Salivary adenolymphoma; study and report of five cases.
Explore the source record for details and available documents.
SEARCH · PubMed Health
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
Explore the source record for details and available documents.
Adenolymphoma of the salivary glands (here reported for the first time in two brothers whose father also might have had the disease) is typically a benign neoplasm for which excision is the treatment of choice. Incomplete excision may be followed by regrowth, which in some cases has been eliminated by roentgen therapy. Most such tumors are single and uninodular, but they may be multiple and bilateral.
Samples of 32 adenolymphomas and 10 intact salivary glands were studied using histological, histochemical (Grimelius and congo red staining), microscopic and immunohistochemical methods employing polyclonal antibodies to myosin, human carboanhydrase III and monoclonal antibodies to cytokeratin polypeptides No. 8 and 17, epithelial membrane antigen and T- and B-lymphocytes as well as peroxidase--antiperoxidase reaction. Binding of monoclonal antibodies to cytokeratin No. 8 and epithelial membrane antigen was observed in glandular cells of cysts whereas proliferating cells forming "Sandersen's cushions" showed binding of polyclonal antibodies to myosin, carboanhydrase III and monoclonal antibodies to cytokeratin No. 17. Tumor stroma revealed T- and B-lymphocytes incretory granulocytes and amyloid spaced along the fiber structures. It is inferred that adenolymphoma is a tumor arising exactly in salivary glands. The epithelial component of this tumor forms following tumor transformation of epithelial and myoepithelial cells of the distal part of salivary gland ducts. T- and B-lymphocytes contribute to formation of tumor stroma. Epithelial membrane antigen is an effective marker of the epithelial component of tumor.
Explore the source record for details and available documents.
Myoepithelial and basal cells were identified by a monoclonal antibody raised against keratin. This antibody (CK B1) which detects myoepithelial cells in normal salivary glands, labels spindle shaped and polygonal cells in pleomorphic adenomas. Most cells in adenoid cystic carcinomas and some basal cells in adenolymphomas were also positive for this antibody. The oncocytic epithelium of adenolymphoma was negative. An inverse reaction was seen with an antibody against cytokeratin 18. The antibody CK B1 seems to be of interest for the detection of myoepithelial/basal cells in salivary glands and salivary gland tumours.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
A series of 76 cases of adenolymphoma (Warthin's tumor) of the salivary glands is presented with emphasis on its epidemiological, clinico-pathological and therapeutic features; together with the analysis of the clinical records and of the epidemiological data, this study has reevaluated the histopathological features of the 76 cases of Warthin's tumor on hematoxylin-eosin stained slides. On these bases, the authors underline the frequent multifocality and/or bilaterality of Warthin's tumor (11.3% of cases), its frequent association with tumors of other sites (11.3% of cases), the prevalence in males (M:F ratio = 24:1) and in adults (mean age: 57 years) of this type of tumor. Furthermore, this study confirms the parotid gland as the elective site for Warthin's tumor and the possibility to categorize this entity into four different histological types. The latter finding should be kept in mind especially when fine needle aspiration (FNA) is used as a preoperative diagnostic procedure for Warthin's tumor to avoid misleading diagnosis and overtreatment. From the analysis of the results the authors underline the need for a complex and multidisciplinary approach to the diagnosis of Warthin's tumor in order to allow conservative surgery with preservation of the facial nerve.