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Body composition, body fat distribution, and resting metabolic rate in healthy centenarians.

Our study investigated body composition and body fat distribution in healthy centenarians. Body composition, body fat distribution, and resting metabolic rate (RMR) were studied in 40 adult subjects aged < 50 y, 35 aged subjects > 75 y, and 15 healthy centenarians aged > 100 y. Body composition was determined by bioimpedance analysis, body fat distribution was calculated as waist-hip ratio (WHR), and RMR was calculated by using the Arciero-Poehlman formula. Healthy centenarians had a cognitive impairment and degree of disability greater than aged subjects. Despite such differences, fat-free mass (FFM) and RMR were not different in centenarians compared with aged subjects but were lower than in adult subjects. In contrast, healthy centenarians had a WHR lower than that of aged subjects but not different from that of the adult subjects. After the level of physical activity and degree of disability were adjusted for, FFM (44 +/- 2.7 and 40 +/- 1.1 kg; P < 0.05) and RMR (6757 +/- 761 and 5891 +/- 723 kJ/24 h; P < 0.05) were significantly higher in healthy centenarians than in aged subjects, respectively. Independent of age, sex, body weight, degree of disability, level of physical activity, and fasting plasma triiodothyronine, there was a strong correlation between RMR and FFM (r = 0.50, P < 0.05) in healthy centenarians. In conclusion, healthy centenarians had a lower FFM and higher body fat content than aged subjects. Level of physical activity and degree of disability seem to be the major determinants for explaining such differences.

Adipose Tissue↗

Measurement issues related to studies of childhood obesity: assessment of body composition, body fat distribution, physical activity, and food intake.

This article reviews the current status of various methodologies used in obesity and nutrition research in children, with particular emphasis on identifying priorities for research needs. The focus of the article is 1) to review methodologic aspects involved with measurement of body composition, body-fat distribution, energy expenditure and substrate use, physical activity, and food intake in children; and 2) to present an inventory of research priorities.

Absorptiometry, Photon↗

Body composition, body size estimation, and attitudes towards eating in male college athletes.

A number of different parameters relating to eating history and body composition were examined in male college athletes during the course of an athletic season. Wrestlers, who often lose weight to meet the requirements of the sport, were compared with other athletes (swimmers, nordic skiers) who typically maintain weight during vigorous training. By the end of the athletic season, the wrestlers had reduced body weights and reported a reduction in caloric intakes. Wrestlers scored higher than swimmers and nordic skiers on scales measuring dietary restraint and attitudes towards eating (EAT). The groups differed primarily on items dealing with fluctuations in body weight and with dieting behaviors. There were no significant differences between groups on the estimates of body size and no effect of seasonal training. However, a small subsample of the wrestlers who scored high on the restraint and EAT scales also showed distortions in estimates of body size. Wrestlers may represent a population at risk for the newly reported sports-induced disturbances in eating.

Adolescent↗

Puberty and body composition.

Body composition during puberty is a marker of metabolic changes that occur during this period of growth and maturation, and, thus, holds key information regarding current and future health. During puberty, the main components of body composition (total body fat, lean body mass, bone mineral content) all increase, but considerable sexual dimorphism exists. Methods for measuring body composition (e.g. densitometry and dual-energy X-ray absorptiometry) and degree of maturity will be discussed in this review. Components of body composition show age-to-age correlations (i.e. 'tracking'), especially from adolescence onwards. Furthermore, adipose tissue is endocrinologically active and is centrally involved in the interaction between adipocytokines, insulin and sex-steroid hormones, and thus influences cardiovascular and metabolic disease processes. In conclusion, pubertal body composition is important, not only for the assessment of contemporaneous nutritional status, but also for being linked directly to the possible onset of chronic disease later in life and is, therefore, useful for disease risk assessment and intervention early in life.

Adolescent↗

Genetic aspects of body composition.

Body composition is reviewed as a composite of several traits each with their distinctive genetic basis, including major effects of genes at single loci. Studies involving twins, adopted offspring, and other family relatives have demonstrated the high heritability (0.4-0.7) of many of the traits involved. Genotype-environment interactions with diet and activity occur in domesticated animals and humans and associations with voluntary choice of diet and level of activity are unfavorable. Body composition is the main reference for a normal homeostatic mechanism involving appetite and energy expenditure control. Identification of major genes controlling products, such as leptin, indicate mechanisms for this control and its manifestations in leanness and obesity. The plasticity of certain aspects of body composition can be exploited by livestock breeders, although the side effects are unpredictable. They also promise the possibility of gene therapy in these hitherto intractable conditions. Novel major genes that are being rapidly uncovered in many species may enable future deployment of gene therapy. The control of body composition is likely to remain a challenge because of the unfavorable genetic correlations and the failure of ordinary, fallible humans to thwart the complex genetically programmed destiny they have inherited.

Adoption↗

Symposium on nutritional requirements of the surgical patient. 1. Nutrition and body composition.

Body composition measurements were determined by a multiple isotope dilution technique to assess nutritional status of patients and to determine the efficacy of nutritional support. The body composition of 75 patients with severe malnutrition was characterized by a contracted body cell mass with a relatively expanded extracellular mass. An elective operation of moderate severity resulted in a 14% decrease in the body cell mass while the extracellular mass increased by 10%. The 4% postoperative decrease in body weight did not accurately reflect the change in the body cell mass. The efficacy of total parenteral nutrition (TPN) with lipid as the major caloric source was compared with TPN with hypertonic dextrose. With lipid a daily infusion of 44.2 Cal/kg (185 kJ/kg) was required to maintain the body cell mass while with the solution containing hypertonic dextrose 34.7 Cal/kg (155 kJ/kg) was required--a 27% difference. Total parenteral nutrition with hypertonic dextrose is therefore more efficacious than TPN with lipid as the major caloric source.

Amino Acids↗

Nutritional consequences of total gastrectomy: the relationship between mode of reconstruction, postprandial symptoms, and body composition.

Body composition, postprandial symptoms, and social performance were assessed in 41 patients who were free of tumors 16 to 63 months (median, 41 months) after total gastrectomy with Roux-en-Y esophagojejunostomy (n = 15) or jejunal interposition (n = 26). There were no significant differences with respect to age, sex, initial tumor stage, interval since operation, and premorbid weight/height2 (body mass index). The lowest postoperative body mass index (BMI) was 72% +/- 3% of the preillness BMI in patients with Roux-en-Y reconstruction and 79% +/- 2% in patients with jejunal interposition (p less than 0.05). At the time of the study the relative BMI was 88% +/- 2% of the preillness BMI in patients with jejunal interposition but only 81% +/- 3% in patients with the Roux-en-Y reconstruction (p less than 0.01). Muscle mass and lean body mass estimated from anthropometric and bioelectric impedance measurements were correlated with sex (p = 0.0001) and with the mode of reconstruction (p = 0.02) independently, which was confirmed by multiple linear regression. The postprandial symptoms were not significantly associated with changes in body composition except for an inverse relationship between Sigstad's dumping score and the extracellular mass/body cell mass ratio (r = 0.553; p = 0.0002). Of the patients under 60 years of age, 10 of 15 patients with jejunal interposition and two of eight patients with Roux-en-Y reconstruction were back at work (p = 0.057). The persons who had resumed their work had a significantly higher relative BMI (90% +/- 2% vs 82% +/- 3%), lean body mass (53 +/- 3 kg vs 46 +/- 3 kg), and muscle mass (25 +/- 2 kg vs 21 +/- 1 kg) than persons in early retirement. We concluded that preserving the duodenal transit should be a main objective of gastric replacement after total gastrectomy.

Anastomosis, Roux-en-Y↗

Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance.

OBJECTIVE: To determine whether diet and endurance exercise improved adiposity-related measurements in Japanese Americans with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS: This study compared the effects of an American Heart Association (AHA) step 2 diet (<30% of total calories as fat, <7% saturated fat, 55% carbohydrate, and < 200 mg cholesterol daily) plus endurance exercise for 1 h three times a week (treatment group) with an AHA step 1 diet (30% of total calories as fat, 10% saturated fat, 50% carbohydrate, and <300 mg cholesterol) plus stretching exercise three times a week (control group) on BMI, body composition (% fat), and body fat distribution at 6 and 24 months of follow-up in 64 Japanese American men and women with IGT, 58 of whom completed the study. RESULTS: At 6 months, the treatment group showed significantly greater reduction in percent, body fat (-1.4 +/- 0.4 vs. -0.3 +/- 0.3%); BMI (-1.1 +/- 0.2 vs. -0.4 +/- 0.1 kg/m(2)); subcutaneous fat by computed tomography at the abdomen (-29.3 +/- 4.2 vs. -5.7 +/- 5.9 cm(2)), thigh (-13.2 +/- 3.6 vs. -3.6 +/- 3.0 cm(2)), and thorax (-19.6 +/- 3.6 vs. -8.9 +/- 2.6 cm(2)); and skinfold thickness at the bicep (-2.0 +/- 0.6 vs. 1.1 +/- 0.6 mm) and tricep (-3.7 +/- 0.8 vs. -0.9 +/- 0.6 mm), which continued despite moving to home-based exercise for the last 18 months. CONCLUSIONS: Diet and endurance exercise improved BMI, body composition, and body fat distribution and, thus, may delay or prevent type 2 diabetes in Japanese Americans with IGT.

Asian↗

Limits of body mass index to detect obesity and predict body composition.

Body mass index (BMI) is commonly used to identify obesity. In this study, we determined how accurately BMI could determine body composition and identify obese from non-obese individuals. Fat-free mass and body fat were determined with bioelectrical impedance. Adiposity was calculated as body fat per body mass and as body fat divided by body height (m2). Obesity was defined as a BMI of at least 30 kg/m2 or an amount of body fat of at least 25% of total body mass for men and at least 30% for women. Obesity as defined by percentage of body fat was always present with a BMI of at least 30 kg/m2. However, 30% of men and 46% of women with a BMI below 30 kg/m2 had obesity levels of body fat. The greatest variability in the prediction of percentage of body fat and body fat divided by height (m2) from regression equations using BMI was at a BMI below 30 kg/m2. In conclusion, using impedance-derived body-fat mass as the criterion, people with BMI of at least 30 kg/m2 are obese. However, significant numbers of people with a BMI below 30 kg/m2 are also obese and thus misclassified by BMI. Percent of body fat and body fat divided by height (m2) are predictable from BMI, but the accuracy of the prediction is lowest when the BMI is below 30 kg/m2. Therefore, measurement of body fat is a more appropriate way to assess obesity in people with a BMI below 30 kg/m2.

Adipose Tissue↗

Anthropometry, body composition and body image in dieting and non-dieting 8-16-year-old Swedish girls.

Anthropometry, body composition and body image were studied in 122 Swedish 8-16-y-old girls and their parents. The subjects participated in a 3-y prospective longitudinal study and were selected randomly after stratification for grades from those scoring in the upper vs. the lower thirds of the Children's Eating Attitudes Test (ChEAT) score distribution. The ChEAT was completed 6 mo before the present study together with a demographic and dieting questionnaire and a questionnaire for the estimation of body size. In total 43% (n = 52) admitted ever dieting ("Dieters") and 25% (n = 30) admitted that they were currently trying to lose weight. The anthropometric and body composition data indicated that ChEAT High-scorers and Dieters were somewhat fatter than Low-scorers and Non-dieters, although this pattern was not shown among the 8-y-olds or the 14-y-olds (High-scorers). The mothers of the ChEAT High-scorers were found to be somewhat fatter than the other mothers. A current vs. ideal body shape discrepancy was shown for both High-scorers and Dieters, with a larger discrepancy for the Dieters. All groups believed that their parents were aspiring for a leaner body.

Adolescent↗

Does body mass index adequately capture the relation of body composition and body size to health outcomes?

Body mass index (BMI) has become the most commonly used index of body composition in epidemiologic research. It has displaced weight, height, and other measures of body composition. In this paper, the authors show that use of BMI alone does not always capture adequately the joint relation of body composition and body size to health outcomes, and that such use often represents implausible restrictions on the relation. Use of body mass index and height or weight and height will often be needed to describe this relation and to control confounding by these variables.

Adipose Tissue↗

Body composition, not body weight, is related to cardiovascular disease risk factors and sex hormone levels in men.

To clarify the independent relationships of obesity and overweight to cardiovascular disease risk factors and sex steroid levels, three age-matched groups of men were studied: (i) 8 normal weight men, less than 15% body fat, by hydrostatic weighing; (ii) 16 overweight, obese men, greater than 25% body fat and 135-160% of ideal body weight (IBW); and (iii) 8 overweight, lean men, 135-160% IBW, but less than 15% fat. Diastolic blood pressure was significantly greater for the obese (mean +/- SEM, 82 +/- 2 mmHg) than the normal (71 +/- 2) and overweight lean (72 +/- 2) groups, as were low density lipoprotein levels (131 +/- 9 vs. 98 + 11 and 98 + 14 mg/dl), the ratio of high density lipoprotein to total cholesterol (0.207 +/- 0.01 vs. 0.308 +/- 0.03 and 0.302 +/- 0.03), fasting plasma insulin (22 +/- 3 vs. 12 +/- 1 and 13 +/- 2 microU/ml), and the estradiol/testosterone ratio (0.076 +/- 0.01 vs. 0.042 +/- 0.02 and 0.052 +/- 0.02); P less than 0.05. Estradiol was 25% greater for the overweight lean group (40 +/- 5 pg/ml) than the obese (30 +/- 3 pg/ml) and normal groups (29 +/- 2 pg/ml), P = 0.08, whereas total testosterone was significantly lower in the obese (499 +/- 33 ng/dl) compared with the normal and overweight, lean groups (759 +/- 98 and 797 +/- 82 ng/dl). Estradiol was uncorrelated with risk factors and the estradiol/testosterone ratio appeared to be a function of the reduced testosterone levels in obesity, not independently correlated with lipid levels after adjustment for body fat content. Furthermore, no risk factors were significantly different between the normal and overweight lean groups. We conclude that (a) body composition, rather than body weight per se, is associated with increased cardiovascular disease risk factors; and (b) sex steroid alterations are related to body composition and are not an independent cardiovascular disease risk factor.

Adult↗

Ultrasound as an approach to assessing body composition.

Body composition is an important indicator of nutritional status. The most commonly used indirect method for estimating body fat is based on measurements of subcutaneous fat tissue. It has been suggested that ultrasonic measurements may be more precise than those of the caliper and therefore may yield more accurate measures of subcutaneous fat tissue. This study was designed to correlate ultrasonic and caliper measurements of subcutaneous fat with body density determined by hydrostatic weighing. Subcutaneous fat thickness was measured at seven body sites (triceps, biceps, subscapula, waist, suprailiac, thigh, and calf) with a Lange skinfold caliper and an ADR ultrasonic scanner, equipped with a display-screen, 7MHz transducer, and electronic calipers. Regression equations to predict body density, and hence body fat, were derived for each technique using a minimal number of body sites. The sample consisted of 124 white men, aged 18 to 30 yr. Mean body density determined by hydrostatic weighing was 1.07 g/ml (SD +/- 0.01) and mean body fat was 12.7% (SD +/- 5.8). Both ultrasonic and caliper measurements of waist, thigh, and triceps had the highest correlation with body density. Regression equations using these three sites in all possible two-site combinations were derived for each technique. The predictions of body density from these equations did not differ significantly. These results suggest that in free-living, nonobese, white men, body fat can be estimated with nearly the same degree of accuracy using either the caliper or ultrasonic technique.

Adipose Tissue↗

Failure to demonstrate an effect of dietary fatty acid composition on body weight, body composition and parameters of lipid metabolism in mature rats.

The objectives of the present study were to examine the effects of dietary fatty acid composition on body composition and on several parameters of lipid metabolism in adipose tissue and to assess the ease of weight loss with restricted dietary intake. Rats were fed diets containing 14% fish oil, safflower oil or beef fat plus 2% corn oil. These diets were fed ad libitum for 4 wk (first phase). A number of the animals from each group were killed, and the others were fed 50% of their first-phase food intake for an additional 4 wk (second phase). The diets used in the second phase contained 3% of the above fats plus 2% corn oil. Food consumption, food efficiency and body weights were monitored. After the rats were killed, fatty acid composition of epididymal fat pads was examined. In addition, in vivo lipolysis and in vitro lipogenesis in epididymal fat pads were examined. The results indicate that dietary fatty acid composition had no effect on body weight, food consumption, in vivo lipolysis and in vitro lipogenesis in epididymal fat pads. In addition, although dietary fatty acid manipulation resulted in alteration in adipose tissue fatty acid composition, it had no effect on the rate of weight loss, body composition, in vivo lipolysis and in vitro lipogenesis in epididymal fat pads. It is concluded that dietary fatty acid composition does not play a role in body composition and in lipid metabolism in adipose tissue of mature rats.

Animals↗

Postmenopausal weight status, body composition and body fat distribution in relation to parameters of menstrual and reproductive history.

OBJECTIVES: In the present study the association between menstrual and reproductive history patterns and weight status, fat distribution and body composition during postmenopause was tested. METHODS: In 106 healthy postmenopausal women ranging in age from 48 to 58 years (x = 53.7 year) the weight status was classified according to the recommendations of the WHO. Additionally body composition was estimated by dual energy X-ray absorptiometry and fat distribution was calculated using the fat distribution index. Weight status, body composition and fat distribution were correlated with self-reported parameters of menstrual and reproductive history (age at menarche, average cycle length, number of births, age at first and last birth, average pregnancy weight gain, age at menopause). RESULTS: It was shown that number of births, age at first birth and pregnancy weight gain were related significantly to the postmenopausal weight status, body composition and fat distribution. CONCLUSION: An early first birth a low number of births and a high weight gain during pregnancies can be assumed as risk factors for overweight, a higher amount of adipose tissue, android fat patterning and therefore for the development of the metabolic syndrome during postmenopause. In contrast no adverse effect of menstrual and reproductive parameters on postmenopausal bone mass was found.

Adipose Tissue↗

Association between body composition and body mass index in young Japanese women.

The National Nutrition Survey of Japan indicated a trend toward a decreasing body mass index (BMI; kg/m2) among young Japanese women. Current studies suggest that not-high BMI often does not correlate with not-high body fat percentage. Recently, the classification of BMI in adult Asians was proposed by the International Obesity Task Force. The addition of an "at risk of overweight" category, BMI as 23.0-24.9, was intended to prevent chronic diseases. We investigated the association between body fat percentage (BF%) and BMI to evaluate the screening performance of BMI focused on individual preventive medicine. The subjects consisted of 605 female college students. The subjects' ages (y), heights (cm), body weights (kg), BMIs, and BF percents with underwater weighing expressed as the means +/- SD were 19.6 +/- 0.5, 158.7 +/- 5.6, 53.8 +/- 7.2, 21.3 +/- 2.4, and 24.9 +/- 4.9, respectively. We defined high BF% as +/- 85th percentile of BF% (29.8%). High-BF% individuals are often not classified into BMI > or = 23.0 because their BMI readings are very broad (18.4-31.7). In comparison to the screening performances (specificity and sensitivity), BMI > or = 23.0 (85.3% and 52.1%, respectively), rather than BMI > or = 25.0 (96.7% and 29.8%, respectively), is recommended for the mass evaluation of fatness. For this reason, the BMI "at risk of overweight" category is characterized as the threshold of increasing the appearance ratio of high-BF% individuals. In conclusion, the BMI > or = 25.0 kg/m2 category is determined as high BF%, regardless of body composition measurement for mass evaluation as a result of quite high specificity. Even so, body composition measurement is necessitated by the individual evaluation of fatness focused on preventive medicine because BMI performed a poor representation of body composition, especially BMI < 25.0 kg/m2 individuals.

Adipose Tissue↗