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At least 19 recordsLinked to original sources
PubMed2006

Intracytoplasmic sperm injection by testicular sperm in patients with aspermia or azoospermia after cancer treatment.

The aim of this retrospective study was to evaluate the efficiency of testicular biopsy and intracytoplasmic sperm injection (ICSI) in patients with aspermia or non-obstructive azoospermia (NOA) after cancer treatment. From 1996 to 2003, 30 men with a history of cancer, affected by aspermia or NOA and without sperm cryopreserved before cytotoxic treatment underwent testicular sperm extraction (TESE). In these men, clinical, hormonal and histological characteristics were compared; 13 underwent 39 TESE-ICSI cycles using frozen-thawed testicular spermatozoa (TESE-ICSI group). In the same period, 31 ICSI cycles were performed in 20 men with aspermia or NOA using ejaculated sperm frozen before cancer treatment (ejaculated sperm-ICSI group). Fertilization, blastocyst development, pregnancy and miscarriage rates were compared between the groups. Testicular volume, serum follicle-stimulating hormone level and Johnsen score indicated complete although reduced spermatogenesis in men with aspermia and abnormal spermatogenesis in men with NOA. After TESE, sperm retrieval was positive in 92% of men with aspermia and 58% of men with NOA. In TESE-ICSI patients with NOA a significantly lower proportion of embryos developed to the blastocyst stage than in patients with aspermia and in those after ICSI with frozen-thawed ejaculated sperm (23% vs. 43% and 47%, p = 0.03 and p < 0.01 respectively). In all groups the miscarriage rates were high; in patients with aspermia and NOA, characterized by increased age, the miscarriage rate tended to be higher in spite of similar female age and female indications of infertility. In patients affected by aspermia or NOA after cancer treatment and without sperm cryopreserved before treatment, TESE-ICSI using testicular sperm provide a chance to father a child.

Cell Separation↗
PubMedDate not supplied

[The clinico-morphological aspects of aspermia].

The clinico-morphologic, clinico-endocrinologic, and morpho-endocrinologic parallels were studied in 126 males with aspermia who underwent genitography and biopsy of the testes. On the basis of the findings, the structure of male sterility in aspermia was exactly identified and the differential diagnostic value of certain values was established; a correlation between the blood follitropine content and the degree of spermatogenesis inhibition in testicular aspermia was revealed in particular. Testosterone excreted in the urine and circulating in blood plasma is reduced by more than three times in this case, while the plasma estradiol level increases 1.5 times. Obturation aspermia accounts for 12.7% and testicular aspermia for 87.3% of all cases of aspermia. Further search for clinico-laboratory and laboratory differential diagnostic criteria in aspermia is necessary. The modern methods of treatment are ineffective.

Adult↗
PubMed2002

[Sexual hormone and sperm cytological test in patients with aspermia].

OBJECTIVES: To test the serum sexual hormone and sperm cytology in aspermia patients. METHODS: Radioimmunoassay (RIA) and Wright-Giemsa stain were used to detect serum sexual hormone and sperm cytology in 45 aspermia patients. RESULTS: Among the 45 patients, spermatogenetic cells were detected in 16 patients(35.6%). The level of serum testerone were decreased in 16 patients, and FSH, LH were increased in 13 cases as well as that of PRL in 4 cases. CONCLUSIONS: These results suggested that the testis function was demaged, the ratio of T/LH could further reflect the function of Leydig cells, the detection of PRL were significant only in diagnosis of aspermia induced by hypermia. It is an important index in identifying obstructive and non-obstructive aspermia and has important significance in estimating the extention of testis demage and commanding the clinical treatment of serum hormone detection and sperm cell analysis.

Gonadal Steroid Hormones↗
PubMed2003

[A study of aspermia-related genes by genchips and analysis of the RAP1A gene].

OBJECTIVE: To study the differential gene expression profiles between the normal and aspermia human testes by genechips. METHODS: Probes were prepared from mRNA extracted from both normal and aspermia testes and employed on Biostar H-40s genechips to detect the differential gene expression profiles. A distinctly up-regulated gene RAP1A was analyzed by bibliogrphic retrieval. RESULTS: Six hundred and twenty-three differential expressed genes were found, among which the distinctly up-regulated gene RAP1A was closely related to human sperm regulation. CONCLUSIONS: Screening the differential gene expression profiles between the normal and aspermia human testes by genechips can be used in the study of aspermia-related genes.

Adult↗
PubMed1982

Recovery from aspermia induced by low-dose radiation in seminoma patients.

Gonadal dosimetry and spermatogenic activity was monitored in patients given radiation therapy (RT) after unilateral orchiectomy for seminoma. The RT given was, with minor variations, 3200 rad in 16 fractions in four weeks to the para-aortic and ipsilateral pelvic inguinal lymphatics in order to include the orchiectomy scar. The incidental amount of radiation to the remaining testicle averaged 78.4 +/- 7.4 rad and ranged from 32-178 rad as determined by thermoluminescent dosimetry. Induction of aspermia was documented in ten out of 14 patients who received over 65 rad to the gonad. At lower doses, aspermia may not have occurred or was of short duration. Recovery of sperm in the semen occurred in 12 patients within 30-80 weeks after start of treatment. The data suggest that the time of recovery may be dose dependent within the range of 19-148 rad. During the period of recovery, patients with oligospermic semen may be fertile and should be so advised.

Adult↗
PubMed1991

Clinical approach for evaluating dogs with azoospermia or aspermia.

There are various causes for azoospermia and aspermia in dogs. Unfortunately, even when the site and cause of infertility are determined, reversing the disorder may be difficult. As new information are gathered on the maturation of canine spermatozoa, testicular immunity, microsurgical techniques for anastomosing occluded ducts, and the physiologic control of testicular and ejaculatory function, however, new therapies might be developed to prevent or reverse azoospermia and aspermia.

Animals↗
PubMed2002

Aspermia and chronic testicular pain after imperforate anus correction. Cryopreservation of sperm cells extracted from whole orchiectomized testis: case report.

This paper describes an unusual association of aspermia and untreatable, chronic testicular pain in a young man who underwent 14 surgical interventions for an imperforate anus. Physical examination and ultrasonography revealed left epididymal and vas enlargement, normal-sized testes, tubular ectasia of the left rete testis and a small intraprostatic paramedian left cyst. Retrograde ejaculation and urogenital infections were excluded, and the FSH and karyotype results were normal. The patient gave his consent to an exploratory intervention with possible radical left orchiectomy. The patency of the left distal seminal duct was unexpectedly normal, and no sperm were found in the epididymis or vas deferens despite their obstructive appearance. Sperm were only found in a 'testicular touch' preparation. The removed testis was immediately opened and most of the testicular lobules were removed, thus allowing the extraction of 25 x 10(6) sperm, which were cryopreserved in 35 straws. An 8-month follow-up examination documented the complete absence of pain and, during the next few months, it is planned to use the thawed sperm for ICSI. Radical orchiectomy plus the cryopreservation of sperm extracted from the whole testis must be considered in the case of the co-existence of chronic unilateral testicular pain and aspermia.

Adult↗
PubMed1992

An aspermia rat mutant (as/as) with spermatogenic failure at meiosis.

A newly identified aspermia rat mutant was investigated on testicular histology and mode of inheritance of the defect. Average testis weight of mutants was about one-third of that of phenotypically normal males. Spermatogenesis was interrupted at meiosis. Pachytene spermatocytes significantly decreased in number. Secondary spermatocytes and few round spermatids were seen, but no elongated spermatids and sperms were observed. A large basophilic inclusion-like body existed in the cytoplasm of late pachytene spermatocytes. Genetic analysis revealed an autosomal recessive transmission of the defect. Aspermia (As) was designated for the locus.

Animals↗
PubMed2004

Fine mapping of a region of rat chromosome 12 close to the aspermia (as) locus and comparison with the human orthologous regions.

The aspermia mutation of the rat exhibits male sterility caused by arrest of spermatogenesis, which is controlled by an autosomal single recessive gene (as). The as locus has been mapped on rat chromosome 12. We recently identified a causative mutation for the aspermia phenotype of the as homozygous rats in the gene encoding Fkbp6, a member of the immunophilins FK506 binding proteins. In this paper, we report the fine mapping of the as locus by linkage analysis combined with comparative mapping using rat, mouse, and human genomic sequences and expression analysis of genes located in the as region. We constructed a fine linkage map of the region of rat chromosome 12 close to the as locus by using 13 microsatellite markers and localized the as locus to a 1.0-cM interval. Comparison of the linkage map with physical maps of rat, mouse, and human refined the as critical region in a 2.2-Mb segment of the rat physical map between the D12Nas3 and D12Nas8 genes, which includes the Fkbp6 gene. A centromeric part of this segment corresponds to the region commonly deleted in Williams syndrome, a human complex developmental disorder, on human chromosome 7q11.23. The expression analysis of 23 genes located on the 2.2-Mb segments in various mouse tissues identified genes exclusively or strongly expressed in the testis.

Animals↗
PubMedDate not supplied

[Transient obstructive aspermia and transient obstructive oligospermia].

The article is a continuation of a series of papers dealing with changes of ejaculatory ducts associated with various diseases of the prostatic gland and posterior urethra. Clinical description of patients, earlier treated for aspermia or oligospermia is presented. In some of the patients with such clinical manifestations, complete or partial compression of the ejaculatory ducts by the inflamed prostate or seminal bulb may be the cause and the disorder may be transitory rather than continuous. Twenty-six cases of transitory aspermia are reported, with special reference to laboratory and instrumental findings and treatment results. A group of patients (43) with transitory oligospermia is also described, and the results of investigation and treatment are presented.

Adult↗
PubMed1983

[Transport aspermia following retroperitoneal lymphadenectomy and its treatment].

After retroperitoneal lymphadenectomy disturbances of ejaculation (retrograde ejaculation, transport aspermia) are typical postoperative complications. An own case with transport aspermia is reported, in whom a retrograde ejaculation could be induced after intravenous application of the alpha-sympathomimetic drug midodrin. After masturbation the semen was collected from the bladder and the spermatozoa were inseminated. Immediately after the first instrumental insemination a pregnancy was obtained.

Humans↗
PubMed1977

Yq deletion, aspermia, and short stature.

A large Yq deletion involving both the fluorescent and part of the non-fluorescent segment in a 36-year-old phenotypic normal male is presented. His short stature and aspermia gives strong support, after a complete review of the literature, to the existence of factors involved in the control of both characteristics in the non-fluorescent segment of the long arm of chromosome Y, distally within band 11.

Adult↗
PubMed1979

Imipramine for aspermia after lymphadenectomy.

During radical retroperitoneal lymphadenectomy the hypogastric sympathetic plexus is necessarily partially sacrificed, with resultant failure of part of the ejaculatory mechanism and aspermia. We have observed this condition to be reversible with imipramine.

Adult↗
PubMed1993

Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes.

The morphology of the testis of the mutant As (aspermia) strain rat with severely interrupted spermatogenesis was investigated in the present study. The most advanced development in spermatogenesis was observed at the step 8 at which spermatids had basally-oriented acrosomes. Multinucleate giant cells derived from round spermatids were frequently encountered within the seminiferous tubules. The functionally normal status of the blood-testis barrier between adjacent Sertoli cells was confirmed by morphological and lanthanum tracer studies. By light microscopy, a peculiar structure was found within the pachytene spermatocyte, consisting of numerous particles of approximately 25 nm in diameter. By histochemical and electron microscopic studies, this structure was identified as an aggregate of ribosomes. Neither immature spermatogenic cells up to the pachytene phase, nor Sertoli cells nor interstitial regions showed a recognizable abnormality. It seems that the testicular disruption in the As mutant rat is due to the abnormality in the protein synthetic pathway in pachytene spermatocytes.

Animals↗
PubMed1993

Age-related changes in blood concentrations of FSH, LH and testosterone and testicular morphology in a new rat sterile mutant with hereditary aspermia.

A new rat mutant showing aspermia was investigated. Groups of 4-7 mutant male rats were killed at 3, 5, 10, 15 and 25 weeks of age. Examination by microscope showed apparent abnormalities in the seminiferous epithelium from 3 weeks of age onward. Inclusion-like bodies were observed in the cytoplasm of pachytene spermatocytes from 3 weeks old and instead of spermiation, polynuclear giant cells were formed within the seminiferous epithelium after 5 weeks of age. Histological analysis of seminiferous epithelium of adult mutant rats also showed a marked decrease in the number of preleptotene, leptotene and pachytene spermatocytes and tubules containing only spermatogonia and Sertoli cells in the seminiferous epithelium increased with age. However, the combination of other cellular elements of germ cells in the seminiferous epithelium was similar to that in normal rats and the distribution rate of these seminiferous tubules was close to that of normal rats, indicating that cyclicity of seminiferous epithelium was still maintained in the mutant rats despite the lack of spermiation. Plasma concentrations of FSH and LH were significantly higher in the mutant male rats than in normal male rats at 5 and 10 weeks of age onward, respectively. Plasma concentrations of testosterone were lower in the mutant male rats than in normal male rats. Silastic capsules containing testosterone were implanted into the unilateral testis of adult mutant male rats and animals were autopsied 5 weeks later. However, intratesticular administration of testosterone did not affect restoration of spermatogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1990

[The diagnostic criteria of aspermia].

A study is presented of the clinical, endocrinological, morphological indices in 126 patients with sterility. In testicular aspermia the androgenic-estrogenic balance reduced in all kind sterility independent of the clinical signs of hypoandrogenization and degree of disorder of spermatogenesis. A correlative dependence was revealed between the level of follitropin in the blood plasma and degree of inhibition of spermatogenesis in secretory sterility.

Adult↗
PubMed1979

[Obstructive aspermia. successful treatment by transurethral resection of the verumontanum. A case report (author's transl)].

After a barren marriage for 2 1/2 years the 22 years old male patient presented for consultation. The examinations confirmed obstructive aspermia with acceptable spermatogenesis. The site of obstruction involved the colliculus seminalis. Transurethral resection of the colliculus was performed. Following a protracted postoperative andrological treatment pregnancy ensued with uncomplicated delivery.

Adult↗