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At least 19 recordsLinked to original sources
PubMed1997

Risks of cardiac operations for elderly patients: reduction of the age factor.

BACKGROUND: Age has been considered an important risk factor for cardiac operations. Recent refinements have been designed to reduce cardiac, neurologic, and renal complications. METHODS: Analysis of cardiac surgical outcomes including mortality, length of stay, complications, and costs were undertaken for a consecutive series of 285 patients 70 years old and older and 568 patients younger than 70 years who underwent operation during 1991 through 1995. Management included antegrade and retrograde cold and warm blood cardioplegia, epicardial echocardiography, retrosternal dissection for reoperations, maintenance of "normal" arterial pressure, and measures to avoid renal dysfunction. Parsonnet risk stratification and multiple regression were used to account for risk factors. RESULTS: The 30-day mortality rate for elderly patients was 1.8% (5/285) and 1.8% (10/568) for patients less than 70 years old (p = not significant). The hospital mortality rate for the elderly patients was 3.2% (9/285) versus 2.5% (14/568) for the younger group (p = not significant). The frequencies of complications were not different. Over the 5-year period, length of stay decreased from 12.5 +/- 1.5 days to 8.9 +/- 0.9 days for patients 70 years old and older and from 11.5 +/- 0.1 to 6.4 +/- 0.3 days for patients less than 70 years old. Hospital charges for the elderly group were 13% higher. CONCLUSIONS: Modern cardiac surgical techniques and clinical practices have reduced the importance of the age factor.

Age Factors↗
PubMedDate not supplied

[Some factors of collagen aging factors in vivo and in vitro].

The literature data on different factors of collagen aging, the main connective tissue protein, have been analyzed. Mechanisms of reactions that are involved in both old aging and non-enzymatic course of protein aging are discussed. Factory influencing, non-enzymatic protein glycation during-related pathology and some ways for its inactivation by different substances are reviewed.

Aging↗
PubMed1977

[On the biophysical interpretation of ageing-factors (author's transl)].

The ageing-factor is a measure for the rate of ageing. In the model of vitality the error rate mu corresponds to the ageing-factor. The ageing-factors of several physical functions can be determined from the ascent of decrease of these functions. The standardized ageing-factors of the considered physiological functions range from 0.001 to 0.017 year--1 and are smaller than the ageing-factor of the whole organism. The date of the occurrence of pathological manifestations as a result of ageing-conditioned decrease of functions can be estimated by means of the ageing-factors.

Adolescent↗
PubMed1976

[The ageing-factors of several physical functions in man (author's transl)].

The ageing-factor is a measure for the rate of ageing. In the model of vitality the error rate mu corresponds to the ageing-factor. The ageing-factors of several physical functions can be determined from the ascent of decrease of these functions. The standardized ageing-factors of the considered physical functions range from 0,001 to 0,017 year-1 and are smaller than the ageing-factor of the whole organism. The date of the occurrence of pathological manifestations as a result of ageing-conditioned decrease of functions can be estimated by means of the ageing-factors.

Activities of Daily Living↗
PubMed1997

[Growth and aging factors in physiological senility and Alzheimer's disease].

INTRODUCTION: Both the normal and pathological development and involution of the CNS are regulated by an important set of both, 'growth factors' (inducing growth, differentiation, survival, adaptation or plasticity in neurons) and 'ageing factors' (inducing involution, atrophy, necrosis or apoptosis). In neurodegenerative diseases, significant deficits of growth factors and important presence of ageing factors are being detected, mainly in Alzheimer's disease (AD). DEVELOPMENT: In this review, the most important growth factors (NGF, BDNF, neuromodulators, glial factors, etc.) and ageing factors (amyloid, tanatins, calcium, mitochondrial factors, etc.) in the pathogenesis of the AD are discussed. CONCLUSIONS: The knowledge and assessment of these endogenous factors must have an important role in the diagnosis and treatment of the cognitive impairment that characterizes senility and AD.

Aged↗
PubMed2006

Age differences in the sixth personality factor: age differences in interpersonal relatedness among Canadians and Hong Kong Chinese.

Cross-cultural studies on personality in which a combined etic-emic approach has been used have found a 6th personality factor--Interpersonal Relatedness--in addition to the usual Big Five. The authors examined age differences in Interpersonal Relatedness among Canadians and Hong Kong Chinese after statistically controlling for the Big Five. Age differences in some aspects of Interpersonal Relatedness were found among Hong Kong Chinese but not among Canadians, suggesting that development of some personality characteristics may differ across cultures.

Adolescent↗
PubMed2004

Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: identification of responders incorporating the age factor.

To identify responders when protein-bound polysaccharide (PSK) is used in adjuvant immunochemotherapy after curative resection of colorectal cancers, we examined the host and tumor factors that affect the prognosis incorporating the age factor. A total of 101 patients who had undergone macroscopic curative resection of colorectal cancer were treated with mitomycin C + fluoropyrimidine oral antineoplastics + PSK (MFP therapy) for two years in principle. These cases were divided into two age groups of <65 years [n=55; 54.8 +/- 8.3 years (mean +/- SD)] and > or =65 years (n=46; 69.1 +/- 3.3 years). Host factors including humoral factors (complement C3 and C4), immunosuppressive acidic protein (IAP), lymphocyte transformation (cellular factors) induced by various mitogens [phytohemagglutinin (PHA), pokeweed mitogen (PWM), and PSK], and tumor markers (CEA, CA19-9) were measured. The cases were divided by the cut-off value of each parameter into > or = cut-off value and < cut-off value groups, and the 5-year survival rates were compared. The cut-off values obtained for these parameters and the tumor factor (Dukes class) were subjected to multivariate analysis to identify the markers that affect prognosis. The 5-year mortality rate was 74.5% in the <65 age group and 56.8% in the > or =65 age group, with a tendency of better prognosis in the <65 age group (p=0.1109). Compared to the <65 age group, the > or =65 age group showed higher levels of C3 (2-way ANOVA: p=0.0582), C4 (p=0.0009) and IAP (p=0.0110) over time, but lower PSK-induced stimulation index (SI) as an indicator of cellular immunity) (p=0.0001) and PHA-induced SI (p=0.2650) over time. These results indicated that compared to patients aged <65 years, patients aged > or =65 years were characterized by lowered cellular immunity in addition to augmented complement production and an aggravated immunosuppressive state, suggesting the presence of some differences in host immune function with aging. Using the Cox proportional hazard model, the prognostic determinant was found to be Dukes C in the <65 age group, and CEA level in the > or =65 age group. The present results suggested that analysis of prognostic determinants of this therapy should take into account the age factor. Especially in elderly subjects, responders to PSK may be identified using the preoperative CEA value.

Adult↗
PubMed1986

[Age factors and patterns in senile depression].

On the basis of a comparative age-specific analysis of 115 patients with depression which first manifested itself at the age over 60, the author shows the dependence of a number of clinical characteristics (typology of manifest attacks, their duration, as well as the likelihood of the development of individual nosological forms of affective psychoses) on the age at which the disease first manifested itself. The nature of the modifying effect of the age factor on the clinical manifestations of late-age depression is discussed.

Age Factors↗