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Placement of a crystalline lens and intraocular lens: Retinal image quality.

The influence of changes of both crystalline lens and intraocular lens (IOL) misalignment on the retinal image quality was investigated. The optical model of the eye used in investigations was the Liou-Brennan model, which is commonly considered as one of the most anatomically accurate. The original crystalline lens from this model was replaced with an IOL, made of rigid polymethylmethacrylate, in a way that recommend obligatory procedures. The modifications that were made both for crystalline lens and IOL were the longitudinal, the transversal, and the angular displacement.

Computer Simulation↗

Does visual restitution training change absolute homonymous visual field defects? A fundus controlled study.

AIM: To examine whether visual restitution training (VRT) is able to change absolute homonymous field defect, assessed with fundus controlled microperimetry, in patients with hemianopia. METHODS: 17 patients with stable homonymous visual field defects before and after a 6 month VRT period were investigated with a specialised microperimetric method using a scanning laser ophthalmoscope (SLO). Fixation was controlled by SLO fundus monitoring. The size of the field defect was quantified by calculating the ratio of the number of absolute defects and the number of test points; the training effect E was defined as the difference between these two ratios before and after training. A shift of the entire vertical visual field border by 1 degrees would result in an E value of 0.14. RESULTS: The mean training effect of all right eyes was E = 0.025 (SD 0.052) and all left eyes E = 0.008 (SD 0.034). In one eye, a slight non-homonymous improvement along the horizontal meridian occurred. CONCLUSIONS: In one patient, a slight improvement along the horizontal meridian was found in one eye. In none of the patients was an explicit homonymous change of the absolute field defect border observed after training.

Adult↗

Occipital hypoperfusion in Parkinson's disease without dementia: correlation to impaired cortical visual processing.

OBJECTIVE: The purpose of this study was to analyse changes in regional cerebral blood flow (rCBF) in Parkinson's disease (PD) without dementia. METHODS: Twenty eight non-demented patients with PD and 17 age matched normal subjects underwent single photon emission computed tomography with N-isopropyl-p-[(123)I]iodoamphetamine to measure rCBF. The statistical parametric mapping 96 programme was used for statistical analysis. RESULTS: The PD patients showed significantly reduced rCBF in the bilateral occipital and posterior parietal cortices (p<0.01, corrected for multiple comparison p<0.05), when compared with the control subjects. There was a strong positive correlation between the score of Raven's coloured progressive matrices (RCPM) and the rCBF in the right visual association area (p<0.01, corrected for multiple comparison p<0.05) among the PD patients. CONCLUSIONS: This study showed occipital and posterior parietal hypoperfusion in PD patients without dementia. Furthermore, it was demonstrated that occipital hypoperfusion is likely to underlie impairment of visual cognition according to the RCPM test, which is not related to motor impairment.

Aged↗

The costs of ignoring high-order correlations in populations of model neurons.

Investigators debate the extent to which neural populations use pair-wise and higher-order statistical dependencies among neural responses to represent information about a visual stimulus. To study this issue, three statistical decoders were used to extract the information in the responses of model neurons about the binocular disparities present in simulated pairs of left-eye and right-eye images: (1) the full joint probability decoder considered all possible statistical relations among neural responses as potentially important; (2) the dependence tree decoder also considered all possible relations as potentially important, but it approximated high-order statistical correlations using a computationally tractable procedure; and (3) the independent response decoder, which assumed that neural responses are statistically independent, meaning that all correlations should be zero and thus can be ignored. Simulation results indicate that high-order correlations among model neuron responses contain significant information about binocular disparities and that the amount of this high-order information increases rapidly as a function of neural population size. Furthermore, the results highlight the potential importance of the dependence tree decoder to neuroscientists as a powerful but still practical way of approximating high-order correlations among neural responses.

Action Potentials↗

A simple competitive account of some response properties of visual neurons in area MSTd.

A simple and biologically plausible model is proposed to simulate the optic flow computation taking place in the dorsal part of medial superior temporal (MSTd) area of the visual cortex in the primates' brain. The model is a neural network composed of competitive learning layers. The input layer of the network simulates the neurons in the middle temporal (MT) area that selectively respond to the visual stimuli of the input motion patterns with different local velocities. The output layer of the network simulates the MSTd neurons that selectively respond to different types of optic flow motion patterns including planar, circular, radial, and spiral motions. Simulation results obtained from this model show that the behaviors of the output nodes of the network resemble very closely the known responsive properties of the MSTd neurons found neurophysiologically, such as the existence of three types of MSTd neurons that respond, respectively, to one, two, or three types of the input motion patterns with different position dependences, and the continuum of response selectivity formed by the three types of neurons.

Animals↗

Perimetric defects and ganglion cell damage: interpreting linear relations using a two-stage neural model.

PURPOSE: To better understand the relations between glaucomatous perimetric defects and ganglion cell damage, a neural model was developed to interpret empiric findings on linear relations between perimetric defects and measures of ganglion cell loss. METHODS: A two-stage model computed responses of ganglion cell mosaics (first stage), then computed perimetric sensitivity in terms of processing by spatial filters (second stage) that pool the ganglion cell responses. Cell death and dysfunction were introduced in a local patch of the first-stage ganglion cell mosaic, and perimetric defect depth was computed for the corresponding region of the visual field. Calculations were performed for both sparse and dense ganglion cell mosaics and for spatial filters with peak frequencies from 0.5 to 4.0 cyc/deg. RESULTS: The model yielded nonlinear functions for perimetric defect depth in decibel versus the percentage of ganglion cell damage, but functions for lower spatial frequencies became linear when perimetric defect was expressed as a percentage of normal. The relations between perimetric defects and percentage of ganglion cell loss were determined primarily by spatial tuning of the second-stage spatial filters. For averaging sensitivities across different visual field locations, linear units (arithmetic mean) can more closely approximate mean ganglion cell loss than decibel units (geometric mean). Fits to data from experimental glaucoma required ganglion cell dysfunction in addition to ganglion cell loss. CONCLUSIONS: Pooling by second-stage spatial filters can account for empiric findings of linear relations between perimetric defects and measures of ganglion cell loss.

Glaucoma↗

Effect of visual restitution training on absolute homonymous scotomas.

The authors examined 16 patients with stable homonymous visual field defects (HVFDs) with static automated perimetry (SAP). Training effect E was defined as difference of the proportions of absolutely defective locations in all test locations, before and after visual restitution training (VRT). E was 0.05 +/- 0.05 (mean +/- SD). The authors observed a relevant training effect (E >or= 0.12) in two subjects, but only monocularly. VRT has little effect on absolute HVFDs in SAP.

Adult↗

Characterization of the spatial-frequency spectrum in the perception of shape from texture.

The major cue to shape from texture is the compression of texture as a function of surface curvature [J. Exp. Psychol. 13, 242 (1987); Vision Res. 33, 827 (1993)]. A number of computational models have been proposed in which compression is measured by detection of changes in the spatial-frequency spectrum [Comput. Graphics Image Process. 5, (1976)]. We propose that the visual system uses a strategy of characterizing the frequency spectrum by a simple set of measures and of tracking the changes in this characterization rather than determining changes in the shape of the actual spectra. Our evidence is based on a number of psychophysical demonstrations that use stimuli with specifically tailored frequency spectra, constructed from white noise filtered in the frequency domain. Our evidence suggests that the visual system determines the average peak frequency of the spectrum and uses this measure as its characterization. Changes in fp are strongly correlated with the degree of surface curvature, and, over a range of stimuli, fp takes account of the variance in local estimates of the frequency spectrum. One computes fp by determining the peak frequency at each spatial location and then averaging these frequency values over a local spatial region. We show that fp is related to the second-order moment but is more biologically plausible and shows superior ability to function in the presence of noise. As a test of this model, we have constructed a neural network architecture for computing shape from texture. Our model is limited to orthographically projected, homogeneous textures without in-surface rotation. The early stages of the model consist of multiple simple-cell units tuned to different orientations and spatial frequencies. We show that these simple cells are inadequate for the determination of compression but that the outputs of complex-cell-like units after normalization generate estimates of surface slant and tilt. The network shows qualitative agreement with human perception of shape from texture over a wide range of real and artificial stimuli.

Form Perception↗

Albertian errors in head-mounted displays: I. Choice of eye-point location for a near- or far-field task visualization.

A theoretical investigation of rendered depth and angular errors, or Albertian errors, linked to natural eye movements in binocular head-mounted displays (HMDs) is presented for three possible eye-point locations: the center of the entrance pupil, the nodal point, and the center of rotation of the eye. A numerical quantification was conducted for both the pupil and the center of rotation of the eye under the assumption that the user will operate solely in either the near field under an associated instrumentation setting or the far field under a different setting. Under these conditions, the eyes are taken to gaze in the plane of the stereoscopic images. Across conditions, results show that the center of the entrance pupil minimizes rendered angular errors, while the center of rotation minimizes rendered position errors. Significantly, this investigation quantifies that under proper setting of the HMD and correct choice of the eye points, rendered depth and angular errors can be brought to be either negligible or within specification of even the most stringent applications in performance of tasks in either the near field or the far field.

Computer Simulation↗

Assessing the significance of quantitative trait loci in replicable mapping populations.

Replicable populations, such as panels of recombinant inbred or doubled haploid lines, are convenient resources for the mapping of QTL. To increase mapping power, replications are often collected within each RI line and a common way to analyze such data is to include in the QTL model only a single measurement from each line that represents the average among the replicates (a line means model). An obvious, but seldom explored, alternative, is to include every replicate in the model (a full data model). Here, we use simulations to compare these two approaches. Further, we propose an extension of the standard permutation procedure that is required to correctly control the type I error in mapping populations with nested structure.

Animals↗

Giant intrasellar arachnoid cyst manifesting as adrenal insufficiency due to hypothalamic dysfunction--case report--.

A 67-year-old man first noticed loss of pubic and axillary hair in 1992 and then a visual field defect in 2001. He experienced loss of consciousness attributed to hyponatremia in April 2002. Magnetic resonance imaging showed a giant intrasellar cystic mass, 40 mm in diameter, that had compressed the optic chiasm. The patient complained of chronic headache, and neurological examination revealed bitemporal hemianopsia. Preoperative endocrinological examination indicated adrenal insufficiency, and hypothyroidism due to hypothalamic dysfunction. The patient underwent endonasal transsphenoidal surgery. The cyst membrane was opened and serous fluid was drained. Histological examination identified the excised cyst membrane as arachnoid membrane. The patient's headaches resolved postoperatively, but the bitemporal hemianopsia and endocrinological function were unchanged. This arachnoid cyst associated with hypothalamic dysfunction might have been caused by an inflammatory episode in the suprasellar region.

Adrenal Insufficiency↗

Thyrocervical trunk-external carotid artery bypass for positional cerebral ischemia due to common carotid artery occlusion. Report of three cases.

Medically refractory positional cerebral ischemia and concomitant orthostatic hypotension associated with chronic common carotid artery (CCA) occlusion are rare. The authors detail their experience with three cases treated exclusively by an extracranial bypass in which the thyrocervical trunk was used as the donor vessel. Postoperatively grafts were patent and symptoms resolved in all three patients, although orthostatic hypotension remained. Postural cerebral ischemia due to CCA occlusion can be treated by extracranial bypass surgery. The thyrocervical trunk is a suitable donor for reconstruction of the external carotid artery in these cases.

Aged↗

Moyamoya disease initially presenting visual field defect.

Progressive narrowing of distal carotid arteries and the development of compensatory fine networks are the characteristic findings of moyamoya disease. Cerebral infarction in moyamoya disease is due to a decreased blood flow and shows an uneven distribution in the distal bed of the anterior and middle cerebral arteries. The progression of disease in the posterior circulation follows that in the anterior circulation. Posterior circulation symptoms due to cerebral infarction usually occur in the advanced stage of the disease and follow the anterior circulation symptoms. We encountered an unusual case of moyamoya disease which initially presented with a transient visual field defect. One month later our patient developed blindness and her cerebral angiography showed advanced moyamoya disease.

Adult↗

The use of computers in occupational therapy for visual-scanning training.

This study examined the effect of computer-assisted remediation, with the use of specific visual-scanning software, in the retraining of a functional scanning deficit. Three subjects who displayed significant deficits in visual scanning were selected. A single-subject study was conducted, involving an ABA multiple baseline across-subjects design. Introduction of computer-based intervention with visual-scanning software occurred after 2 to 3 weeks of the gathering of baseline data. Removal of this intervention followed six to nine sessions of 15 to 30 min each over 3 weeks, and data were collected over a 2-week return-to-baseline phase. The dependent variables--speed, accuracy, and the number of re-referencing glances--were measured on functional performance of a grocery-shelf scanning task. Analysis with the two standard deviation band method did not reveal a significant change in performance on the functional task between the three phases. Visual and graphic analyses confirmed that computer intervention did not significantly affect performance on the functional task. The clinical significance of the results suggest that software-assisted remediation may not be an appropriate modality for achievement of a functional occupational therapy outcome.

Craniocerebral Trauma↗

[Current viewpoints on etiology and physiopathology of migraine].

Migraine is an inheritable disease, and the mutation causing a rare variant of migraine (familial hemiplegic migraine) has now been demonstrated. The mutated gene encodes a subunit of a brain-specific calcium channel in cell membranes. Brains of patients with recurrent migraine attacks seem to behave differently from other brains, also when examined outside attacks, in that they commonly demonstrate lack of habituation when exposed to serial stimuli. The patho-physiological process of the attack might well consist of a spreading cortical depression starting in the occipital region and gradually involving other parts of the cortex. It is primarily a cerebral process secondarily accompanied by reduced cerebral blood flow, later converting into increased flow. The pain of migraine probably is mediated by way of the trigeminal nerve which releases vasoactive peptides leading to dilatation of the greater blood vessels. During an attack there is increased metabolism in cranial parts of the brain stem, demonstrated as areas of increased blood flow in PET studies. This increased metabolism persists even when the symptoms of migraine have disappeared after drug treatment, perhaps because the migraine attacks may be generated in this region. The primary dysfunction in migraine probably is located in the brain rather than in blood vessels.

Adolescent↗

[Congenital toxoplasmosis: presentation of a case].

We report a case of a 4 months old boy with esotropia of the left eye with large bilateral chorioretinal toxoplasmic macular scars. Chorioretinal scars are the most common eye finding in congenital toxoplasmosis and are often located in the macular region. Most infants with congenital infection are asymptomatic at birth but will develop retinal and/or neurologic damage later in life with consequent loss of vision. A routine examination of the fundus and computed tomography of the head can be negative. Serologic testing is essential for the diagnosis and the follow-up of the infection. Every infant with evident or suspected congenital infection by Toxoplasma gondii must be treated by Pyrimethamine, Sulphadiazine and Folinic Acid during at least the first year of life with regular serologic testing and ophthalmologic examination. Neurologic outcome is better with treatment and the risk of chorioretinitis seems reduced.

Child, Preschool↗