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Results for “Basal Cell Carcinoma”

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At least 19 recordsLinked to original sources

PubMed1975

Basal cell carcinomas and basal cell carcinoma-like changes overlying dermatofibromas.

Three patients had pigmented nodular basal cell carcinomas overlying dermatofibromas and 19 patients had basal cell carcinoma-like changes. We agree with the view generally held that acanthosis, pseudoepitheliomatous hyperplasia, basal cell buddings, and hair follicle-like proliferations of basal cells represent reactive changes of a spectrum of epidermal alterations overlying dermatofibromas. Contrary to the general opinion, however, we believe that basal cell carcinoma-like changes, superficial multicentric basal cell carcinomas, and nodular basal cell carcinomas represent neoplastic changes of such a spectrum.

Adult↗

PubMedDate not supplied

Basal cell carcinoma of the vulva.

Basal cell carcinoma was found in eight of 61 cases of vulvar malignancy occurring over a 20-year period. This incidence of basal cell carcinoma was 13.1%, higher than the expected 2%-5% reported previously in the literature. Symptoms of a mass, usually discharge, pruritus or bleeding, were commonly ignored for long periods of time by the elderly patient. The specific location and size were difficult to ascertain from hospital records. Therapy is always surgical with wide local excision recommended. Local recurrence will be noted in 10%-20%, as vulvar basal cell carcinoma is a multicentric lesion and, therefore, long-term follow-up, as with any malignancy, is mandatory. Adequate identification and reporting may well show that this lesion is more common than has been previously thought.

Adult↗

PubMed1979

Heterotransplantation of human basal cell carcinomas in "nude" mice.

Human basal cell carcinomas, obtained from 10 subjects were transplanted to 25 "nude" mice. Two methods of transplantation were used and compared. Grafting gave better results than subcutaneous implantation. Tumor cells were identified in 5 mice, however only 2 of them developed lesions with histology similar to human basal cell carcinoma. Grafts, in which tumors developed, were obtained from superficial basal cell carcinoma. No reasons for the cause of the low percentage of successful transplantation and slow rates of growth of the transplants are found; however, possible immunological, vascular and environmental factors are discussed.

Animals↗

PubMed1979

Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.

Fibroblast cultures derived from human basal cell carcinomas demonstrated an increased capacity to synthesize and secrete collagenase. Although the levels of collagenase were up to 8-fold greater than those of normal control cell lines, this phenotypic trait was not permanent and was expressed only for a few passages following primary explanation. The basal cell carcinoma fibroblast collagenase was secreted as a proenzyme. The kinetics of activation and the catalytic efficiency of the basal cell carcinoma fibroblast enzyme were equal to control collagenase, indicating that increased activity was due to increased synthesis of enzyme protein. Increased synthesis of collagenase was not due either to altered cell growth or to an overall increase in protein synthesis. Furthermore, synthesis of another major protein, of another major protein, collagen, was not enhanced. The data suggest that the tumors may have stimulated adjacent fibroblasts to produce more collagenase which is of importance in tumor invasion.

Basal Cell Carcinoma↗

PubMed1979

Granular cell basal cell carcinoma. A distinct histopathologic entity.

In two cases of basal cell carcinoma with prominent granular cell features, light microscopic examination showed a tumor with the general configuration of a nodular basal cell carcinoma. Focally, there were masses of cells with eosinophilic, granular cytoplasm and large cytoplasmic inclusions, strongly suggestive of granular cell myoblastoma. Ultrastructural observations in one case showed numerous lysosome-like organelles that were similar to those described for granular cell myoblastoma, but were identical to those described for the granular cell variant of ameloblastoma, a tumor that frequently resembles basal cell carcinoma. Additional features included tonofilaments and desmosomes, both of which support an epithelial origin for the granular cells in this rare variant of basal cell carcinoma.

Aged↗

PubMed1976

Ultrastructural comparison of the interface between epithelium and stroma in basal cell carcinoma and control human skin.

Comparative ultrastructural studies of basal cell carcinomas, seborrheic keratoses, actinic keratoses, and control nontumor skin from human patients demonstrate structural differences between invasive and noninvasive tumor cells. Compared to the other specimen groups, biopsies of basal cell carcinomas reveal a decrease in hemidesmosomes and an increase in actin-like microfilaments in cells at the margins of the tumors. Benign tumors, i.e., seborrheic keratoses and actinic keratoses, have hemidesmosome areas and microfilament contents resembling control nontumor skin. The most striking hemidesmosome areas and microfilament contents resembling control nontumor skin. The most striking increase in microfilaments is in the most infiltrative "morphea" variants of basal cell carcinoma. These findings, in the context of other published reports, suggest that increased microfilaments are related to enhanced motility of invasive carcinoma cells in vivo and that decreased hemidesmosomes may be related to loss of cell to substratum or "anchorage" dependence of growth in malignant cells.

Actins↗

PubMed1978

Hamartomatous basal-cell carcinoma.

A 25-year-old woman developed a basal-cell carcinoma in the skin over the right scapula. The histopathology of the lesion revealed elements of typical basal-cell carcinoma as well as adenoid, trichoepitheliomatous, and ductal differentiation. Hamartomatous basal-cell carcimoma is a rare variant of ordinary basal-cell carcinoma as well as adenoid, trichoepitheliomatous, and viduals. It is a less aggressive neoplasm and may remain stationary for years. Its recognition as an entity brings awareness that basal-cell carcinomas sometimes occur in young persons.

Adult↗

PubMed1977

Basal cell carcinoma with metastasis. Review of literature.

Basal cell carcinoma (BCC) is the most common form of skin cancer, accounting for 65% to 75% of all malignant skin tumors. Metastic BCC is very rare--only 109 documented cases have been reported to date. The mean time of survival after metastasis has been reported to be ten months. No effective therapeutic modality is known for its treatment. We are reporting a case of metastatic BCC in which we have found deficiency of cell-mediated immunity. Postmortem studies showed a co-existing squamous cell carcinoma in thelungs, brain, liver, and spleen. The most unusual finding in the postmortem study was evidence of juxtaposition of BCC and epidermoid carcinoma with distinct histologic dimorphism. We speculate that a combination of immunodeficiency and stromal independence is needed for metastases in BCC.

Adult↗

PubMed1978

Tendency of fluorouracil to conceal deep foci of invasive basal cell carcinoma.

Topical fluorouracil treatment of invasive basal cell carcinomas (BCC) is not recommended because it often produces the appearance of control with superficial inhibition of the tumor as the deeper extensions continue to grow, which results in a needless delay in obtaining effective treatment. These conclusions are based on data obtained during the microscopically controlled excision of 103 invasive BCCs of the face that had recurred after topical fluorouracil treatment.

Administration, Topical↗

PubMed1977

Quantitation and immunocytochemical localization of human skin collagenase in basal cell carcinoma.

Human skin collagenase was quantitated by radioimmunoassay in 21 basal cell carcinomas. Immunoreactive collagenase protein was found to be approximately 2-fold greater in extracts of these tumors than in extracts of normal skin, suggesting that this enzyme may be important in the pathogenesis of soft tissue destruction in vivo. To further define the role of collagenase in such destruction, immunofluorescent staining with specific antiserum to human skin collagenase was used to localize collagenase in the basal cell carcinomas. The enzyme was found only in the stromal elements surrounding the tumor islands. No staining of the epithelial components of the basal cell carcinomas was found. These findings suggest that the normal connective tissue elements may have been stimulated to produce an increased amount of collagenase and emphasize the importance of epithelial-stromal interaction in soft tissue invasiveness.

Basal Cell Carcinoma↗

PubMed1979

Frozen section control in the surgery of basal cell carcinoma of the eyelid.

Two groups of patients, 37 with primary basal cell carcinoma of the eyelid and 16 with basal cell carcinoma of the eyelid previously treated by other physicians were reviewed. All of the tumors were excised with at least 3 to 4 mm of normal-appearing tissue at each margin of resection. All of the excised specimens were submitted for frozen section studies of the margins. A total of 20 (54.04%) of the previously untreated tumors and eight of the previously treated tumors had at least one margin involved with tumor cells. Repeated excisions under frozen section control were done until all of the margins were free of tumor cells. To date, none of the patients treated in this manner had a recurrence of the tumor.

Adult↗

PubMed1979

Comparison of treatment modalities for recurrent basal cell carcinoma.

We studied 97 patients with recurrent basal cell carcinomas; 20 were treated by surgery, 35 by radiation, 40 with chemosurgery, and two patients had no treatment (because their lesions were too far advanced). There was a treatment failure rate of 11 percent for radiation therapy, 12 percent for chemosurgery and 5 percent for surgical excision. Recurrent BCC requires a careful selection of the mode of therapy, aggressive treatment, and careful long-term follow-up. Using these principles, an excellent cure rate can be achieved by all the 3 modes of therapy included in this report.

Adult↗

PubMed1979

A study of basal cell carcinoma of the inner canthus, 1967-72.

Basal cell carcinoma was the commonest malignant lesion at the inner canthus. Reconstruction following excision was most commonly achieved with a post-auricular full thickness graft. Provided excision is adequate, a local flap is a good alternative. There is no evidence that the use of a graft increased recurrence, but it may have allowed earlier detection. The primary recurrence rate after primary surgical excision was 3.6 per cent. Recurrence occurred in several cases when histology indicated incomplete excision. Follow-up under these circumstances should be continued for up to 10 years. When adequate primary surgical excision was performed, there was no evidence that rodent ulcer of the inner canthus behaves differently or has a worse prognosis than at other sites. There has probably been undue concern in the past about epiphora following resection of the lacrimal drainage system.

Adult↗

PubMed1979

Basal cell carcinoma in a hair transplant recipient site.

A basal cell carcinoma developed in the central scalp of a forty-one year old man at the recipient site of a hair transplant plug that was placed five years previously. The patient was never noted to have premalignant or other malignant skin lesions. Although the relationship is probably coincidental, medico-legal factors dictate consideration of a cause and effect relationship.

Adult↗

PubMed1978

Basal cell carcinoma: a practical approach to diagnosis and therapy.

Basal cell carcinoma is the most common cancer of the skin, and the majority of those afflicted are elderly Caucasians with sun-damaged skin. Knowledge of the indications for and contraindications to the various treatment modalities is required in order to choose the proper treatment for each patient. Only long-term follow-up can detect recurrent or new lesions.

Adult↗

PubMed1979

Basal cell carcinoma treated with MTDQ and irradiation.

Patients with basal cell carcinoma of the skin were treated with combined MTDQ (6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline)) administration and irradiation. Significantly better results were obtained with a skin exposure of 2 000 R combined with MTDQ than with the same dose alone. The results were comparable to those obtained with an exposure of 4 000 R. MTDQ administration induced decrease of tissular malonaldehyde concentration and suggested the peroxide-decomposing action of the radiation sensitizer.

Adult↗

PubMed1979

Immediate flap reconstruction after excision of basal cell carcinoma of the face.

The authors review 175 basal cell carcinomas of the face, treated primarily by surgery. The overall cure rate was 97%. Among these cases, 53 were treated by excision and immediate local flap reconstruction. Analysis of results in the latter group encourages the use of this method for virgin, untreated tumors provided basic rules of surgical oncology are followed. Furthermore, it has a definite advantage cosmetically over more conservative methods. If radiotherapy has been the initial treatment, however, immediate reconstruction after excision of a recurrent tumor should be contemplated reluctance.

Adult↗

PubMed1978

Treatment of basal cell carcinoma of the eyelid.

109 cases treated for basal cell carcinoma of the lid are presented. Of the 79 patients who received radiation treatment alone, 65 (82%) were recurrence-free at two years and of the 45 followed for five years, 31 (69%) were recurrence-free. Of the 30 cases radically excised, 27 (90%) were cured at two years, and all of the 15 who were followed for five years. Small tumours were cured as effectively with irradiation (98%) as with excision (92%). Larger tumours with a diameter of more than one cm seemed to have a less favourable result with radiotherapy, 20/33 for two years and 9/21 for five years, than with excision, 6/7 and 5/5, respectively.

Adult↗