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Results for “Brucella Vaccine”

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At least 19 recordsLinked to original sources
PubMed1989

Selection of a Brucella vaccine strain of low residual virulence by chemical mutagenesis.

Following incubation of the oral vaccine Brucella suis strain 2 with diethyl sulphate (DES), a mutant designated strain S105 was selected by screening surviving bacteria for reduced virulence for mice. Strain 105 also showed low residual virulence for guinea-pigs and, unlike the parent strain, did not initiate abortion in pregnant sheep and goats after parenteral administration. Nevertheless, it was as effective as the parent strain in stimulating protective immunity to Brucella melitensis when given as an oral vaccine to sheep under both experimental and field conditions.

Animals↗
PubMed1986

Orally administrable brucellosis vaccine: Brucella suis strain 2 vaccine.

An orally administrable brucellosis vaccine, Brucella suis strain 2 vaccine was developed in China. The characteristics and merits of the vaccine are described. It is effective for oral vaccination of sheep, goats, cattle and pigs and has been widely used for prevention of animal brucellosis in China over the past 15 years. About 30-40 million doses of the vaccine are produced every year.

Administration, Oral↗
PubMed1973

Stimulation of anti-Brucella vaccination in mice by tetramisole, a phenyl-imidothiazole salt.

The effect of tetramisole (hydrochloride of racemic 2, 3, 5, 6,-tetrahydro-6-phenyl-imidazo [2, 1-b] thiazole) on immunization was investigated in mice vaccinated by killed Brucella melitensis cells suspended in incomplete adjuvant. Immunity to Brucella abortus challenge was estimated by the reduction in number of B. abortus colonies per gram of spleen in those mice which escaped full immunization and also by calculation of mean infective doses for each group of mice. All tetramisole treatments significantly reduced the number of B. abortus live cells in spleen from infected mice. Tetramisole, injected twice (at the time of vaccination and 48 h later), induced a significant 3.5-fold increase of the protection brought about by Brucella vaccine alone. A single injection of 1.25 mg/kg at the time of vaccination resulted also in a significant increase of the immunity given by vaccination. No modifications of the vaccine potency were observed if tetramisole administration preceded vaccination. In such a mouse assay, tetramisole-induced stimulation was not accompanied by specific antibody increases, although measured by three serological tests.

Antibodies, Bacterial↗
PubMed1978

[Jet method of administration of live brucella vaccine].

A good survival of brucellae in the organism with the development of a stable and prolonged immunity was noted in vaccination of guinea pigs with live brucella vaccine prepared from the Br. abortus strain 19-BA. Local reactions were weak, and no general reactions were observed. In using the jet method of vaccination with the injectors bpi-4 and bi-2 on a limited group of persons (194) the local and general untoward response was weak, but in immunological respect this method proved to be effective when the vaccine was administered in a dose of 2.5 x 10(8) of microbial cells. Jet method can be recommended for express vaccination against brucellosis.

Animals↗
PubMed1976

A recent trial comparing two 45/20 adjuvant Brucella vaccines.

Two commercially prepared killed 45/20 adjuvant Brucella abortus vaccines were compared, under controlled experimental conditions, with regard to local reactions at the site of injection, serological reactions and immunogenicity. Preliminary trials were carried out in yearling cattle and guinea pigs. Three groups of 13 maiden heifers were involved. One group was vaccinated with Abortox, one group was vaccinated with Duphavac and the third group was kept as unvaccinated controls. Following service, eight, ten and eleven heifers were found pregnant in each group respectively. All were infected at mid-gestation with 15.5 x 10(6) organisms of Brucella abortus S544 (Weybridge 1955). Brucella abortus was recovered from all of the controls, from two of the Abortox vaccinates and from three of the Duphavic vaccinates. The serological reactions are discussed.

Abortion, Veterinary↗
PubMed2002

Serological differentiation of Brucella-vaccinated and -infected domesticated animals by the agar gel immunodiffusion test using Brucella polysaccharide in mongolia.

To investigate Brucella infection in cattle, sheep, goat, reindeer and yak in Mongolia, serological reactions of Brucella-infected and -vaccinated domestic animals were compared by the agar gel immunodiffusion (AGID) test with a polysaccharide (poly-B) of the B. Abortus strain S-19. The sensitivity and specificity were compared with conventional serological tests that are commonly used in Mongolia, such as the rose Bengal test, the tube agglutination test and the compliment fixation test. A total of 73.3, 100, 100, 95.8 and 61.9% of the sera from suspected cattle, yak, goat, sheep and reindeer, respectively, that were positive in the compliment fixation test, were also positive in the AGID test. Sera from vaccinated cattle, sheep and goat were positive over 90% by conventional tests 3 months after vaccination, but were negative by the AGID. These results suggest that the AGID test may be useful to differentiate infected and vaccinated animals in the field.

Animals↗
PubMed2006

[The application and research advances of Brucella vaccines].

Brucellosis is a crucial zoonosis caused by Brucella, which has some traits of wide hosts, great infectivity and difficulty in cure. Brucellosis caused great losses to farming and people's health. Vaccination is the main measure used to control Brucellosis, and some attenuated Brucella strains were often used as vaccines. To find more effective vaccines, Scientists are now constructing recombinant strains, DNA vaccines and subunit vaccines, as well as inducing new attenuated strains from isolations. The present applications of B. abortus strain 19 (S19) , B. melitensis Rev. 1 (Rev. 1), B. suis strain 2 (S2), B. abortus strain 45/20 (45/20) and rough strain B. abortus 51 (RB51) were discussed. And some recent research work on Brucella vaccines, such as Brucella recombinant vaccines, DNA vaccines and so on, were reviewed in this paper.

Animals↗