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At least 19 recordsLinked to original sources
PubMed1978

[State of the stroma in melanoma in patients with different delayed hypersensitivity reaction to neoplasm antigen].

The data are reported on studying the stromal response of 19 melanomas of analogous localization, showing the same type of growth, histological structure, the level of invasion and area of ulceration in patients with positive and negative delayed hypersensitivity reaction to injection of the polysaccharide fraction from melanoma tissue. A high degree of pronouncement of lymphoid-cellular infiltration of tumor stroma correlated with a positive delayed hypersensitivity response, whereas a low degree -- with a negative one.

Adult↗
PubMed1990

[Prospects of the use of neoplasm antigens as markers of gynecologic diseases].

CA-125 antigen was assayed in 108 patients with the most prevalent gynecologic diseases by enzyme immunoassay. Its blood levels were found to be under 35 U/ml in the patients with inflammatory diseases. In endometriosis and benign ovarian tumors CA-125 concentrations in the blood were elevated. Malignant tumors of the ovaries were detected in 80 percent of the examinees. CA-125 levels reduced after surgical treatment in 72 percent of patients. These data permit a conclusion that CA-125 diagnostic agent may be used to monitor the course of the postoperative period and assess the late results of treatment.

Adolescent↗
PubMed1982

Tumor antigens in neoplasms of the human parotid gland.

In a collection of parotid gland tumors the presence of different antigens was studied by immuno-histochemical methods. The series was composed of different tumors: adeno- and cystadenocarcinomas, adenoid-cystic carcinomas, salivary duct carcinomas, mucoepidermoid tumors, squamous cell carcinomas and anaplastic carcinomas. The following substances were studied: 1. Substances normally present in salivary glands like lysozyme and lactoferrin. 2. Oncofetal antigens: carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP). 3. Different classes of intermediate-sized filaments: prekeratin and vimentin. The presence of lactoferrin and carcinoembryonic antigen could be demonstrated in the glandular differentiated tumors, whereas the squamous cell carcinomas, although CEA positive, were lactoferrin negative. The anaplastic carcinomas were negative for lactoferrin and CEA. Lysozyme and AFP could not be demonstrated in the tumors of our material. Mucoepidermoid tumors and squamous cell carcinomas were clearly positive for prekeratin filaments whereas the stromal part showed a vimentin filaments in the cytoplasm of fibroblasts. These antigens provide a useful tool to distinguish between the epithelial and mesenchymal tumors.

Antigens, Neoplasm↗
PubMedDate not supplied

Variation of the HL-A antigens during neoplasm evolution.

The study deals with the tissue antigen frequency in a group of 1648 patients with different clinical forms of cancer, hospitalized in the Oncological Institute, Bucharest. The authors do not find a correlation between a tissue antigen predominance and the occurrence or development of a certain form of cancer. Nevertheless a loss of some tissue antigens was noticed in severe advanced cases with multiple metastases. This fact can be observed also in patients irradiated during serotypings or treated with cortisone. At least 5 weeks after irradiation or in patients with favourable response to the treatment, with temporary important remission, the recurrence of the histocompatibility antigens can be obtained in subsequent examinations.

Breast Neoplasms↗
PubMed1991

[Immunohistochemical study of meconial antigens in neoplasms and mucosa of the colon and rectum].

The expression of 4 meconial antigens--beta-1-MA, beta-2-MA, MMA, gamma-MA in neoplastic and preneoplastic colonic mucosa was studied. Meconial antigens were revealed in small amount in adult normal colonic epithelium. The mucosa adjacent to tumours was rich in these antigens. Cellular localization of meconial antigens in these parts of colonic mucosa was similar to that of embryonal alimentary tract. beta-1-MA was found in 96%, beta-2-MA--73.6%, MMA--82.8%, gamma-MA--31.8% of colonic carcinomas.

Antigens↗
PubMed1973

Tumour-associated transplantation antigens of neoplasms induced by a naturally occurring murine sarcoma virus (FBJ-MSV).

FBJ osteosarcoma virus (FBJ-MSV) isolated originally from a spontaneously arising osteosarcoma in a CF1 mouse is the only known naturally occurring murine sarcoma virus (MSV). It is unique among strains of MSV in producing primarily sarcomata in mice. The capacity of tumour cells transformed in vivo by this agent to elicit specific transplantation immunity in syngeneic hosts was investigated. A low level of resistance (10(4)-10(5) cells) was consistently induced by implantation of x-irradiated (15,000 rad) tumours or surgical excision of developing subcutaneous grafts. By contrast intraperitoneal inoculation of virus containing cellfree extracts of FBJ-MSV sarcomata was a far less effective immunization procedure. Confirmatory evidence for the antigenicity of these neoplasms was obtained in tests in which preincubation of tumour cells with lymphoid cells from specifically immune donors inhibited in vivo outgrowth of the FBJ-MSV cells in untreated syngeneic recipients. The induction of host resistance to FBJ-MSV cells by immunization with identical and independently-induced FBJ-MSV tumours established that FBJ-MSV cells possess common cell surface antigenic specificities in a manner analogous to those of experimental neoplasms induced by other oncogenic DNA and RNA viruses. Since FBJ-MSV cells release infectious virus it was not possible in this system to establish whether the tumour-rejection antigen was cellular or virion in nature. The antigenic weakness of FBJ-MSV cells in syngeneic hosts is comparable with that of virus-induced murine leukaemias of the Gross (G) or "wild" type subgroup to which category FBJ-MSV also belongs. These features suggest that FBJ-MSV exemplifies naturally occurring sarcomagenic viruses more closely than those of the Friend-Moloney-Rauscher-Graffi (FMRGr) subgroup which in general induce highly antigenic neoplasms.

Animals↗
PubMed1989

The expression of Lewis antigens in neoplasms of the gastrointestinal tract.

The indirect immunoperoxidase technique has been used to demonstrate Lea and Leb antigens in paraffin sections of both morphologically normal gastric and colonic mucosae and their neoplastic counterparts. Expression differed in various regions of the gastrointestinal tract: Leb occurred most frequently in the stomach and Lea most frequently in the colon. Coexpression of Lea and Leb occurred in only 5% of cases of normal mucosa, in 65% of gastric carcinomas and in 82% of carcinomas of the colon. Furthermore, 75% of cases of intestinal metaplasia in gastric mucosa and 30% of tubular adenomas, 50% of villous adenomas and 70% of tubulovillous adenomas in the colon co-expressed Lea and Leb antigens. In this study, the expression of Lewis antigens in carcinoma was found to differ from that of adjacent normal mucosa in 95% of cases of gastric carcinoma and 100% of cases of colonic carcinoma. The differences were shown by antigen acquisition and/or deletion. Similar changes were shown in 88% of cases of intestinal metaplasia in gastric mucosa, 20% of cases of tubular adenomas and 57% of cases of villous and tubulovillous adenomas of colon.

Adenoma↗
PubMed1985

[Carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen in gastrointestinal neoplasms. Comparison of markers].

CA 19-9, a new antigenic tumor marker for gastrointestinal tumors, has been assayed with Carcinoembriogenic antigen, in 90 healthy patients and 47 patients with gastric cancer (20) and colorectal cancer (27). A good specificity has been found for this antigen (97.7%). Its sensibility seems to be slightly superior to that of CEA. However the sensibility for tumors at Mo stage (38%) is indeed scarcely, on the contrary it clearly elevated for tumors at advanced stage (M1)(76%).

Adult↗