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Results for “CARBON, RADIOACTIVE”

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At least 19 recordsLinked to original sources
PubMedDate not supplied

[Biological action of radioactive carbon. Biological effects of large amounts of radioactive carbon (14C-glycine)].

In experiments on CBA X C57B16 mice a study was made of the acute effects of radiocarbon (14C-glycine) administered intraperitoneally in doses of 130, 60, 30 and 15 mBq/animal (the total cumulative doses absorbed within the body were, at an average, 29.5, 14.2, 7.1 and 3.6 Gy, respectively). In the first group, the animals developed grave radiation affections (50% death, average life-span of 17.6 days); in the second group, the affection was less serious, and in the third and fourth groups, the affection was light. A mean tissue absorbed dose in the died animals was 6-11 Gy.

Animals↗
PubMedDate not supplied

[The biological action of radioactive carbon. The metabolic kinetics and biological effects of the combined action of radioactive carbon (14C-glucose) and sodium nitrite chronically administered].

A study was made of the effect of sodium nitrate (3.1 and 0.3 g/l) on the metabolism kinetics and the biological effects of 14C-glucose (13 kBq/rat/day) that were chronically administered to rats. After both separate and combined administration of the radiation and chemical agents, no substantial changes were detected in the kinetics of metabolism and biological effect of 14C. Six months after the onset of the experiment, the reproductive function of the experimental rats was impaired.

Absorption↗
PubMed2004

Samuel Ruben's Contributions to Research on Photosynthesis and Bacterial Metabolism with Radioactive Carbon.

The earliest experiments on the pathways of carbon in photosynthetic and heterotrophic metabolism using radioactive carbon, (11)C, as a tracer were performed by Samuel (Sam) Ruben, Martin Kamen, and their colleagues. The short half-life of (11)C (20 min), however, posed severe limitations on identification of metabolic intermediates, and this was a major stimulus to search for a radioactive carbon isotope of longer half-life. (14)C was discovered by Ruben and Kamen in 1940, but circumstances prevented continuation of their research using the long-lived isotope. Because of the untimely accidental death of Ruben in 1943, there are very few published accounts on the life and work of this extraordinary scientist. This paper summarizes highlights of Ruben's outstanding accomplishments.

Journal Article↗
PubMedDate not supplied

[Delayed effects of acute radiation injuries by radioactive carbon (14C-glycine)].

A study was made of late biological effects of radioactive carbon (14C-glycine) applied in acute doses. The course of radiation sickness, at its acute stage, is similar to that of acute radiation sickness caused by external gamma-irradiation. The recovery is slow, and the disease becomes chronic exhibiting metabolism disturbances and early death of animals. Radioactive carbon has a pronounced blastomogenic action.

Animals↗
PubMed1976

Imaging small pulmonary ischemic lesions after radioactive carbon monoxide inhalation.

A new method is described for imaging small ischemic regions in the lung immediately after a single breath of radioactive carbon monoxide (11CO). A tungsten-collimated scintillation camera is used to visualize the 0.51-MeV annihilation photons due to the 11C. In normal dogs the entire field is cleared of 11CO within 10 sec. However, in dogs with experimentally occluded 2-mm-diam segmental arteries, the ischemic but well-ventilated segment appears as a region of persistent high radioactivity, due most likely to temporary entrapment of 11CO-labeled red blood cells in the ischemic region. This technique also provides a simple noninvasive means for instantly labeling the systemic circulation without left heart catheterization.

Animals↗
PubMed2004

Trapping radioactive carbon dioxide during cellular metabolic assays under standard culture conditions: description of a unique gas-capturing device.

Measurement of carbon dioxide levels has been employed to follow cellular metabolic reactions for quite some time. By radio-labeling substrate molecules and evaluating the radioactivity levels of the carbon dioxide released, insight into metabolic pathways can be gleaned. Currently, no carbon dioxide capturing device is available that can be used with large volume cell monolayers growing under standard conditions within a regular commercially available culture flask. In this note we describe a simple device for collecting radio-labeled carbon dioxide from a standard culture flask. The device is independent of the culture flask, but can be attached for metabolic measurements allowing cells to be grown under standard conditions prior to study. The presented design permits convenient transfer of the device between flasks without contaminating or disturbing cells growing within the flasks. Data are presented demonstrating the reproducibility of measurements made with multiple devices with different substrate concentrations and varying periods of time, ranging up to 3 h.

Biophysics↗