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Blood group incompatibility and cervical hostility in relation to sterility.

Fifty-two sterile couples, characterized by persistent and unexplained incompatibility between spermatozoa and cervical mucus, without any other evident factor to explain their sterility, were investigated for the possible role of blood group incompatibility as a cause of their sterility. After a study of the distribution of blood groups in sterile and fertile couples, the distribution of blood group substances in pairs of husbands and wives, and the effect of blood group antibodies on sperm migration, it seems highly unlikely that blood group incompatibility contributes significantly to cervical hostility and the resulting sterility.

ABO Blood-Group System

Significance of HLA and blood-group incompatibility in spontaneous abortion.

The frequencies of antigen-incompatible matings within the HLA, Rhesus, Lutheran, MN, S. Lewis, Kell, P and Duffy systems were studied in 481 parents of karyotyped spontaneous abortuses. The results were compared with the calculated mating frequencies in control samples consisting of 1,197 (HLA) and 12,123 (the remaining eight systems) individuals, respectively. The only significant difference observed at the 5% level was an increased frequency of matins in which the mother was Lu (a+) and had a karyotypically abnormal abortus. It is concluded that antigen incompatibility between the parents within the nine systems studied is not important in the aetiology of early spontaneous abortion or causative in the origin of chromosome anomalies in the foetus.

Abortion, Spontaneous

[Fractionation of human erythrocytes according to their sedimentation behaviour caused by gravity. II. Application for the differential diagnosis of erythroblastosis caused by incompatibility in the abo blood group system (author's transl)].

In contrast to Rh-erythroblastosis the diagnosis of A/B0-erythroblastosis by means of serological methods is often impossible. Further biochemical investigations, the demonstration of elevated erythrocyte sedimentation rates in polyvinylpyrrolidone and of typical microsphaerocytes in blood smears can support the diagnosis. Using a modified method by Danon et al. the authors demonstrate an additional population of heavy erythrocytes in the blood of patients suffering from A/B0-erythroblastosis, the relative amount of which correlates with the severity of the disease. The fast method seems to permit prognostic predictions in cord blood.

ABO Blood-Group System

Correlation of cord bilirubin levels with hyperbilirubinaemia in ABO incompatibility.

We studied 91 offspring of ABO incompatible preganacies and 30 controls resulting from O--O pregnancies to test whether cord bilirubin levels could be used to predict the severity of hyperbilirubinaemia in ABO incompatibility. Blood group, direct Coombs's test, and serum bilirubin estimations were carried out on cord blood, and bilirubin estimations at 12, 24, 36, and 48 hours of life.

ABO Blood-Group System

Pretransfusion blood group serology. Limited value of the antiglobulin phase of the crossmatch when a careful screening test for unexpected antibodies is performed.

The limited value of the antiglobulin phase of the cross match when a careful antibody screening is performed was demonstrated by analyzing 73,407 compatibility tests for 23,857 patients. By the blood grouping and screening of these patients, 178 cases were detected with unexpected blood group antibodies that had not been previously observed. Unexpected antibodies were detected in an additional 13 patients by the saline phase of the cross-match. In addition, the antiglobulin phase disclosed only one patient with a very weak anti-Lea and two patients whose sera gave doubtful reactions, possibly representing antibodies, but too weak to be identified.

ABO Blood-Group System

Unexpected red cell antibodies in donors and patients at Siriraj Hospital.

The incidence of unexpected red cell antibodies in patients and donors at Siriraj Hospital were found to be 4.91% and 4.33% respectively. Anti Lewis, anti P1 and anti Mia were the most common antibodies detected. Antibodies of Rh system were the next, in which anti E was more common than anti D. Anti Jka, Jkb, Fyb, Dia, S and rare antibodies such as anti K, Ge1, Mta and H were also detected in this study.

Blood Donors