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At least 19 recordsLinked to original sources
PubMed1979

Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration.

Chinese patients with arthralgia during treatment with an antituberculosis regimen containing pyrazinamide were allocated at random to 3 anti-arthralgia treatment series in a controlled double-blind study. One series (18 patients) received soluble aspirin 2.4 g daily, the second (23 patients) allopurinol 200 mg daily, and the third (19 patients) placebo only, for 8 weeks. The response was assessed both by independent assessors and by the patients themselves using a diary card. The serum uric acid concentration was measured before and during anti-arthralgia treatment. The joints most commonly affected were the shoulders, the knees and the fingers, and symptoms and signs were in general neither severe nor protracted. For most of the patients in all 3 series the joint symptoms and signs improved during the 8 weeks, but a higher proportion of patients in the aspirin and placebo series than in the allopurinol series experienced improvement, this being most rapid in the aspirin series. Only in the aspirin series was the mean serum uric acid concentration lower during treatment than before it, and this effect was related to the dose in mg per kg. It is concluded that the arthralgia was often self-limiting, that aspirin had a small beneficial effect, that allopurinol, in the dosage studied, may have had a slightly deleterious effect, but that it would be worth studying larger dosages of allopurinol because the dosage studied did not affect the serum uric acid concentration.

Adolescent↗
PubMed1986

Thermographic diagnosis in athletes with patellofemoral arthralgia.

Pain in front of the knee is common in athletes and is often called patellofemoral arthralgia, but it is difficult to prove that the pain arises in that joint. Thermograms of 30 athletes clinically considered to have patellofemoral arthralgia were compared with those of a similar number of unaffected athletes matched for age and sex. A comparison was also made with thermograms of two older groups of 30 patients with knee involvement from either rheumatoid arthritis or osteoarthritis. Twenty-eight of the athletes with patellofemoral arthralgia had a diagnostic pattern on thermography. The anterior knee view showed a rise in temperature on the medial side of the patella and the medialis knee view showed that this temperature rise radiated from the patellar insertion of the vastus medialis into the muscle itself. The possible aetiological role of quadriceps muscle imbalance in athletes with patellofemoral arthralgia is discussed in relation to these findings.

Adolescent↗
PubMed1991

Intestinal permeability in patients with chronic urticaria-angioedema with and without arthralgia.

We evaluated the clinical response to oligoallergenic dietary treatment and the intestinal absorption of a protein antigen, cow milk beta-lactoglobulin (BLG) in 24 patients with chronic urticaria/angioedema syndrome 13 of whom also suffered from joint symptoms. Sixteen patients (77% of those with arthralgia) responded to diet (RD) with marked reduction of symptoms; the others did not respond (NR). Ten (all but one RD with arthralgia) had increased permeability to BLG after oral administration of cow milk. Four with high titers of IgG to BLG showed the highest absorption of BLG and the groups with arthralgia showed higher BLG levels than those without arthralgia. In all cases, specific IgE to cow milk was absent. These data suggest that the symptoms of a subgroup of patients with chronic urticaria, and especially patients with joint complaints that subside with diet, are related to excess intestinal permeability. The measurement of gut permeability to food proteins may be useful to define those who may benefit from dietary restriction.

Adolescent↗
PubMed1987

Immune complexes in food-induced arthralgia.

Ten patients are described who, in addition to other allergic symptoms, suffered from arthralgia. Dietary exclusion relieved the symptoms and specific food challenge reproduced them. IgG anti-IgE autoantibodies were high in patients with arthralgia in the serum and in the synovial fluid as compared with normals and the majority of patients with rheumatoid arthritis, traumatic arthralgia, and osteoarthritis used as controls. In three food-allergic patients IgG anti-IgE was detectable in a complexed form in the serum samples examined before and after food challenge. The finding of IgG anti-IgE autoantibody in a group of patients with allergic arthralgia is quite exciting. It raises the possibility of distinguishing a subgroup of arthralgic patients not having a classical rheumatoid arthritis, who may have a definable external exacerbating cause for their symptoms. A larger detailed survey is now in progress.

Adult↗
PubMed1977

Hereditary deficiency of the third component of complement in a child with fever, skin rash, and arthralgias: response to transfusion of whole blood.

A previously well 34-month-old male presenting with fever, skin rash, and arthralgias was found to lack C3 by immunochemical (undetectable) and hemolytic (1% normal) assays. No infectious agent could be demonstrated. Protein levels of Clq. C4, C5, properdin, and C3b-INA and hemolytic activities of complement components C1 to C9 except C3 were normal or elevated; total hemolytic complement activity was 13% of normal and was reconstituted by purified C3. Properdin factor B was 702 (normal 175 to 275) mug/ml, and was not cleaver upon addition of zymosan or cobra venom factor. The serum had normal immune adherence activity, but was deficient in ability to opsonize Candida albicans for uptake and Escherichia coli for killing by neurophils, generate neutrophil chemotactic factors and inhibit the growth of E. coli; these activities were restored by purified C3. A transfusion of 320 ml 1-hour-old normal whole blood on the fifty-second day resulted in transitory elevation of the C3 level to 25 mg/dl with a fall-off (approximately 2 1/2% per hour) to undetectable levels by 69 hours; it was followed by disappearance of the skin rash and arthralgias and return to normal of the previously elevated temperature and CRP levels. C3 levels in family members (seven of 24 half-normal), lack of anti-C3 activity, normal C3b-INA levels and a normal rate of catabolism of transfused C3 indicated that the deficiency was inherited with autosomal codominance and involved decreased synthesis of C3. Thus, this child is a unique individual with inherited C3 deficiency presenting with absence of repeated infections, whose symptoms of fever, skin rash, and arthralgia were abated by whole blood transfusion.

Blood Transfusion↗
PubMed1976

Acne arthralgia.

A syndrome of arthralgia associated with one form of acne is described. Orthopaedic surgeons should be alert to the association of profound arthralgia and myalgia with this particular variant of acne vulgaris. Thirteen patients are described, all of whom are adolescent boys with a chronic moderately active acne which suddenly became extremely aggressive and toxic. The symptoms and signs included proximal arthralgia and myalgia, fever, elevated sedimentation rate, and altered immunoglobulins. Control of acne and conservative physical therapy resulted in complete resolution of the musculoskeletal complaints.

Acne Vulgaris↗
PubMed1989

[Whipple's disease: abdominal lymphoma, intermittent fever and recurrent arthralgias].

A diagnostic laparotomy was performed on a 41-year old woman who, having suffered from recurrent arthralgias for several years and intermittent fever for many months, was found to have extensive enlargement of abdominal lymph-nodes, raising the suspicion of malignant lymphoma. Frozen-tissue biopsy was highly suspicious of Hodgkin's lymphoma, but light- and electron-microscopy revealed Whipple's disease, confirmed in an endoscopically obtained duodenal mucosal biopsy. The arthralgia quickly responded to antibiotic treatment. This case demonstrates the potential difficulties and errors in the diagnosis of Whipple's disease.

Abdominal Neoplasms↗
PubMed1991

Linear IgA dermatosis with severe arthralgia.

Linear IgA dermatosis with severe arthralgia is a rare clinical syndrome. Streptococcal infection may be important in its pathogenesis. The rash and arthralgia respond to dapsone although additional treatment with non-steroidal anti-inflammatory drugs and/or corticosteroids may be necessary. A case is presented which illustrates these features.

Adult↗
PubMed1978

Arthralgias and arthritis in viral infections.

Arthritis and arthralgias are common in many viral infections. They are particularly prominent with hepatitis B virus and rubella infection, where they may be the major presenting symptom. "Lyme arthritis" is also associated with a virus. Similar symptoms are occasionally seen with adenovirus, Coxsackie and echovirus infection. Joint lesions are due to the deposition of immune complexes and not direct viral infection. While the arthritis is usually transient and self-limited, the physician must consider viral infections as etiologic agents of arthralgias and arthritis.

Adult↗
PubMed1990

Comparative diagnosis of specific temporomandibular joint arthralgias by means of computerised tomography.

In general, it is not easy to make the correct clinical diagnosis of a specific internal derangement of the arthralgias. The ten types of internal derangements, with desynchronisation between the meniscus and the condyle, may present clinically with localised sounds, such as clicking, grating and grinding, or without any sounds. Computerised tomography is one of the few non-invasive aids used for obtaining a more accurate diagnosis of arthralgia or anatopathological problems of the joint. The sagittal and coronal alignment of the skull and joint in the gantry, the specific highlighting of the meniscus and use of different types of occlusal splints, are all necessary for the accurate diagnosis of an internal derangement. The examination of 118 such joints is presented in this paper.

Humans↗
PubMed1985

[Arthralgia and neurologic deficit. A differential diagnostic review].

The diagnostic classification of arthralgia and non-characteristic neurological deficit is a challenge for the neurologist and the internist if both symptoms arise simultaneously or in combination. Diseases with the combined appearance of both symptoms are grouped into those with early and more or less simultaneous onset, those starting with arthralgias followed by neurological deficits, neurogenic arthropathies, and those presenting both symptoms as complications of ongoing internal disease. A diagnostic procedure is set out and recommended.

Arthritis↗
PubMed1989

Relation between the therapeutic effect of moxibustion in treating arthralgia and SP and enkephalin in nervous tissues.

Moxibustion can accelerate the relief of arthralgia of rats suffering from adjuvant arthritis. At the same time, it promotes the recovery of SP in the sciatic nerve, and maintains SP and leu-enkephalin at a higher level in the lumbar spinal cord. The results show that the therapeutic effect of moxibustion in treating arthralgia bears some relation to activating the spinal enkephalin system and modulating the function of primary afferent neurons.

Animals↗
PubMed1989

Pregnancy associated RPGN (rapidly progressive glomerulonephritis) with repeated attacks of purpura and arthralgia.

A 35-year-old woman at 28 weeks' gestation presented with purpura, arthralgia and proteinuria. After a skin biopsy had suggested necrotizing vasculitis, prednisolone was administered. Renal biopsy following delivery disclosed crescents in about 60% of glomeruli. After stopping prednisolone, purpuric lesions and arthralgia reappeared. A second renal biopsy demonstrated cellular crescents in about 80% of glomeruli. The symptoms disappeared on restarting prednisolone. However, the patient progressed to renal failure in 8 months. Histological examinations of the kidney and skin suggested microscopic PN.

Adult↗
PubMed1987

[Essential cryoglobulinemia with glomerulonephritis as a variant of the purpura-arthralgia-nephritis syndrome].

The syndrome of mixed cryoglobulinemia is clinically characterized by the findings of purpura, arthralgia and glomerulonephritis, the latter developing in up to 50% of the cases. The cryoglobulins have rheumatoid factor activity and serum levels of complement factor C4 are significantly reduced. A report is presented on seven patients with a typical purpura-arthralgia-nephritis syndrome and two patients with essential cryoglobulinemia, rheumatoid factor activity and glomerulonephritis without extrarenal manifestations of vasculitis. Based on these observations, measurement of rheumatoid factor activity is recommended in serum of patients with unclassified glomerulonephritis.

Complement C3↗
PubMed1988

Linear IgA dermatosis with severe arthralgia.

Two patients aged 8 and 34 years, with linear IgA dermatosis and systemic symptoms are described. Both presented with fever and sore throat 5 to 10 days before the onset of their rash and both developed severe arthralgia accompanying the skin eruption. The joint pains resolved when the skin eruption was treated.

Adult↗
PubMed1992

Recurrent cutaneous erythralgia and arthralgia.

Two cases are reported of Vietnamese men who presented in young adult life with recurrent, painful, erythematous patches (which we have termed "erythralgia") over and adjacent to joints and accompanied by marked constitutional symptoms of malaise and lethargy, arthralgia and in one patient, fever. In the other, from the onset of the disease there were nodules over the bony prominences and in the interphalangeal regions of the fingers. The duration of the disease was over 12 years, the duration of each episode without therapy was one week and the interval between episodes was one to two weeks. In addition the patients showed a raised ESR and peripheral neutrophil leucocytosis of over 70%. There was a rapid response, within hours, to non-steroidal anti-inflammatory agents. Skin biopsies taken at varying stages of the disease episode failed to demonstrate neutrophils thereby failing to satisfy one major criterion of Sweet's Syndrome. Direct immunofluorescence studies were negative. Biopsy of the nodules did not show rheumatoid pathology. The serum rheumatoid factor was negative. Investigations failed to demonstrate any recognised pattern of cutaneous or rheumatologic disease; infections such as borreliosis were excluded. Both patients showed evidence of past hepatitis B infection. As recurrent painful cutaneous erythema is an uncommon phenomenon in dermatology except where the patient is suffering from recurrent cellulitis of the lower limbs, the patients reported here exhibit a pattern of disease not previously described.

Adult↗
PubMed1985

Defective leukocyte interferon response in children with recurrent infections accompanied by arthralgia.

Children with recurrent and/or unusually severe infections were investigated for possible defects in the interferon (IFN)-natural killer (NK) cell system. Two series, each of 13 children, were examined, one in 1982 and one in 1983. Healthy children, seven in 1982 and eight in 1983, served as controls. Peripheral blood mononuclear leukocytes were examined for IFN production induced by the IFN-alpha inducers Sendai virus and Escherichia coli and by the IFN-gamma inducers Concanavalin A and Lens culinaris lectin. None of these inducers discriminated patients from controls. However, the bacteria Staphylococcus aureus Cowan I (SACol), inducers of atypical IFN in null lymphocytes, yielded significantly lower IFN production in infection-prone children than in controls, particularly in children with recurrent infections accompanied by arthralgia. No differences in basal NK activity or in the in vitro enhancement of such activity by IFN-alpha were found between patients and controls.

Bacterial Infections↗