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At least 19 recordsLinked to original sources
PubMed1980

Prostaglandins and thromboxanes in amniotic fluid during rivanol-induced abortion and labour.

Abortion or delivery were induced by extra-amniotic instillation of Rivanol during the second trimester in twelve patients and during the third trimester in two patients with fetal death and one patient with fetal acrania. Serial sampling of amniotic fluid was performed through a transabdominal catheter and the levels of free arachidonic acid (AA), prostaglandin F2 alpha (PGF2 alpha), prostaglandin E2 (PGE2), 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TXB2) were determined. The levels of AA, PGF2 alpha, PGE2, 6-keto-PGF1 alpha and TXB2 in amniotic fluid increased significantly during induction with the exception of AA in fetal death which was high and remained constant during induction. Furthermore, PGF2 alpha, 6-keto-PGF1 alpha and TXB2 were all significantly correlated to AA. These observations suggested that free AA is released during Rivanol-induction of abortion and labour giving an increased synthesis of PGF2 alpha, PGE2 prostacyclin and thromboxane A2 in the fetal membranes and the decidua but not in the fetus. This increase might be relevant for the initiation and progress of abortion and labour in these patients.

Abortion, Induced↗
PubMed1980

[The coagulation system in Rivanol-induced abortion (author's transl)].

Second-trimester abortion was induced in 20 women by extra-amniotic instillation of rivanol. Studies were conducted into partial thromboplastin time (APIT), prothrombin, platelet count as well as into fibrinogen and fibrin split products. Twenty women with spontaneous abortion in the second trimester were used for control. APTT was elevated at the time of abortion, and both prothrombin as well as fibrin were elevated 24 hours after expulsion in response to rivanol-induced abortion. At the time of abortion, the fibrin split products in all cases or rivanol-induced abortion were higher than those of the control group. Yet, they were back to normal after another 24 hours. The platelet count did not change in the two groups during treatment. - The above results are likely to suggest that in both spontaneous abortion and rivanol-induced abortion the coagulation system is activated at similarly low levels, which seems to underline an unambiguous superiority over the use of hypertonic solutions for induced abortion.

Abortifacient Agents↗
PubMed1987

Second trimester abortion by rivanol with or without cervical dilatators. A randomized comparison.

Fifty women undergoing second trimester legal abortion were randomly assigned to one of three groups: 1. given Rivanol and left with balloon catheter in the cervical canal with addition of oxytocin infusion. 2. same treatment as above but catheter removed and replaced by a Lamicel cervical dilatator, 5 mm in diameter; 3. as group 2, but with a 6 mm Laminaria tent inserted. Induction-abortion interval and need for analgesics were recorded, as well as possible side effects and complications. No statistical differences were found between the three groups for any of the parameters. We have thus not been able to show any advantages of using Laminaria or Lamicel osmotic cervix dilatators in second trimester abortions.

Abortion, Induced↗
PubMed1978

Arachidonic acid in amniotic fluid after extra-amniotic instillation of rivanol for midtrimester abortion.

Free arachidonic acid was measured by gas liquid chromatography in amniotic fluid in 13 women during induction of midtrimester abortion. The abortions were induced by extraamniotic instillation of 0.1% Rivanol. Serial sampling of amniotic fluid were performed through a transabdominal catheter up to 22 hrs. Free, total arachidonic acid showed a significant increase from 26 +/- 8 ng/ml to 293 +/- 102 ng/ml at 22 hrs. The percentage of free arachidonic acid in total free fatty acids increased significantly from 2.2 +/- 0.5 to 6.1 +/- 1.6+ during the same time. The results suggest a selective release of arachidonic acid during Rivanol-induced abortion.

Abortion, Induced↗
PubMed1977

[Clinical results of two-time abortion technics with special regard to ascending genital infections].

If risk of the one-time mechanical dilatation will be too high (with young first gravidae and progressed pregnancy) the methods of the two-time interruptio should be applied. As long as there will not be available sufficient quantities of Prostaglandin-analoga the present method of choice is the abort-induction by means of the extra-amnial application of Prostaglandin F2alpha. In 101 cases when extra-amnial Pg F2alpha with an average induction time of four hours, the contamination rate was checked and no danger of ascension appeared. If prostaglandines will not be available, metranoicter or laminarias should be applied in the first trimenon when there is a high risk of dilatation, in the second trimenon extra-amnial instillation methods should be used. In both the cases only can be spoken of interruptios low if risks of they are made up under guard of broad spectrum antibiotics--after negative proof of blastomyces (buddings). This recommendation results from microbiological researches made up with 423 patients under the aspect of possible hospital infections. With induction times longer than 18 hours, the cavum uteri proved accelerating contaminated microbially. There were found microbes in the cavum uteri respectively at laminarias and metranoicters of, enterobacteria (45,7%), staphylococci (24,7%), hemolyzing and anhemolytic streptococci (17,6%), enterococci (8,0%), Corynebacteria (3,0%) and blastomyces (buddings) (1,0%).

Abortion, Induced↗
PubMed1977

[The advantages of the extra-amniotic transcervical instillation of rivanol in therapeutic abortions (author's transl)].

Our experience with the transcervical extra-amniotic instillation of 70 ml 0.1% Rivanol solution in 154 cases of first trimestre, second trimestre abortions and intra-uterine fetal deaths is reported. This simple and safe method has several advantages which render it suitable for out-patient usage should the rate of therapeutic abortions increase even more. The gentle dilatatory effect on the cervix is remarkable and is noticeable after 24 hours. Dilatation with the Hegar-dilators becomes unnecessary. There were no major complications. The stress on the patient is minimized.

Abortion, Therapeutic↗
PubMed1982

Uterine activity and placental histology in abortion at mid-trimester by rivanol and catheter.

Artificial abortions were performed on 7 patients during mid-pregnancy by intra-uterine instillation of 0.1% rivanol and catheters. The changes in uterine contractility during the treatment were monitored continuously by intra-amniotic pressure recording. Uterine activity developed a gradual but steady increase and abortion was completed within 22 to 47 hours. A significant increase in uterine contractility started after a lag of several hours. Neither hypertonus nor hyperactivity was noted during the treatment. The fetus was delivered unaffected in all cases. The placentas delivered showed normal histological integrity, and an autoradiographic study established the viability of trophoblasts. These results suggest that the abortive effect of rivanol and catheter on the uterus and placenta is different from that induced by other chemicals.

Abortifacient Agents↗
PubMed1979

Lysozyme in amniotic fluid during rivanol-induced second trimester abortion.

The concentrations of lysozyme and free arachidonic acid in amniotic fluid were determined in eight patients during induction of second trimester abortion. Abortion was induced by extraamniotic instillation of 150 ml 0.1% Rivanol. Lysozyme increased in all patients during the induction reaching significancy after 60% of the induction-abortion time. This suggests a leakage of lysosomal enzymes from the fetal membranes. Free arachidonic acid relative to total free fatty acids increased parallell to lysozyme.

Abortion, Induced↗
PubMed1990

Uterine contractility during pregnancy and the effect of abortifacient drugs.

There are a number of compounds in clinical use for termination of pregnancy. Treatment with all of them will result in increased uterine contractility. PGF2 alpha and PGE2 as well as different prostaglandin analogues all have a direct stimulatory effect on the myometrium, while other compounds such as hypertonic saline and Rivanol seem to act mainly through a stimulation of the endogenous production of PGF2 alpha. Treatment with antiprogestins which compete with progesterone at the receptor level or which inhibit progesterone biosynthesis results in an increased uterine contractility probably through a release from progesterone inhibition. If the withdrawal of progesterone also induces an increased endogenous prostaglandin production is unclear. The medical method to induce abortion which best resembles the physiological events during a spontaneous abortion is probably treatment with antiprogestins (receptor blockers or progesterone biosynthesis inhibitors) followed by prostaglandin.

Abortifacient Agents↗
PubMed1990

Intrauterine administration of drugs for termination of pregnancy in the second trimester.

Medical methods have been used for many years to terminate mid-trimester pregnancy, ranging from irritant chemicals and traditional plants to ecbolic agents and solutions instilled locally into the uterus. These methods had serious limitations, with relatively high rates of maternal mortality and morbidity. Surgical evacuation requires special skills not available to all practitioners and many doctors consider second trimester dilatation and evacuation as a surgical taboo. In recent years several approaches evolved and reached the clinics, presenting safer and more effective options. Intra-amniotic instillation of hypertonic solutions, particularly saline or urea, proved in many hands to be a good method for pregnancies beyond 15 weeks of gestation. Due to a long latency period after instillation, these agents are often supplemented by an intravenous oxytocin infusion. Extraovular hypertonic saline or ethacridine (Rivanol) have their advocates, particularly in the grey-zone of pregnancy range from 13-15 weeks. In the last two decades, intrauterine prostaglandins were added to the methods in current use. Extra-amniotic prostaglandins (E2, F2 alpha or 15-methyl F2 alpha) were originally given in repeated doses or as a continuous local drip, but later a single instillation was used, usually mixing the drug with a viscous solution or gel. Intra-amniotic prostaglandins, in much higher doses, particularly the 15-methyl analogue, proved highly effective and relatively safe, especially when combined with laminaria tent insertion in the cervix. Various combinations of methods have provided a wide spectrum of data which is difficult to evaluate at present. Studies comparing different methods were mainly attempted in the mid-seventies. The outcome raised many pertinent questions and left many major issues unresolved. Most of the comparisons were not randomized or well-controlled and only referred to the natural prostaglandin compounds. The analogues, however, seem to offer several advantages and the role of additional methods such as laminaria or antiprogestins remains to be further evaluated.

Abortifacient Agents↗
PubMed1981

Abortion during mid-pregnancy by rivanol-catheter supplemented with PGF2 alpha drip-infusion or quinine hydrocholoride.

Abortion during mid-pregnancy was performed in 200 patients by extra-amniotic insertion of Nelaton catheters and instillation of 0.1% rivanol solution. To shorten the abortion time, quinine hydrochloride was given orally in one group (n=100), and intravenous infusion of prostaglandin F2 alpha (PGF2 alpha) was undertaken in the other group (n=100). The abortion rate after 72 hours was higher in the PGF2 alpha group (96%) than that in the quinine group (91%), but the difference was not statistically significant. The abortion time was significantly shorter in the PGF2 alpha group than in the quinine group (p less than 0.01). This method, together with supplementary treatment with oxytocic substances, proved to be an effective mid-pregnancy abortion method. The risks of endometritis, gastro-intestinal complications, and/or heavy bleeding either during or post-abortive were minimal.

Abortion, Induced↗
PubMed1990

Induction of second trimester abortion by intraamniotic instillation of Rivanol (ethacridine) combined with oxytocin infusion.

We report our experience of 0.1% intraamniotic Rivanol in the interruption of 100 midtrimester pregnancies (15-24 gestation weeks). The mean injection to abortion interval was 37.2h and there were no complications. Intraamniotic Rivanol injection combined with oxytocin infusion seemed an effective and safe method for terminating second trimester pregnancies.

Abortifacient Agents↗