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Spatial distribution of endogenous retinoids in the murine embryonic mandible.

Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

Animals↗

Gemination and twinning in the permanent dentition.

Gemination and twinning are uncommon developmental anomalies of the hard dental tissue. These aberrations are manifested either as anomalous teeth or as supernumerary teeth. Six cases of gemination and twinning are presented in this article. A simplified classification of these anomalies has been suggested.

Adolescent↗

Variables and criteria in prevalence studies of dental anomalies of number, form and size.

Prevalence studies of dental anomalies of number, form and size have varied greatly in their findings. The purpose of this paper is to demonstrate from published studies the effect of variables in sampling techniques and examination methods and to suggest diagnostic criteria. In sampling the ethnic background, the sex distribution, age and derivation of the group studied are shown to be important, but the consumption of near optimum concentrations of fluoride in drinking water does not appear to influence findings. For the examination, a dental history is important and full radiographic coverage essential. Findings should be recorded separately for each dentition, while these anomalies should be studied as a group rather than singly. Diagnostic criteria are proposed for supernumerary teeth, hypodontia, invaginated teeth, double teeth, megadontia and microdontia.

Adolescent↗

Proliferation of Schwann cells and regulation of cyclin D1 expression in an animal model of Charcot-Marie-Tooth disease type 1A.

Overexpression of PMP22 is responsible for the most common form of inherited neuropathy, Charcot-Marie-Tooth disease (CMT) type 1A. The PMP22-transgenic rat (CMT rat) is an animal model of CMT1A, and its peripheral nerves show the characteristic features of ongoing demyelination and remyelination that is also seen in CMT1A patients. Since Schwann cell proliferation is a prominent feature of peripheral nerves in inherited peripheral neuropathies, we examined proliferation and the expression of cyclin D1 in CMT rats. D-type cyclins are required for the initial steps in cell division and nuclear import is crucial for the function of cyclin D1 in promoting cell proliferation. Like normal myelinating Schwann cells in wild-type rats, remyelinating Schwann cells in CMT rats show perinuclear cyclin D1 expression. Schwann cells with nuclear cyclin D1 expression, as well as proliferating Schwann cells, were both associated with demyelinated axonal segments. Supernumerary onion bulb Schwann cells, however, do not express cyclin D1 and were not proliferating. Thus, cyclin D1 expression and its subcellular localization correlate directly with distinct physiological states of Schwann cells in this animal model of CMT1A.

Animals↗

Taurodontism and pyramidal molars.

The present study was conducted to investigate the occurrence of taurodontism and pyramidal molars in Goa children, hitherto considered rare in Indians. Radiographs of 300 children of 9 to 13 years were evaluated. The criteria of Keene (1966) was used to designate taurodonts. Ten children showed taurodontism: involving mandibular second molars in eight cases, maxillary first molars in three cases; and pyramidal molars in three cases, four cases showed associated findings. Hypodontia of one to fourteen teeth was observed in all four cases. In addition one case showed thinning of maxillary central incisors, rotation of lateral incisors, impacted supernumerary and a canine and polydactyly of hands and feet. The condition does not appear rare in this population group.

Adolescent↗

"Otodental" dysplasia.

The case of a 3 11/12-year-old Chinese boy with the dental abnormalities of "otodental" dysplasia is reported. Hearing was normal. Dental anomalies consisted of delayed eruption of globe-shaped molars, bulbous deciduous canines, and double pulp chambers in the molars. Radiographs taken 4 years later showed taurodontic molars, supernumerary microdontic teeth, retarded formation of premolars, and probable aplasia of the mandibular second premolars.

Child↗

Radix paramolaris in permanent mandibular molars: identification and morphology.

The Royal Dental College, Copenhagen, houses an extensive collection of human teeth which have been extracted in Denmark. The collection presently includes 203 permanent mandibular molars with a root complex containing a facially-located supernumerary root. This macrostructure is named radix paramolaris (RP). By analyzing the large number of specimens available it was possible to establish uniform and precise criteria for the identification of RP on M1 inf, M2 inf, and M3 inf. The analyses included both separate and non-separate RP. The representation of the RP variants according to tooth type was mapped. Furthermore, the following clinically relevant variables with respect to RP were registered: degree of separation, divergence, apical bend, apical gracility, and fusion. Because of the nature of the material, the study was mostly qualitative and non-metric. The results are aimed primarily at clinical dentists, dental morphologists, and dental anthropologists.

Denmark↗

[Caries, gingivitis and dental abnormalities in patients with cleft lip and palate].

Oral health was studied in 31 children aged 10-12 years with cleft lip and palate and compared to 31 noncleft controls matched for sex and age. We found a difference in the prevalence and activity of caries with increase in cleft lip and palate patients. The unilateral crossbite and the congenitally missing teeth were more common in cleft palate children and the supernumerary teeth were fewer. Almost all children used fluoride tablets.

Case-Control Studies↗

Radix entomolaris: identification and morphology.

The Royal Dental College, Copenhagen, houses an extensive collection of human teeth, extracted in Denmark. At present, the collection includes 398 permanent mandibular molars with a root complex containing a lingually-located supernumerary root. This macrostructure is called radix entomolaris (RE). By analyzing the large number of available specimens it was possible to establish uniform and precise criteria for the identification of RE on M1 inf, M2 inf, and M3 inf. The analyses included separate as well as non-separate RE. The representation of the RE variants according to tooth types was mapped. Furthermore, the following relevant clinical variables with respect to RE were registered: degree of separation, divergence, apical bend, apical gracility, and fusion. Because of the nature of the material, the investigation was mostly qualitative and non-metric. The results should be of interest to clinical dentists, dental morphologists, and dental anthropologists.

Classification↗

A radiographic survey of dental anomalies in Black pediatric patients.

During seemingly routine check-ups, the dental practitioner must be ever aware of "quiescent" abnormalities or irregularities. Knowledge of special problems occurring within a certain patient population is of great value to the practitioner when evaluating the individual patient. Numerous studies have been conducted evaluating the pediatric Caucasian population; however, no comparable studies for the Black pediatric population have been done. This study sought to establish prevalence rates for the Black pediatric population with regards to the following anomalies: congenitally missing teeth, supernumerary teeth, dens in dente, odontomas, dentinogenesis imperfecta, gemination, fusion and concrescence. The radiographs (panographs mandatory), history forms and treatment progress records of 2,267 children (1,136 males and 1,131 females) were analyzed. Radiographs of poor quality were eliminated and attempts were made to include only children of Black American heritage. Prevalence rates established for a predominantly Black pediatric population were: 4.4%, congenitally missing teeth; 1.49%, supernumerary teeth; 0.26%, dentinogenesis imperfecta (Brandywine type); 0.44%, odontomas; 0.22%, gemination; and 0.12%, fusion. Evidence of dens in dente was found in only one erupted supernumerary maxillary paralateral, and the detection of only one case of concrescence occurred; both have prevalence rates of 0.04%. No other study has produced such a high rate of dentinogenesis imperfecta (.26%), except that conducted within the tri-racial group itself. In addition, if assumptions are to be made from this investigation for the general population, supernumeraries and odontomas may be present significantly more often in the Black than Caucasian pediatric population.

Adolescent↗

[Treatment of Riga-Fede's disease by resin-coverage of the incisal edges and seven cases of natal and neonatal teeth].

This report concerned 2 cases (1-month and 8-day-old boy and 5-month and 27-day-old boy) of Riga-Fede's disease. The cases were treated with photopolymerized resin coverage of the incisal edges. Generally, the treatment methods for Riga-Fede's disease are discing and extraction of the traumatized teeth. The photopolymerized resin coverage proved to help in the rapid healing of the ulcerations. This method is useful because it is easy and is able to avoid a false pulp exposure of the hypoplastic natal and neonatal teeth by discing. 7 cases of natal and neonatal teeth were encountered at the Pedodontic Clinic of Niigata University Dental Hospital during 8 years from September 1979 to August 1987. 1) 7 cases were 3 boys and 4 girls, aging from 21 days after birth to 3 months 19 days. 2) Only one baby had a low birth weight. 3) The natal teeth accounted for 6 cases and the neonatal teeth accounted for 1 case. All were lower central primary incisors (5 on the right side, 1 on the left side and 1 bilateral). There were no supernumerary teeth. 4) 5 cases were of hypoplastic teeth. 5) Riga-Fede's disease was recognized in 3 cases. 6) The prognosis was 1 case of shedding, 2 cases extracted and 4 cases remaining. 7) Mesial inclination of the neighboring teeth and narrowness of the extracted space wee observed in the cases where extraction was performed at an early age. 8) Microradiogram and undemineralized specimens of the extracted tooth revealed that the tooth was very thin and mineralization was so poor and there was almost no root formation.

Child, Preschool↗

Some observations on the dentition of an isolated group in northeast Poland.

Clinical examination of the teeth and the mouth was carried out on a group of 133 "Old Believers," 54 males and 79 females, and a control group of 138 Poles living in the same area of Augostova in northeast Poland, 63 males and 75 females. Studying the frequency of Carabelli's cusp, shovel-shaped incisors, missing teeth, microdonita, supernumerary teeth, and torus palatinus in both groups, it was found that Carabelli's cusp and torus palatinus are more frequent among Poles. Such differences could be attributed to differences in ethnic origin of the two groups.

Ethnicity↗

Gemination of maxillary incisors.

Gemination is defined as a shape anomaly of teeth caused by an incomplete division of a single tooth bud. Its aesthetic and functional implications usually require a complex endodontic, restorative, periodontal, surgical, and orthodontic treatments. Three cases of gemination of maxillary incisors, resolved by different therapeutic approaches, are reported. The 1st case (germination of 2.1) was resolved by a simple crown-plasty. The 2nd case (gemination of 1.1 and 2.1) was resolved by a crown-plasty of 2.1 and an interradicular section of 1.1 with extraction of lateral root. The 3rd case (2.2 supernumerary and gemination of 1.2) was resolved by sacrifice of 1.2, extraction of 2.2 and its implantation in 1.2 region. In order to obtain an acceptable aesthetic and functional restoration, as in the cases presented, a good team-work, where all the specialists contribute to the selection of the more suitable treatment possible, is mandatory.

Adult↗

Oral surgical management of cleidocranial dysostosis.

A patient with cleidocranial dysostosis is presented to further support the early active surgical management of the dental complications of this disease. There is good evidence to show that the permanent teeth have the ability to erupt once the deciduous dentition, supernumeraries, and overlying alveolar bone are removed. The aetiology of this failure of eruption is considered to be an abnormality in alveolar bone remodelling, compounded by overactivity of the dental lamina. The clinical experience gained from this patient substantiates this theory.

Adolescent↗

Upper lip swelling caused by a large dentigerous cyst.

Swelling of the upper lip can result from various diseases such as salivary tumors, infectious and inflammatory diseases and cysts. Among the latter, dentigerous cysts, typically involving unerupted teeth, are sometimes associated with supernumerary teeth in the maxillary anterior incisors region called the mesiodens. We report an unusual case of a large dentigerous cyst associated with an impacted mesiodens in a 42-year-old male who presented with a slow-growing swelling in the upper lip.

Adult↗

Cleidocranial dysplasia: radiological appearances on dental panoramic radiography.

OBJECTIVE: To report the effectiveness of dental panoramic radiography in identifying features pathognomonic for cleidocranial dysplasia. METHODS: Panoramic radiographs of nine male Caucasian patients with cleidocranial dysplasia are analysed. RESULTS: In addition to the established dental complications of failure of eruption of the permanent dentition and multiple supernumerary teeth, morphological abnormalities of the maxilla and mandible, particularly in the ascending ramus and coronoid process were present. CONCLUSION: Dental panoramic radiography is a valuable adjunct in confirming the diagnosis of cleidocranial dysplasia.

Adolescent↗

The syndrome of ankyloblepharon, ectodermal defects and cleft lip and palate: an autosomal dominant condition.

Seven patients from four families are reported who had an inherited condition of which the main features were ankyloblepharon, ectodermal defects and cleft lip and palate. The ectodermal defects were partial or complete hair loss, absent or dystrophic nails, pointed widely spaced teeth and partial anhidrosis. Associated anomalies included lacrimal duct atresia, supernumerary nipples, syndactyly and auricular deformities. The inheritance of this abnormality was consistent with that of an autosomal dominant trait. The relationship between this and similar syndromes is discussed.

Adult↗

[Dental anomalies associated with incontinentia pigmenti or Bloch-Sulzberger syndrome].

We report dental anomalies related to the Bloch- Sulzberger Syndrome better known as Incontinentia Pigmenti (IP). IP is an X related hereditary disease that occurs for about 95% of all patients in females and is lethal for the male foetus. Because of severe skin lesions in the neonatal period the disease is more known by dermatologists than dentists. Beside the skin lesions other associated deficiencies can be present like: ocular injuries, anomalies of hair and nails, defects of the central nervous system, malformations of the extremities and anomalies of the teeth. We report 8 female patients of different ages, out of 5 families. All were diagnosed with IP after DNA examination. Dental manifestations related to IP are: delayed eruption, oligodontia, agenesis, peg-shaped or malformed teeth, supernumerary teeth and supplementary cusps. IP is under diagnosed if the symptoms are limited to agenesis of only a few teeth and inconspicuous skin lesions. Dentists are ideally placed to identify individuals with IP and should refer patients with a presumption of IP to proper medical specialists.

Adolescent↗