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At least 19 recordsLinked to original sources

Effects of body constitution and age on maximum pacing rate of activity-modulated rate responsive pacemakers.

UNLABELLED: The pacing rate of activity-modulated pacemakers is triggered by vibrations running through the body. Whether the body constitution predicts maximum pacing rate and may facilitate rate response programming was studied in 16 patients with Activitrax pacemakers. Rate response parameters were programmed to a fixed setting in VVIR/VOOR mode (lower pacing rate 60 ppm, upper pacing rate 125-130 ppm, activity threshold medium/7). Body vibrations were induced by a treadmill exercise test with increasing speed. Maximum pacing rates were measured at the stage of symptom-limited tolerance. Exercise tests with a duration of 7.3 +/- 2.9 minutes resulted in a maximum pacing rate of 98 +/- 22 ppm ranging from 60-122 ppm. Maximum pacing rates did not differ between male (n = 10; 102 +/- 21 ppm) and female (n = 6; 92 +/- 24 ppm). Correlations between maximum pacing rates and body constitutional factors were not significant with r = -0.15 (weight), r = 0.39 (height), r = 0.07 (body surface area), and r = -0.27 (skin-fold thickness). The correlations with body mass index (r = -0.53) and age (r = -0.53) were initially significant, but not after Bonferroni-Simes-Hommel correction. The age-dependent relationship may be caused by the shorter exercise duration of older patients indicated by the correlation between exercise duration and maximum pacing rate (r = 0.77), as well as with age (r = -0.73). CONCLUSIONS: body constitution did not modify body vibrations and did not allow prediction of maximum pacing rates; therefore, it is no aid for the programming of rate response parameters.

Aging

[Body constitution of growing inbred animals under hypo-, normo- and hyperkinetic conditions].

The work was carried out in inbred mice C57BL/6, CBA, CC57Br/M strains, interstrain hybrids of the first generation FF1 and in rats of August and Wistar strains. Only one-month-old male animals, which were kept for two months under the conditions of hypo-, normo- and hyperkinesia were used in the study. Statistically significant relation between underloading, overloading and habitus changes was demonstrated. It was stated that habitus changes under the conditions of hypo-, normo- and hyperkinesia were genetically determined. Hereditary predisposition of the reactionary norm and the phenomenon of heterosis manifest themselves under different motor regimens.

Animals

Heredity of osteochondrosis, body constitution and leg weakness in the pig. A correlative investigation using progeny testing.

Sixty-three boars of the Swedish Landrace and the Yorkshire breed were progeny tested. Production variables were correlated with frequency of osteochondrotic lesions at three sites, length of radius, and presence of leg weakness in 416 offspring. Osteochondrotic lesions in distal femur and humerus were found to be correlated with desirable production variables. No correlation existed between presence of osteochondrosis and leg weakness. Analysis of variance showed that breed and boar within breed influenced frequency and distribution of osteochondrosis. The pigs of the Yorkshire breed were less affected. Heritability estimates ranged from 0.14 to 0.30 for the osteochondrotic lesions at three sites. It should be noted that these figures are preliminary because of the limited number of offspring. It was concluded that a possibility exists to lower frequency of osteochondrosis in the pig with only some loss of valuable production qualities.

Animals

Constitution and body proportions in different strains of rats. A study of race formation in breeding isolates.

(1) There are considerable differences in body constitution in different strains of rats, ranging from very robust to very gracile forms. The differences are greater in the larger males than in the smaller females. (2)Craniofacial and postcranial proportions of the trunk in domesticated strains of rats differ either uniformly or mosaically from the wild form. (3)Nasal shape differs greatly in rats ranging from extreme leptorrhine to extreme platyrrhine forms, giving a total range greater than in human populations. (4)Fisher 344 rats have long tails and extremities and Buffalo and GRL short tails and extremities. (5)Wistar and ACI rats have longer tails than wild rats but do not differ significantly from wild rats in the relative length of their other extremities. (6)The relationship between tail and extremity length is under genetic control which is concordant in Fisher, Buffalo and GRL rats, but discordant in the Lewis, Wistar and ACI strains. (7)There is no connection between relative extremity length and total body constitution since short-limbed strains occupy both the highest (Buffalo) and lowest (GRL) levels o f robusticity, and strains that do not differ in relative extremity length from wild rats differ greatly from each other in constitutional type (Wistar and ACI). (8)Differences of relative extremity length and nasal shape in rats have their parallels in human populations. But in human populations they follow Allen's ecological "rule" and can be duplicated experimentally. In rats here used, however, they do not result from any known ecological pressures, but from the genetic factors acting in breeding isolates.

Animals

[The effect of body constitution on work capacity evaluated by means of mechanical efficiency].

The utilizable sources of energy of the human organism are relatively restricted where by interindividual differences are not substantial, while differences in physical performance are extreme. The capacity to transform chemical energy into mechanical work, sometimes described also as the work capacity of the organism is evaluated by means of mechanical efficiency--ME. In men with varying amounts of training (incl. untrained ones), differing significantly as to the percentage of body fat (3.8-17.2%), assessed by measurement of ten skinfolds, the authors assessed ME on a treadmill. The highest ME values were recorded in trained sportsmen (endurance runners--32.4%), lowest in untrained middle-aged men (16.9%). The authors found a close negative correlation of ME and maximal oxygen consumption per kg body weight and values of body fat percentage. With the increasing percentage of body fat the values of ME decline, the prerequisites for effective transformation of chemical energy of the organism into mechanical work are reduced and the work capacity of the organism declines.

Adult

[Ergometric determination of cardiac output in 1500 Swiss children and adults of both sexes, aged 5 to 65 years. Relation to body constitution, sex, age and work capacity in the step test (Part 2)].

The stroke volume of the heart during exercise in upright position (steptest) was determined in 1500 Swiss children and adults of either sex, aged 5 to 65 years. The use of the simplified ergometric method (Strehler) allowed to carry out these determinations mainly in series and without any difficulty. Average absolute values are presented for each year during childhood and adolescence and for each decade in the period of adult life. The stroke volume is lower in the female than in the male group; this refers to absolute values as well as to values relative to body size. The absolute values are approximately proportional to body weight, to the cube of body height and to a standard volume calculated from body height and body weight. There is a typical age-depending course of the relationship between stroke volume and body size (standard volume), the development of the stroke volume showing a minimum before and a maximum during puberty. Provided work load in per cent of the maximal working capacity is the same the stroke volume of the heart during exercise in upright position remains unchanged until the age of about 55 to 60 years. The practical scope of the investigation was to collect data for the setting up of a new stroke volume standard.

Adolescent

Is the biomechanical principle of 'antagonistic compensation' valid also on the genetic level?

According to 'antagonistic compensation', appendicular bones rendered hypofunctional by surgical means, become shorter and more robust. In normal Buffalo rats, appendicular bones are short and very robust and in Fisher rats they are long and gracile. Total body constitution is robust in Buffalo rats and gracile in Fisher rats. In GRL rats, appendicular bones are short but body constitution is gracile and the robusticity of the appendicular bones is intermediate between Fischer and Buffalo rats. Thus, total body constitution and relative length of the appendicular bones determine their robusticity, shorter bones being more robust than longer bones. In other words, the relationship between bone length and robusticity is the same in experimentally produced antagonistic compensation and genetically determined normal condition of rats.

Animals