Gonorrhea. Recommended treatment schedules--1974.
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Although the preponderant majority of gonococcal strains is belonging to the most susceptible micro-organisms in respect of the action of antibiotics, certain variations of sensitivity which might be of importance not only for the genetics of microbes, but also for biochemistry and, above all, for therapy may occur also among them, perhaps as a consequence of along-time pressure by antibiotics. In a preceding study (J. Hyg. Epidem. Microb. Immunol. (Prague) 12,296, 1968), the authors analyzed the situation in Czechoslovakia from 1957 to 1967 by means of 911 strains of N. gonorrhoeae isolated from male patients suffering from gonorrhoea. It was also pointed out that there was a certain tendency towards reduced efficacy of penicillin G and a presence of streptomycin-resistant strains. In later years, the studies were extended to include also strains isolated from female patients and sensitivity to some more modern antibiotics was tested. In the present report, a survey is given of the state of antibiotics resistance among gonococci in Czechoslovakia in a chronological order of 17 years which is intended to serve as a basic information for those who are dealing with this subject.
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Pseudomonas aeruginosa was isolated from the viscera of diseased and dead birds (young and adult chickens) as well as from 9 poultry houses on seven farms. Its typing was performed on the basis of the blue-green coloration of the cultures, their hemolytic activity, the pleasant odour of lime-tree, the growth in culturing at 42 degrees C, the presence of the pyocianin pigment, and the positive results of the cytochromoxidase test after Gaby and Hadley and the biochemical test after Kovacs. The pathogenicity of the agent was demonstrated through the experimental parenteral infection of chicks, albino mice, and guinea pigs. Pseudomonas aeruginosa cultures showed weak sensitivity and good resistance to the various drugs tested. Most active proved streptomycin, kanamycin, and spectam.
Nine hundred patients (250 females and 650 males) attending the Clinic for the Treatment of Venereal Diseases had throat swabs taken as a routine; 1-1% (1-6% of females and 0-92% of males) were found to have faucial gonorrhoea. This figure appears to be similar to that found by Odegaard and Gunderson (1973) in Norway. The treatment regime used in the clinic in Perth appeared to be satisfactory, as there were no failures. It is stressed that all patients suspected of suffering from venereal disease should have their throats swabbed as a routine. Information as to whether or not oral sex is practised should be obtained.
Three trials were conducted to evaluate the efficacy of Linco-Spectin (LS) water medication on Mycoplasma synoviae (MS) air-sacculitis in broilers under controlled experimental conditions. Day-old chicks were vaccinated against infectious bronchitis and Newcastle disease virus and exposed to a broth culture of MS by the respiratory route. In each trial, one-half of the flock was treated with 2 g of LS per gallon of drinking water for the first five days of life, and the other half was kept as a control. At two and eight weeks postinoculation (PI) birds were weighted individually and examined serologically, culturally, and grossly for MS airsacculitis. Linco-Spectin water medication was effective in controlling MS airsacculitis in broilers.
Cultures were made from the urethra of 2,370 male Social Hygiene Clinic patients who were not directly associated with gonorrhea by signs, symptoms or epidemiology were cultured for N. gonorrhoeae. Of these asymptomatic individuals, 37 or 1.6% were found to be urethrally infected. Gram stain smear examinations of urethral specimens from these men were positive in about one-half of the cases.
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The case of a patient with a recurrence of gonorrhoea due to a concomitant gonorrhoic infection of a paraurethral duct, which was not healed by the initial routine penicillin treatment, is reported.
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