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[Biometry, hematology, plasma biochemistry and plasma and tissues enzymology of the red partridge (Alectoris rufa) (author's transl].

The following parameters have been estimated in 15 red partridges (young adults of both sexes): 1. Biometry: relative weight of 10 organs (liver, kidneys, heart, brain, spleen, lungs, small gut, coecum, stomach, gizzard). 2. Hematology (mean +/- S.D.): Erythrocytes, 3.4 X 10(6) +/- 0.3 X 10(6) cells/mm3; packed cell volume 0.46 +/- 0.17; haemoglobin 103 +/- 27 g/l; mean red blood cell volume, 135.6 +/- 10.4 micrometer3; haemoglobin per red blood cell, 32.2 +/- 5,2 pg; haemoglobin concentration in red blood cells, 24.0 +/- 2.9 %; leukocytes, 36.9 X 10(3) +/- 7.8 X 10(3) cells/mm3; heterophilic, 32.3 +/- 8.3 %; basophilic, 5.3 +/- 1.5 %; eosinophilic, 1.4 +/- 1.5 %; lymphocytes, 56.1 +/- 7.3 %; monocytes, 4.6 +/- 1.4 %. 3. Blood biochemistry: Na +, 155 +/- 6 mEq/l; K +, 6.5 +/- 1.2 MEq/l; Cl--, 107 +/- 4 mEq/l; Pi, 53.3 +/- 14.4 mg/l; urea, 0.19 +/- 0.05 g/l; uric acid, 33.2 +/- mg/l; creatinin, 14.7 +/- 0.9 mg/l; glucose, 2.77 +/- 0.35 g/l; cholesterol, 1.38 +/- 0.36 g/l; total proteins, 44.1 +/- 5.9 g/l; albumin, 50.0 +/- 8.7 %; alpha globulins, 3.9 +/- 1.5 %; beta globulins, 7.5 +/- 2.2 %; gamma1 globulins, 31.5 +/- 5.6 %; gamma2 globulins 8.0 +/- 3.5 %. 4. Serum enzymology: Alkaline phosphatase, 8177 +/- 5078 u/l; SGOT, 356 +/- 138 u/l; SGTP 28.3 +/- 12.5 m/l; LDH, 955 +/- 570 m/l; GLD 12.6 +/- 12.4 u/l; CPD, 136 +/- 77 u/l; choline esterase, 2181 +/- 506 u/l. 5. Tissue enzymology: the 7 preceding enzymes have been estimated in 10 tissues listed in 1.

Alkaline Phosphatase

[Biometry of the malignant glaucoma (author's transl)].

The survey of a population of 7 patients with malignant glaucoma, whose 3 were bilateral, showed that the total length of these eyes was weaker, the corneal radius shorter, the anterior chamber more shallow and the insertion of the lens more anterior than that of eyeballs with angle-closure glaucoma on the whole. These latter, we must remind, are already smaller than normal eyes. But this lessening of size does not affect the corneal diameter which remains always normal. And the lens, which is greater than normally in the angle-closure glaucoma, in the contrary is normal or smaller in the malignant glaucoma. The authors think that this little size of the lens allows it to be dislocated anteriorly through the limbal ring after the operation, and so is the cause of the post-surgical malignant glaucoma.

Biometry

Clinical evaluation of an inexpensive ultrasound oculometer for ocular biometry.

We measured anterior chamber depth and axial length in 200 human eyes with the Echo-Oculometer and the Digital Biometric Ruler. There was good agreement between measurements with the two instruments. The echo-Oculometer is much less expensive than any other instrument available for measuring ocular axial length and satisfactorily provides information for calculation of power of intraocular lenses.

Anterior Chamber

[Ultrasonic biometry of the fetal crown-rump length between 7 and 20 weeks gestation (author's transl)].

In 370 examinations on 258 patients with known gestational age crown-rump length (CRL) of the fetus was determined by sonar between 7 and 20 weeks. From the results the mean and "2 SD" limits of CRL were derived by means of a non linear regression analysis. The measurements were further analysed to determine gestational age for a given CRL. Besides a velocity curve of CRL growth was calculated. It showed a maximum of 1.8 mm per day at 14 weeks. It was confirmated that sonar measurements of crown-rump length are very useful to estimate maturity of the fetus. The accuracy was found to be best in early measurements (+/-6 days at 7 weeks -+/-11 days at 20 weeks). In regard to clinical decisions reading errors have to be taken into consideration. To avoid them control examinations should be carried out.

Anthropometry

Foetal twin ultrasound biometry.

Biparietal diameter growth differs considerably in the twin gestation compared to the singleton gestation; thus the use of a specific standard is recommended. A shift toward lower values is noticed in monochorial twins. In the case of the abdominal diameter growth, instead, no significant difference is found between twins and singletons.

Cephalometry

Pilocarpine therapy in glaucoma: effects on anterior chamber depth and lens thickness in patients receiving long-term therapy.

The effect of pilocarpine hydrochloride on the anterior chamber depth and lens thickness was measured in 20 eyes of patients with chronic open-angle glucoma who were receiving long-term glaucoma therapy with pilocarpine. Measurements were made with high-resolution ultrasonic biometry. This study demonstrated that regardless of their age (58.4 years, average) and the fact that they had been regularly using pilocarpine from two to four times a day, 85% of these patients demonstrated narrowing of the anterior chamber (AC) depth (average, 0.19 mm) and thickening of the lens (average, 0.21 mm) with each instillation of pilocarpine. In approximately 15% of eyes, a repeatable deepening of the AC depth and flattening of the lens was noted.

Administration, Topical

The WHO multinational study of vascular disease in diabetes: 2. Macrovascular disease prevalence.

14 national groups have collaborated under WHO auspices to select, from local defined populations of individuals with clinical diabetes, groups of approximately 500 within the age range 35--55 yr stratified by age, sex, and known duration of diabetes. In each center, the selected patients were submitted to a standardized study protocol, which included systematic inquiry (WHO questionnaire) for the presence of symptoms of angina pectoris, history of myocardial infarction, presence of intermittent claudication, and cigarette smoking history. Examination included standard biometry, blood pressure measurement, 12-lead (centrally Minnesota coded) electrocardiography, and central laboratory measurement of serum cholesterol and creatine. Ophthalmoscopic and urinary examinations were also included. The prevalence of arterial disease symptoms and electrocardiographic abnormalities show very large variation between countries, the lowest rates generally being found in the Oriental samples and the highest in the European. "Risk factors" for arterial disease (blood pressure, serum cholesterol, and cigarette smoking) also vary widely between diabetic groups. Although data are not yet complete, these differences appear unlikely to explain the variation in the atherosclerotic morbidity observed. Diabetic women were at least as vulnerable to arterial disease as diabetic men. A high prevalence of nonspecific abnormalities of the repolarization phase of the ECG was found, even in groups where ischemic abnormalities were rare. The origin of these is uncertain; they may represent variable local changes or possibly diabetic cardiomyopathy. This preliminary report confirms and quantifies previous indications that the impact of atherosclerotic disease on persons with diabetes varies considerably between national groups, in broad terms, running parallel with the variations in prevalence in the populations in general and suggesting that cultural and/or ethnic factors are more important determinants of atherosclerosis in diabetic individuals than is the diabetic state per se.

Adult

[New aspects in diagnosis and therapy of placental insufficiency. Placental perfusion measurements; placental perfusion test (PPT) and betamimetic long term treatment (clinical and experimental data (authors transl)].

The rate of utero-placental blood flow depends on functional components (perfusion pressure and flow resistance within the area of the vascular bed of the placenta), as well as on morphological factors (regressive changes in the placenta). Different primary maternal conditions and diseases may lower the rate of placental flow, leading to placental insufficiency; the highest percentage, by far, of placental dysfunction is found in patients suffering from gestosis. Hypocirculation initially present in cases of EPH gestosis and caused by arteriolar spasms triggers off a vicious circle involving placental infarction and severe reduction in the utero-placental perfusion rate. This in turn leads to fetal hypotrophy, a high rate of premature births and perinatal mortality. Verification of HPL, HCG, alpha-Fetoprotein or E3 in maternal serum and amniotic fluid or urine greatly improved the recording of partial placental functions. Along with ultrasonic biometry, cardiotocography and amnioscopy, these hormonal parameters allow only indirect assessment of the placental function. On the other hand, measurements of the utero-placental flow offers a direct approach. In order to evaluate the placental flow measurements it is imperative to obtain a curve indicating the course over the last third of the pregnancy-in addition to establishing a general normal range. In case of placental insufficiency, it is necessary to determine whether this is due to functional disorders alone, or to more extenisve morphological changes. A placental perfusion test (PPT) was developed in order to make this distinction. Beta2-mimetic treatment is indicated if functional factors predominate, whereby it appears essential to obtain the requisite experimental data for precise quantification of beta-mimetic action.

Adrenergic beta-Agonists