Studies in sickle cell anemia; inheritance factor, including effect of interaction of genes for sicklemia and thalassemia.
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Results for “ANEMIA, SICKLE CELL/heredity”
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Are certain blood dyscrasias an effect of racial mixture?
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[The genetic basis of sickle cell anemia].
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The population genetics of two inherited blood dyscrasias in man.
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Familial differences in the proportion of abnormal hemoglobin present in the sickle cell trait.
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Observations on the inheritance of sickle-cell hemoglobin and hemoglobin C.
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Linkage studies of genes for sickling and MNS blood groups; negative findings.
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Absence of linkage between the genes responsible for the sickling phenomenon, the MN blood types, and the S-agglutinogen.
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[Pernicious anemia in two families; follow-up].
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Two cases of sickle cell disease presumably due to the combination of the genes for thalassemia and sickle cell hemoglobin.
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Data pertaining to the population dynamics of sickle cell disease.
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[Some hereditary blood disorders].
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Factors in the pathogenesis of sickle cell anemia: a consideration of heredity and abnormalities in hemo globin structure.
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A case of sickle-cell anaemia occurring in a mulatto girl with an English mother.
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Clinical features of genetic variants of sickle cell disease.
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Abnormal hemoglobins; clinical disorders resulting from various combinations.
Within the past few years it has been noted that abnormal types of hemoglobin found in certain persons are associated with definite clinical disorders. At least four different varieties of sickle cell anemia are now recognized, three of them being heterozygous and one homozygous. When the gene for sickling is represented once, the person is asymptomatic and is said to have "sickle cell trait." However, when the sickle cell trait is present in combination with certain other hemoglobin abnormalities such as hemoglobin C or D or with thalassemia trait, symptomatic clinical disease results. The homozygous condition, in which two genes for hemoglobin C are present in the same person, has been observed in a few instances. A similar condition as regards hemoglobin D has not as yet been recognized.
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The genetics of human haemoglobin differences: problems and perspectives.
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[Study of a family afflicted with hereditary sickle-cell anemia].
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