[Skin reactions to adhesive plasters and elastic adhesive bandages].
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Cutaneous depigmentation due to adhesive plaster was observed in four patients. It occurred after an eczematous reaction, was irreversible and strictly limited to the contact area. There is evidence that the depigmentation was induced, at least in two patients, by the polyvinyl/rubber-plastic sheet of the adhesive plaster. Patch tests and animal experiments did not permit to identify the depigmenting component or contaminant of the plastic sheet. Light- and electron microscopy showed a complete disappearance of the epidermal melanocytes in the depigmented skin. During the first year after damage, they were mostly replaced by indeterminate cells. Later on the predominant basal non-keratinocytes of the epidermis were Langerhans cells.
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.
The stimulating effect of curiozin gel and plaster application on the engraftment of skin autografts from various areas of body was studied in rats. Curiozin gel in a single dose of 75 mg was used for the daily treatment of autografts over the entire postoperation period of time. The adhesive plaster was applied onto skin autografts for 5 days after skin transplantation. The skin autografts in the test group exhibited normalized volume blood flow dynamics, reduced duration of the inflammatory reaction, and improved the quality of engraftment as compared to the untreated control group. The best healing and blood-flow-normalizing effect was achieved by combined application of curiozin gel and adhesive plaster.
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