PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “ANTHELMINTICS/pharmacology”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1960

Screening of cesticidal compounds on a tapeworm Hymenolepis nana in vitro.

A simple and convenient in vitro technique is described for the screening of compounds for action against Hymenolepis nana and probably many other intestinal worms. The results obtained from this test are in broad agreement with the findings of clinical experience and of a small series of in vivo tests. Among the substances tested, the most active ones were oil of chenopodium, dichlorophen, extract of cashew nut (Anacardium occidentale), antimony potassium tartrate, and BIQ 20 [eicosamethylenebis(isoquinolinium iodide)].

Anacardium↗
PubMed1961

Anthelmintic activity of methyridine against experimental nematode infections in mice.

Critical studies using mice infected experimentally with nematodes (Nematospiroides dubius, Nippostrongylus muris and Heterakis spumosa) have shown methyridine to be an extremely effective anthelmintic when administered orally or subcutaneously. Comparisons of the two treatment regimes show subcutaneous administration to be the more efficient in terms of absolute dose, but neither treatment has a significant advantage in therapeutic safety margin. Methyridine has a more uniform anthelmintic action than either phenothiazine or bephenium against adult forms of the three test nematodes. In addition the drug possesses activity against all stages of certain immature nematode infections.

Animals↗
PubMed1961

Studies on the mode of action of methyridine.

Methyridine [2-(beta-methoxyethyl)pyridine] reached the blood and all regions of the alimentary canal following oral or subcutaneous administration of therapeutic doses of the drug. Concentrations in the lower gut were highest following subcutaneous administration, and there was a close association between blood and intestinal levels suggesting that the drug is excreted into the alimentary canal along its whole length. In vitro experiments with intact nematodes (Ostertagia spp. from sheep; Nematospiroides dubius and Heterakis spumosa from mice; and Nippostrongylus muris from rats) and with preparations of Ascaris sp. have demonstrated that methyridine passes through the cuticle and exerts an "irreversible" paralysing effect on the worms. This action is obtained within 1 hr at concentrations similar to peak levels shown to be present in the alimentary canal following the administration of therapeutic doses. Concentrations of the drug were found to be higher in the abomasum than in the intestine of sheep and yet the anthelmintic activity of methyridine is greatest against intestinal nematodes. No significant differences in the resistance of various nematode species to the drug were demonstrated, but the amount of methyridine entering ascarids was significantly greater at pH 8 than at pH 5 or 3. In addition, the in vitro anthelmintic activity of the compound was greatest in alkaline solutions, which probably accounts for the differences in anthelmintic activity noted in various parts of the alimentary canal. The paralysing effect of methyridine on nematodes is probably due to a neuromuscular block of the decamethonium type, and this can also be produced in the host by over-dosage. It is suggested that nematode tissues are more sensitive to this action than vertebrate tissues.

Abomasum↗