[Physiological and ethological principles of environmental requirements, conforming to the animal protection law, for domestic animals].
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Random examination of domestic animals revealed the frequent presence of free-living amebae in their bodies. In diseased or dead cows, dogs, pigs, rabbits, pigeons, and turkeys 15 strains of amebae were found, belonging to the genera Acanthamoeba (A. polyphaga), Hartmannella (H. vermiformis), and Vahlkampfia (V. avara, V. enterica, V. inornata). They were usually accompanied by other infectious agents in different parts of the host bodies. Pathogenicity of 3 isolates could not be demonstrated by inoculation of laboratory animals. Some features of the isolates differed from those previously known for members of these genera. These strains may be considered amphizoic amebae according to Page (1974).
Atopy to dander from domestic animals occurs rather frequently in atopic patients, especially danders from the cat, guinea-pig, horse, rabbit, and golden hamster. There is no clear sex difference. The age group in which the phenomenon is found most frequently is from 21 to 30 years. As in hay-fever patients during the season, we found a double-peaked frequency curve for the blood eosinophilia. Animal-dander atopy was diagnosed particularly in patients with asthma and/or with atopic eczema. The strength of skin reactions to a series of three tenfold dilutions of standardized test extracts appears to be a good index for the origin of clinical symptoms after contact with the relevant animals.
Wild and domestic animals from 3 geographic-climatologic areas in northern California were tested for antibodies against Toxoplasma gondii. A total of 2,796 serum samples representing 37 species of wild mammals, 35 species of wild birds, and 5 species of domestic animals were tested by the indirect hemagglutination test. Of 1,174 wild mammal serums tested, 10.8% were positive, which compared with 14.7% of the 1,221 domestic mammal serums. Of 229 wild carnivores tested, 45% were seropositive, including 69% of 86 bobcats, 28% of 58 coyotes, 48% of 25 raccoons, 27% of 26 gray foxes, 22% of 32 striped skunks, a civet cat, and a mink. Serologic evidence of infection was found in 38% of 47 rural domestic cats, but none of the 7 dogs tested was seropositive. Of 160 murid rodents (rats and house mice) in rural habitats, 4% were seropositive, which compared with 2% of 399 cricetine rodents (mostly deer mice) collected from wilderness habitats. Seven percent of 56 wild Artiodactyla (deer and feral pigs) were seropositive, which compared with 15% of 1,048 domestic sheep tested. Of 401 birds tested, 3.5% had antibodies against T gondii. The highest prevalence of antibodies among birds was in crows (14%). Toxoplasma was isolated from 1 raven, by mouse inoculation. In general, the highest prevalence of seropositive carnivores, rodents, and sheep was in the coastal region below 100 ft elevation, where the weather is cool and damp for much of the year. In the central valley the highest prevalence among sheep was in areas under irrigation. The prevalence of antibodies was lowest in the mountain areas, where climatologic extremes prevail at various seasons of the year.
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A retrospective study of 15 thymomas in domestic animals showed four animals had antemortem signs of dyspnea and grossly visible lumps in the thoracic inlet. The neoplasms were single, multilobulated, encapsulated masses in the anterior mediastinum or thoracic inlet. Cells with clear cytoplasm comprised the bulk of two canine thymomas, whereas the remaining neoplasms had a mixed population of ovoid and spindle-shaped cells. There were lymphocyte populations of varying density in all thymomas. Three thymomas contained structures similar to hyalinized cells and Hassall's corpuscles of normal thymus. Metastatic lesions were not seen but there were implantations on the pericardium in one cat. There was capsular invasion in the ovine thymomas.
In 5 domestic animal species of the Liberian rain forest, investigations were done on the infection rates with trypanosomes of the subgenera Nannomonas, Duttonella and Trypanozoon and on possible reservoir hosts for Trypanosoma (T.) brucei gambiense. Serological screening (indirect fluorescent antibody test) revealed that infection rates with Trypanosoma spp. were in N'Dama cattle 80.4%, in pigs 76.0%, in dogs 48.5%, in goats 35.1% and in sheep 28.1%. In N'Damas, antibodies to T. (N.) congolense and to T. (D.) vivax predominated and were distributed homogeneously; in pigs, antibodies to T. (N.) congolense were found most frequently. In dogs, antibodies to T. (N.) congolense and to T. (T.) b. brucei, and in goats and sheep antibodies to all 3 species were distributed homogeneously. Strong serological reactions (titres greater than 1:320) to T. (T.) b. brucei antigen were found most frequently in pigs (20.0%), in cattle (9.8%) and in dogs (9.5%). As suspicious reservoir hosts for T. (T.) b. gambiense, pigs (117) and dogs (105) were examined parasitologically in order to isolate Trypanozoon stocks for further infraspecific characterization. 56.4% of the pigs (14.5% Trypanozoon, 23.1% mixed Trypanozoon/Nannomonas, 18.8% Nannomonas), and 38.2% of the dogs (2.9% Trypanozoon, 14.3% mixed Trypanozoon/Nannomonas, 21.0% Nannomonas) were found to be infected. The sensitivities of the thick smear, the haematocrit centrifugation technique and the animal inoculation using Mastomys natalensis were described. 32 trypanosome stocks containing Trypanozoon were stabilized.
Results are presented of a serological examination of 1,547 domestic animals (cattle, pig, sheep, horse, goat, dog, cat) from 9 Tyrolian districts (Austria), performed in order to disclose the incidence of leptospirosis. Completely significant titres were domonstrated by means of the MAL test in the serotypes icterohaemorrhagiae or copenhageni, sorex-jalna, bratislava, sejroe and saxkoebing. In addition, antibodies were confirmed against L. bataviae, L. pomona, L. tarassovi and L. bulgarica, but the titres were insignificant. Of the animals examined, 7.2% gave positive reactions in titres of 1: 800 and above (for dogs and cats 1: 100 and more); positive reactions were obtained from 8.8% of cattle serum, 6.8% of pig-, 1.1% of sheep-, 3.3% of dog-, 18.2% of cat serum. A positive reaction was obtained with the serum of one out of the 9 horses examined, the sera of the two goats examined were negative. he percentage of positivity in animals from the individual districts ranged from 1.0 to 17.0, and variations were found also in the distribution of serotypes in the individual districts. The results indicate that the percentage of positivity in domestic animals from Tyrol decreases as the altitude of the localities increases.
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The authors investigated a total of 435 domestic animals in Afghanistan by micromodification of indirect hemagglutination test. Camels showed the highest incidence of infection (73.7%). Of 9 zebu 3 were positive. The incidence of infection in goats was 31.6%, in sheep 20.4%, in buffaloes 20.4%. The lowest percentages of positive titres was detected in cattle (15.7).
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Three species of domestic animals (rabbits, sheep and goats) and two species of primates Erythrocebus patas monkeys and baboon (Papio anubis) were infected with Jos virus. None of the infected animals developed viraemia or overt clinical disease. Complement-fixing and neutralising antibodies were demonstrated in sera of infected animals.
Arsenic poisoning is one of the more important causes of heavy metal poisoning in domestic animals. Two species--dogs and cattle--are intoxicated more frequently than other animals; yet sporadic instances of poisoning have been observed in cats, horses, and pigs. Cases observed by veterinary clinicians are either peracute, acute, or chronic intoxications. Frequently the initial and only indication that a severe problem exists with peracute poisoning in a cattle herd is dead animals. Chronic intoxications are also observed in cattle. Acute intoxication is the most common form of arsenic poisoning observed and documented in the dog. Also intoxicated dogs were younger, i.e., 2-6 months of age. Arsenic is a severe alimentary tract irritant in domestic animals, and treatment in most instances consists mainly of symptomatic and supportive treatment. The source of intoxication, when it can be determined, is usually dips, sprays, powders, or vegetation contaminated by pesticides containing arsenic.
A survey of polyarteritis nodosa in domestic animals is presented, including a description of the patho-morphological lesions and a discussion on the causal factors. This vascular disease occurs in domestic animals in association with both viral infections (infectious plasmacytosis in mink), bacterial infections (erysipelas in swine), and protozoan infections (nosematosis in blue foxes). The conclusion is drawn that the observations in domestic animals support the view that immunological disturbances are involved as pathogenetic mechanisms. Nosematosis is dealt with in more detail; the infecting agent (fig. 1), Nosema cuniculi (Encephalitozoon cuniculi), is a widespread mamalian parasite, which causes cerebral and renal lesions in blue foxes of the same type as in animals of other species. In addition, the vascular system throughout the body is affected, resulting in patho-morphological alterations corresponding to classical polyarteritis nodosa (Fig. 2). In the early stages of involvement, masses of parasitic organisms are regularly found within the walls of affected arteries (Fig. 3). This disease is frequently lethal, and always accompanied by elevated values of gamma globulins. Both the hypergammaglobulinemia and the tissue lesions, seem at times, at least in part, to be reversible.
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Intensive research in the field of the immunology of protozoan blood parasitoses has led to a further clarification of the interrelations between parasites and hosts. Progress in the analysis of the antigen character of the parasites and investigations of the immune response form the basis for extending serological diagnosis and improved vaccines. The effectiveness of the vaccines against babesioses could be increased. Vaccines have been tested successfully against tropical theileriosis and East Coast fever. It is only with African trypanosomes that immunoprophylaxis seems to be impossible at present.
Using the Sabin-Feldman dye test, sera from wild and domestic animals in New Mexico, Arizona and Colorado were tested for the prevalence of antibodies to Toxoplasma gondii. The prevalence of positive titers (greater than or equal to 1:8) in animals from these areas was: New Mexico (178 of 569, 31%), Arizona (11 of 56, 20%), and Colorado (2 of 7, 29%). The overall prevalence of antibodies to Toxoplasma was 30% (191 of 632). Nine of 17 fecal samples from wild zoo felines contained Toxoplasma-like oocysts which were inoculated per os and intraperitoneally into mice. Mice from six of these nine inoculations later showed positive dye test titers and tissues from five of these six groups had tissue cysts when examined histologically.