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PubMed2005

The traveling salesman problem as a new screening test in early Alzheimer's disease: an exploratory study. Visual problem-solving in AD.

BACKGROUND AND AIMS: In the clinical setting, brief general mental status tests tend to detect early-stage Alzheimer's disease (AD) less well than more specific cognitive tests. Some preliminary information was collected on the diagnostic accuracy of the Traveling Salesman Problem (TSP) compared with the Mini-Mental State Examination (MMSE) in recognizing early AD from normal aging. METHODS: Fifteen AD outpatients (mean +/- SD MMSE: 24.45 +/- 2.61) and 30 age- and education-matched controls were submitted in a single blind protocol to a paper-and-pencil visually-presented version of the TSP, containing a random array of 30 points (TSP30). The task consisted of drawing the shortest continuous path, passing through each point once and only once, and returning to the starting point. Path lengths for subjects' solutions were computed and compared with the optimal solution given by a specific evolutionary algorithm called GenD. RESULTS: TP30 discriminated significantly better between AD subjects and controls (ROC curve AUC = 0.976; 95% CI 0.94-1.01) compared with the MMSE corrected for age and education (ROC curve AUC = 0.877; 95% CI 0.74-1.005). A path length of 478.2354, taken as "cut-off point", classified correctly subjects with a sensitivity of 93.3% and a specificity of 99.3%, whereas a score corrected for age and education of 25.85 on the MMSE had a sensitivity of 73.3% and a specificity of 96.7%. CONCLUSIONS: The TSP seems to be particularly sensitive to early AD and independent of patient's age and educational level. The high diagnostic ability, simplicity, and independence of age and education make the TSP promising as a screening test for early AD.

Aged↗
PubMed1991

Girls who use "masculine" problem-solving strategies on a spatial task: proposed genetic and environmental factors.

This study investigated strategy and performance differences between right-handed boys and girls on a mental rotation task. Based on predictions from Casey and Brabeck's (1990) theory of sex differences, the study was also designed to identify a target group of right-handed girls with the optimal combination of genetic and environmental factors (high math/science achievers with nonright-handed immediate relatives). They were predicted to show strategies and performance more similar to those of the boys than to those of both the low math/science achieving girls and the high math/science girls with all right-handed immediate relatives (predicted to have the nonoptimal genotype). Strategy preference was measured using selective interference, whereby subjects solved mental rotation items concurrently with either verbal or visual-spatial interference tasks. Group comparisons were made on the amount of decrement in mental rotation performance as a result of the two types of interference tasks. This provided a basis for comparing the groups on the use of visual-spatial or verbal strategies on the mental rotation task. The boys: (1) did not show a significant advantage over the girls on the mental rotation items, but (2) did depend more on visual-spatial strategies than the girls, and (3) depended less on verbal strategies than the girls. The target girls: (1) outperformed the low math/science achieving girls on the mental rotation items and did not show a significant advantage over the other high math/science group, (2) depended more on visual-spatial strategies than both the other two groups of girls, and (3) depended less on verbal strategies than the low math/science girls, while showing no significant difference compared to the nonoptimal high math/science girls. Examining within-group differences, the boys preferred visual-spatial strategies, while the girls in both the nontarget groups preferred verbal ones. However, for the target girls, no within-subject strategy differences were found. The present findings support the theory that, like the boys, the target girls depend more on visual-spatial strategies than do other girls. It is possible that the target girls use a combination of visual-spatial and verbal strategies when solving mental rotation tasks.

Adolescent↗
PubMed2006

Integrating social science and design inquiry through interdisciplinary design charrettes: an approach to participatory community problem solving.

Interdisciplinary collaborations that aim to facilitate meaningful community outcomes require both the right mix of disciplinary knowledge and effective community participation, which together can deepen collective knowledge and the capacity to take action. This article explores three interdisciplinary design charrettes, intensive participatory workshops that addressed specific community problems and provided a context for integrating design and social science inquiry with local community knowledge. Evaluation data from the charrettes shed light on how students from the design and social science disciplines experienced the charrettes, and on their interactions with community members. Key advantages to this interdisciplinary, community-based collaboration included expanded knowledge derived from the use of multiple modes of inquiry, particularly the resulting visualization tools that helped community members understand local issues and envision novel solutions. Key drawbacks included difficulties in balancing the two disciplines, the tendency for social scientists to feel out of place on designers' turf, and the increased disciplinary and interpersonal conflicts arising from a more diverse pool of participants.

Community Health Planning↗