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A comparison of antifibrillatory drugs in the heart-lung preparation.

Quinidine, amethocaine, Trasentin and atropine have been tested for their ability to stop atrial fibrillation produced in the heart-lung preparation of the dog by stimulating the right atrium in the presence of acetylcholine. The results suggest that atropine acts by specifically antagonizing acetylcholine, but that amethocaine and Trasentin act chiefly by virtue of their quinidine-like properties.

Acetylcholine↗

Fibrillation and potassium influx.

Absolute influx and efflux of potassium-42 have been measured in isolated rabbit atria during acetylcholine-induced fibrillation. The efflux of potassium was increased three to four times; influx was not changed. The data are interpreted as indicating that an inhibition of active K uptake is not involved in the initiation of fibrillation, and that the process results from a marked increase in Na permeability.

Animals↗