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PubMed1986

P & T Committee problem-solving in a Canadian specialty hospital.

Princess Margaret Hospital in Toronto is a specialty hospital that deals primarily with cancer patients from Ontario Province. In an exclusive Hospital Formulary interview, Dr. Ron Feld, chairman of Princess Margaret's P & T Committee, discusses some of the special challenges and problems that their P & T Committee, working in a specialized referral setting, has faced. He also briefly describes the similarities and differences between Canadian and American P & T practices. Included in his discussion are the formulary addition request process, cost containment strategies, adverse reaction reporting, and the role of the P & T Committee in patient and physician education.

Canada↗
PubMed1995

The "inverse problem" solved for a three-dimensional model of the cochlea. I. Analysis.

With nonactive cochlear models of the "classical" type, it is impossible to stimulate the characteristic type of frequency selectivity that is revealed by modern mechanical measurements of the motion of the basilar membrane (BM). Locally active models of the cochlea have been proposed to alleviate this problem but it remains uncertain whether the real cochlea is active in this sense. The present study was undertaken to investigate this subject in a more general and systematic way than has hitherto been done. The "inverse" problem is solved for a three-dimensional (3-D) model and a procedure is developed for recovering the BM impedance needed to stimulate the given BM response function. In the present paper the theoretical basis of the procedure is presented, and an analysis is given of the validity of the method and the errors involved. It is shown why the inverse problem is "ill-posed" and why the results of our procedure are more accurate in the region of the response peak than in the more basal region of the model. The latter finding serves to delimit the domain within which results of an inverse procedure (for instance, in the short- or long-wave approximation) are to be judged. In a subsequent paper the technique developed will be applied to actual data sets from the literature on mechanical BM measurements.

Auditory Perception↗