The inhibition by DPNH of the transformation of pregnenolone to progesterone by a rat adrenal preparation.
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Adrenal Glands↗
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The effect of calcium ions and freezing on the in vitro synthesis of pregnenolone by rat adrenal preparations.
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Adrenal Glands↗
A preliminary report on the intermediates in the conversion in vitro of cholesterol to pregnenolone in adrenal preparations.
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Adrenal Glands↗
Metabolism of 3H-11-deoxycorticosterone and 4-14C-11 beta-hydroxyprogesterone by rat adrenal preparations.
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Adrenal Glands↗
The effect of temperature and of cofactor concentrations on the conversion of 4- 14 C-progesterone to corticosterone by rat adrenal preparations.
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Adrenal Glands↗
Obligatory role of the delta 5-bond of cholesterol for steroid formation by adrenal preparations.
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Adrenal Cortex Hormones↗
Biogenesis of the corticosteroids. II. Conversion of C14-progesterone in cell-free hog adrenal preparations.
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Adrenal Cortex↗
An effect of ACTH on the metabolism of 1,2 3 H corticosterone by a cell free rat adrenal preparation.
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Adrenal Glands↗
The effect of melatonin on the biosynthesis of corticosteroids in beef adrenal preparations in vitro.
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Adrenal Cortex Hormones↗
Effect of ions on the enzymatic cortisol 2 - and 6 -hydroxylase activities of liver and adrenal preparations from two guinea pig genotypes.
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Adrenal Glands↗
The occurrence and metabolism of 20 alpha-hydroxycholesterol in bovine adrenal preparations.
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17-alpha-Hydroxypregnenolone↗
Biosynthesis and transformation of 20 alpha, 21-dihydroxycholesterol by rat adrenal preparations.
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17-alpha-Hydroxypregnenolone↗
Formation of corticosteroids from acetate and cholesterol in cell-free hog adrenal preparations.
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Acetates↗
Metabolism of 17-alpha, 20-alpha-dihydroxycholesterol and 17-alpha, 20-beta-dihydroxy-20-isocholesterol by guinea pig adrenal preparations. Formation of 3-beta-, 17-alpha-dihydroxypregn-5-en-20-one from these sterols and from cholesterol.
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Adrenal Glands↗
A method of preparing adrenal cell suspensions and its applicability to the in vitro study of adrenal metabolism.
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Adrenal Glands↗
[Allergic diseases: progress in diagnosis and therapy. II. Approach to diagnosis and treatment. 2. New mode of application of anti-allergy preparations. 2) Adrenal cortex steroid preparations].
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Adrenal Cortex Hormones↗
Guanine nucleotides and Ca-dependent exocytosis. Studies on two adrenal cell preparations.
Exposure of 'leaky' adrenal medullary cells to GTP-y-S inhibits Ca-dependent exocytosis in bovine cells, but stimulates exocytosis in chicken cells. The inhibitory action on bovine cells persists in the presence of TPA suggesting that in this tissue an inhibitory GTP-binding protein may modulate the action of protein kinase C on exocytosis.
Adrenal Glands↗
Biotransformation of pregnenolone - 7alpha-3H, progesterone - 7alpha-3H and dehydroepiandrosterone - 7alpha-3H by porcine fetal and maternal adrenal homogenate preparations.
The biotransformation of pregnenolone-7alpha-3H and of progesterone-7alpha-3H by porcine fetal and maternal adrenal homogenates at 56 and 112 days of pregnancy and of dehydroepiandrosterone-7alpha-3H by fetal adrenal homogenates has been investigated in vitro. Both pregnenolone-7alpha-3H and progesterone-7alpha-3H were metabolized extensively by maternal adrenal preparations, the principal radioactive metabolites isolated being cortisol, corticosterone, 11-deoxycortisol, deoxycorticosterone, 11beta-hydroxyprogesterone and androstenedione. In addition, 17alpha-hydroxyprogesterone, 20alpha-dihydroprogesterone and cortisone were formed from both substrates and 17alpha-hydroxypregnenolone and progesterone were formed from pregnenolone. Although essentially the same radioactive metabolites were isolated after incubation of fetal adrenal glands with pregnenolone-7alpha-3H or progesterone-7alpha-3H, a greater proportion of the radioactivity was associated with corticosteroids at 112 days of pregnancy than at 56 days. 11beta-Hydroxyandrostenedione and androstenedione were isolated and identified together with an unknown polar metabolite, after incubation of fetal adrenal tissue with dehydroepiandrosterone-7alpha-3H. These results are discussed in relation to feto-placental steroid biosynthesis and metabolism and the role of the fetal adrenal in the initiation of parturition in the pig.
Adrenal Glands↗