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At least 19 recordsLinked to original sources
PubMed1958

A method for recording the effects of anthelmintics on the movements of Ascaris lumbricoides.

Adult roundworms (Ascaris lumbricoides) obtained from pigs were suspended in modified Tyrode solution at 37 degrees in fine nylon stockings, and the movements of the stockings were recorded. This method of suspension avoided damage to the cuticle or occlusion of the alimentary tract of the worm.Piperazine salts caused gradual narcosis, the time of onset of which was related linearly to the logarithm of the concentration of drug in the bath. The method is suitable for the assay of preparations of piperazine. Tetrachlorethylene, hexylresorcinol, and oil of chenopodium all caused stimulation of movement before the worm was immobilized. Santonin caused incoordination of the movements of the anterior end of the worm; the movements of the body were apparently unaffected. Piperazine is the safest preparation available for the treatment of ascariasis.

Animals↗
PubMed1958

The schistosomicidal and toxic effects on some alphaomega-di (p-aminophenoxy)alkanes and related monoamines.

An account is given of the results obtained with a number of p-aminophenoxyalkanes which were examined for activity against Schistosoma mansoni in mice and for the presence of retinotoxicity in cats. The first compound to be found active, 1:5-di(p-aminophenoxy)-pentane dihydrochloride (M & B 968A), was modified in a variety of ways in an attempt to increase its activity and to eliminate its ocular effects. It was found that a p-aminophenoxyalkyl group was common to all the active compounds, but that the rest of the molecule could be any of several different groups, including alkoxy, phenoxy, and phenyl groups, without diminishing the activity. Although at least one p-aminophenoxyalkyl group was essential for schistosomicidal activity, ocular toxicity was also shown by a p-aminophenylalkyl derivative in which the ether linkage was absent.

Alcohols↗
PubMed1958

Action of diethylcarbamazine in vitro on infective larvae of Wuchereria bancrofti.

Infective larvae of Wuchereia bancrofti were obtained from laboratory infected Culex fatigans and maintained in serum containing diethylcarbamazine. There was no difference in the survival time of these larvae and larvae maintained in control serum without diethylcarbamazine. In one of the three experiments reported the survival time of the larvae was much longer than in the other two experiments. It is suggested that this may have been due to the presence of filarial antibodies which killed the larvae in two of the sera used. In the serum which did not contain antibodies, the larvae survived very much longer.

Animals↗