviae to tylosin and selected antibacterial drugs by a microtiter technique.

A microtiter technique was used for determination of the sensitivity of Mycoplasma hyosynoviae to antibiotics and other drugs. Use of a biphasic agar-broth medium in microtiter plates allowed direct visualization of growth. Results were more reproducible with this system than when broth alone was used and evaluation based on color change was required. Attempts to adapt the test for use with Mycoplasma hyorhinis were not successful. Minimal inhibitory concentrations of 12 drugs and drug combinations for 12 strains of M. hyosynoviae are presented. Drugs with the lowest minimal inhibitory concentrations were tylosin (0.37 mcg/ml)and lincomycin (0.88 mcg/ml), both of which have been used for treatment and control of M. hyosynoviae arthritis. Comparison of the minimal inhibitory concentrations of tylosin for 43 isolates of M. hyosynoviae obtained in 1959 and 1960 and from 1966 through 1971 indicated the possibilty of decreasing sensitivity to the drug although differences between recent isolates and earlier ones were not statistically significant.

Acetates↗
PubMed1975

Gonorrhea--recommended treatment schecules, 1974.

Gonorrhea, the nation's second most frequently reported communicable disease, will affect more than a million persons this year. The following is the latest treatment schedule issued by the USPHS Center for Disease Control, Atlanta.

Adolescent↗