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At least 19 recordsLinked to original sources
PubMed1956

An ascites tumor appearing during the passage of Eperythrozoon coccoides in mice.

A strain of Eperythrozoon coccoides was maintained in a pure state for 16 months in unsplenectomized Princeton mice by the intraperitoneal injection of parasitized blood, at intervals of 1 to 3 weeks. In the 39th passage three out of five mice developed marked ascites with innumerable neoplastic cells in the peritoneal fluid. By passage of this fluid the tumor cells and the eperythrozoon were transferred together, with the rapid development of ascites and early death of the animals. On continued passage of ascitic fluid and blood from the mice of the 39th successive group both the tumor and the eperythrozoon were ultimately obtained in a pure state. Development of the passaged tumor was uninfluenced by the eperythrozoon but growth of the latter appeared enhanced in the presence of the neoplastic cells. Throughout 50 passages in mice the ascites tumor has not altered in character. The intraperitoneal injection of ascitic fluid was irregularly followed by the appearance of tumor cells in the blood, the rate of the carriage being 26 per cent in sixty-five animals. The subcutaneous and intramuscular injection of the fluid resulted in solid, highly invasive, local growths which did not metastasize. The solid growths proved transferable in series yet after 20 passages still produced the ascites tumor on intraperitoneal injection of their cells.

Animals↗
PubMed1952

Albumin and globulin circulation in experimental ascites; relative rates of interchange between plasma and ascitic fluid studied with C14-labeled proteins.

Plasma containing carbon(14)-labeled albumin and globulin, obtained by feeding epsilon-C(14)D,L.-lysine to a donor dog, has been injected intravenously and intraperitoneally into recipient dogs with experimental ascites. The circulation and interchange of total plasma protein between circulating blood and ascitic fluid have been confirmed and the participation of both albumin and globulin in this interchange has been demonstrated. Labeled albumin tends to reach equilibrium in plasma and ascitic fluid in a shorter period of time (1 to 2 days) than does globulin (2 or more days), after administration of labeled plasma by either route. Evidence is presented that the rate of transfer of albumin across the peritoneal membrane is at least three times faster than that of globulin in terms of weight.

Albumins↗