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At least 19 recordsLinked to original sources
PubMed2006

The antispasmodic activity of Buddleja scordioides and Buddleja perfoliata on isolated intestinal preparations.

The antispasmodic activity of extracts from the aerial parts of Buddleja scordioides and Buddleja perfoliata (family: Scrophulariaceae) was studied on isolated tissue preparations from rabbit and guinea pig intestine. The chloroformic extract from the plants exhibited a significant relaxation on the spontaneous contraction of isolated rabbit jejunum at concentrations ranging from 1 to 400 microg/ml, and also caused an inhibitory effect on both K+ and Ca2+ induced contractions in the same tissue. The extracts at moderate doses (50 microg/ml) reduced 5-hydroxytryptamine (5-HT), acetylcholine and histamine induced contractions on isolated guinea pig ileum. Therefore, B. scordioides and B. perfoliata possess similar relaxant mechanism of action, in view of the fact that both inhibit K+ induce contraction and act through serotoninic, muscarinic and histaminic receptors. So, these data support the idea that the extracts may interfere either with calcium mobilization from intracellular stores, or with calcium interaction with regulatory proteins (e.g., calmodulin), or in other steps in the calcium signaling pathway. This leads us to suggest that the spasmolytic effect of both Buddleja species on smooth muscular contractility are due to the same or similar compounds occurring in these two species, which might be present in similar quantities.

Animals↗
PubMed1995

Study on anti-cataract drugs from natural sources. II. Effects of buddlejae flos on in vitro aldose reductase activity.

The inhibitory effects of nine crude drugs were tested on unpurified rat lens aldose reductase, an enzyme involved in the complications of diabetes. Among the crude drugs, a 70% methanolic extract of Buddlejae Flos (flower of Buddleja officinalis) exhibited the highest inhibition. Luteolin, luteolin-7-O-beta-D-glucopyranoside, apigenin and acacetin-7-O-alpha-L-rhamnopyranosyl-(6-1)-beta-D-glucopyranoside isolated from Buddlejae Flos showed the inhibitory activity, the IC50 (concentration of 50% inhibitory percentage) values of which were 0.21, 0.28, 0.58 and 0.75 microM, respectively. It is suggested that the inhibitory effect of Buddlejae Flos on aldose reductase is partially attributable to these flavonols or their glycosides.

Aldehyde Reductase↗
PubMed2001

Analytical method for Buddleja colorants in foods.

Buddleja yellow colorant derived from Buddleja officinalis Maxim. has recently been approved for use as a new kind of natural colorant for food additives in China. In order to distinguish Buddleja yellow colorant from other yellow colorants, two known phenylpropanoid glycosides, acteoside (= verbascoside) and poliumoside, were isolated from the colorant as marker substances for Buddleja yellow colorant. Poliumoside has not been detected in B. officinalis Maxim. previously. These phenylpropanoid glycosides were not detected in the fruits of Gardenia jasminoides Ellis or in the stamens of the flowers of Crocus sativus L., which also contain crocetin derivatives as coloring components, using a photodiode array and mass chromatograms. Thus, an analytical HPLC method was developed to distinguish foods that have been colored with yellow colorants containing crocetin derivatives, using phenylpropanoid glycosides as markers.

Food Analysis↗
PubMed1984

Ethnopharmacology of some Buddleja species.

Buddleja species play a minor role in the ethnopharmacology of several areas of the world where they are indigenous. Phytochemical investigation of the genus has been somewhat neglected but a picture is emerging of the type of constituents which are present in reasonable quantities, namely iridoid and flavonoid glycosides. Many of the uses of Buddleja in folk medicine such as a topical antiseptic and a diuretic can be partially explained at least by the known biological activity of compounds identical or similar to those found in the genus. Other reputed uses are, as yet, without explantation due to the incomplete state of knowledge of the chemistry and, to an even greater extent, the pharmacology of Buddleja.

Analgesics↗
PubMed2003

Terpenoids in Buddleja: relevance to chemosystematics, chemical ecology and biological activity.

The terpenoids reported from Buddleja species are described. The antifungal activity of chloroform extracts of B. cordata and B. davidii stembark against the soil fungi Fusarium culmorum and Sordari fimicola is reported, with buddledin A shown to be the major compound responsible. The terpenoids present support the view that the Buddlejaceae should be classified in a taxon with Scrophulariaceae rather than Loganiaceae. Ecological aspects of the terpenoids are considered in relation to insects and soil fungi and the role of terpenoids in the chemical basis of the use of Buddleja in traditional medicine is also discussed, especially with regard to their anti-inflammatory properties.

Animals↗
PubMed2004

[Studies on fingerprinting of Flos Buddleja by RP-HPLC].

OBJECTIVE: To establish fingerprinting of Flos Buddleja by using RP-HPLC for the quality control. METHOD: The HPLC condition was as follows: Inertsil ODS-3 C18 analytical column (4.6 mm x 250 mm, 5 microm), gredient eluation with MeCN (0.1% TFA)-H2O (0.1%TFA), flow rate 1.0 mL x min(-1), detection wavelength 254 nm. 10 commercial samples were analyzed to establish a fingerprinting. RESULT: Among the obtained fingerprinting, most of the detected peaks were separated effectively. The accuracy, repeatability and stability of this method were satisfied. The RSDs of relative retention time and area of aimed peaks which existed in all samples wereless than 5%. Theresults were in accordance with the request of fingerprinting. CONCLUSION: The established fingerprinting can be used for the quality control of Flos Buddleja.

Buddleja↗
PubMed1989

Anti-hepatotoxic activity of extracts and constituents of Buddleja species.

The aqueous extracts of three species of Buddleja which are used in traditional medicine for the treatment of liver ailments have shown an inhibitory effect against induced cytotoxicity of cultured hepatocytes. Fractionation of one of these extracts, from B. globosa leaves, resulted in the isolation of five iridoids, two phenylpropide glycosides, and a flavonoid glycoside. Two of the iridoids were found to be novel compounds, 7-p-methoxycinnamoylaucubin (1) and 7-p-methoxycinnamoylcatalposide (2). One of the phenylpropides, echinacoside, has not previously been reported from Buddleja. Testing of the isolated compounds in the cultured hepatocyte system indicated that the activity is most likely due to the flavonoid and phenylpropide constituents. Phenylpropide glycosides have not previously been shown to have a liver-protectant effect.

Flavonoids↗
PubMed2005

Photoprotective activity of Buddleja scordioides.

The purpose of this study was to determine the photoprotective properties of the methanolic extract of Buddleja scordioides, as well as verbascoside and linarin which were isolated from this extract, and linarin acetate prepared in the laboratory. The photoprotective effect of substances against UV-B induced cellular death was evaluated by challenge experiments using Escherichia coli. Verbascoside and linarin acetate showed the highest protection. The sun protection factor (SPF) of the methanolic extract, linarin, linarin acetate, and verbascoside was evaluated by guinea pig bioassays. Verbascoside showed the largest SPF measurement.

Animals↗
PubMed2004

Saponins from the flower buds of Buddleja officinalis.

Five new saponins, mimengosides C-G (1-5), were isolated from the flower buds of Buddleja officinalis along with five known compounds, namely, songaroside A, acteoside, phenylethyl 2-glucoside, echinacoside, and phenylethyl alcohol 8-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside. The structures of 1-5 were elucidated using spectroscopic and chemical methods, and these compounds were evaluated for their inhibitory effects against HL-60 leukemia cells.

Buddleja↗
PubMed2006

Neuroprotective effect of Buddleja officinalis extract on transient middle cerebral artery occlusion in rats.

The flower buds of Buddleja officinalis MAXIM (Loganiaceae) are used to treat headache and inflammatory diseases in traditional Korean medicine. In the present study, the neuroprotective effects of the methanolic extract of B. officinalis (BOME) and of its hexane fraction (BOHF) were investigated in a middle cerebral artery occlusion (MCAo, 120 min occlusion, 24 h reperfusion) Sprague-Dawley rat model. BOME or BOHF (100 mg/kg, p.o.) was twice administered 30 min before the onset of MCAo and 2 h after reperfusion. BOME and BOHF treated groups showed infarct volumes reduced by 33.9% and 68.2%, respectively, at 2 h occlusion. In BOHF treated animals, cyclooxygenase-2 and iNOS inductions were inhibited in ischemic hemispheres at both the mRNA and protein levels. Furthermore, in vitro studies showed that BOME and BOHF both inhibited LPS-induced nitric oxide production in BV-2 mouse microglial cells. These results suggest that the anti-inflammatory and the microglial activation inhibitory effects of B. officinalis extract may contribute to its neuroprotective effects in brain ischemia.

Animals↗
PubMed2001

[Studies on chemical constituents from Buddleja lindleyana Fert].

OBJECTIVE: To study the chemical constituents of Buddleja lindleyana. METHOD: Separation by chromatographic methods and identification by spectral analysis. RESULT: Seven compounds vanillic acid, daidzein octacosanoic acid, beta-sitosterol-3-O-beta-D-glucopyranoside, stigmasterol-3-O-beta-D-glucopyranoside, alpha-spinasterol-3-O-beta-D-glucopyranoside, betulin acid were isolated. CONCLUSION: All the compounds were obtained from this plant for the first time.

Buddleja↗
PubMed2004

[Study on the chemical constituent from Buddleja purdomii].

OBJECTIVE: To study the chemical constituents from Buddleja purdomii W. W. Smith. METHODS: The constituents were isolated and purified by various chromatographic methods and structurally identified by spectral analysis. RESULTS: 4 compounds were identified as vanillin (I), vanillic acid (II), acteoside (III), acteoside isomer (IV). CONCLUSION: All these compounds were obtained from this plant for the first time.

Benzaldehydes↗
PubMed2005

[Study on the chemical constituents of Buddleja purdomii].

OBJECTIVE: To study the chemical constituents of Buddleja purdomii W. W Smith. METHODS: The constituents were isolated and purified by various chromatographic methods and structurally identified by spectral analysis. RESULTS: 4 compounds were obtained as cryptomeridiol (I), aucubin (II), galactilol (III), daucosterol (IV). CONCLUSION: All these compounds are obtained from this plant for the first time.

Buddleja↗
PubMed1998

Two flavonoid triglycosides from Buddleja madagascariensis.

The structures of two new flavonoid triglycosides isolated from leaves of Buddleja madagascariensis have been established as hesperetin and diosmetin 7-O (2",6"- di-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranosides using mass and NMR spectroscopy. Scutellarien 7-glucoside is reported from this plant for the first time.

Carbohydrate Sequence↗
PubMed2001

Effects of Buddleja globosa leaf and its constituents relevant to wound healing.

An aqueous extract of Buddleja globosa leaves, used traditionally in Chile for wound healing, was tested for the ability to stimulate growth of fibroblasts in vitro and for antioxidant activity in the same fibroblast cell system challenged with hydrogen peroxide. Low concentrations of the extract gave an increase in fibroblast growth which was not statistically significant but cytotoxicity was observed at concentrations greater than 50 microg/ml. The extract showed strong antioxidant effect and fractionation led to the isolation of three flavonoids and two caffeic acid derivatives, each of which was shown to contribute to the antioxidant effect at concentrations below 10 microg/ml. These activities would accelerate the healing of wounds.

Antioxidants↗