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The handsearching of 2 medical journals of Bahrain for reports of randomized controlled trials.

OBJECTIVE: To identify reports of randomized trials by handsearching 2 Bahrain medical journals, which are indexed in the biomedical database EMBASE and to determine any added value of the handsearching by comparing the reports found by handsearching with what would have been found by searching EMBASE to examine (i) the precision and sensitivity of the EMBASE index term Randomized Controlled Trial (RCT) and (ii) The Cochrane Collaboration's systematic electronic search of EMBASE (which uses 4 index terms and 9 free-text terms). METHODS: All issues of the Bahrain Medical Bulletin (BMB) (1979-2004) and the Journal of the Bahrain Medical Society (JBMS) (1989-2004) were handsearched in February 2005 for reports of RCTs or Controlled Clinical Trials (CCTs), according to Cochrane eligibility criteria. RESULTS: Out of 395 articles in BMB we found reports of 12 RCTs and 4 CCTs. Distribution by country of corresponding author: Jordan (4 RCTs, one CCT), Bahrain (one RCT, one CCT), India (3 RCTs, one CCT), Kuwait (one CCT), Saudi Arabia (2 RCTs), USA/Bahrain (one RCT), and Oman (one RCT); and by specialty: Anesthesia (8), Surgery (1) Pediatrics (1), Radiotherapy (1), Community Medicine (1), Sports Medicine (1), Obstetrics/Gynecology (3). The Journal of the Bahrain Medical Society included reports of 14 RCTs and 3 CCTs, out of 97 articles. Distribution by country of corresponding author: Jordan (9 RCTs, 2 CCTs), Bahrain (3 RCTs), Egypt (one RCT), Kuwait (one RCT), and Saudi Arabia (one RCT); and by specialty: Anesthesia (7), General Surgery (3), Obstetrics/Gynecology (1), Radiotherapy (1), Pediatrics (1), Orthopaedic Surgery (1), Education (1) Ear Nose and Throat (1) Ophthalmology (1). Overall, of the 33 reports of trials found by handsearching both journals, only 23 were included in EMBASE of which only 6 had been indexed with the term RCT. Of the 23 reports of trials included in EMBASE, 16 had been identified in the Collaboration s systematic search of EMBASE. Two reports of trials could have been retrieved by this search but there was insufficient information in the title and abstract to code these as trials. The EMBASE records for the remaining 5 reports of trials did not contain terms currently used by The Cochrane Collaboration to identify reports of randomized trials in this database. CONCLUSION: The handsearching of these journals will help minimize publication bias by locating randomized trials not previously identified and, through their inclusion in the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, will ensure reports of randomized trials will not remain buried through indexing bias.

Bahrain↗

Incidence and severity of gestational diabetes in Bahrain and Australia.

The incidence and severity of gestational diabetes in a series of 5,199 predominantly Arab patients in Bahrain, and 2,643 of mixed racial origin in Australia were studied. The incidence of gestational diabetes in Bahrain (5.4%) was less than in Australia (7.2%) but the more severe degrees were 3 times more common in Bahrain (p less than 0.001). The incidence of gestational diabetes was significantly increased with increasing maternal age and parity. A notable difference between the 2 populations occurred in the groups weighing less than 70 kg. Although Bahrain had a higher proportion of patients weighing less than 70 kg (64.7% versus 55.9%; p less than 0.001) there was a significantly higher incidence of gestational diabetes in this group in the Australian series (13.9% versus 3.7%, p less than 0.001). Postnatal testing of 165 gestational diabetics in Bahrain and 194 in Australia indicated that although the severe degrees of glucose intolerance were more likely to persist postnatally, it was impossible to predict in the individual patient the change in glucose tolerance that would occur after delivery. All gestational diabetics should therefore have a postnatal glucose tolerance test.

Adult↗

Perinatal mortality in Bahrain.

A review of 583 perinatal deaths at the Ministry of Health hospitals in Bahrain, during the years 1985-1987 revealed a perinatal mortality rate of 19.6 per 1,000 total births. Lethal congenital malformations accounted for 145 (24.9%) deaths. Of the 438 normally formed infants there were 42.2% antepartum, 115 (26.3%) intrapartum and 138 (31.5%) early neonatal deaths; in 82.7% of cases the death was considered to be unavoidable. The population of Bahrain for 1986 according to the Central Statistics Organization (1) was 435,065, the majority of which was served by the Ministry of Health Maternity Service with approximately 10,000 deliveries per annum. The Ministry of Health provides maternity services through one main maternity hospital and 2 peripheral hospitals with consultant obstetric care. In addition to these, there are 3 maternity units run by midwives. High risk cases are usually delivered in the main hospital as there is a neonatal intensive care unit attached to it. The latter also acts as a referral centre for all sick babies in Bahrain. An analysis of the causes of perinatal deaths is an effective way of assessing the efficiency of maternity services. The objective of this study was to identify and improve the various factors influencing perinatal mortality in Bahrain.

Bahrain↗

Campaign to control genetic blood diseases in Bahrain.

UNLABELLED: Genetic blood diseases are frequent in Bahrain as in all Middle Eastern countries. Previous neonatal screening in 1984-1985 showed that the birth prevalence of sickle cell disease (SCD) was 2.1%, of sickle cell trait 11% and of glucose-6-phosphate dehydrogenase (G6PD) deficiency 25%. The Ministry of Health recognized the importance of controlling these diseases. In 1984, the first genetic clinic was established, which started the educational campaigns. Information booklets were prepared and distributed widely in schools and clubs in an attempt to increase awareness about these diseases among students and the public. In 1991, the Bahrain Hereditary Anemia Society was formed. In 1992, the Minister of Health formed a national committee for the prevention of genetic diseases in Bahrain. Screening of all pregnant women began, followed by newborn testing if the mother was found to be a carrier. In 1993, a premarital counseling (PMC) service was organized and in 1998, a student-screening project began. At this stage, we want to update the national birth prevalence figure by screening Bahraini newborns for these genetic diseases. This will help to design prevention programs and to measure the effect of health education on the previous birth prevalence figure. SUBJECTS AND METHODS: A newborn screening study was conducted to determine the effects of this long-term campaign (16-18 years). Cord blood samples from 2,000 Bahraini newborns were tested for hemoglobinopathies and G6PD deficiency using HPLC. RESULTS: 18 newborns were found to have SCD. The new birth prevalence figure for SCD in Bahrain is 0.9%, which indicates a 60% decline in the birth prevalence rate. CONCLUSION: With the continuation of education, awareness campaigns, screening of carriers and PMC, we expect the number of affected children born to be reduced tremendously over the next few years.

Anemia, Sickle Cell↗

Rhinosporidiosis in Bahrain, Arabian Gulf.

Rhinosporidiosis occurred in Bahrain only in Indian expatriate workers who had the disease in India before coming to Bahrain. The pathological and clinical aspects of the disease as well as its possible health hazard in Bahrain are discussed.

Adult↗

Sickle cell disease and pregnancy in Bahrain.

OBJECTIVE: To determine the morbidity and outcome of pregnancies complicated by homozygous sickle cell disease (SCD) in Bahrain. METHODS: A controlled study was conducted of all the pregnancies of women with SCD who were delivered at Salmaniya Medical Complex and affiliate hospitals in Bahrain between January 1, 1998, and December 31, 2002. RESULTS: There were 351 pregnancies with SCD, giving an incidence of 0.67%. The mean+/-S.D. age of women with SCD was 28.8+/-5.7 years. These women, who were mostly from Shia villages, had more spontaneous abortions than the 351 controls (32% and 12%, respectively). Compared with the control group, the mean+/-S.D. number of pregnancies among women with SCD was 5.0+/-1.9 vs. 5.7+/-3.1; birth weight, 2,965+/-540 g vs. 3,457+/-497 g; rate of preterm deliveries, 25.9% vs. 12%; incidence of intrauterine growth restriction, 10% to 13% vs. 4% to 7%; Apgar scores at 1 and 10 min, 8.1+/-0.8 and 8.8+/-0.8; and cesarean section rate, 19.0% vs. 12.7%. There were no differences in the rates of pre-eclampsia, antepartum and postpartum hemorrhage, or stillbirth. There were 4 maternal deaths directly related to SCD complications. Hemoglobin analysis was performed in 86% of the women with SCD. Of these women, 60.6% had homozygous SCD with raised levels of fetal hemoglobin (more than 5% HbF); 9.6% had sickle cell hemoglobin with beta-thalassemia disease; and 1.4% had sickle cell hemoglobin only. Vaso-occlusive crises were the most common cause of hospital admissions during pregnancy (42.2%), while hemolytic and sequestration crises accounted for 28.0% and 0.6% of admissions. CONCLUSION: Mortality, morbidity, and perinatal loss are still considerable among women with SCD in Bahrain. To reduce mortality and morbidity, there is a need for a multidisciplinary team able to deal with pregnancy complications due to SCD.

Adult↗

Seroepidemiology of rubella in Bahrain.

Although the Ministry of Health of the State of Bahrain has set priorities for vaccination against a number of communicable diseases including the six target diseases of the Expanded Program of Immunization, no such policy for rubella immunization exists. The incidence of rubella in Bahrain is not precisely known nor is the magnitude of the problem of Congenital Rubella Syndrome. A survey of schoolchildren and primigravidae attending antenatal clinics was undertaken in Bahrain to determine the level of natural immunity against rubella in these groups, which we hope would help us in formulating a vaccination policy. We have found that 67.8% of the 6-7 year old children are susceptible to rubella and that by the age of 18 years susceptibility drops to 10.4%. The decrease in susceptibility was significant until the age of 14 years after which the change became minimal. Efforts should ideally be focused on immunizing all susceptible females before they get married. However, at present, it would be more economical to vaccinate all girls premaritally than to screen and vaccinate those susceptible. When a cheaper screening test for assessing immunity against rubella becomes available, a policy of premarital and post-partum screening followed by vaccination of susceptibles should be put into practice.

Adolescent↗

Diabetes mellitus in Bahrain: an overview.

Bahrain has faced a rapid transition in its socio-economic status, which resulted in great changes both in life-style and in patterns of health and disease. There has been a marked decline in infectious diseases and an increase in chronic diseases. Diabetes mellitus has become one of the most common public health problems in the country. In 1988 it was estimated that 3.4% of total deaths in Bahrain were due to diabetes. A community-based study among mothers aged 18 to 48 years showed that 8.5% of them had diabetes. The percentage was found to be higher among elderly Bahrainis (12.9%). Obesity, lack of physical activity, alteration in food habits, and change in social conditions have all played a vital role in the changing prevalence of diabetes in this country. The current programmes to manage and control diabetes are limited and ineffective. Thus measures to treat diabetes should be given a high priority in the national health policy. Training of physicians in the management of diabetes, public education, epidemiological surveys, and nutritional evaluation of local foods are among the most important measures needed to control diabetes in Bahrain.

Adolescent↗

Tobacco consumption and chemical analysis of cigarettes in Bahrain.

A 10.0% random sample of smokers in Bahrain was identified from a previous national morbidity survey which was completed in February 1983. Tobacco consumption and the average yields of tar, nicotine, and carbon monoxide (CO) of seven brands of cigarettes were examined. The 1982 adult tobacco consumption (2.3 kg) in Bahrain was generally lower than in developed countries. Similarly, cigarette per person consumption (734) was less than 69 other countries out of 130 that had data available. Tar, nicotine, and CO analysis of the five leading brands and two others which were previously popular in Bahrain showed that the average yields were mostly comparable with the same brands in the UK.

Adolescent↗

Validity of death certificates for coding coronary heart disease as the cause of death in Bahrain.

This study aimed to examine the accuracy of death certificates for coding coronary heart disease (CHD) as the underlying cause of death in Bahrain. Of the 1714 deaths occurring in Bahrain in 1993, 371 were classified as resulting from CHD. In this study the hospital diagnosis of 109 deaths (52 as CHD and 57 as other causes) were reviewed and re-diagnosed using hospital records. The coding of 459 death certificates (151 as CHD and 308 as other causes) by the Directorate of Public Health was similarly reviewed. The sensitivity and specificity of the hospital diagnosis were 76% and 72% respectively and those of the Directorate of Public Health were 85% and 89% respectively. National mortality statistics in Bahrain, which are based on death certificate data, may overestimate the frequency of CHD. Therefore, it is important that measures are taken to improve the accuracy of certification.

Abstracting and Indexing↗

Human papillomavirus infection among women attending health facilities in the Kingdom of Bahrain.

OBJECTIVE: To investigate the occurrence of human papillomavirus (HPV) infection and the associated risk factors in Bahrain's female population. METHODS: This study was carried out between March to December 2004, which includes cervical scrapings for Pap smear and HPV-DNA testing using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis, obtained from 100 women attending the Gynecology Clinic at Salmaniya Medical Center and Sheikh Sabah Health Center in the Kingdom of Bahrain. We distributed questionnaires that include the sociodemographic data as well as information on risk factors such as smoking, parity, and the contraceptive used. RESULTS: Eleven women (11%) with normal cytology were HPV-positive. The RFLP analysis detected HPV-types 16, 18, 45, 62 and 53. Positive women were significantly older (43.3 +/- 10.1 years) than negatives (36.5 +/- 9.9 years; p=0.04), however, there was no difference in age of first sexual contact (positive: 18.1 +/- 5.7 years versus negative: 20.6 +/- 4.4 years). Polygamy, smoking and hormonal contraception was not identified as risk factors, but positive women showed higher parity. CONCLUSION: In this study on HPV infection in Bahrain, the 11% positivity with high risk HPV types, in the presence of normal cytology suggests that in addition to the cervical cancer screening program, offer of HPV testing deserves consideration.

Adult↗

A study of knowledge and attitudes towards the use of evidence-based medicine among primary health care physicians in Bahrain.

OBJECTIVE: A study of perceptions and attitudes towards the use of evidence-based medicine (EBM) among family physicians in Bahrain. METHODS: A systematically developed, anonymous, self administered 13 item questionnaire was mailed to 124 Bahraini family physicians in the Ministry of Health, Bahrain between January and April 2004. The response rate was 65%. Data were analyzed using the Statistical Package for Social Sciences (Windows version 11.00). RESULTS: The respondents (n=81) were mainly female (65.4%) with a mean age of 40 (SD 7.7) years, with 12.7 (SD 8.3) years since graduation. Forty-two percent had attended EBM workshops and 61% claimed to use EBM in their practice. Those who had attended a workshop were more likely to assert that they were practicing EBM (82% versus 47%; p=0.001). Less than 10% selected patient s choice as a component of EBM. The 81.5% of respondents agreed their patients were willing to participate in decision making but 50% felt that only 10-25% of their patients were capable. No time (53.1%) and no ready access to resources (73.5%) were the most cited barriers, 32% of respondents agreed that EBM is not applicable to their culture. CONCLUSION: Most family physicians in Bahrain claimed to use EBM in their practice, particularly if they had attended an EBM workshop. However, most of them did not consider patients values as a component of EBM. A substantial minority considered that EBM is inapplicable to their culture.

Adult↗

Intestinal parasites in the state of Bahrain.

Intestinal parasites infections are common in the state of Bahrain, but the incidence is decreasing due to improvement in health and social standards. A community-based study sample of all population of Bahrain was done including all ages and nationalities. From 1st July 1984 to 28th February 1986, the first community-based study sample of all population of Bahrain was done including all ages and nationalities. A total number of 2123, about 0.006 of the population of 1981 census was chosen for the study. The study shown that 739 persons were infected with intestinal protozoa and helminths. The figure representing 34.8% of total sample size, whom 283 persons were symptomatic, about 38.3% of total infected sample size. Giardia lamblia and Trichuris trichuria were the most common parasites among the infected persons.

Bahrain↗

Ethnomycological aspects of the desert truffle among native Bahraini and non-Bahraini peoples of the Kingdom of Bahrain.

This research was conducted to assess the general knowledge, attitude, and practice of native Bahraini and non-Bahraini peoples of Bahrain about ethnomycological aspects and traditional folklore of the desert truffle. The findings were obtained through interviews and a specially designed structured questionnaire administered to subjects who were randomly recruited. A total of three species were identified from the southern parts of Bahrain. Tirmania nivea "Zubaidi" was found to be the most preferred expensive and common type of truffle in the region to both groups of respondents due to its good light smell, delicacy, and soft white tissues. This was followed by Terfezia claveryi "Ikhlasi". Non-Bahraini respondents are more likely to believe that rain and soil (34%) or heavy thunder rains (23.4%) are the main factors responsible in truffle development, while Bahrainis perceive that an early heavy rainy season (57.8%) or soil type coupled with heavy rains (26.5%) are the most important reasons in truffle formation. Both respondent groups agree that heavy rains (>200 mm) during mild to warm weather, locally recognized as "Al-Wasm", coupled with heavy evening or early morning dewfalls and thunder and lightning are considered essential requirements for truffle formation. Trufflers in both groups similarly agree that mainly enjoying a good time was their motivations to collect truffles and not medicinal purposes. Truffle collection as a means for financial supplement and to pass this tradition from one generation to the next is no doubt another factors contributing for the collection. An analogous response from both groups indicated their unwillingness to buy truffles at relatively high price (mean 64%) or even off season but never objected to affordable price (mean 80.5%). About 95% of the non-Bahraini and 72% of the Bahraini respondents indicated their readiness to eat truffles for sexual reasons based on a physician's advice. The method used by almost 71% of the Bahraini respondents includes looking for an earth bulge with cracks on smooth surfaced sandy-loam soil whereas non-Bahrainis search randomly in unexploited desert habitats (49%) but not always looking for truffles, but by the presence of its host plant Helianthemum spp. (16.3%). For both groups, boiling the cleaned sliced truffle in salts and spices (mean 31%), or by deep-frying in local lamb ghee and spices (26%) is the most preferred way of eating truffles, while eating raw truffles is very rare. Finally, chilling cleaned truffles (45.6%) is the main method of preservation for short periods used by the Bahraini respondents, otherwise freezing (30.4%) is used for prolonged preservation, compared to non-Bahraini respondents who prefer freezing as the primary method (51.4%). Some Bedouins preserve clean truffles by pickling in 3-6% vinegar and salt. The influence of soil and environmental factors on truffle development and the role of desert truffles on traditional information, socioeconomic, ecology and sociocultural folklore in Bahrain are discussed.

Anti-Infective Agents↗

Pharmacoepidemiology of antihypertensive drugs in primary care setting of Bahrain between 1998 and 2000.

PURPOSE: To compare pattern of antihypertensive drug utilization in 1998 with 2000 following the: (a) publication of 1999 World Health Organization/International Society of Hypertension (WHO/ISH) guidelines for drug management of hypertension; and (b) introducing new antihypertensives to the essential drug list, in primary care, Bahrain. METHODS: Retrospective prescription-based survey carried out in seven out of 20 primary care health centers in Bahrain. A total of 9272 patients comprising 6543 with uncomplicated hypertension and 2729 with diabetic hypertension were studied. RESULTS: Between 1998 and 2000, the prescription rate of beta-blockers and methyldopa significantly declined (p < 0.0001) while the rate of angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs) increased (p < 0.0001) in uncomplicated hypertension. However, in diabetic hypertension there was a non-significant decline in utilization of beta-blockers, CCBs, methyldopa, and diuretics whereas a significant increase in prescribing of ACE inhibitors (p < 0.0001). Inclusion of Perindopril into the essential drug list resulted in an overall increase in utilization of ACE inhibitors: use of captopril and enalapril declined while lisinopril and perindopril increased. Substitution of immediate-release (IR) indapamide by sustained-release (SR) formulation did not change the overall utilization of diuretics; however, intra-class changes were evident with a significant decline in use of thiazide diuretics and concomitant increase in use of SR indapamide by 2000. CONCLUSIONS: The antihypertensive prescribing pattern is influenced by WHO/ISH guidelines as well as by introduction of new antihypertensives to primary care essential drug list in primary care. The choice of a drug is also influenced by presence of co-morbidity with diabetes mellitus.

Adrenergic beta-Antagonists↗

The hamate facet of the lunate: a radiographic study in an Arab population from Bahrain.

Based on the presence of a facet for the hamate two types of lunate bone have been described in the wrist; type I is without a facet for the hamate while type II bears a facet on the medial surface for articulation with the proximal pole of the hamate. Compared to type I lunates, type II lunates have been shown to have different kinematics, are more prone to clinically relevant degenerative changes in the hamato-lunate joint and may cause ulnar-sided wrist pain. The incidence of type II lunates seems to vary in different populations. Postero-anterior (PA) view of plain radiographs of the hand was studied in Arab subjects from Bahrain (n=381; 307 males and 74 females) to determine the incidence of type I and type II lunates. The mean age of the subjects was 31.1 years, the range being 18-80 years. In the population studied, only 148 (38.8%) of the 381 wrists showed type II lunate; 121 (31.7%) were found in males and 27 (7.1%) in females. There was no significant difference in the mean age of subjects with type I or type II lunates (P=0.16). There was no correlation between side and gender with the presence or absence of a hamate facet on the lunate. The incidence of type II lunate was much lower than reports in the literature of populations from the Western world, which could be attributed to a genetic variation in the Arab population in Bahrain. These data indicate that osteoarthritis of the hamate or lunate is less likely to be a cause of ulnar-sided wrist pain in Bahraini Arabs.

Adolescent↗

The quality of groundwater in Bahrain.

The quality of groundwater and house tap water throughout the State of Bahrain has been investigated with respect to pH, salinity, conductivity, bicarbonate, chloride, sulfate, sodium, potassium, magnesium, calcium, nitrite, nitrate, ammonia and phosphate. Groundwater showed elevated levels for salinity, chloride, sulfate, sodium and magnesium, with ranges of 1.40-9.30 ppt, and 110-4407, 239-1385, 247-2165, and 36-313 mg l-1, respectively. These values increased from western Bahrain reaching maximum values along the southeastern coastal zone. Nitrate concentration ranged from 1.3 to 23.3 mg l-1 with an average value of 4.4 mg l-1. The results of the study indicate deterioration of groundwater in localized areas. In the case of tap water, the observed ranges for salinity, chloride and sodium were 0.7-1.5 ppt, and 280-750 and 140-400 mg l-1, respectively. The quality of tap water was assessed by comparing values with WHO guidelines.

Ammonia↗

Polycyclic aromatic hydrocarbons, nickel and vanadium in air particulate matter in Bahrain during the burning of oil fields in Kuwait.

Inhalable air particulate matter (APM) was collected in Bahrain from July 31, 1991 to August 4, 1991, during the burning of the oil fields in Kuwait. The filters collected were black and the levels of APM ranged from 139 to 673 micrograms m-3 with an average value of 199 micrograms m-3. APM were analysed for their contents of PAHs, Ni and V. Analysis was carried out for 32 PAHs and total PAHs ranged from 3.1 to 9.1 ng m-3 and averaged 5.3 ng m-3. The highest individual PAH levels were benzo[ghi]perylene, benzo[b]fluoranthene, benzo[a]pyrene and indeno[1,2,3-cd]pyrene. The concentration of Ni and V ranged from 7 to 42 and 11 to 42 ng m-3, with an average value of 22 and 26 ng m-3, respectively. A strong correlation was found between Ni and V (r = 0.98, P less than 0.01). The results show that the smoke from burning oil wells in Kuwait has contributed to the concentrations of particulate matter, PAHs, Ni and V in APM in Bahrain.

Air Pollutants↗