Acute fatty liver of pregnancy.
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The status of vitamins A, B1, B2, B6, B12, C, D, and E as well as that of beta-carotene, biotin, and folate in the blood of over 500 epileptics was compared with that of a normal population. Male and female epileptics showed a poorer supply of vitamins B2, biotin, folate, and 25-hydroxycholecalciferol; the males, of only vitamin B6, B12, and E, and the women, of only vitamin A. Concentrations of beta-carotene and vitamin E in female epileptics were higher. The evaluation of relations between vitamin concentrations and mean daily dose, total dose of anticonvulsants, and duration of therapy suggested a possible influence of anticonvulsant medication on vitamins B1, B2, B6, C, D, E, beta-carotene, biotin, and folate. Concentrations of B vitamins as well as of folate were distinctly lower in patients under monotherapy with enzyme-inducing drugs than in those under valproate sodium. There was no relationship between bone mineral content and 25-hydroxycholecalciferol levels and between the neurographic parameters and the neurotropic vitamins of the B group, which also had no influence on concentration performance. Patients with poorer results in tests of the function of the central and the peripheral nervous system displayed a tendency towards lower vitamin-C levels. There were indications of potential links between immunological status and vitamin B6 and biotin. Males and females with a poorer supply of vitamin C, as well as males with lower riboflavin levels, showed a tendency towards macrocytic anaemia. Cerebellar disturbances were associated with lower concentrations of folate, of vitamin C or D, and possibly of biotin. The incidence of gingival hyperplasia could be linked to riboflavin, to biotin, and possibly also to vitamin C, D, or folate status.
Sixty-nine boys and girls between 10 and 14 years, with evidence of subclinical vitamin deficiencies and poor iron status were enrolled into the study at the beginning of the rainy season. Children were allocated to three treatment groups to receive five times weekly either a placebo, 200 mg ferrous sulphate or 5 mg riboflavin and 150 mg ascorbic acid. Before receiving the supplement, and 9 weeks later, children performed an exercise regimen on a treadmill during which expired air was collected and heart rate measured. There was a general deterioration in the running performance of the children during the study period which was not affected by either the iron or the vitamin supplement.
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Any obesity operation, whether malabsorptive or based upon the production of early satiety, produces weight loss by causing a net reduction in the delivery of nutrients to the portal circulation. The malabsorption caused by jejunoileal bypass produces numerous severe micronutrient deficiencies along with other potentially damaging conditions. Although there are numerous reports of such deficiencies following gastric restrictive procedures (particularly gastric bypass), the conditions are almost always more easily treated than those after intestinal bypass, and resultant clinical illnesses are rare. Physicians should be aware that any obesity procedure carries a risk of nutritional deficiency.
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Thirty-four Wistar rats were fed a marginal or normal vitamin A diet and received daily for 14 days an intragastric intubation of oil supplemented with 0, 20, or 60 mg X kg-1 of cyclosporine A. The hepatic content and concentration of vitamin A were significantly decreased by cyclosporine treatment, whereas no modification occurred in kidney or serum vitamin A levels. No induction of hepatic cytochrome P-450 was observed in treated animals. These results suggest that cyclosporine interferes with vitamin A stores; thus, vitamin A supplementation may be useful in patients receiving cyclosporine therapy. Drug-metabolizing enzymes, which are cytochrome P-450 dependent, did not seem to be involved in the hepatic vitamin A decrease observed.
Etiologies of confusion are discussed, including vascular, infectious, toxic-metabolic, tumorous, convulsive, and vitaminologic. Other diverse conditions are reviewed, including normal-pressure hydrocephalus.