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At least 19 recordsLinked to original sources
PubMed1977

The effect of N-nitrosobis(2-oxopropyl)amine after oral administration to hamsters.

Oral administration of N-nitrosobis(2-oxopropyl)amine (BOP) in drinking water to Syrian golden hamsters for 90 days resulted in a high incidence of intra- and extrahepatic bile duct neoplasms. Only a few pancreatic neoplasms and no lung and kidney tumors developed, in contrast to results obtained after subcutaneous BOP administration.

Adenoma, Bile Duct↗
PubMed1979

[Carcinoma of the convergence of the hepatic ducts. A case treated with extended hepatic resection].

The case of a patient with carcinoma of the convergence of the hepatic ducts successfully treated with more extensive hepatic resection is reported. Stress is laid on the problems of exact preoperative diagnosis and of treatment. Most operations are in fact purely palliative and the literature contains very few cases of hepatic resection for neoplasia of the convergence.

Bile Duct Neoplasms↗
PubMed1975

Adenocarcinoma of the bile ducts. Relationship of anatomic location to clinical features.

Case histories of 23 patients with adenocarcinoma of the bile ducts presenting at the Cleveland Clinic from January 1960 through March 1974 were reviewed and a comparison was made between carcinoma in the hepatic duct system and carcinomas in the common bile ducts. There were 14 cases of hepatic duct carcinoma and 9 cases of carcinoma of the common bile ducts. It was found that age, sex, presenting symptoms, physical examination, and laboratory findings were similar regardless of the location of the carcinoma. Moreover, the location of the carcinoma did not influence whether the correct diagnosis was made at the initial operation. Percutaneous cholangiography, operative cholangiography, and endoscopic retrograde cholangio-pancreatography (ERCP) were successful in making the diagnosis in both locations. The tumors differed in pathology. The hepatic duct carcinomas were often scirrhous; the more distal carcinomas were adenocarcinomas of varied grades of differentiation. The location influenced the type of surgery; resection was more common in the distal common bile duct cases. The average survival rate was less than 2 years for both locations. Radiation and/or 5-fluorouracil therapy did not appear to increase this survival rate. Since the prognosis is so poor, attention must focus on means of earlier diagnosis.

Adenocarcinoma↗
PubMed1976

Newer angiographic observations in cholangiocarcinoma.

Three new angiographic features of cholangiocarcinoma are bile duct dilatation, venous obstruction and arterio-arterial collaterals. Differentiation of the lucencies of dilated bile ducts (cylindrical in shape) from those due to metastases (spherical) is discussed. Because of its high reliability and the difficulties of operative diagnosis, angiography can play an important diagnostic role in patients with suspected cholangiocarcinoma.

Adenoma, Bile Duct↗
PubMed1976

[2-stage operations in cancer of the pancreatic head and major duodenal papilla].

As the first moment of the operation laparoscopic cholecystostomy was employed in 63 patients. In 6 patients due to their grave condition no other operative interventions were performed. In 35 patients during the second operation various biliodigestive anastomoses were constructed. In 3 patients transduodenal papillectomy with lymphodenectomy was performed. Pancreatoduodenal resection was employed in 19 cases, three patients died postoperatively. The author's personal modification of pancreatoduodenal resection was used.

Ampulla of Vater↗
PubMed1976

Transhepatic percutaneous cholangiography.

Transhepatic percutaneous cholangiography continues to be a significant tool in the diagnosis of jaundice. It allows direct, easily achieved graphic delineation of the biliary system. Although specific diagnosis may not be possible, the site and extent of obstruction and the differentiation from intrahepatic parenchymal disease may be determined with a high degree of success.

Adenocarcinoma↗
PubMed1976

[Cancer of th e exrahepatic bile ducts].

The authors have summarized their experience with observations and treatment of 101 patients with cancer of extrahepatic bile ducts. Based on personal authors' findings it is concluded, that cancer of bile passages can frequently develop against the background of cholelithiasis. Taking into account little efficacy of surgical therapy, the prophylaxis of cancer development, namely an early operation for cholelithiasis, is believed by the authors to be the most effective measure.

Bile Duct Neoplasms↗
PubMed1979

[Repeated operations in the treatment of cancer of the extrahepatic biliary tracts].

Repeated interventions in carcinoma of the ducts were carried out upon 14 patients. The operations happened to be very beneficial for the most of patients and raised the survival period by 3 month to 2 years 4 months. The clinical course of carcinoma of the gallbladder is the most unfavorable. Only in 1 of 3 cases with mechanical jaundice--an aftermath of carcinoma of the gallbladder--the repeated intervention resulted in the formation of the biliodigestive anastomosis. Repeated interventions in carcinoma of the extrahepatic bile ducts are expedient and should enter the scope of routine interventions.

Aged↗
PubMed1979

[Percutaneous transhepatic drainage of the biliary tree (author's transl)].

For some mechanical jaundice surgery may be hazardous or even of no use. Percutaneous transhepatic drainage of the biliary tree is a new technique allowing a quick and durable resolution of the jaundice. It is a non drastic procedure which can be done under local anesthesia. Here is the report of the authors first case. They propose the likely indications of such a drainage.

Aged↗
PubMedDate not supplied

[Hepatodigestive shunts in the treatment of cancer of the liver with obstructions of the intrahepatic bile ducts].

The authors discuss the inductions and the usefulness of hepato-digestive derivations in the treatment of hepatic cancers associated with obstruction of intra-hepatic biliary pathways. A total of 32 hepato-digestive derivations in the left hepatic lobe have been carried out in a number of 62 cases, the remaining 30 cases being treated by a double hepato-digestive derivation on the III-rd and the VI-th segment (hepatogastro- or hepato-jejunostomy with or without disjointed--"in omega"--100 p). Pre- and intraoperational cholangiography is considered as mandatory in view of selecting the type of the intervention.

Bile Duct Neoplasms↗