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PubMed2005

[Validation of food security and social support scales in an Afro-Colombian community: application on a prevalence study of nutritional status in children aged 6 to 18 months].

We conducted a cross-sectional study on 193 mothers of children 6 to 18 months of age in an African-Colombian community, with the objectives: (1) to adapt and validate the Community Childhood Hunger Identification Project scale, the DUKE-UNC-11 social support scale, and the Quebec Longitudinal Study of Child Development (QLSCD) partner support scale, and (2) to identify any existent relationship between nutritional status in infancy and both food insecurity and social support. We determined construct validity using factor analysis and theoretical models-based non-parametric correlations. Length-for-age and weight-for-length Z-results were calculated. Factor analyses reduced the hunger scale to one factor, the DUKE-UNC-11 scale to two factors, and the QLSCD scale to one factor. The Cronbach's alpha test ranged between 0.70 and 0.90. Both food insecurity and social support scales were correlated with mother's social conditions, and social support was positively associated with social networks and mother's self-perceived health status. Food insecurity, emotional-social support, and partner's negative support were associated with lower height-to-age and therefore a higher ratio of chronic malnutrition. The study supports the appropriateness of the instruments to measure the expressed concepts.

Colombia↗

PubMed1979

Theoretical, practical, and social issues in behavioral treatments of obesity.

Although showing superior maintenance, behavioral treatments of obesity typically produce small weight losses at a decelerating rate. Rather than reflecting poor compliance with treatment, these findings are consistent with known compensatory metabolic changes that operate to slow weight loss and promote regain. Other problems associated with dieting include failure of caloric regulation, hyper-responsivity to food palatability, and hunger, which is greater under conditions of moderate restriction and unpredictability of access to food. The inevitability of treatment failure in many instances must be faced and efforts made to prevent further worsening of the obese patient's self-esteem. Prognosis and treatment planning may be aided by consideration of the historical difficulties of weight loss, the degree of hunger experienced on diets, which may reflect important physiological differences among individuals, and the use of food to optimize arousal level. Full involvement of the patient in setting goals and planning treatment is recommended.

Behavior Therapy↗

PubMed2001

Glucose for smoking cessation: does it have a role?

Nicotine replacement therapies and amfebutamone (bupropion) have both been shown to aid smoking cessation. However, even with the best support most attempts to stop smoking fail, and many smokers prefer not to use medications in their quit attempts. Oral dextrose (glucose) has been proposed as a possible aid to smoking cessation which would be very inexpensive and might be used by some smokers as well as or instead of medications. It is hypothesised that single doses of nicotine relieve hunger in smokers so that over time smokers therefore come, in certain situations, to interpret sensations associated with hunger as craving for a cigarette. Adaptation to long term nicotine intake leads to exacerbation of these sensations during periods of abstinence. Chewing dextrose tablets results in a rapid increase in blood glucose levels that would be expected to yield a small reduction in these sensations which might then translate into a reduction in craving. An intervention that reduced craving might help smokers to maintain abstinence. Placebo-controlled studies have provided some support for the hypothesis that chewing glucose tablets can reduce desire to smoke during abstinence, and the one adequately powered study carried out so far found that glucose tablets increased 1-month abstinence rates significantly compared with a placebo. Definitive trials are now required but, given their low cost, glucose tablets may be a useful aid for some smokers.

Glucose↗

PubMed2001

Pharmacology of appetite suppression: implication for the treatment of obesity.

Given the current global epidemic of obesity there is a demand for new anti-obesity drugs to overcome the problem. Many pharmacological agents reduce food intake and significantly decrease body mass when administered to animals but affect feeding behaviour in a profoundly different way indicating the variety of biological mechanisms by which such agents act (appetite verses non-appetite). More limited clinical data demonstrates that some of the same drugs produce decreases in food intake and weight loss in humans. A few of these drugs do so by modifying the functioning of the appetite system as measured by subjective changes in feelings of hunger and fullness (indices of satiety). These drugs that modify the daily flux of appetite could be considered as 'appetite suppressants' with clinical potential as anti-obesity agents. Drugs that can be considered suitable candidates for appetite suppressants are agents that enhance peripherally satiety peptide systems (such as CCK, Bombesin/GRP, Enterostatin and GLP-1), alter the CNS levels of various hypothalamic neuropeptides (NPY, Galanin, Orexin, CART and Melanocortins) or monoamine neurotransmitters (such as serotonin, nor-adrenaline and possibly dopamine). Recently, the hormone leptin has become regarded as a key hormonal signal linking adipose tissue status with a number of key central nervous system circuits (NPY, CART, CRF, Melanocortins and possibly Orexins). This tonic system may also provide drug targets for the control of appetite. Any changes induced by a potential appetite suppressant should be considered in terms of the (i) psychological experience and behavioural expression of appetite, (ii) metabolism and peripheral physiology, and (iii) functioning of CNS neural pathways. In humans, such modulation of appetite will involve changes in total caloric consumption, subjective changes in feelings of hunger and fullness, preferences for specific food items, and general macronutrient preferences. These may be expressed behaviourally as changes in meal patterns, snacking behaviour and food choice. Within the next 20 years it is certain that clinicians will have a new range of anti-obesity compounds available to choose from. Such novel compounds may act on a single component of the appetite system or target a combination of these components detailed in this review. Such compounds used in combination with life style changes and dietary intervention may be critical in dealing with the rising world epidemic of obesity.

Animals↗

PubMed2004

The pharmacology of human appetite expression.

The discovery of the adiposity signal leptin a decade ago revolutionised our understanding of the hypothalamic mechanisms underpinning the central control of ingestive behaviour. Subsequently, the structure and function of various hypothalamic peptide systems (Neuropeptide Y (NPY), Orexins, Melanocortins, Cocaine and Amphetamine Regulating Transcript (CART), Galanin/Galanin Like Peptides (GALP) and endocannabinoids) have been characterised in detail in rodent models. The therapeutic benefit of targeting these systems remains to be discovered. More is becoming known about the pharmacological potential of peripheral, meal-induced, episodic endogenous peptides. Hormones such as Cholecystokinin (CCK), Gastrin Releasing Peptides (GRP), Glucagon-Like Peptide I (GLP-1) Enterostatin, Amylin, Peptide YY (PYY) and Ghrelin are released prior to, during and/or after a meal, controlling intake and subjective feelings of appetite (hunger and satiety). In addition, there is an expanding body of literature detailing the effects of a wide variety of drugs on human appetite and food intake. Some of these drugs act upon CNS monoamine systems such as Serotonin (5-HT). Dopamine (DA) and Noradrenaline (NA), have long been implicated in appetite regulation. Detailed examination of both the effect of agonising endogenous gut peptide systems and the effect of various monoaminergic drugs on the expression of human appetite can provide a greater understanding of mechanisms underpinning normal appetite regulation. However, such an understanding must be based on knowledge of the effect of the treatment on meal size, eating rate, meal pattern, food choice and the subjective experience of appetite flux (hunger and satiety), and notjust food intake.

Appetite↗

PubMed2001

Does perceived exertion depend on glycemic index of foods ingested throughout three hours before a one-hour high-intensity exercise?

The purpose of this study was to assess the relationships between perceived exertion (RPE) and plasma glucose concentrations or hunger feelings during a 1-hr. bicycle submaximal exercise after ingestion of pre-exercise test foods with a different glycemic index. Each of endurance-trained male triathletes ingested three different glycemic index (GI) foods (HighGI: glucose, LowGI: whole-wheat biscuit or water) throughout the 3 hr. before exercise at 80% maximal oxygen uptake (VO2 max). RPE values increased as a logarithmic function of time. This result is opposite to results obtained with longer exercise bouts up to 3 hr. duration. RPE and hunger ratings were not significantly different for the three test foods whatever the time. Moreover, RPE did not correlate with plasma glucose concentrations during exercise. Consequently, RPE did not depend on the GI of the pre-exercise test foods during a 1-hr. exercise at 80% VO2 max. Physiological and psychological factors other than glycemic index may have mediated the perceptual responses during a 1-hr. high-intensity exercise. It is possible that during endurance exercise of longer duration, the level of blood glucose mediates the intensity of peripheral exertional perceptions arising from active skeletal muscle during prolonged exercise.

Adult↗

PubMed1990

Attention and disordered eating behavior: II. Disattention to turbulent inner sensations as a risk factor in the development of anorexia nervosa.

The Slade model for development of anorexia nervosa proposes that the female may seek success and control in her life by pursuing a thin body through dieting when faced with serious personal problems. Extending upon this model, the present program of research has sought to identify those characteristics of women generally at-risk for anorexia nervosa that would make dieting behavior especially successful, permitting the progression from food restraint into food aversion. The present studies considered whether heightened and stress-related inner stimulation could interfere with the at-risk woman's sensitivity to hunger sensations, thereby decreasing her motivation to eat. A series of analyses conducted within two studies indicated: (1) a relationship between elevated daily stress, concern over being over-whelmed by inner feelings, and a loss of discrimination regarding sources of inner feelings, (2) a tendency to narrow attentional focus when overloaded with excessive internal stimulation, and (3) diminished sensitivity to hunger sensations for women generally at-risk for anorexia nervosa given a narrowed attentional focus.

Adolescent↗

PubMed2002

Daily variations in cortisol levels and binge eating disorder.

Morning and afternoon levels of cortisol for 73 volunteers (67 women and 6 men) were compared in relation to their Binge Eating Disorder scores, Body Mass Indexes, and self-reports of mood and hunger. Cortisol level was not significantly correlated with binge eating or mood or hunger for either time period. However, it was inversely related to body mass, with lower cortisol levels associated with greater body mass.

Adult↗

PubMed1982

Role of peptides from gastrointestinal cells in food intake regulation.

Many peptides are contained in specific cells distributed throughout the gastrointestinal tract. Some are known to be released by the presence of specific components of food and to affect specific gastrointestinal functions related to digestion and absorption of nutrients. For many of the more recently identified peptides, however, stimuli for release and physiological functions are unknown. Improved radioimmunoassay techniques have allowed measurement of serum concentration changes of peptides that act via endocrine but not neurocrine or paracrine modes of action. Peptides that may play a role in the control of food intake include cholecystokinin (CCK), bombesin (BBS) and pancreatic polypeptide (PP) as possible satiety components and opiates as possible hunger components. All four have been found in the brain as well as in the gastrointestinal tract. Systemic administration of each has been shown to affect food intake, but whether doses used produced changes that normally occur during a meal awaits further development of radioimmunological assays. In the obese, the decreased sensitivities to, or decreased concentrations of the satiety components CCK, BBS and PP and the increased concentrations of the hunger component, B-endorphin, may contribute to the imbalance of food intake and energy expenditure, which leads to the accumulation of adipose tissue.

Animals↗

PubMed1997

Effects of amount and type of dietary fibre (soluble and insoluble) on short-term control of appetite.

Fibres which are soluble or insoluble in water have different physiochemical properties and may therefore be expected to exert different effects on post-ingestive satiety signals. This study compared the effects on short-term (24 h) appetite of two equienergetic high (22 g) fibre breakfasts, an equienergetic low fibre breakfast and a low energy, 'light' breakfast. Psyllium gum (the soluble fibre) and wheat bran (the insoluble fibre) were incorporated into breakfast cereals and consumed at breakfast by sixteen healthy, normal weight males after an overnight fast using a repeated measures, counterbalanced design. Ad libitum energy intake was assessed at a test snack 1.5 h after breakfast, later in the day using food boxes and the following day using food diaries. Motivation to eat and gastrointestinal sensations were tracked for the next 24 h. Hunger ratings showed a trend towards the subjects being less hungry and they consumed significantly less energy at snack time after the high insoluble than after the high soluble fibre breakfast cereal. The soluble fibre breakfast produced a greater suppression of snack intake than the light breakfast, but smaller suppression than the other breakfasts. Interestingly there was a trend toward reduced hunger and voluntary energy consumption following the soluble fibre compared with the insoluble fibre much later in the day (9.5-13.5 h after breakfast) although this was not significant. There was no significant effect of breakfast type on total day energy intake. The results suggest that different types of fibre modulate the timecourse of appetite control and may produce alterations in the experience of motivation and patterns of eating without necessarily effecting total energy intake.

Adolescent↗

PubMed1976

A chronobiological investigation of fitness for work in women on a 220 cal 24 h protein diet.

In a group of nine healthy but obese women a set of tests were used to estimate several physiological and psycho-physiological variables: self-rating of hunger, mood and physical vigor, self-recording of grip-strength, muscular fatigue test, eye-hand skill, tempo, etc. Measurements were performed every 6-hours, at fixed times, during 24-hours, once a week, before (non-restricted spontaneous food intake) and for three weeks on a 220 cal. special protein diet (calcium caseinate: 55g, associated with potassium salts, water and vitamins). Findings relating to the metabolic and hormonal variables while on this diet have already been reported: (a) The diet does not alter the circadian acrophase (peak) of the variables and (b) two distinct metabolic steps occur: first a peak of gluconeogenesis and second, a phase when ketone bodies and fatty acids are used almost exclusively as source of fuel. The present findings show that so long as nitrogen remains in balance this restricted diet (a) does not change the grip strength and the muscular fatigue test; (b) does not alter the mood, the physical vigor etc. and (c) induces a statistically significant fall in "hunger" (self-rating method). We conclude that this low protein diet is compatible with non-strenuous work.

Adolescent↗

PubMed2000

Altering the temporal distribution of energy intake with isoenergetically dense foods given as snacks does not affect total daily energy intake in normal-weight men.

The objectives of the present study were to examine the effects of (1) ingesting mandatory snacks v. no snacks and (2) the composition of isoenergetically-dense snacks high in protein, fat or carbohydrate, on food intake and energy intake (EI) in eight men with ad libitum access to a diet of fixed composition. Subjects were each studied four times in a 9 d protocol per treatment. On days 1-2, subjects were given a medium-fat maintenance diet estimated at 1.6 x resting metabolic rate (RMR). On days 3-9, subjects consumed three mandatory isoenergetic, isoenergetically dense (380 kJ/100 g) snacks at fixed time intervals (11.30, 15.30 and 19.30 hours). Total snack intake comprised 30% of the subjects' estimated daily energy requirements. The treatments were high protein (HP), high carbohydrate (HC), high fat (HF) and no snack (NS). The order was randomized across subjects in a counterbalanced, Latin-square design. During the remainder of the day, subjects had ad libitum (meal size and frequency) access to a covertly manipulated medium-fat diet of fixed composition (fat:carbohydrate:protein, 40:47:13 by energy), energy density 550 kJ/100 g. All foods eaten were investigator-weighed before ingestion and left-overs were weighed after ingestion. Subjective hunger and satiety feelings were tracked hourly during waking hours using visual analogue scales. Ad libitum EI amounted to 13.9 MJ/d on the NS treatment compared with 11.7, 11.7 and 12.2 MJ/d on the HP, HC and HF diets respectively (F(3,21) 5.35; P = 0.007, SED 0.66). Total EI values were not significantly different at 14.6, 14.5, 15.0 and 14.2 MJ/d respectively. Snack composition did not differentially affect total daily food intake or EI. Average daily hunger was unaffected by the composition of the snacks. Only at 12.00 hours did subjects feel significantly more hungry during the NS condition, relative to the other dietary treatments (F(3,18) 4.42; P = 0.017). Body weight was unaffected by dietary treatment. In conclusion, snacking per se led to compensatory adjustments in feeding behaviour in lean men. Snack composition (with energy density controlled) did not affect the amount eaten of a diet of fixed composition. Results may differ in real life where subjects can alter both composition and amount of food they eat and energy density is not controlled.

Adult↗

PubMed1999

The effects of swimming and running on energy intake during 2 hours of recovery.

OBJECTIVE: To determine energy intake in the 2 hrs after swimming (S) and running (R) at the same relative exercise intensity and duration (71.8 +/- 2.5% VO2max; 45 min) to evaluate whether a difference in recovery energy intake could explain the greater body fat observed in swimmers relative to runners. METHODS EXPERIMENTAL DESIGN: this was a randomized crossover design. SETTING: running exercise was conducted on a motorized treadmill (Quinton) while swimming was conducted in a 45.7 m pool. PARTICIPANTS: eight well-trained competitive male triathletes participated in this investigation. INTERVENTIONS: subjects were blinded to the purpose of the study and swam and ran on separate occasions for 45 min at 71.8 +/- 2.5% of VO2max. Subjects were then placed in a room with a variety of foods and beverages for 2 hrs after R and S. MEASURES: energy intake (kJ/2 hrs and kcal/2 hrs) was determined by weighing and measuring the food remaining in the room after 2 hrs of postexercise recovery. Expired gases, heart rates, and Ratings of Perceived Exertion were obtained at 15 min intervals throughout exercise. Blood samples for serum glucose and lactate were obtained preexercise and immediately, 15 min, and 135 min postexercise. Perceived hunger and thirst ratings were obtained after the subjects were seated in the room containing the food. RESULTS: Serum glucose was significantly (p < or = 0.05) higher after R compared to S immediately after exercise (5.4 +/- 0.3 mmol/L for R and 4.2 +/- 0.1 mmol/L for S) but no significant differences were observed for hunger using a five point Likert scale (3.3 +/- 0.3 for R and 3.4 +/- 0.3 for S), energy intake (4584 +/- 611 kJ/2 hrs; 1095 +/- 146 kcal/2 hrs for R and 4383 +/- 484 kJ/2 hrs; 1047 +/- 116 kcal for S) or blood lactate. CONCLUSION: The type of exercise, swimming or running, did not significantly influence energy intake during 2 hours of postexercise recovery.

Adult↗

PubMed1999

Effects of red pepper on appetite and energy intake.

Two studies were conducted to investigate the effects of red pepper (capsaicin) on feeding behaviour and energy intake. In the first study, the effects of dietary red pepper added to high-fat (HF) and high-carbohydrate (HC) meals on subsequent energy and macronutrient intakes were examined in thirteen Japanese female subjects. After the ingestion of a standardized dinner on the previous evening, the subjects ate an experimental breakfast (1883 kJ) of one of the following four types: (1) HF; (2) HF and red pepper (10 g); (3) HC; (4) HC and red pepper. Ad libitum energy and macronutrient intakes were measured at lunch-time. The HC breakfast significantly reduced the desire to eat and hunger after breakfast. The addition of red pepper to the HC breakfast also significantly decreased the desire to eat and hunger before lunch. Differences in diet composition at breakfast time did not affect energy and macronutrient intakes at lunch-time. However, the addition of red pepper to the breakfast significantly decreased protein and fat intakes at lunch-time. In Study 2, the effects of a red-pepper appetizer on subsequent energy and macronutrient intakes were examined in ten Caucasian male subjects. After ingesting a standardized breakfast, the subjects took an experimental appetizer (644 kJ) at lunch-time of one of the following two types: (1) mixed diet and appetizer; (2) mixed diet and red-pepper (6 g) appetizer. The addition of red pepper to the appetizer significantly reduced the cumulative ad libitum energy and carbohydrate intakes during the rest of the lunch and in the snack served several hours later. Moreover, the power spectral analysis of heart rate revealed that this effect of red pepper was associated with an increase in the ratio sympathetic: parasympathetic nervous system activity. These results indicate that the ingestion of red pepper decreases appetite and subsequent protein and fat intakes in Japanese females and energy intake in Caucasian males. Moreover, this effect might be related to an increase in sympathetic nervous system activity in Caucasian males.

Adult↗

PubMedDate not supplied

Uremic anorexia: a consequence of persistently high brain serotonin levels? The tryptophan/serotonin disorder hypothesis.

Anorexia is a frequent part of uremic syndrome, contributing to malnutrition in dialysis patients. Many factors have been suggested as responsible for uremic anorexia. In this paper we formulate a new hypothesis to explain the appetite disorders in dialysis patients: "the tryptophan/serotonin disorder hypothesis." We review current knowledge of normal hunger-satiety cycle control and the disorders described in uremic patients. There are four phases in food intake regulation: (1) the gastric phase, during which food induces satiety through gastric distention and satiety peptide release; (2) the post absorptive phase, during which circulating compounds, including glucose and amino acids, cause satiety by hepatic receptors via the vagus nerve; (3) the hepatic phase, during which adenosine triphosphate (ATP) concentration is the main stimulus inducing hunger or satiety, with cytokines inhibiting ATP production; and (4) the central phase, during which appetite is regulated through peripheral (circulating plasma substances and neurotransmitters) and brain stimuli. Brain serotonin is the final target for peripheral mechanisms controlling appetite. High brain serotonin levels and a lower serotonin/dopamine ratio cause anorexia. Plasma and brain amino acid concentrations are recognized factors involved in neurotransmitter synthesis and appetite control. Tryptophan is the substrate of serotonin synthesis. High plasma levels of anorectics such as tryptophan (plasma and brain), cholecystokinin, tumor necrosis factor alpha, interleukin-1, and leptin, and deficiencies of nitric oxide and neuropeptide Y have been described in uremia; all increase intracerebral serotonin. We suggest that brain serotonin hyperproduction due to a uremic-dependent excess of tryptophan may be the final common pathway involved in the genesis of uremic anorexia. Various methods of ameliorating anorexia by decreasing the central effects of serotonin are proposed.

Amino Acids↗

PubMed1976

Comments on the division of labor in occupations concerned with food.

The roles of men and women in relation to food have always been sharply defined: animals belonged to men and plants and food preparation to women. Thus, when the land-grant colleges were established, men were taught animal husbandry and agricultural methods; in home economics, women learned the "home-making" arts, including nutrition and were concerned with people. But, as nutrition became more scientific, men took it over, separating it from home economics. In so doing, less attention was paid to the human elements in food production. World food policies are now made without regard to feeding people, and women have been progressively left out in the decision-making. The increase in nutritional knowledge in the last half century has had little effect on policies. Because Americans set the pattern the rest of the world will emulate, we must come to the realization that we cannot alleviate hunger with money alone-hunger is relieved with food, and food supplies are finite. Real sacrifices in terms of food itself, such as were made in World Wars I and II, will be necessary. Knowledge that millions are truly hungry may convince mothers to feed their children and families in different ways.

Agriculture↗

PubMed2003

Changes in food intake and growth rate in mice under hypergravity.

Mice exposed to hypergravity, especially soon after start of exposure, diminished the body weight and the food intake. The amount of food intake was kept less than that of the ground control during hypergravity breeding for 2 weeks. Furthermore, the weight of testis relative to the body weight increased compared to that of 1 G control although the relative weights of liver and kidney were not changed. The purpose of this study was whether the low growth rate of the body weight and the increase of the relative testis weight were induced by the decrease of the food intake under hypergravity. We divided 3 weeks old male mice to 3 groups; the 1 G (ground control), the food restricted (FR) under 1 G, and the 3 G group. The 3 G group bred for 2 weeks under the centrifuge at 3 G. The FR group was given the same amount of food as the group ate. The changes in the body weight and the relative weights of testis, spleen and seminal vesicle of the FR group were similar to those of the 3 G group. The hunger test revealed that only the FR group was hunger. Our results suggested that the decrease of the food intake both in response to hypergravity and the food restriction induced the decrease of the body weight but the increase of the relative testis weight.

Animals↗

PubMed2003

Food insecurity in metropolis of the developing world--observations from central district of Karachi, Pakistan.

OBJECTIVE: To assess the prevalence of household food insecurity at various income levels in urban areas of Karachi. METHODS: A cross sectional survey of different localities in the central district of Karachi was carried out. The data was collected through household interviews of housewives conducted by trained nutritionist. Housewives were interviewed about food security status of the household. RESULTS: A total of 797 families were visited from the central district of Karachi. Mean Food Security Score increased with income level. The difference was statistically significant (ANOVA) between 1st and second (P=0.000) and 2nd and 3rd group (P=0.000) but not between 3rd and fourth group. At the very low and low income levels 83% & 51% families respectively were food insecure in any degree, while this percentage was very low at the middle (6.3%) and high income level (1.8%). The difference in prevalence of food insecurity between the VLI and LI, and, LI and MI income groups was statistically significant (chi.sq. test, p<0.001 in each case). Hunger (because of lack of money) was experienced in the preceding year only by "very low income" (37%) and "low income" families (17%). Use of coping strategies was most frequently mentioned for parents and then for children and only occasionally for infants or grand parents. Females were more likely to be effected by food insecurity than males. Meat, milk and fruits were the food groups which were preferred and considered healthy but were avoided because of lack of money by a majority (51%-86%) of families. CONCLUSIONS: In spite of having an impression of being an affluent city of Pakistan, the prevalence of food insecurity with and without hunger is rampant not only among very low income (slum dwellers) but also among low income families of Karachi.

Cross-Sectional Studies↗