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An incremental approach to genetic-algorithms-based classification.

Incremental learning has been widely addressed in the machine learning literature to cope with learning tasks where the learning environment is ever changing or training samples become available over time. However, most research work explores incremental learning with statistical algorithms or neural networks, rather than evolutionary algorithms. The work in this paper employs genetic algorithms (GAs) as basic learning algorithms for incremental learning within one or more classifier agents in a multiagent environment. Four new approaches with different initialization schemes are proposed. They keep the old solutions and use an "integration" operation to integrate them with new elements to accommodate new attributes, while biased mutation and crossover operations are adopted to further evolve a reinforced solution. The simulation results on benchmark classification data sets show that the proposed approaches can deal with the arrival of new input attributes and integrate them with the original input space. It is also shown that the proposed approaches can be successfully used for incremental learning and improve classification rates as compared to the retraining GA. Possible applications for continuous incremental training and feature selection are also discussed.

Algorithms↗

A repeatable inverse kinematics algorithm with linear invariant subspaces for mobile manipulators.

On the basis of a geometric characterization of repeatability we present a repeatable extended Jacobian inverse kinematics algorithm for mobile manipulators. The algorithm's dynamics have linear invariant subspaces in the configuration space. A standard Ritz approximation of platform controls results in a band-limited version of this algorithm. Computer simulations involving an RTR manipulator mounted on a kinematic car-type mobile platform are used in order to illustrate repeatability and performance of the algorithm.

Algorithms↗

Velocity fluctuation reduction in vector Doppler ultrasound using a hybrid single/dual-beam algorithm.

In order to reduce the fluctuations in the velocity magnitude estimate, we propose a modification to the standard algorithm for reconstructing the (two component) vector velocity from the measured Doppler shifts in two directions. This uses the standard dual-beam algorithm, combined with temporal smoothing, to find only the velocity angle, then uses the single-beam algorithm to estimate the velocity magnitude. We present initial data showing the significant reduction in velocity estimate fluctuation that this hybrid method achieves compared to the standard algorithm.

Algorithms↗

Autofocusing in medical ultrasound: the scaled covariance matrix algorithm.

This work develops a class of ultrasound phase aberration correction/autofocusing algorithms that are based upon the properties of the covariance matrix of the channel signals for time-delay focused resolution/speckle cells. The scaled covariance matrix (SCM) algorithms are designed to blindly estimate and correct focusing timing errors due to thin layers of unanticipated fatty tissue located in the near field of the transducer array. An important aspect of the algorithm is that the scaling of the covariance matrix elements fundamentally establishes a channel independent phase reference relative to which the aberrant channel phases are estimated. The model development involved the combination of a rigorous mathematical analysis of the scattering of ultrasound in random scattering media and extensive statistical simulation studies with phase aberrations imposed upon both the transmit and received channel signals. Under the assumption of a near field aberration model, the statistical simulation analyses showed that the SCM algorithms in simulation are capable of accurately estimating relative time delay channel errors with rms timing errors up to approximately 62 ns, with interchannel correlation lengths as short as 1.4 mm.

Algorithms↗

Focused beam control for ultrasound surgery with spherical-section phased array: sound field calculation and genetic optimization algorithm.

This study aims at a sound field calculation for the spherical-section phased array and an optimization algorithm for the focus patterns of phased array ultrasound surgery. An efficient field calculation formula represented as an explicit expression is derived by the strategies of projection and binomial expansion. An optimization algorithm based on genetic algorithm is constructed by the suitable fitness function and the selection strategies. The simulation results of 256-element spherical-section phased array show the capability of controlling focus accurately and effectively with the combined method made up of the explicit expression method and the genetic optimization algorithm. The simulation results of single focus, multiple foci, on-axial focus, and off-axial focus further convince the feasibility of three-dimensional (3-D) focus steering with excellent acoustic performances. A single focus with the focus dimension of 1.25 mm x 1.25 mm x 7 mm and with the intensity of 6080 W/cm2 is formed. The multiple-focus pattern can enlarge the treatment volume 22 times larger than that of single focus with a sonication. In addition, a comparison between the explicit expression approach and the point source approach testifies to the applicability of the explicit expression approach. The experiment and simulation results of 16-element array actually confirm the feasibility of the combined method.

Algorithms↗

Evaluation of the spectral fit algorithm as functions of frequency range and deltakaeff.

Considerable effort has been directed at quantifying the properties of the tissue microstructure (i.e., scatterer correlation length) to diagnose disease and monitor treatment. In vivo assessments have had limited success due to frequency-dependent attenuation along the propagation path (i.e., total attenuation) masking the frequency dependence of the scattering from the tissue microstructure. Previously, both total attenuation and scatterer correlation length, given by the effective radius, were solved simultaneously by a two-parameter minimization of the mean squared error between a reference spectrum, modified by the attenuation and scatterer effective radius, and the backscattered waveforms using an algorithm termed the spectral fit algorithm. Herein, the impact of frequency range (largest frequency minus smallest frequency) and deltakaeff (largest kaeff value minus smallest kaeff value; k is wave number and aeff is scatterer effective radius) used by the spectral fit algorithm on estimating the scatterer effective radius, and total attenuation was assessed by computer simulations while excluding frequencies of the backscattered power spectrum dominated by electronic noise. The simulations varied the effective radius of the scatterers (5 microm to 150 microm), the attenuation of the region (0 to 1 dB/cm-MHz), the bandwidth of the source, and the amount of electronic noise added to the radio frequency (rf) waveforms. The center frequency of the source was maintained at 8 MHz. Comparable accuracy and precision of the scatterer effective radius were obtained for all the simulations whenever the same deltakaeff was used to obtain the estimates. A deltakaeff of 1 gave an accuracy and precision of approximately 15% +/- 35%, and a width of 1.5 gave an accuracy and precision of approximately 5% +/- 15% consistently for all of the simulations. Similarly, the accuracy and precision of the total attenuation estimate were improved by increasing the frequency range used by the spectral fit algorithm.

Algorithms↗

PFIT and PFRIT: bioinformatic algorithms for detecting glycosidase function from structure and sequence.

The identification of the enzymes involved in the metabolism of simple and complex carbohydrates presents one bioinformatic challenge in the post-genomic era. Here, we present the PFIT and PFRIT algorithms for identifying those proteins adopting the alpha/beta barrel fold that function as glycosidases. These algorithms are based on the observation that proteins adopting the alpha/beta barrel fold share positions in their tertiary structures having equivalent sets of atomic interactions. These are conserved tertiary interaction positions, which have been implicated in both structure and function. Glycosidases adopting the alpha/beta barrel fold share more conserved tertiary interactions than alpha/beta barrel proteins having other functions. The enrichment pattern of conserved tertiary interactions in the glycosidases is the information that PFIT and PFRIT use to predict whether any given alpha/beta barrel will function as a glycosidase or not. Using as a test set a database of 19 glycosidase and 45 nonglycosidase alpha/beta barrel proteins with low sequence similarity, PFIT and PFRIT can correctly predict glycosidase function for 84% of the proteins known to function as glycosidases. PFIT and PFRIT incorrectly predict glycosidase function for 25% of the nonglycosidases. The program PSI-BLAST can also correctly identify 84% of the 19 glycosidases, however, it incorrectly predicts glycosidase function for 50% of the nonglycosidases (twofold greater than PFIT and PFRIT). Overall, we demonstrate that the structure-based PFIT and PFRIT algorithms are both more selective and sensitive for predicting glycosidase function than the sequence-based PSI-BLAST algorithm.

Algorithms↗

Stochastic algorithms for Markov models estimation with intermittent missing data.

Multistate Markov models are frequently used to characterize disease processes, but their estimation from longitudinal data is often hampered by complex patterns of incompleteness. Two algorithms for estimating Markov chain models in the case of intermittent missing data in longitudinal studies, a stochastic EM algorithm and the Gibbs sampler, are described. The first can be viewed as a random perturbation of the EM algorithm and is appropriate when the M step is straightforward but the E step is computationally burdensome. It leads to a good approximation of the maximum likelihood estimates. The Gibbs sampler is used for a full Bayesian inference. The performances of the two algorithms are illustrated on two simulated data sets. A motivating example concerned with the modelling of the evolution of parasitemia by Plasmodium falciparum (malaria) in a cohort of 105 young children in Cameroon is described and briefly analyzed.

Algorithms↗

An energy algorithm improves symptoms in some patients with gastroparesis and treated with gastric electrical stimulation.

Gastric electrical stimulation (GES) is effective to improve symptoms of nausea and vomiting in most patients, but very little is known about the effect of varying stimulation parameters. We analysed stimulation parameters in a pilot study of 22 patients (12 idiopathic, four diabetic and four postsurgical) with drug-refractory gastroparesis who did not respond optimally to initial settings. Patients underwent high-frequency/low energy GES using identical initial stimulation parameters: 5 mA of current, 330 micros pulse width, 14 Hz for 0.1 s on and 5.0 s off. Due to lack on optimal response, 22 patients underwent alteration of an algorithm using stimulation parameters. At follow-up (mean of 4.3 years) a dose-response relationship for charge, power and energy were compared with baseline for the whole group and for each diagnostic subgroup by anova data are reported as mean +/- SE. Based on the mean of individual dose-response curves, differences in data are charge, current per pulse and energy per pulse were noted for the whole group at follow up vs baseline. The subgroup of patients with postsurgical gastroparesis required the most energy using the algorithm. In conclusion, an algorithmic approach to identify optimal stimulation parameters in GES for individual patients is associated with symptom improvement. Also, certain subgroups appear to have different energy parameters. Based on this preliminary data, the use of an algorithm for some patients with GES is feasible and may have potential for clinical application. A randomized-controlled trial of different stimulation parameters for GES seems warranted.

Adult↗

A modified electrocardiographic algorithm for differentiating typical atrioventricular node re-entrant tachycardia from atrioventricular reciprocating tachycardia mediated by concealed accessory pathway.

Non-invasive prediction of tachycardia mechanism is becoming clinically important in the era of catheter ablation for curing supraventricular tachycardia. Twelve-lead electrocardiograms (ECGs) during sinus rhythm and atrioventricular node re-entrant tachycardia (AVNRT) or atrioventricular reciprocating tachycardia (AVRT) with a narrow QRS complex were obtained from 154 consecutive adult patients who had received successful radiofrequency catheter ablation. The ECGs of initial 104 patients were analysed by three observers without knowledge of the electrophysiological diagnosis. The two arrhythmias were accurately diagnosed in 68% of cases. Three criteria were found to be discriminators of tachycardia mechanism by univariable analysis. Pseudo r/Q/S waves predicated AVNRT in 92% of cases (sensitivity 71%; specificity 95%). Retrograde P wave predicated AVRT in 86% of cases (sensitivity 75%; specificity 85%), RP interval > or =100 ms in 93% (sensitivity 71%; specificity 94%) and ST-segment elevation in lead aVR in 83% (sensitivity 71%; specficity 83%). According to the initial results, we proposed a modified stepwise ECG algorithm which used pseudo r/S/Q waves, RP interval and ST-segment elevation in lead aVR during tachycardia. Two observers assessed the modified algorithm in the remaining 50 patients. The algorithm was able to correctly diagnose the tachycardia mechanism in 84% and 87%, respectively. Using the modified algorithm can improve the accuracy and simplify the differential diagnosis between typical AVNRT and AVRT via concealed accessory pathway in adult patients.

Adult↗

Improved diabetes control by using 'close adjustment algorithms'.

BACKGROUND: Intensive insulin therapy increases the frequency of severe hypoglycemia despite markedly improved glycemic control in patients with type 1 diabetes mellitus. To determine the optimal dose of insulin, the authors designed algorithms based on self-monitored blood glucose levels. METHODS: Each dose of insulin was composed of two components: a basal dose determined on the basis of blood glucose levels over the previous two days and an additional dose determined on the basis of blood glucose level just before insulin injection. The patients were instructed to adjust each dose according to the algorithms. The authors investigated the effects of using algorithms on glycemic control, anthropometric data, body composition, and lipid profile in seven females with type 1 diabetes 12-20 years old. RESULTS: After 3 months, the daily dose of insulin increased significantly from 0.93 +/- 0.18 to 1.16 +/- 0.26 units/kg of body weight, and haemoglobin A(1C) decreased significantly from 8.27 +/- 1.33 to 6.50 +/- 0.64%. Severe hypoglycemia, however, did not occur. Body mass index increased significantly from 21.7 +/- 2.7 to 22.7 +/- 2.9 kg/m(2) with no increase in the percentage of body fat. All lipid-profile data showed a decreasing trend. CONCLUSIONS: Algorithms developed on the basis of self-monitored blood glucose levels are useful in determining the optimal dose of insulin and can improve glycemic control and lipid metabolism.

Algorithms↗

Prospective study to develop an algorithm for investigation by endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography.

BACKGROUND: Identifying cost-efficient and patient-friendly pathways for those who present with suspected pancreatico-biliary disease remains a challenge. Algorithms must be tailored to improve decision-making. We assessed suitable criteria from which an algorithm for selection for endoscopic retrograde cholangiopancreatography (ERCP) or magnetic resonance cholangiopancreatography could be developed. METHODS: Data on clinical, ultrasound and liver function test findings and outcome were recorded for consecutive patients undergoing ERCP and patients were stratified into different indications and a therapeutic ratio (TR) obtained for each (TR = number of therapeutic ERCP/total number of ERCP). RESULTS: One hundred and twenty ERCP were attempted with 112 cannulations (93.3%). Seventy-one therapeutic procedures were attempted with 64 (90.1%) successes. Forty-two (35%) investigations were normal. Seven (6%) patients suffered complications. Thirteen indications were used. The TR varied according to the indication. The TR for jaundice with biliary dilatation was 0.85. In contrast, asymptomatic patients with deranged liver function test and normal gall bladder on USS had a TR of 0.17. Gallstones with cholestatic liver function test yielded a TR of 0.54. A TR of 0.7 was considered an appropriate 'cut-off' for triage to ERCP or magnetic resonance cholangiopancreatography. An algorithm was generated based on these data. From this cohort, 50 (42%) patients would have been more appropriately investigated by magnetic resonance cholangiopancreatography, although 20 (40%) would have required therapy afterwards. CONCLUSIONS: An algorithm that separates indications by TR (TR > 0.7) may provide a cost-efficient, patient-friendly pathway for investigation and improve the use of resources.

Adult↗

A novel insulin delivery algorithm in rats with type 1 diabetes: the fading memory proportional-derivative method.

An algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error-weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6-h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well-controlled and significantly lower than in Version 1 (118 +/- 2.0 vs. 130 +/- 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery.

Algorithms↗

Improved rate responsive algorithm in QT driven pacemakers--evaluation of initial response to exercise.

The QT pacemaker is a rate modulated pacemaker that uses the evoked QT interval as an indicator to determine its optimal pacing rate. Despite the generally favorable clinical results with this form of pacing, some flaws in the system have been reported, such as the frequently observed rather slow initial response of the pacing rate to physical exercise, and the phenomenon of oscillation of the heart rate. These problems can be attributed to the rate adaptive algorithm used in the current QT pacemaker. Recently, in a reexamination of the relationship between evoked QT interval and pacing rate, a curvilinear relationship between these parameters has been demonstrated. As a result, a new algorithm has been developed for the next generation of the QT pacemaker. Before this new algorithm was implemented in new implantable devices, it was evaluated in a multicenter clinical investigation, with emphasis on the initial response of the pacing rate to exercise. This study was carried out by means of special software in the programmer of the QT pacemaker. By employing real-time bidirectional telemetry, it was possible to submit the study population, consisting of 37 patients with implanted QT pacemakers of the current generation, to identical exercise tests. Comparing these exercise tests, it appears that a considerable gain in speed of response to exercise can be achieved by using the same sensor with a faster reacting, nonlinear rate adaptive algorithm.

Aged↗

A new algorithm to solve endless loop tachycardia in DDD pacing: a multi-center study of 91 patients.

ELTs (endless loop tachycardias) are a common occurrence associated with DDD pacing. In order to detect and treat ELTs, an innovative automatic pacemaker algorithm was devised and evaluated. The basic principle of the algorithm rests on the relative stability of the ventriculoatrial conduction time (VACT) during ELTs. ELTs are suspected when the VACT remains stable and adheres to certain programmable limits referred to as VACT stability (16 or 31 msec); it is confirmed when the VACT remains stable after a programmable shortening of the AV delay (AVD) value, referred to as AVD shortening (47 or 63 msec). Ninety-one patients, 54 males and 37 females, were implanted with such an algorithm-specific device between January 10 and September 9, 1989. The reasons for implantation were as follows: 55 patients were implanted for AV block, 31 for sinus node dysfunction, and 2 for carotid sinus syndrome. Pacing parameters were programmed to favor ELT initiation (long AVD, short postventricular atrial refractory period [PVARP] and high atrial sensitivity) followed by basic programming of the algorithm (VACT stability set at 16 msec and AVD shortening set at 47 msec. Once this was done, a 24-hour Holter recording was obtained. Eighty-eight patients were thus analyzed, three being excluded from the final report due to the poor quality of the Holter tracings. In 43.2% of the sampling (38 patients), multiple episodes of ELT were identified, exhibiting a mean rate of 120 beats/min. In 26 of 38 cases (68.4%), the rate of ELT was found to be slower than the upper rate limit (URL).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Clinical experience with Thera DR rate-drop response pacing algorithm in carotid sinus syndrome and vasovagal syncope. The International Rate-Drop Investigators Group.

This study examined the effectiveness of cardiac pacing using the Thera DR rate-drop response algorithm for prevention of recurrent symptoms in patients with carotid sinus syndrome (CSS) or vasovagal syncope. The algorithm comprises both diagnostic and treatment elements. The diagnostic element consists of a programmable "window" used to identify heart rate changes compatible with an evolving neurally mediated syncopal episode. The treatment arm consists of pacing at a selectable rate and for a programmable duration. Forty-three patients (mean age 53 +/- 20.4 years) with CSS alone (n = 8), CSS in conjunction with vasovagal syncope (n = 4), or vasovagal syncope alone (n = 31) were included. Thirty-nine had recurrent syncope, while the remaining four reported multiple presyncopal events. Prior to pacing, 40 +/- 152 syncopal episodes (range from 1 to approximately 1,000 syncopal events) over the preceding 56 +/- 84.5 months. Postpacing follow-up duration was 204 +/- 172 days. Three patients have been lost to follow-up and in one patient the algorithm was disabled. Among the remaining 39 individuals, 31 (80%) indicated absence or diminished frequency of symptoms, or less severe symptoms. Twenty-three patients (23/29, or 59%) were asymptomatic with respect to syncope or presyncope. Sixteen patients had symptom recurrences. Of these, seven experienced syncope (7/39, or 18%) and 9 (29%) had presyncope: the majority of patients with recurrences (6/7 syncope and 7/9 presyncope) were individuals with a history of vasovagal syncope. Consequently, although symptoms were observed during postpacing follow-up, they appeared to be of reduced frequency and severity. Thus, our findings suggest that a transient period of high rate pacing triggered by the Thera DR rate-drop response algorithm was beneficial in a large proportion of highly symptomatic patients with CSS or vasovagal syncope.

Adolescent↗

Performance of basic ventricular tachycardia detection algorithms in implantable cardioverter defibrillators: implications for device programming.

Around 20% of patients with third generation implantable cardioverter defibrillators receive inappropriate therapy, usually triggered by atrial fibrillation. This is because the criteria used for ventricular tachycardia detection by current implantable cardioverter defibrillators are based on the analysis of a sequence of RR intervals and may be inappropriately satisfied by supraventricular tachyarrhythmias. Algorithms for ventricular tachycardia detection were challenged against the full RR interval sequences from 482 spontaneous episodes of atrial fibrillation and 260 spontaneous episodes of ventricular tachycardia to determine their ability to discriminate between the arrhythmias. The sensitivities and specificities of the algorithms were calculated over a wide range of programmable parameters. For a given window length and detection interval, the most stringent algorithms, that required all beats to be classified as "fast", were more specific than those allowing a proportion of "normal" intervals, even after adjustment for differing sensitivity. These differences were less marked for faster tachycardias. Specificity increased with the detection window length to a limit of approximately 18 beats. We conclude that ventricular tachycardia is detected with the highest specificity if all beats in an analyzed sequence are required to be "fast," even after lengthening of the tachycardia detection interval to maintain sensitivity. Further improvement in algorithm performance may require the incorporation of criteria such as tachycardia onset and stability.

Algorithms↗

A cardiac evoked response algorithm providing threshold tracking: a North American multicenter study. Clinical Investigators of the Microny-Regency Clinical Evaluation Study.

The purpose of this study was to evaluate a pacing system using the recognition of cardiac evoked response for the automatic adjustment of pacing output. Patients were prospectively followed after primary implantation of VVIR pacemakers using AutoCapture (St. Jude Medical CRMD). Sensing and pacing thresholds, polarization signal, evoked response, and AutoCapture performance were evaluated with serial visits and 24-hour Holter monitoring. Three hundred ninety-eight patients (mean age 71 +/- 15 years) were followed for an average duration of 1 year (3 days-1.75 years) with the algorithm functional in > 90% of patients. Backup pacing in the event of exit block was confirmed in all patients. Pacing thresholds remained stable at 0.89 +/- 0.34 V with a pulse width of 0.31 ms (with chronic output autoset at 0.3 V above the actual threshold). Evoked response exhibited a small but statistically significant increase with time (8.92 mV at implant, 9.60 mV at 12 months), however, this finding did not result in any change in AutoCapture function during our follow-up period. The polarization signal remained stable with minimal variation (1.12 mV at implant, 1.18 at 12 months). No clinical adverse events were observed using the AutoCapture algorithm. In this initial experience with the AutoCapture algorithm the evoked response and polarization measurements remained adequate, allowing the system to function in the majority of patients with safe, low output pacing. High energy backup pacing provided an added safety feature over fixed output devices in cases of unexpected threshold rises. Longer follow-up is required for continued long-term validation of the algorithm.

Aged↗