SEARCH · PubMed Health
Results for “TOXOPLASMOSIS, CONGENITAL”
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Immunogenetics in pathogenesis of and protection against toxoplasmosis.
Explore the source record for details and available documents.
[On the epidemiology and serology of toxoplasmosis].
Explore the source record for details and available documents.
[Toxoplasma infection and pregnancy. Causes and possible time of fetal infection].
Explore the source record for details and available documents.
Observations on cerebral and cerebellar microgyria.
Explore the source record for details and available documents.
[Perinatal infections--epidemiologic aspects].
Explore the source record for details and available documents.
[Latent connatal toxoplasmosis].
Explore the source record for details and available documents.
Application and evaluation of a classification system and case definitions of Toxoplasma gondii infection.
Explore the source record for details and available documents.
Interlaboratory comparison of polymerase chain reaction for the detection of Toxoplasma gondii DNA added to samples of amniotic fluid.
To investigate the accuracy of the polymerase chain reaction (PCR) method for the detection of Toxoplasma gondii in clinical specimens, aliquots of amniotic fluid to which known amounts of Toxoplasma gondii DNA had been added were tested by five European Centres. Four laboratories were able to detect DNA at levels equivalent to ten tachyzoites or less, including two that detected DNA equivalent to a single parasite. Two laboratories erroneously found one of eight negative control samples to be positive. These findings confirm that the high level of sensitivity associated with the PCR method can be readily achieved under routine laboratory conditions, but they also underscore the potential for both false-positive and false-negative findings to occur. Furthermore, the results confirm the urgent need for an external quality assurance scheme to support laboratories employing PCR in a clinical context for the detection of Toxoplasma gondii.
T-cell subpopulations of fetuses infected by Toxoplasma gondii.
Explore the source record for details and available documents.
An anti-human immunoglobulin M monoclonal antibody for detection of antibodies to Toxoplasma gondii.
An anti-human mu-chain monoclonal antibody, Tibi 82, was produced and tested for specificity by radioimmunoassay. Its reliability in detecting IgM antibodies to Toxoplasma gondii was tested by two reverse immunosorbent methods (IgM-ISAGA and IgM-SPIHA) and the IgM fluorescent antibody test (IgM-IFA) on 400 sera. Whereas the results obtained with Tibi 82 and with two polyclonal reagents were highly correlated, the third commercial polyclonal reagent provided many false negative results. By standardizing IgM binding, Tibi 82 allowed the comparison of IgM-ISAGA with IgM-SPIHA on 100 sera: 17% of the sera tested showed discrepancies due to the different toxoplasma antigens used. Although Tibi 82 facilitated the reading of results and enhanced sensitivity and specificity of the double-sandwich IgM-IFA method, the latter was still less sensitive than IgM-ISAGA with Tibi 82. Tests with the monoclonal antibody were consistently superior to tests with polyclonal antibodies.
Stevens-Johnson syndrome with isolation of Mycoplasma pneumoniae from skin lesions.
Explore the source record for details and available documents.
[The diagnosis of toxoplasmosis in pregnancy].
Explore the source record for details and available documents.
[Toxoplasmosis as a probable mutagenic factor].
Explore the source record for details and available documents.
Status of toxoplasma antibodies in recurrent fetal loss in U.A.E. women.
A retrospective analysis to determine the status of toxoplasma (IgG & IgM) antibodies in UAE women with recurrent fetal loss was done using immunofluorescence assay. Two thousand three hundred and fourty three patients with one or more fetal loss were studied over a period of five years. In patients with fetal loss, the range of toxoplasma IgG seropositivity varied from 24.2-30.6%. There were 3 patients with IgM positive. Only in a single patient one of her two abortions could be attributed to acute toxoplasmosis. Habitual fetal loss cannot be attributed to chronic toxoplasmosis. Also, 67.2% of the women of child bearing age group in U.A.E were found to be seronegative, highlighting the need for routine antenatal screening to detect primary acute toxoplasmosis.
Three-dimensional ultrasonography in obstetrics: the clinical value.
To investigate the clinical value of three-dimensional ultrasonography (3DUS) in obstetrics, various 3DUS rendering methods including surface mode, transparent mode and multiplanar mode were employed to scan 30 fetuses in second and third trimester by using the transabdominal volume transducer. The results showed that surface mode could vividly demonstrate the surface morphologic features of the fetuses, as well as the stereo-shape and the spatial relationship among the surface structures. The face, limbs, umbilical cord and outer genitalia of the fetus could be well displayed by surface mode. Transparent mode could reveal the bony structures under the surface, such as ribs, vertebrae, crania, etc. The result was not affected by the sophisticated curvature of these bony structures and the success rate was up to 100%. When rendered by multiplanar mode, the region of interest (ROI) could be viewed from different directions. It should be concluded that 3DUS could serve as a supplement to two-dimensional ultrasonography (2DUS). 3DUS might play an important role in prenatal diagnosis and enhance the diagnostic confidence level of the physicians.
Radiological signs in newborns exposed to primary Toxoplasma infection in utero.
A total of 44 181 serum samples from 16 733 pregnant women were analyzed for findings suggesting primary Toxoplasma infection. Thirty-seven newborns exposed to maternal primary Toxoplasma infection in utero were studied prospectively with ultrasound, CT, and MRI for signs of intrauterine infection. Their mothers had been treated during pregnancy, and all infants were treated. The children were assigned to three groups according to their mothers' serological status, and the radiological results were compared with the clinical outcome. Although radiological signs were scarce, ultrasound findings combined with maternal serology were found to be significantly related to clinical outcome.