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At least 19 recordsLinked to original sources
PubMed1978

Antigenic properties of Bioplast.

The influence of heat treatment (at 150 +/- 2 degrees C for 2 hours) on the antigenicity of human Bioplast fibrin powder and human fibrin Bioplast plates was tested in an experimental study. Untreated and heat-treated fibrin powder with incomplete Freund's adjuvant was subcutaneously injected in rabbits. In addition, untreated and heat-treated plates, to which incomplete Freund's adjuvant was added, were subcutaneously implanted. A booster dose was given 8 weeks after the start of the experiment. Blood samples were collected up to 4 weeks after the second injection or implantation, and the sera were tested for precipitating antibodies by the double diffusion technique (OUCHTERLONY'S method). Unlike previous investigators, we found antibodies in sera from rabbits injected or implanted with heat-treated Bioplast products. Thus, the claim that the antigenic properties of all kinds of fibrin can be fully eliminated by heat treatment does not appear to be tenable. In order to avoid the risk of sensitization in man, it is probably advisable to use only human fibrin for the production of Bioplast fibrin powder and Fibrin Bioplast plates for clinical use in human beings.

Animals↗
PubMed2026

Bioplastic biodegradability shapes microbial communities in a coastal brackish environment.

Microorganisms are metabolically versatile and central to marine ecosystems, yet the potential of marine microbial communities to degrade different bioplastics and the effect of environmental factors are poorly understood. Employing multi-seasonal in situ and in vitro experiments, we assessed the biodegradation of six commonly used bio-based bioplastic materials at a coastal site in the brackish Baltic Sea and characterized the associated microbial communities using metagenomics and metatranscriptomics. Cellulose acetate (CA), polybutylene succinate (PBS), and polyhydroxybutyrate/valerate (PHB) degraded at varying rates across materials, seasons, and experimental settings, with up to 28% weight attrition after 97 weeks in situ (CA) and 56% carbon loss as CO2 after 4 weeks in vitro (PBS). The three biodegraded plastics developed similar microbial communities that differed markedly from those on the other materials (cellulose acetate propionate, polyamide, and polyethylene) and in the water column. The main microbial populations on the biodegraded plastics included aerobic and facultative anaerobic heterotrophs with a broad capacity for carbohydrate metabolism. Populations with the potential for nitrogen fixation and denitrification were more prevalent on the biodegraded plastics, suggesting that bioplastic biodegradation is constrained by and coupled to the marine nitrogen cycle. Based on the metatranscriptomic signal of key genes involved in the initial hydrolysis of CA, PBS, and PHB, we identified diverse microbial populations that can potentially drive the biodegradation of these materials in the Baltic Sea, many of which encoded the potential to degrade multiple bioplastics. We propose the term 'bioplastisphere' to denote the distinctive microbial communities associated with biodegradable plastics.

Seawater↗
PubMed1975

Resorption of 125I-labeled fibrin bioplast from the dorsal muscle of rats.

Fibrin bioplast is an implant material made from plasticized fibrin. The resorption and route of elimenation of 125I-tagged bioplast plates implanted into the back muscle of rats have been studied in 18 experiments. Variation in radioactivity of the implant, appearance of the activity in the urine and fecal output, supplemented with information on the radioactivity of the implant site and that of isolated organs, reveal that the elimination of bioplast begins on the 12th day and proceeds at an even rate without pathological tissue reactions. By the 42nd day 10 to 12% of the original material is present. The elimination of the implant material is complete and occurs mainly with urine through the kidneys.

Animals↗
PubMed1977

An introductory report on the use of Bioplast in ophthalmic surgery.

Bioplast is an excellent material for implants. It lends itself readily to cutting and suturing and is easily applied. It is highly suited to ophthalmic surgery. It has the great advantage of having no antigenic properties and is quickly absorbed. Our cases recovered without complications, and the results were satisfactory both functionally and cosmetically. For these reasons we recommend Bioplast in ophthalmology.

Fibrin↗
PubMed1975

Studies on antibody response after implantation of Fibrin Bioplast preparations.

The authors implanted Fibrin Bioplast into the subcutaneous connective tissue, peritoneal cavity, and medullary cavity of tubular bones and into bone deficiencies produced by drilling of 22 rabbits, 38 guinea-pigs and 14 dogs. Immunodiffusion, passive haemagglutination and anaphylactic studies were performed and the delayed hypersensitivity reaction of the tuberculin type examined. Properly heat treated Fibrin Bioplast offered the least danger to the host organism.

Animals↗
PubMed1977

Skin replacement with Bioplast fibrin in Ophthalmology.

The study includes 40 cases of skin replacement performed by an ophthalmologist over a period of 4 years. An absorbable implant material, Bioplast fibrin, was used as a graft following the extirpation of 12 eyelid tumors, the treatment of eight fresh, destructive skin injuries, and the removal of deforming scars around the eyes, in 20 cases. The biocompatible implant provided barrier properties preventing infection or excessive fluid loss. The resorption rate was adjusted to 3-4 weeks. These grafts were gradually replaced by new epithelial tissue growing in from the periphery of the wound edge. The new tissue had the elasticity and cosmetic appearance of surrounding skin. Thus, small periorbital skin tumors can now be removed without the necessity of doing a split thickness skin graft to cover the defect.

Adolescent↗
PubMed1977

Bioplast fibrin implants in nasoseptal perforation.

This study includes 9 cases of nasoseptal perforation following submucous septectomy. Sheets from Bioplast fibrin, an absorbable biomaterial, were implanted to prevent thepersistence of perforations. Postoperative mucosal growth on both implant surfaces ensured closure in 6 of the 9 cases. The method has the advantage of simplicity and it is commendable in the case of smaller defects when the mucosa is not markedly atrophic.

Female↗
PubMed1976

Bioplast fibrin coagulum in large cystic defects of the jaw.

The present study comprises a series of 85 patients with jaw cysts with a diameter greater than 20 mm, the majority in the 30-50 mm group. Following enucleation of the cyst, a coagulum consisting of Bioplast fibrin powder, thrombin, the patient's venous blood and an antibiotic was implanted and primary closure performed. The clinical course was uneventful and the operative area healed by first intention in all cases. The nursing period was shortened. Radiographic follow-up showed rapid ossification. The favorable results are attributed to the absence of dead spaces, the role of fibrin in the regeneration process, and a retarded effect of the antibiotic.

Adolescent↗
PubMed1976

Scleral buckling with Bioplast fibrin in retinal detachment.

The study includes a series of 38 patients with retinal detachment of different aetiology. Scleral reduction combined with the intrascleral implantation of absorbable Bioplast fibrin scleral buckling rods was performed and reattachment achieved in 31 cases. The implant material is biocompatible and is eliminated from the eye in the course of a few weeks.

Adolescent↗
PubMed1979

Bioplast fibrin film for conjunctival replacement.

The study includes 43 cases of conjunctival grafting in chemical burns and traumatic pterygium. Resorbable Bioplast fibrin film was used as a readily available, biocompatible conjunctival subsitute. The implant was absorbed and the site occupied by fresh conjunctival tissue in a few weeks. The composition of tear proteins was restored to normal as fast as after free conjunctival grafting. The results were also satisfactory in terms of cosmetics.

Biocompatible Materials↗
PubMed1975

Treatment of stress incontinence by a fibrin bioplast.

A new simple method of treating urinary stress incontinence is to fix a fibrin implant vaginally to the bladder neck and upper urethra. The support provided by the implant is maintained after its resorption by the fibrous tissue which replaces it. The two-year cure rate in 85 patients was 93 per cent.

Adult↗
PubMed1979

Experimental dermatoplasty of skin defects with an absorbable bioplastic preparation.

Experimental dermatoplasty was performed with fibrin sponge preparation in the rabbit, during the course of which the whole skin thickness was substituted. The fibrin sponge was fixed to the skin-edges with surgical adhesive. The gradually absorbed fibrin was replaced by the migrating epithelium such that epithelization developed gradually. In special cases this method can be recommended for clinical purposes.

Animals↗