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At least 19 recordsLinked to original sources
PubMed1983

Sebaceous adenocarcinoma of the eyelid.

Sebaceous adenocarcinoma is a rare neoplasm of the eyelid that often masquerades as a chalazion, blepharitis, or blepharoconjunctivitis. Controversy exists as to the proper mode of therapy for patients with a tumor confined to the eyelid. We believe that wide local excision (5 to 6 mm of normal tissue) with frozen section analysis and eyelid reconstruction is the preferred treatment. Only 1 of 11 patients had a recurrence with this technique. No regional or distant metastasis has occurred in an average of 68 months of follow-up.

Adenocarcinoma↗
PubMed1977

Sebaceous adenocarcinoma of the eyelid. Definition of surgical margins.

Carcinoma of the sebaceous glands of the eyelid carries a serious prognosis. Although uncommon, the diagnosis must be frequently considered owing to the similarity of the early signs of adenocarcinoma to those of chalazion. Three cases with proved sebaceous adenocarcinoma of the eyelid are reviewed to relate subtle evidence of clinical and histopathological malignancy to surgical management.

Adenocarcinoma↗
PubMed2002

Sebaceous adenocarcinoma of the external auditory canal in a New Zealand white rabbit.

A rare sebaceous gland carcinoma of the external auditory canal in a rabbit is described. The tumour was characterized histologically by foci and cords of markedly pleomorphic cells with abundant cytoplasm and variable numbers of vacuoles. A single pulmonary mass had similar histological characteristics. This is the first such tumour reported in a rabbit.

Adenocarcinoma, Sebaceous↗
PubMed1987

Sebaceous adenocarcinoma of meibomian gland origin with targetoid intra-nuclear inclusions.

Neoplastic proliferation of the meibomian glands is most often characterized by a tarsal tumor of the eyelid conjunctiva, having the clinical appearance of a chalazion. As such, the tumor is frequently not recognized as a neoplasm and is treated conservatively as an inflammatory lesion. A protracted clinical course combined with repeated surgical excisions typify this slow-growing tumor of sebaceous gland cells. In addition to the usual features of polygonal cell shape, abundant cytoplasm, and numerous fat vacuoles, we describe the presence of a peculiar nuclear inclusion seen only in the parenchymal cells of this tumor, and having the appearance of concentric layers of electron-dense material surrounding an opaque electron lucent core.

Adenocarcinoma↗
PubMed2006

Sebaceous lymphadenocarcinoma of parotid gland.

The sebaceous lymphadenocarcinoma of the salivary glands is extremely rare and represents carcinomatous transformation of sebaceous lymphadenoma. There are only four reported patients in the medical literature. A patient who presented with a recent increase of a left infraauricular mass, of more than 10 years duration, underwent surgery. The microscopic examination revealed a typical sebaceous lymphadenoma with transition to a sebaceous adenocarcinoma. After postoperative adjuvant radiotherapy, the patient remains disease-free at 24 months postoperatively. We here report a fifth case of this tumor and the youngest age at diagnosis among reported cases.

Adenocarcinoma, Sebaceous↗
PubMed2005

Cutaneous mass aspirate from a Golden Retriever: "glandular guile".

A 3-year-old, neutered, male Golden Retriever was presented for evaluation of a 10 X 9 X 5 mm, firm, red, raised, cutaneous mass located over the left cranial thorax and noted incidentally by the owner. On cytologic evaluation of a fine-needle aspirate of the mass, the interpretation was a malignant tumor with predominantly mesenchymal features. Differentials included liposarcoma, atypical amelanotic melanoma, anaplastic sarcoma, and anaplastic carcinoma. Following complete excision of the mass, a diagnosis of sebaceous adenocarcinoma was made based on histologic features, positive immunostaining for pancytokeratin, and negative staining for vimentin, Melan-A, and S-100. There was no evidence of metastasis on physical examination or thoracic radiographs, and the prognosis was good. The unique and previously unreported cytologic features of this small, sebaceous adenocarcinoma were the extreme pleomorphism, including marked anisocytosis, anisokaryosis, and multinuclearity, and the paucity of epithelial features.

Adenocarcinoma, Sebaceous↗
PubMed1986

Conjunctival map biopsy to determine pagetoid spread.

Sebaceous adenocarcinoma (meibomian gland cancer) can be localized at times to one specific area of the eyelid; at other times, it spreads diffusely by pagetoid invasion throughout the conjunctiva. The pagetoid spread is often impossible to visualize. I used a map biopsy of the conjunctiva to determine the extent of involvement of sebaceous adenocarcinoma in 12 patients. Sixteen conjunctival biopsy specimens were taken from various areas of the palpebral and bulbar conjunctiva. An analysis of these specimens helped to delineate the area of tumor involvement, which aided in determining whether to treat these cases by full-thickness eyelid resection or orbital exenteration.

Adenocarcinoma↗
PubMed1990

Sebaceous gland carcinoma of the eyelid: case report.

This paper reports a case of sebaceous adenocarcinoma of the meibomian gland in a 69-year-old man. The tumour was excised and histopathological examination revealed the characteristic features of sebaceous adenocarcinoma.

Adenocarcinoma↗
PubMed1978

Bioassay of 5-nitro-o-anisidine for possible carcinogenicity.

A bioassay of 5-nitro-o-anisidine for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. 5-Nitro-o-anisidine was administered in the feed at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay for low and high dose rats were 0.4 and 0.8 percent, respectively. Dose A and B mice were fed dietary concentrations of 0.8 and 1.6 percent when initially placed on test, but after week 15 the concentration fed to dose B mice was reduced to 0.4 percent. After a 78-week period of chemical administration, observation of rats continued for up to an additional 28 weeks and observation of mice continued for up to an additional 19 weeks. For each species, 50 animals of each sex were placed on test as controls for the group receiving the higher concentration and 49 to 50 animals were of each sex were placed on test as controls for the group receiving the lower concentration. In both species, adequate numbers of animals in all groups survived long enough to be at risk from late-developing tumors. Feeding of 5-nitro-o-anisidine to rats was associated with increased incidences of tumors of the integumentary system. Basal-cell carcinomas, trichoepitheliomas, squamous-cell carcinomas and sebaceous adenocarcinomas each occurred in the skin of high dose male rats at statistically significant incidences. For both male and female rats, carcinomas (the combined incidence of sebaceous adenocarcinomas, ceruminous carcinomas and squamous-cell carcinomas) of the Zymbal's gland or the skin of the ear were significant in the high dose groups. In the clitoral gland of dosed female rats, the incidence of carcinomas and the incidence of adenomas were each significant. Among mice, the incidence of hepatocellular carcinoma was statistically significant for dose B females when compared to their appropriate controls. Under the conditions of this bioassay, dietary administration of 5-nitro-o-anisidine was carcinogenic in Fischer 344 rats, causing tumors of the integumentary system in males and females and of the clitoral gland in females. The compound was also carcinogenic to female B6C3F1 mice, causing hepatocellular carcinomas.

Journal Article↗